pre-miRNA Information | |
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pre-miRNA | hsa-mir-6751 |
Genomic Coordinates | chr11: 65129916 - 65129978 |
Description | Homo sapiens miR-6751 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-6751-3p | ||||||||||||||||||||||||||||||
Sequence | 43| ACUGAGCCUCUCUCUCUCCAG |63 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Meta-analysis | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TRIB1 | ||||||||||||||||||||
Synonyms | C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1 | ||||||||||||||||||||
Description | tribbles pseudokinase 1 | ||||||||||||||||||||
Transcript | NM_025195 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TRIB1 | |||||||||||||||||||||
3'UTR of TRIB1 (miRNA target sites are highlighted) |
>TRIB1|NM_025195|3'UTR 1 TCCCCAAAACCTCAGAAACCTCATAATTCTTAACACCTGGCATTTCCATTTCTAAAGATGGACAGGCCCTTTGGCGTGGT 81 ACCAACCAGATAATGACTGCATCAGGATGAAAGCTGCTGAACTCGGCATGGCGCCTCCTCTTCTCTGTTGGGATGAGTGA 161 CTTTATTGATTTGAGCAGCATATGCTGTGATTGGCTGCCCTGCAAATTTGTTTCCCTTAAGGAACCCTCACCAACTATCT 241 CTGCTGGATTTGGGAGTTCCGCATCTTTTGTGGAGGGCAGAGTATGGACATCTTACACCCGGTGGTCAAGTGTGTAATAA 321 ACTTGAGCATTCGAATGGGAGAAAAAGCAAATCGCACAATGACATATTTTGAGTAATAACCGTATTTTTCACAGGGTGAC 401 AAATTGGGCCAATAAATCTGCCATCTTTGAACTCATCTTTGGTGGCTAGACTGCTACGGCAGCTTCTCTGATGGGAAAGT 481 TCCTTTTTTGGCTTAACACTCACCCTTTCTTCACACTCACATTTACCAATGACTCTGCTCCGTTTTTGGAGCAGACTGTT 561 TTAAGTTGCTCAGGAGCCTGATGGAACCATGAACCGAGACTCTTCTCTGTTTCCTGCCAAGACCTCATCTGCACTAATGC 641 CTTCTCCCTGACCTTGACACTTCCCCCTTTAGCTATAAAAGCACTTACCAGCCGAACGTGGAACAGTATCACAAAAGATT 721 CCATCTCCCAACGATTTCAGAACTCTGAGCTCAGAGAGACTCCAGATTTTAAAAAATAATTTGAGTGCTTGGAAACTATT 801 AGCTTTTTAAGTTCCTTCCAAATATGTTAGTACCTACCCTTTACTTTTTCCCCAAGACCATCTCAGGGTGGAGCATTCTG 881 TCTAAGAGAAGAAAGATAAGGAGGCTCCCACCCACCTCTCCCAAGAGCAGACATTAAACATCTTTGTGCTTTGAAGAGAG 961 TGAATTTTGGATAGTCTTGTGATTCTCAGACTAACTTCCAGAATTATACTTTAACCCCTCCCAGATATGGTCCGCCTTTG 1041 GCATTGTGTGTACATCTGCAGTTTTGCATGGTGGGTTGTTAATATTTCAAATGTGTGGTTTATGAATACGTCTGTATAAT 1121 CGGCTTCTGGAGTGAAACAGCAAACCCCAAATCTTCAAAGTTGGAAGGAACTTTAAAAATCATCCGGTCCAATCTCTTTC 1201 CTCTTTCTGCCACCTCCCAAGGCAGAAATCCCCTCTTCAGCTTCTTTTGTAGGTGGGAATCCAGCCTCTGTTAGATATGT 1281 CCAGAGATGGAAACTCACTCCCCTACAAAAGATGGAGCTTAATGGAGAAATTGCAACTTTCATTAAAAAACAAATTCAGA 1361 TGAAATATCAGTAACTGTCTTGGACAGTGCTGAAATCAGGTGGTTAAACGGGTAAACAAAATATACTGTATTTTGAGAAA 1441 TGGCACAAAAACAGGCAGTCATCTTTAAGGGCTATGCCTAGGCAAACTACTAACATGCATTGTGAGAATGCCGTGTATAC 1521 CTCACGTACTGTGTACTTTGTACATATATTTTACCTTTTATACCTATGTTCGATTTTGTTTTGTTTTGTTTTGTTCTGGC 1601 TTTGAGGCTTGTTTTGTTGTCTGTGTCTGTCTGAATAACCTGCGTGTCTAAAACCACGTGAAATGTGAATGATTATTGGC 1681 AATATTACCTTGACAGAATCATGGGACTTTGAGAAGAGGGAGGACAGAGGCCTCTGTCGCACTAACGCTCTCGTGGTTGC 1761 TCGACTGTTGTATCTGTGATACATTATCCGACTAAGGACTCTGGGCTGGCAGGGCCTTCTGCCGGGAAAGCTAGAAACAC 1841 TAGGTTCTTCCTGTACATACGTGTATATATGTGAACAGTGAGATGGCCGTTTCTGACTTGTAGAGAAATTTTAATAAACC 1921 TGGTTTCGTAAATAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545213 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000311922.3 | 3UTR | CAACGAUUUCAGAACUCUGAGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT130738 | GATAD2B | GATA zinc finger domain containing 2B | ![]() |
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2 | 4 | ||||||
MIRT134924 | CCND2 | cyclin D2 | ![]() |
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2 | 2 | ||||||
MIRT273034 | ZBTB18 | zinc finger and BTB domain containing 18 | ![]() |
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2 | 2 | ||||||
MIRT276645 | KPNA3 | karyopherin subunit alpha 3 | ![]() |
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2 | 6 | ||||||
MIRT446531 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ![]() |
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2 | 2 | ||||||
MIRT456268 | TDRKH | tudor and KH domain containing | ![]() |
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2 | 12 | ||||||
MIRT494454 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 2 | ||||||
MIRT494965 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT496689 | KREMEN1 | kringle containing transmembrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT496697 | RGS11 | regulator of G protein signaling 11 | ![]() |
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2 | 2 | ||||||
