pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF277   
Synonyms NRIF4, ZNF277P
Description zinc finger protein 277
Transcript NM_021994   
Expression
Putative miRNA Targets on ZNF277
3'UTR of ZNF277
(miRNA target sites are highlighted)
>ZNF277|NM_021994|3'UTR
   1 GAGTACTTGAAAACCTAGAAGAAACTACCACAGAAGCAATTTTTCATGTTTTTCTCCTATGAGACAGATATGAAAGAACA
  81 ATTTAAATTTGAACATCAACAAAAGATTGGTCCTTGGTGAAATAAACTTTTCAAAAATGAATGTTCTTTTCAAAAAATAA
 161 AGTAGAAAAATGCACTTACTAAGAACATGAAAAAAAATGAAGTAGGAAAATAAGATGAAGACTTTGTATTTTGGCTGTAA
 241 AGTTTTATTGTGTGATCATCTTAAATTATCTCACTTCATTAAACTCATAATTATATATAGAAGTATATGTCAATTACAAA
 321 GAAATGAAATGTTCAAATTATTTATAAACCTGATTTTTCAATCAGTAGTTTCAGTCTCCTCCCCAAGGACCTTCTTCATC
 401 CAACAAGTTGCAAAATTTGAATATCCCTTCTGTACTATATTGGGTGAGCTGTAAATGTAATGACTAAAAGAAAAGCCACA
 481 GAAGAAAGAAGAAATGGTCAAAGACGTGGATAATATGCAAATTGGCCATTATATTAGAACAATCAAGAGCTGACTGTGTT
 561 ATTACCACTTTCTGCCTAGGGTGGCCAAATTCCCTAGAAATAGACATCAAGCCAGTTAACTTCACTTTTCCCTGCAATTT
 641 GTATGTCACTAACATTTAAATGCCATTTTTTAAAAACATAACCACAATACCATTATGACACCTAAAAAACATTAACATTA
 721 ACTTAATATCATCTGTTTTCAGTTTTTCCCACTTGTCTCAAAATGTATGTTTACAATATTATCAGTTTCATTACTGATGA
 801 ATATTATATGCCTCCTGATAAGATGTACTGAGGAGGACAGAATATCACTTTTGTAGATTTATACCAAAAATGCATAATTT
 881 GGATATAATGAAGAAACAGTCAAATCCAAGTTTGAGGCTGGGCACAGTAGCTCATATCTGTAATCCCAGCACTTTGGGAG
 961 GCCAAGGCAGAGGATCACATGAGGTCAGGAGTTCAAGATCAGCCTGGCCAACGTGGCAAAACCCCATCTCTACGAAAAAT
1041 ACACAGATTAGCCAGGCATGGTGGAATGCACCTATAGTCCCAGCTACTTGGGAGGCTGAAGCACAAGAATCGCTTGAATC
1121 CAGGAGGCAAAAGTTGCAGTGAGCCGAGATCACACCACTGCAGTTCAGCCTGGGCAACAGACCAAGACTCTGTCTCAAAA
1201 AAAGG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuCCUCGUUCCGCCGUAGAGa 5'
            | :||||  |  |||||| 
Target 5' acGTGGCAAAACCCCATCTCt 3'
1011 - 1031 127.00 -11.00
2
miRNA  3' uuCCUCGUUCC--GCCGUAGAGa 5'
            | :|| :||  | |:| ||| 
Target 5' ttGAGGCTGGGCACAGTAGCTCa 3'
912 - 934 105.00 -9.00
3
miRNA  3' uuCCUC--GUUCCG-C-CGUAGAGa 5'
            ||||  |||||| | | ||| | 
Target 5' tgGGAGGCCAAGGCAGAGGATCACa 3'
955 - 979 105.00 -15.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20076221 9 COSMIC
COSN30448689 16 COSMIC
COSN29969564 22 COSMIC
COSN30179756 26 COSMIC
COSN28672238 31 COSMIC
COSN26678353 37 COSMIC
COSN30448338 58 COSMIC
COSN31572927 96 COSMIC
COSN31593609 111 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1404588876 6 dbSNP
rs1162519451 17 dbSNP
rs1222753383 18 dbSNP
rs1281315499 22 dbSNP
rs1319682179 27 dbSNP
rs192816480 29 dbSNP
rs764788865 30 dbSNP
rs1330187636 32 dbSNP
rs991231454 40 dbSNP
rs1022845777 45 dbSNP
rs1033556918 47 dbSNP
rs576349148 47 dbSNP
