miRTarBase - #MIRT573291


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pre-miRNA Information
pre-miRNA hsa-mir-6819   
Genomic Coordinates chr22: 36286847 - 36286907
Description Homo sapiens miR-6819 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6819-3p
Sequence 41| AAGCCUCUGUCCCCACCCCAG |61
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1279530967 2 dbSNP
rs967579979 3 dbSNP
rs776891214 4 dbSNP
rs771166635 8 dbSNP
rs747037324 9 dbSNP
rs879248090 11 dbSNP
rs1485325191 12 dbSNP
rs778157316 16 dbSNP
Putative Targets

Gene Information
Gene Symbol DLX4   
Synonyms BP1, DLX7, DLX8, DLX9, OFC15
Description distal-less homeobox 4
Transcript NM_001934   
Other Transcripts NM_138281   
Expression
Putative miRNA Targets on DLX4
3'UTR of DLX4
(miRNA target sites are highlighted)		 
>DLX4|NM_001934|3'UTR
   1 ATCTGGGGAAGGGCGGGTCAGGCCCACAGCCTTCCTGCAAAGCCCAGGACCCAGGCAGTCCACCTGCACCCCTTCTGGGC
  81 TGGGAGGAAACCAGCTCCAGATGGGTTTTCTCTGGAGGACAAGCAGTTAGAGGAGAAAAAGGAATGGAGCAGAGCCTGTA
 161 CCCCTAACCCTAACAGCTAAATCAAGGACCTCAGCCTTATATAATCATTGTCCCCACCACTACCATGGACTGGACACCTT
 241 CACTCCAGCTGGACAAAGACTCTGGAGAGAGAGCCATTGGCTGGAGTTGAGACTGTCCCCAGAACCCTTGGTCTTGCCAC
 321 TCCCCCACTCCTTCTTCCCTCTCTCCCTTTCTCCTCTCCCTGCTTTCTTGAAAAGGACTGAATCGCCACTACAGCCTGGG
 401 TGCAAAATCAGCAAGAAACATTGAGTATTTTTTTTTCTTTGTATGCCTTTGGCCTTGCACAACCCATTTGTGAGCAAAAG
 481 CAGAAGTGGACCACCATCAGCTCCCACCCACCCAGCGATTTTTCCTTGGAGGTCAGCCCGTTACCCCCATAACTGATTTA
 561 CCTACTTACCATACTGGGAGGTAGAAGAGATGCAGAGAAATGTGGAATTTGTGGACCTATGGGTAATTTATGCTTTCCTC
 641 CTAAAAAAAAAAAAAAAGCCCTCTTTCCCACCCCCTCCCCATCTCCCCTTTTTGAATAGATAATGGATCCAATTATCCAT
 721 ATAATTCAATAGGTATTTATTGAGAGGCTCCCTTCTATTCCCCATCCCTAATCCCTAACGAACCCACGGGCACACACTTT
 801 TGGAAACCTGGTAAAGTAACACTTAGGGGGAAATGGGGACAAACTGGCTCTCTGGATTAGTGCGGGTATAGACACCCCCA
 881 AATAGGTGGGTAGGCCCATTGATTCAGCTCCTTGCAGCTGTCTCTGTTCAAAGGAACTGTGCAGATTTAGAACGAATTGG
 961 AGCTTGAGCTTCACACCACCAGCTTCCAGAGATTAAAGTTTGTACAAAACATTGCAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaccccaccccugUCUCCGAa 5'
                       ||||||| 
Target 5' taggtatttattgAGAGGCTc 3'
 730 - 750 140.00 -10.64
2 
miRNA  3' gaCCCCACCCCUGUCUCCGAa 5'
            ||  ||| | ||||| || 
Target 5' aaGGAATGGAG-CAGAGCCTg 3'
 139 - 158 126.00 -12.40
3 
miRNA  3' gaCCCC---ACCCCUGUCU--CCGAa 5'
            ||||   |||||||| |  |||| 
Target 5' agGGGGAAATGGGGACAAACTGGCTc 3'
 825 - 850 111.00 -25.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31496048 31 COSMIC
COSN30148508 35 COSMIC
COSN26258044 41 COSMIC
COSN31589796 75 COSMIC
COSN16035238 79 COSMIC
COSN2531061 93 COSMIC
COSN30101372 95 COSMIC
COSN31612642 118 COSMIC
COSN28201299 194 COSMIC
