miRTarBase - #MIRT572598


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pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PAPLN   
Synonyms -
Description papilin, proteoglycan like sulfated glycoprotein
Transcript NM_173462   
Expression
Putative miRNA Targets on PAPLN
3'UTR of PAPLN
(miRNA target sites are highlighted)		 
>PAPLN|NM_173462|3'UTR
   1 GGATGAAGGCTAGTTCCAGCCCCAGTCCAAAATAGTTCATAGGGCTAGGGAGAAAGGAAGATGGACTCTTGGCTTCCTCT
  81 CTCTGGCTGGCAAAGGGAGTTATCTTCTGGAATACATTAGCTCTTTCAAAAACCCACCCAGTGTTTAGCCTCAACGGCAG
 161 CCAGTTACCAGCTTCTCTCTGTAGCCTTCAGCAGTGTTTGCATCTCTGACATAACCACAGGCTGCTGTTTTCAAGAAGAG
 241 CAATCTGTTTGGATAAGAAAAACCTTTACTTTACAGCTTCCCTTTATAATTTGTTACACAGGAATAGTTAAATGCATTTG
 321 TTTGTTTGTTTTTTGAGACAGAGTTTCACTCTTGTTGCCCAGGCTGGAGGGCAATGGCGCGATCTCAGCTCACTGCAACC
 401 TCCGTCTCCTGGGTTCTTGATTCTCCTGTGTCAGCCTTCTGAGTAGCTAGGATTACAGATGCCTATCACCATGCCTGGGT
 481 AATTTTTGTATTTTTAGTTGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTTCTGACCTCAGATGATCTGC
 561 CCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCATCAATGCATTTTTTTTATTTTTTT
 641 TTTGAGACAGAGTTTCGCACTTCTTGCCCAGGCTGGAGTACAATGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCTG
 721 GGTTCAAGCGCTTCTCCAGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTATGTGCCACCATGCCTGGCTAATTTTGTA
 801 TTTTTAGTAGAGACGGGGTTTCTCCATGTTGGTCAGACTGGTCTTGAACTCCCGACCTCAGGTAATCCGCCCGCCTCGGC
 881 CTCCCAAAATGCTGGGATTAGAGGTGTGAGCCACTGTGCCCAGCCCATCAATGTGTTTTAAAGCTAGCTGTCAGGGTTCC
 961 ACTTAATTTAAAGCTGGGCAGGGAGATGTGTAATGATTTCAAAGTTAACACCTGTTTGTTTTCTAAAGGGCATGCCAAGT
1041 CCTGCTGTATCAGGGAAGTATTCTGTGCTAAAATCAGCGATGGTTCATTGCTCTAGTCTCTCTCACCCTTCTAGGCAGTG
1121 CATCAGTCAGCTCTAAATCTGGTGCAGAGGGTTAACAGCATAACCCTTGTTGGCAAAATGGAATAGATGTTAAGACCTCA
1201 AATAGGGATTTGGGATGAAACAGCTGCAGTTAGCACTGTTATCTGAGCATGAAAGAACTGGAAACGCTCCTTACGTCGAG
1281 ATGTTGGACCTTGAAGCCCTCCTGAGGCCAACATGCAAATCTGGCTGTGACGGTTCATCTGACACCTGTGTAAAGCTGAC
1361 CAGCCTGCTCTGTACAGTGACAATGAGGAGCCCCTCTCTTCCTTAAGTAGGAATCTGTGAAGCAAAATGTTTGCTGCCAA
1441 AGACAAATCAGACTGTCAGTCATTAAAAACAGCATTAGCAGGATGAGGATAGCAATGGGGAAGGGTTGTGGGCAATGCAG
1521 TAACAGGGAAATGGCTTCAGAAATGGTTTGAGTTGGAAGACAACATTCTTCATCTCTCAGGACTTCTAATTCCTTGATGC
1601 TAAAAGAAGAGGCATGGATTCTATGAGCTTCCAAGTCCCTTTCCACTTTAACCTTCTACAAATCTTTCAGAGGACTGCCT
1681 AGTAGCAAAGGTTATTCCTGGACACAGGAAAGACGGGCATTACAGGGACCAAAGCTCTGAAAGGTGACTTTTATTACCAA
1761 CACACTGGCTGGAAAAGGGACAAACCACATCACGGGTGAGTGATACTTCTCAGTCTTCTCTACTCATTCAACAAAGGAAA
1841 TGTGGGCTGGGGCAGAGGTCTTTTTTCATTTAATACTGGAAAAATATTGAAGAGCATCCATGTTCACTTATGGCTGGTTT
1921 TGCTATAGAAATTGGAAAATAAAGGCCACTTTTTTGAAATCCCCAGTTTAATTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUCGAUUGUUA--UGUGACGGa 5'