MIRT504376 | IRF4 | interferon regulatory factor 4 | ![]() |
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2 | 6 | ||||||
MIRT510980 | PFN2 | profilin 2 | ![]() |
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2 | 6 | ||||||
MIRT512548 | MFN2 | mitofusin 2 | ![]() |
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2 | 6 | ||||||
MIRT513639 | TP53INP2 | tumor protein p53 inducible nuclear protein 2 | ![]() |
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2 | 2 | ||||||
MIRT514016 | CAMSAP1 | calmodulin regulated spectrin associated protein 1 | ![]() |
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2 | 4 | ||||||
MIRT514074 | MTRNR2L6 | MT-RNR2-like 6 | ![]() |
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2 | 2 | ||||||
MIRT515300 | C15orf38-AP3S2 | C15orf38-AP3S2 readthrough | ![]() |
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2 | 4 | ||||||
MIRT517285 | AP3S2 | adaptor related protein complex 3 sigma 2 subunit | ![]() |
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2 | 4 | ||||||
MIRT519075 | KCNK6 | potassium two pore domain channel subfamily K member 6 | ![]() |
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2 | 2 | ||||||
MIRT520779 | TCF23 | transcription factor 23 | ![]() |
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2 | 2 | ||||||
MIRT522485 | MFSD9 | major facilitator superfamily domain containing 9 | ![]() |
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2 | 2 | ||||||
MIRT528856 | PKP1 | plakophilin 1 | ![]() |
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2 | 2 | ||||||
MIRT529081 | PATE2 | prostate and testis expressed 2 | ![]() |
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2 | 2 | ||||||
MIRT531209 | PLA2G4D | phospholipase A2 group IVD | ![]() |
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2 | 2 | ||||||
MIRT533988 | TAB3 | TGF-beta activated kinase 1 and MAP3K7 binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT537024 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ![]() |
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2 | 2 | ||||||
MIRT537498 | FAM168B | family with sequence similarity 168 member B | ![]() |
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2 | 2 | ||||||
MIRT553125 | UBE2Z | ubiquitin conjugating enzyme E2 Z | ![]() |
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2 | 2 | ||||||
MIRT555591 | PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase type 1 gamma | ![]() |
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2 | 2 | ||||||
MIRT556370 | LUZP1 | leucine zipper protein 1 | ![]() |
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2 | 2 | ||||||
MIRT569745 | C2orf71 | chromosome 2 open reading frame 71 | ![]() |
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2 | 2 | ||||||
MIRT570149 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | ![]() |
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2 | 2 | ||||||
MIRT571243 | FADS6 | fatty acid desaturase 6 | ![]() |
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2 | 2 | ||||||
MIRT573065 | TRIB1 | tribbles pseudokinase 1 | ![]() |
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2 | 2 | ||||||
MIRT575533 | Map4 | microtubule-associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT575777 | Tnfrsf10b | tumor necrosis factor receptor superfamily, member 10b | ![]() |
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2 | 2 | ||||||
MIRT616558 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 2 | ||||||
MIRT624851 | ABI2 | abl interactor 2 | ![]() |
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2 | 2 | ||||||
MIRT630078 | GRWD1 | glutamate rich WD repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT631479 | KLHL21 | kelch like family member 21 | ![]() |
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2 | 2 | ||||||
MIRT632173 | CCL22 | C-C motif chemokine ligand 22 | ![]() |
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2 | 2 | ||||||
MIRT638397 | QSOX2 | quiescin sulfhydryl oxidase 2 | ![]() |
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2 | 4 | ||||||
MIRT641192 | ISG20L2 | interferon stimulated exonuclease gene 20 like 2 | ![]() |
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2 | 2 | ||||||
MIRT642562 | TEX9 | testis expressed 9 | ![]() |