COSN5417296 259 COSMIC
COSN15668273 346 COSMIC
COSN8838133 396 COSMIC
COSN28201544 531 COSMIC
COSN22193805 541 COSMIC
COSN20114161 658 COSMIC
COSN32062179 658 COSMIC
COSN16268550 908 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1294604807 5 dbSNP
rs771071027 8 dbSNP
rs1236452221 9 dbSNP
rs779118657 12 dbSNP
rs746166227 13 dbSNP
rs1231406055 14 dbSNP
rs1288819494 15 dbSNP
rs192533761 15 dbSNP
rs371538328 16 dbSNP
rs1262499027 17 dbSNP
rs771379511 22 dbSNP
rs1204724080 28 dbSNP
rs758228230 32 dbSNP
rs772784016 34 dbSNP
rs762568207 36 dbSNP
rs766081374 37 dbSNP
rs1018570622 41 dbSNP
rs545074931 41 dbSNP
rs60243053 41 dbSNP
rs751257377 47 dbSNP
rs201620636 48 dbSNP
rs1260801479 51 dbSNP
rs767321711 52 dbSNP
rs1389838209 60 dbSNP
rs1222364214 68 dbSNP
rs1469290048 71 dbSNP
rs1361748457 79 dbSNP
rs578020355 80 dbSNP
rs534056261 88 dbSNP
rs1012671857 93 dbSNP
rs1251854268 100 dbSNP
rs745308063 102 dbSNP
rs1466242206 103 dbSNP
rs528700474 107 dbSNP
rs1348314918 113 dbSNP
rs982188522 116 dbSNP
rs924007689 124 dbSNP
rs774989979 125 dbSNP
rs1370251575 136 dbSNP
rs547446297 140 dbSNP
rs1058560 141 dbSNP
rs1252283370 143 dbSNP
rs766309171 164 dbSNP
rs1058561 174 dbSNP
rs983187143 195 dbSNP
rs1185749978 201 dbSNP
rs989655670 208 dbSNP
rs1399282239 221 dbSNP
rs915486477 223 dbSNP
rs574162987 224 dbSNP
rs1404830866 227 dbSNP
rs932214028 231 dbSNP
rs1050532650 238 dbSNP
rs908885820 254 dbSNP
rs1191257619 255 dbSNP
rs1417034856 274 dbSNP
rs941739431 288 dbSNP
rs979731593 295 dbSNP
rs1445006854 297 dbSNP
rs748762957 299 dbSNP
rs911532838 300 dbSNP
rs944342857 305 dbSNP
rs1347502366 306 dbSNP
rs927243839 307 dbSNP
rs1278256617 309 dbSNP
rs1036138803 317 dbSNP
rs75953192 323 dbSNP
rs1270080582 324 dbSNP
rs1057380091 325 dbSNP
rs1429259187 327 dbSNP
rs142428478 328 dbSNP
rs1335337226 332 dbSNP
rs1048854963 340 dbSNP
rs946123730 346 dbSNP
rs1371578614 355 dbSNP
rs1171394528 356 dbSNP
rs1058562 358 dbSNP
rs904598354 359 dbSNP
rs1379057616 364 dbSNP
rs1229024814 367 dbSNP
rs1474424311 371 dbSNP
rs774477155 385 dbSNP
rs536246242 386 dbSNP
rs1485450757 388 dbSNP
rs901442853 389 dbSNP
rs1207591028 393 dbSNP
rs998418690 417 dbSNP
rs1031079060 428 dbSNP
rs201251660 428 dbSNP
rs956754002 430 dbSNP
rs1275562725 438 dbSNP
rs1483935994 442 dbSNP
rs990057695 443 dbSNP
rs1208433083 444 dbSNP
rs1256792534 446 dbSNP
rs1026240119 447 dbSNP
rs545056071 454 dbSNP
rs146419987 460 dbSNP
rs1058564 466 dbSNP
rs540770434 475 dbSNP
rs561129543 481 dbSNP
rs912134230 488 dbSNP
rs944387156 494 dbSNP
rs1165603454 496 dbSNP
rs1415415852 501 dbSNP
rs1427355349 505 dbSNP
rs1006131767 508 dbSNP
rs1016002582 513 dbSNP
rs1391601488 515 dbSNP