            ||||| :||:|  :|||||:: 
Target 5' aaCAGCT-GCAGTTAGCACTGTTa 3'
 1219 - 1241 133.00 -16.40
2 
miRNA  3' cggucGAUUGUUAUGUGACGGa 5'
               :|| ||| |||||| | 
Target 5' ttttaTTACCAACACACTGGCt 3'
 1749 - 1770 133.00 -12.30
3 
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            |||| :|:::| ||:|||: 
Target 5' atCAGC-GATGGTTCATTGCTc 3'
 1073 - 1093 131.00 -14.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30109667 21 COSMIC
COSN30494442 50 COSMIC
COSN31485237 77 COSMIC
COSN30154848 117 COSMIC
COSN21998684 217 COSMIC
COSN28040627 246 COSMIC
COSN30167212 251 COSMIC
COSN31893591 644 COSMIC
COSN9617786 662 COSMIC
COSN28384677 871 COSMIC
COSN28387037 872 COSMIC
COSN24467091 969 COSMIC
COSN19354059 1153 COSMIC
COSN25391799 1270 COSMIC
COSN29920628 1702 COSMIC
COSN21851901 1812 COSMIC
rs113554206 879 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs961378385 3 dbSNP
rs773035865 5 dbSNP
rs1028202034 6 dbSNP
rs1340073713 9 dbSNP
rs1242962212 10 dbSNP
rs1267301354 17 dbSNP
rs754589209 20 dbSNP
rs760378880 20 dbSNP
rs766330136 21 dbSNP
rs776560027 24 dbSNP
rs1267456815 28 dbSNP
rs759408559 31 dbSNP
rs1188009642 37 dbSNP
rs544361720 41 dbSNP
rs776697554 43 dbSNP
rs1475493436 57 dbSNP
rs913602633 62 dbSNP
rs1403825054 69 dbSNP
rs562926494 72 dbSNP
rs148035618 73 dbSNP
rs548121873 78 dbSNP
rs759175651 80 dbSNP
rs1408095547 86 dbSNP
rs1422458942 87 dbSNP
rs1380285177 94 dbSNP
rs371605631 103 dbSNP
rs925698295 105 dbSNP
rs1293790826 116 dbSNP
rs935793093 118 dbSNP
rs981716038 121 dbSNP
rs1228258711 128 dbSNP
rs140969435 130 dbSNP
rs1322067006 140 dbSNP
rs1156952517 142 dbSNP
rs878978376 143 dbSNP
rs187654744 147 dbSNP
rs567217942 156 dbSNP
rs1008582108 157 dbSNP
rs1489957846 163 dbSNP
rs1264277146 170 dbSNP
rs1222726778 171 dbSNP
rs1462967474 171 dbSNP
rs1258454117 178 dbSNP
rs1040676368 180 dbSNP
rs931437076 182 dbSNP
rs1282551396 190 dbSNP
rs551925045 191 dbSNP
rs900442728 205 dbSNP
rs1004228143 211 dbSNP
rs1260673739 217 dbSNP
rs1384474843 219 dbSNP
rs570469829 219 dbSNP
rs17781907 221 dbSNP
rs551257947 233 dbSNP
rs1011133110 239 dbSNP
rs1426530033 241 dbSNP
rs1479811967 243 dbSNP
rs1431871333 249 dbSNP
rs887610696 253 dbSNP
rs752167574 254 dbSNP
rs1259164039 256 dbSNP
rs1177122599 264 dbSNP
rs1431352137 265 dbSNP
rs374433238 268 dbSNP
rs1262477178 271 dbSNP
rs1221589800 283 dbSNP
rs1325533849 289 dbSNP
rs1288014273 295 dbSNP
rs1384529434 298 dbSNP
rs568088157 300 dbSNP
rs1020716567 302 dbSNP
rs1300137962 303 dbSNP
rs543451326 317 dbSNP
rs5809610 317 dbSNP
rs966891366 317 dbSNP
rs1015700996 324 dbSNP
rs1222948734 327 dbSNP