rs753756411 58 dbSNP
rs757208872 80 dbSNP
rs537058322 81 dbSNP
rs1434792970 82 dbSNP
rs138058026 94 dbSNP
rs1013174430 95 dbSNP
rs116672577 96 dbSNP
rs1379036278 100 dbSNP
rs987843681 101 dbSNP
rs1160906684 120 dbSNP
rs1441020054 123 dbSNP
rs911884396 125 dbSNP
rs576081517 128 dbSNP
rs1186224553 152 dbSNP
rs943495064 157 dbSNP
rs1257770269 162 dbSNP
rs1200851897 167 dbSNP
rs1296310443 174 dbSNP
rs977854476 175 dbSNP
rs1047547 184 dbSNP
rs1039075637 187 dbSNP
rs1218775695 190 dbSNP
rs925477118 190 dbSNP
rs1283713610 203 dbSNP
rs958228255 207 dbSNP
rs1274934466 208 dbSNP
rs1342510075 216 dbSNP
rs1313659313 222 dbSNP
rs541957008 223 dbSNP
rs562252874 244 dbSNP
rs922145281 251 dbSNP
rs1300424832 253 dbSNP
rs946858497 254 dbSNP
rs1042663564 256 dbSNP
rs902725994 262 dbSNP
rs1162149178 264 dbSNP
rs1471498480 269 dbSNP
rs1248375964 272 dbSNP
rs1369839498 280 dbSNP
rs998542707 285 dbSNP
rs1188147269 287 dbSNP
rs933322741 287 dbSNP
rs1047550 288 dbSNP
rs907853647 289 dbSNP
rs1388328196 298 dbSNP
rs1447563189 299 dbSNP
rs895482356 303 dbSNP
rs1012697126 305 dbSNP
rs1208166877 317 dbSNP
rs1037785312 326 dbSNP
rs1266278056 337 dbSNP
rs1218317569 338 dbSNP
rs1022691673 343 dbSNP
rs1451446489 344 dbSNP
rs898364454 345 dbSNP
rs931113320 351 dbSNP
rs1331061135 359 dbSNP
rs1322071079 362 dbSNP
rs963223912 365 dbSNP
rs1384905700 370 dbSNP
rs1392326383 391 dbSNP
rs758214147 405 dbSNP
rs1420992954 422 dbSNP
rs1172584526 426 dbSNP
rs560022312 431 dbSNP
rs1475596440 433 dbSNP
rs1196589429 436 dbSNP
rs895041697 436 dbSNP
rs973603894 437 dbSNP
rs1453243557 438 dbSNP
rs1013435552 441 dbSNP
rs1403926754 458 dbSNP
rs1316352770 462 dbSNP
rs1260170575 480 dbSNP
rs1215559963 482 dbSNP
rs1026238921 491 dbSNP
rs1047551 495 dbSNP
rs987402504 506 dbSNP
rs911915575 507 dbSNP
rs943361087 510 dbSNP
rs1445326622 511 dbSNP
rs1032050795 516 dbSNP
rs1319137749 519 dbSNP
rs1332907182 523 dbSNP
rs974812965 538 dbSNP
rs1362334994 541 dbSNP
rs958456782 542 dbSNP
rs1424260843 543 dbSNP
rs368964744 547 dbSNP
rs1355286575 550 dbSNP
rs1479004256 562 dbSNP
rs1226383928 565 dbSNP
rs1178110814 568 dbSNP
rs1029268408 572 dbSNP
rs1240290224 583 dbSNP
rs946907957 588 dbSNP
rs1205553289 589 dbSNP
rs1442029586 597 dbSNP
rs1042918897 604 dbSNP
rs1221283829 611 dbSNP
rs924127721 612 dbSNP
rs1349252652 628 dbSNP
rs747194676 636 dbSNP
rs564036260 638 dbSNP
rs1373948855 664 dbSNP
rs1246144653 672 dbSNP
rs895495280 673 dbSNP
rs1332764020 677 dbSNP
rs1442535375 679 dbSNP
rs1358210686 689 dbSNP
rs1332009200 692 dbSNP
rs1415896983 697 dbSNP
rs1376031458 708 dbSNP
rs940701743 708 dbSNP
rs1437728219 712 dbSNP