rs1432072169 516 dbSNP
rs1202568238 517 dbSNP
rs1453428768 518 dbSNP
rs1172153868 519 dbSNP
rs1274298163 521 dbSNP
rs1359162653 527 dbSNP
rs1449403299 535 dbSNP
rs971718752 537 dbSNP
rs1305051490 538 dbSNP
rs1359984972 540 dbSNP
rs1373668651 548 dbSNP
rs1278413646 550 dbSNP
rs1439346147 553 dbSNP
rs1396062365 556 dbSNP
rs184512405 563 dbSNP
rs1460865411 566 dbSNP
rs1298670832 571 dbSNP
rs1392017077 574 dbSNP
rs919010643 577 dbSNP
rs1344566397 581 dbSNP
rs963086192 588 dbSNP
rs1419858411 597 dbSNP
rs1407474011 603 dbSNP
rs930373920 605 dbSNP
rs1479014801 608 dbSNP
rs1253707305 609 dbSNP
rs1193552062 613 dbSNP
rs1049388734 614 dbSNP
rs1270389737 624 dbSNP
rs1217006136 625 dbSNP
rs1316731861 629 dbSNP
rs1312493983 637 dbSNP
rs1283062625 639 dbSNP
rs1212177534 640 dbSNP
rs1240241013 641 dbSNP
rs1451400440 642 dbSNP
rs11429140 643 dbSNP
rs1395763539 643 dbSNP
rs143029210 643 dbSNP
rs375951477 643 dbSNP
rs1464083492 644 dbSNP
rs1188619511 646 dbSNP
rs1249575935 647 dbSNP
rs1193132953 654 dbSNP
rs10677419 658 dbSNP
rs1366170235 659 dbSNP
rs1424922680 662 dbSNP
rs1453094469 670 dbSNP
rs949976355 671 dbSNP
rs1187646044 675 dbSNP
rs1485707260 676 dbSNP
rs980013172 677 dbSNP
rs1178912327 682 dbSNP
rs34108300 685 dbSNP
rs1343923202 689 dbSNP
rs1280373239 694 dbSNP
rs529896545 695 dbSNP
rs1297555396 707 dbSNP
rs926940015 711 dbSNP
rs948549548 714 dbSNP
rs537302995 721 dbSNP
rs1416822555 732 dbSNP
rs1376345354 736 dbSNP
rs1173271727 752 dbSNP
rs907127609 777 dbSNP
rs558596931 778 dbSNP
rs781061968 779 dbSNP
rs765565740 780 dbSNP
rs549645073 781 dbSNP
rs1428500091 784 dbSNP
rs1030926684 785 dbSNP
rs1184001151 785 dbSNP
rs4793623 788 dbSNP
rs1042897503 789 dbSNP
rs1438994961 793 dbSNP
rs752832805 796 dbSNP
rs1484372970 798 dbSNP
rs953599871 802 dbSNP
rs1228062376 806 dbSNP
rs942737597 808 dbSNP
rs147873124 811 dbSNP
rs551334219 814 dbSNP
rs901139114 817 dbSNP
rs749267871 818 dbSNP
rs1312430792 819 dbSNP
rs998846453 821 dbSNP
rs8066341 826 dbSNP
rs1208885021 835 dbSNP
rs887350162 838 dbSNP
rs1167782285 839 dbSNP
rs1466706538 841 dbSNP
rs1475703353 845 dbSNP
rs1197753893 849 dbSNP
rs1246888278 851 dbSNP
rs553418982 864 dbSNP
rs1017040442 865 dbSNP
rs1195924160 875 dbSNP
rs1406510671 875 dbSNP
rs1249505004 876 dbSNP
rs534259186 879 dbSNP
rs948621460 879 dbSNP
rs1472553838 887 dbSNP
rs1045502891 893 dbSNP
rs1231679507 897 dbSNP
rs1001212873 898 dbSNP
rs907137495 917 dbSNP
rs1307764565 920 dbSNP
rs1390949798 928 dbSNP
rs1394430937 935 dbSNP
rs1328450606 945 dbSNP
rs554013361 954 dbSNP
rs1052405118 955 dbSNP
rs1350666002 958 dbSNP
rs373728187 967 dbSNP
rs1185991627 968 dbSNP
rs1438420236 974 dbSNP