rs1284557509 333 dbSNP
rs1468720121 340 dbSNP
rs961347499 343 dbSNP
rs992868145 344 dbSNP
rs1034685557 352 dbSNP
rs1475285658 353 dbSNP
rs959023313 354 dbSNP
rs535400007 361 dbSNP
rs555304357 363 dbSNP
rs1242014505 367 dbSNP
rs1237350393 371 dbSNP
rs1260466270 372 dbSNP
rs1486004322 375 dbSNP
rs1024965758 377 dbSNP
rs970371029 379 dbSNP
rs1266292621 380 dbSNP
rs150217236 381 dbSNP
rs931515062 382 dbSNP
rs1229852584 383 dbSNP
rs1270984813 387 dbSNP
rs1366137334 395 dbSNP
rs926088851 396 dbSNP
rs192141339 403 dbSNP
rs781732033 404 dbSNP
rs559227171 405 dbSNP
rs1450469671 406 dbSNP
rs1417159971 416 dbSNP
rs936184650 419 dbSNP
rs988496604 424 dbSNP
rs913006304 431 dbSNP
rs11622792 432 dbSNP
rs1394757190 448 dbSNP
rs1040071790 449 dbSNP
rs1364107576 469 dbSNP
rs900413818 472 dbSNP
rs544745288 474 dbSNP
rs868277430 477 dbSNP
rs1455129411 484 dbSNP
rs544740324 486 dbSNP
rs1384151099 488 dbSNP
rs1181227924 493 dbSNP
rs562834739 500 dbSNP
rs1238047044 514 dbSNP
rs138913783 515 dbSNP
rs187925825 518 dbSNP
rs1303774789 520 dbSNP
rs1274880020 536 dbSNP
rs560038056 536 dbSNP
rs1370403786 539 dbSNP
rs1390122235 541 dbSNP
rs1004739286 543 dbSNP
rs1385048821 545 dbSNP
rs1306887941 549 dbSNP
rs1317941713 553 dbSNP
rs1334466860 554 dbSNP
rs193217669 554 dbSNP
rs932602188 556 dbSNP
rs184425671 562 dbSNP
rs1364634206 563 dbSNP
rs11849947 564 dbSNP
rs1222595661 570 dbSNP
rs575938858 577 dbSNP
rs1024350304 579 dbSNP
rs970466766 584 dbSNP
rs1270359563 586 dbSNP
rs1010812341 598 dbSNP
rs764600490 599 dbSNP
rs549856769 608 dbSNP
rs752281228 609 dbSNP
rs189358741 611 dbSNP
rs192779101 612 dbSNP
rs1490124758 614 dbSNP
rs1268502015 619 dbSNP
rs959032474 621 dbSNP
rs1181511976 624 dbSNP
rs990419876 625 dbSNP
rs1223227477 629 dbSNP
rs201209580 632 dbSNP
rs553764746 632 dbSNP
rs1345239237 633 dbSNP
rs56390227 633 dbSNP
rs1039208308 634 dbSNP
rs1317021991 634 dbSNP
rs1398391193 634 dbSNP
rs369636238 634 dbSNP
rs58861559 634 dbSNP
rs1351739218 635 dbSNP
rs1410160835 638 dbSNP
rs183966632 646 dbSNP
rs1480017809 647 dbSNP
rs1426973257 649 dbSNP
rs748261475 657 dbSNP
rs1298177939 658 dbSNP
rs1247454932 660 dbSNP
rs146312698 669 dbSNP
rs1215226712 683 dbSNP
rs953103164 684 dbSNP
rs577409901 687 dbSNP
rs189129302 690 dbSNP
rs988967313 691 dbSNP
rs569045770 697 dbSNP
rs1281807444 701 dbSNP
rs1221227901 703 dbSNP
rs1367880120 709 dbSNP
rs760469223 715 dbSNP
rs940139006 716 dbSNP
rs1346433521 717 dbSNP
rs1320583145 718 dbSNP
rs181566141 730 dbSNP
rs944509422 731 dbSNP
rs1381620488 733 dbSNP
rs1433545673 745 dbSNP
rs770814329 755 dbSNP
rs1291546129 761 dbSNP
rs1474493815 764 dbSNP