rs973900776 725 dbSNP
rs1177850744 729 dbSNP
rs1472626507 732 dbSNP
rs920659381 732 dbSNP
rs1212689517 759 dbSNP
rs931164166 760 dbSNP
rs1466293211 770 dbSNP
rs776752241 775 dbSNP
rs531290914 779 dbSNP
rs748659486 782 dbSNP
rs1189344954 785 dbSNP
rs1308600223 786 dbSNP
rs1044169659 790 dbSNP
rs894968204 792 dbSNP
rs772617299 795 dbSNP
rs549559581 799 dbSNP
rs1416419880 803 dbSNP
rs994587575 804 dbSNP
rs1026605823 807 dbSNP
rs1417860563 809 dbSNP
rs1362366793 816 dbSNP
rs1159944005 819 dbSNP
rs770328156 820 dbSNP
rs999167235 822 dbSNP
rs1183768201 824 dbSNP
rs1475645180 825 dbSNP
rs1262967358 830 dbSNP
rs185200941 831 dbSNP
rs1489588236 837 dbSNP
rs1032520786 843 dbSNP
rs1457064083 853 dbSNP
rs1009257164 860 dbSNP
rs1215883707 862 dbSNP
rs1320544003 865 dbSNP
rs773523458 868 dbSNP
rs995908616 875 dbSNP
rs1355695029 878 dbSNP
rs529187438 892 dbSNP
rs1277393779 899 dbSNP
rs763320253 900 dbSNP
rs1029196441 901 dbSNP
rs1289334943 904 dbSNP
rs1458355076 907 dbSNP
rs954852010 909 dbSNP
rs1166962580 914 dbSNP
rs547169758 925 dbSNP
rs1320707242 926 dbSNP
rs115344679 933 dbSNP
rs1423163709 940 dbSNP
rs1015140295 941 dbSNP
rs1478966871 948 dbSNP
rs376388455 962 dbSNP
rs190197861 964 dbSNP
rs1285623136 976 dbSNP
rs1379565258 982 dbSNP
rs760285975 985 dbSNP
rs1487775808 1002 dbSNP
rs1227614182 1007 dbSNP
rs564740107 1013 dbSNP
rs973402489 1014 dbSNP
rs920571629 1016 dbSNP
rs1256957427 1027 dbSNP
rs1216607400 1030 dbSNP
rs968573815 1034 dbSNP
rs1296000935 1035 dbSNP
rs1218617116 1038 dbSNP
rs1365399251 1048 dbSNP
rs1328069663 1061 dbSNP
rs570052876 1064 dbSNP
rs962047106 1068 dbSNP
rs537449163 1070 dbSNP
rs1329509859 1071 dbSNP
rs1209426195 1072 dbSNP
rs1374038326 1076 dbSNP
rs939524173 1078 dbSNP
rs1427801986 1079 dbSNP
rs916452682 1088 dbSNP
rs1468507237 1096 dbSNP
rs949182329 1108 dbSNP
rs1196425001 1110 dbSNP
rs1481392924 1112 dbSNP
rs544328604 1113 dbSNP
rs1232241021 1121 dbSNP
rs1440777153 1124 dbSNP
rs916793031 1137 dbSNP
rs1305445884 1140 dbSNP
rs34118662 1144 dbSNP
rs1189833000 1146 dbSNP
rs1238315464 1147 dbSNP
rs948373020 1159 dbSNP
rs574259588 1164 dbSNP
rs1393428637 1165 dbSNP
rs533681296 1170 dbSNP
rs1397469991 1188 dbSNP
rs935009744 1193 dbSNP
rs1464800519 1197 dbSNP
rs1180554318 1204 dbSNP
rs1313450426 1205 dbSNP
rs1174760541 1206 dbSNP
rs1182177754 1206 dbSNP
rs1250718735 1206 dbSNP
rs1439599636 1206 dbSNP
rs535344897 1206 dbSNP
rs58956925 1206 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000361822.3 | 3UTR | AAAAAAAAAAAAAAAAAAAAAAGUCUUUUUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

Error report submission