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2 | 2 | ||||||
MIRT642935 | KRTAP5-9 | keratin associated protein 5-9 | ![]() |
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2 | 2 | ||||||
MIRT649703 | ZNF175 | zinc finger protein 175 | ![]() |
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2 | 2 | ||||||
MIRT650437 | CPXM2 | carboxypeptidase X, M14 family member 2 | ![]() |
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2 | 2 | ||||||
MIRT652113 | TRUB2 | TruB pseudouridine synthase family member 2 | ![]() |
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2 | 2 | ||||||
MIRT652273 | TOMM20 | translocase of outer mitochondrial membrane 20 | ![]() |
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2 | 2 | ||||||
MIRT655215 | PFKM | phosphofructokinase, muscle | ![]() |
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2 | 2 | ||||||
MIRT682778 | ZNF852 | zinc finger protein 852 | ![]() |
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2 | 2 | ||||||
MIRT683001 | MUC20 | mucin 20, cell surface associated | ![]() |
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2 | 2 | ||||||
MIRT684320 | GTF3C4 | general transcription factor IIIC subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT689435 | CYB561 | cytochrome b561 | ![]() |
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2 | 2 | ||||||
MIRT693847 | ZNF107 | zinc finger protein 107 | ![]() |
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2 | 2 | ||||||
MIRT696715 | TAX1BP3 | Tax1 binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT698597 | TEX261 | testis expressed 261 | ![]() |
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2 | 2 | ||||||
MIRT699973 | RREB1 | ras responsive element binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT703310 | GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | ![]() |
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2 | 2 | ||||||
MIRT706796 | RAI1 | retinoic acid induced 1 | ![]() |
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2 | 2 | ||||||
MIRT709004 | CD109 | CD109 molecule | ![]() |
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2 | 2 | ||||||
MIRT709181 | TBC1D10B | TBC1 domain family member 10B | ![]() |
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2 | 2 | ||||||
MIRT709835 | PAQR7 | progestin and adipoQ receptor family member 7 | ![]() |
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2 | 2 | ||||||
MIRT711627 | CORO1C | coronin 1C | ![]() |
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2 | 2 | ||||||
MIRT712634 | RNF103-CHMP3 | RNF103-CHMP3 readthrough | ![]() |
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2 | 2 | ||||||
MIRT713694 | CYB5R4 | cytochrome b5 reductase 4 | ![]() |
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2 | 2 | ||||||
MIRT713752 | SLC9A8 | solute carrier family 9 member A8 | ![]() |
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2 | 2 | ||||||
MIRT714908 | CHMP3 | charged multivesicular body protein 3 | ![]() |
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2 | 2 | ||||||
MIRT716371 | CBLL1 | Cbl proto-oncogene like 1 | ![]() |
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2 | 2 | ||||||
MIRT718303 | XPOT | exportin for tRNA | ![]() |
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2 | 2 | ||||||
MIRT718713 | ANKRD18A | ankyrin repeat domain 18A | ![]() |
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2 | 2 | ||||||
MIRT718740 | ATP9A | ATPase phospholipid transporting 9A (putative) | ![]() |
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2 | 2 | ||||||
MIRT719441 | NPTX2 | neuronal pentraxin 2 | ![]() |
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2 | 2 | ||||||
MIRT720896 | OTUD4 | OTU deubiquitinase 4 | ![]() |
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2 | 2 | ||||||
MIRT722448 | RXFP4 | relaxin/insulin like family peptide receptor 4 | ![]() |
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2 | 2 | ||||||
MIRT723882 | VKORC1 | vitamin K epoxide reductase complex subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT724586 | SYNJ2BP | synaptojanin 2 binding protein | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||
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