rs1250001891 781 dbSNP
rs1209393783 782 dbSNP
rs921578584 784 dbSNP
rs1409441016 789 dbSNP
rs1212750993 794 dbSNP
rs931656075 797 dbSNP
rs1313118300 799 dbSNP
rs1212466576 803 dbSNP
rs2003632 815 dbSNP
rs932651880 828 dbSNP
rs1203201492 829 dbSNP
rs1050219612 831 dbSNP
rs1304511807 832 dbSNP
rs1466392904 834 dbSNP
rs1353681541 837 dbSNP
rs1167993466 838 dbSNP
rs887720243 841 dbSNP
rs1251876899 843 dbSNP
rs574813082 845 dbSNP
rs933470332 849 dbSNP
rs541836875 854 dbSNP
rs560150247 855 dbSNP
rs1052050090 856 dbSNP
rs1189309596 858 dbSNP
rs1444070534 863 dbSNP
rs897230555 869 dbSNP
rs1242254470 870 dbSNP
rs1014302721 873 dbSNP
rs866571268 874 dbSNP
rs781006104 875 dbSNP
rs750623048 876 dbSNP
rs893790086 877 dbSNP
rs1046245260 878 dbSNP
rs113554206 879 dbSNP
rs1042298161 880 dbSNP
rs1001513413 881 dbSNP
rs1356599670 888 dbSNP
rs149641102 889 dbSNP
rs564183903 891 dbSNP
rs1010355261 893 dbSNP
rs1169762428 896 dbSNP
rs1411368163 897 dbSNP
rs1372701639 909 dbSNP
rs1020410488 911 dbSNP
rs762554534 925 dbSNP
rs1383486291 926 dbSNP
rs1166952883 928 dbSNP
rs1424907277 938 dbSNP
rs1250364600 955 dbSNP
rs762926598 963 dbSNP
rs1484240355 964 dbSNP
rs1056158275 975 dbSNP
rs531535632 980 dbSNP
rs763443785 983 dbSNP
rs115164075 986 dbSNP
rs1244797792 993 dbSNP
rs190454347 1001 dbSNP
rs1304765614 1004 dbSNP
rs1198348685 1010 dbSNP
rs1453790910 1012 dbSNP
rs1230072930 1015 dbSNP
rs1350863103 1016 dbSNP
rs756576241 1030 dbSNP
rs1285657767 1031 dbSNP
rs1359410444 1036 dbSNP
rs370141997 1040 dbSNP
rs1404602713 1042 dbSNP
rs1388763253 1054 dbSNP
rs1027756005 1064 dbSNP
rs1458465767 1065 dbSNP
rs1363796621 1073 dbSNP
rs1295590804 1079 dbSNP
rs144316306 1080 dbSNP
rs1201747855 1088 dbSNP
rs1473802989 1097 dbSNP
rs374855805 1097 dbSNP
rs1006226633 1104 dbSNP
rs1199096884 1105 dbSNP
rs953008602 1106 dbSNP
rs984487028 1111 dbSNP
rs1268951496 1116 dbSNP
rs1209975081 1117 dbSNP
rs1485255967 1119 dbSNP
rs1461654708 1126 dbSNP
rs1211958258 1134 dbSNP
rs1015809816 1143 dbSNP
rs909121350 1147 dbSNP
rs976889762 1151 dbSNP
rs922753420 1152 dbSNP
rs954134611 1157 dbSNP
rs940628266 1158 dbSNP
rs1329630850 1159 dbSNP
rs1303677036 1162 dbSNP
rs1036284902 1170 dbSNP
rs779959008 1170 dbSNP
rs1186039902 1171 dbSNP
rs1384322877 1175 dbSNP
rs1420252628 1181 dbSNP
rs565724464 1185 dbSNP
rs1389930385 1189 dbSNP
rs539432989 1193 dbSNP
rs985560784 1203 dbSNP
rs1477237010 1205 dbSNP
rs949260404 1207 dbSNP
rs1045796418 1214 dbSNP
rs1199091745 1222 dbSNP
rs182276861 1227 dbSNP
rs1427507178 1232 dbSNP
rs1245702674 1237 dbSNP
rs905971758 1259 dbSNP
rs1465302019 1263 dbSNP
rs1001482288 1266 dbSNP
rs1201612632 1267 dbSNP
rs1054423096 1275 dbSNP
rs571013136 1276 dbSNP
rs932256 1278 dbSNP
rs1020967754 1279 dbSNP
rs556447106 1281 dbSNP
rs1366631828 1286 dbSNP
rs574676810 1292 dbSNP
rs755349503 1303 dbSNP
rs779312400 1304 dbSNP
rs966215541 1305 dbSNP
rs1056254457 1310 dbSNP
rs35506154 1311 dbSNP
rs1461178494 1328 dbSNP
rs772204338 1332 dbSNP
rs1012445208 1333 dbSNP
rs1449543284 1341 dbSNP
rs190990831 1346 dbSNP
rs1185306665 1352 dbSNP
rs1444022478 1360 dbSNP
rs984452909 1361 dbSNP
rs1194945478 1362 dbSNP
rs777699460 1387 dbSNP
rs1272737428 1394 dbSNP
rs183210767 1397 dbSNP
rs1315380134 1398 dbSNP
rs1016273468 1406 dbSNP
rs545831271 1411 dbSNP
rs1342717199 1427 dbSNP
rs1335290558 1428 dbSNP
rs971981334 1434 dbSNP
rs1368393144 1439 dbSNP
rs917850334 1446 dbSNP
rs1429893002 1448 dbSNP
rs949233950 1480 dbSNP
rs1160905847 1490 dbSNP
rs564426650 1491 dbSNP
rs927396708 1493 dbSNP
rs937385788 1494 dbSNP
rs1489347951 1497 dbSNP
rs185709224 1507 dbSNP
rs1249940921 1511 dbSNP
rs1207532085 1513 dbSNP
rs1483476166 1517 dbSNP
rs893108795 1523 dbSNP
rs1289251610 1526 dbSNP
rs35084104 1526 dbSNP
rs954184895 1534 dbSNP
rs1359147271 1535 dbSNP
rs1197341779 1541 dbSNP
rs1268814118 1560 dbSNP
rs757741319 1563 dbSNP
rs751270308 1588 dbSNP
rs1238836391 1591 dbSNP
rs1348997969 1592 dbSNP
rs946071010 1599 dbSNP
rs1364492756 1602 dbSNP
rs1321023993 1604 dbSNP
rs1174707715 1607 dbSNP
rs543683517 1609 dbSNP
rs902124463 1626 dbSNP
rs1391442260 1660 dbSNP
rs1406176599 1682 dbSNP
rs985955162 1683 dbSNP
rs561758854 1699 dbSNP
rs1182549042 1700 dbSNP
rs1473050066 1701 dbSNP
rs1246332392 1706 dbSNP
rs915289711 1708 dbSNP
rs997689961 1709 dbSNP
rs529095744 1715 dbSNP
rs190076580 1716 dbSNP
rs1291289888 1721 dbSNP
rs1402574944 1728 dbSNP
rs1327654607 1730 dbSNP
rs1290601364 1731 dbSNP
rs1344535102 1733 dbSNP
rs1301921736 1734 dbSNP
rs769537336 1739 dbSNP
rs1016036443 1761 dbSNP
rs1346109767 1762 dbSNP
rs1438037425 1765 dbSNP
rs1438465258 1767 dbSNP
rs961686227 1769 dbSNP
rs559452412 1773 dbSNP
rs1316956598 1778 dbSNP
rs972168112 1789 dbSNP
rs532964043 1791 dbSNP
rs866548693 1794 dbSNP
rs1224123999 1795 dbSNP
rs1469098248 1797 dbSNP
rs1056306241 1799 dbSNP
rs1189674230 1806 dbSNP
rs1479102549 1808 dbSNP
rs971091921 1813 dbSNP
rs1187935483 1814 dbSNP
rs1047849 1815 dbSNP
rs1220354877 1816 dbSNP
rs1270555537 1818 dbSNP
rs1203731187 1821 dbSNP
rs947875906 1827 dbSNP
rs372928095 1833 dbSNP
rs1311941616 1840 dbSNP
rs1049305491 1841 dbSNP
rs936519399 1841 dbSNP
rs990168614 1842 dbSNP
rs1452714700 1843 dbSNP
rs887508723 1851 dbSNP
rs1296246296 1854 dbSNP
rs940422681 1860 dbSNP
rs1036053807 1861 dbSNP
rs914683981 1866 dbSNP
rs998473119 1879 dbSNP
rs567230233 1880 dbSNP
rs762502333 1882 dbSNP
rs796114427 1888 dbSNP
rs1042147476 1890 dbSNP
rs889953689 1891 dbSNP
rs571143430 1892 dbSNP
rs1250482721 1900 dbSNP
rs534579544 1910 dbSNP
rs773703278 1914 dbSNP
rs1483180780 1918 dbSNP
rs1032399395 1919 dbSNP
rs933529453 1927 dbSNP
rs538190859 1933 dbSNP
rs1422321887 1941 dbSNP
rs1273460277 1946 dbSNP
rs889260419 1948 dbSNP
rs1297634739 1949 dbSNP
rs1227704961 1956 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000381166.3 | 3UTR | AGCCCAGGUUGAGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.829 2.3e-4 -0.879 3.8e-5 13 Click to see details
GSE28544 Breast cancer -0.46 1.2e-2 -0.482 8.5e-3 24 Click to see details
GSE19783 ER- ER- breast cancer -0.194 4.3e-2 -0.202 3.7e-2 79 Click to see details
GSE42095 Differentiated embryonic stem cells -0.328 6.3e-2 -0.437 1.9e-2 23 Click to see details
GSE38226 Liver fibrosis -0.344 6.3e-2 0.061 4.0e-1 21 Click to see details
GSE14794 Lymphoblastoid cells 0.15 7.9e-2 0.167 5.8e-2 90 Click to see details
GSE27834 Pluripotent stem cells -0.315 1.2e-1 -0.071 4.0e-1 16 Click to see details
GSE32688 Pancreatic cancer 0.194 1.4e-1 0.224 1.1e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells -0.204 1.7e-1 -0.235 1.3e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.178 2.0e-1 0.056 4.0e-1 25 Click to see details
GSE19536 Breast cancer -0.083 2.1e-1 -0.121 1.2e-1 100 Click to see details
GSE21687 Ependynoma primary tumors 0.1 2.2e-1 -0.014 4.6e-1 64 Click to see details
GSE19350 CNS germ cell tumors -0.2 2.7e-1 0.070 4.1e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.104 3.3e-1 0.063 4.0e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer 0.095 3.5e-1 0.084 3.6e-1 20 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.155 3.6e-1 -0.071 4.3e-1 8 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.077 3.6e-1 -0.185 1.9e-1 25 Click to see details
GSE21849 B cell lymphoma -0.067 3.6e-1 -0.029 4.4e-1 29 Click to see details
GSE17306 Multiple myeloma -0.007 4.8e-1 0.076 3.0e-1 49 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.446 0.13 -0.429 0.14 8 Click to see details
LUSC -0.626 0.19 -0.600 0.2 4 Click to see details
BRCA 0.468 0.27 0.200 0.4 4 Click to see details
THCA -0.443 0.35 -0.500 0.33 3 Click to see details
THCA -0.443 0.35 -0.500 0.33 3 Click to see details
THCA -0.443 0.35 -0.500 0.33 3 Click to see details
THCA -0.443 0.35 -0.500 0.33 3 Click to see details
THCA -0.443 0.35 -0.500 0.33 3 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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