rs574637697 977 dbSNP
rs1456044602 1006 dbSNP
rs1011311250 1011 dbSNP
rs1182116698 1011 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000240306.3 | 3UTR | UUCAAUAGGUAUUUAUUGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-6819-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT358318 PANK3 pantothenate kinase 3 2 2
MIRT454719 UBQLNL ubiquilin like 2 2
MIRT471362 PEG10 paternally expressed 10 2 2
MIRT478101 DLG5 discs large MAGUK scaffold protein 5 2 4
MIRT495554 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT495587 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT508315 RPL18 ribosomal protein L18 2 4
MIRT529183 ADAM33 ADAM metallopeptidase domain 33 2 2
MIRT532035 FHDC1 FH2 domain containing 1 2 2
MIRT545131 ANXA5 annexin A5 2 2
MIRT567288 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT568094 CEBPG CCAAT/enhancer binding protein gamma 2 2
MIRT573291 DLX4 distal-less homeobox 4 2 2
MIRT575169 Fam120c family with sequence similarity 120, member C 2 2
MIRT609495 DNASE1L3 deoxyribonuclease 1 like 3 2 2
MIRT611264 EHD3 EH domain containing 3 2 2
MIRT613580 POC5 POC5 centriolar protein 2 2
MIRT616520 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT617098 ZNF667 zinc finger protein 667 2 2
MIRT618268 DDX51 DEAD-box helicase 51 2 2
MIRT618294 ZNF682 zinc finger protein 682 2 2
MIRT618617 SHOX short stature homeobox 2 2
MIRT619741 SRFBP1 serum response factor binding protein 1 2 2
MIRT619784 NRIP2 nuclear receptor interacting protein 2 2 2
MIRT621119 SP110 SP110 nuclear body protein 2 2
MIRT622530 RAD51 RAD51 recombinase 2 2
MIRT623088 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT623938 FKBP14 FK506 binding protein 14 2 2
MIRT624389 CD84 CD84 molecule 2 2
MIRT624860 ABI2 abl interactor 2 2 2
MIRT628752 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT632243 VTA1 vesicle trafficking 1 2 2
MIRT632987 E2F2 E2F transcription factor 2 2 2
MIRT633695 RBM43 RNA binding motif protein 43 2 2
MIRT633766 CENPBD1 CENPB DNA-binding domain containing 1 2 2
MIRT633808 ZNF91 zinc finger protein 91 2 2
MIRT638914 CBLN2 cerebellin 2 precursor 2 2
MIRT641298 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT642123 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT642179 HEBP2 heme binding protein 2 2 2
MIRT642617 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643325 TMEM151B transmembrane protein 151B 2 2
MIRT644534 TMEM134 transmembrane protein 134 2 2
MIRT645820 OMA1 OMA1 zinc metallopeptidase 2 2
MIRT646093 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646861 SLC35E4 solute carrier family 35 member E4 2 2
MIRT647466 DZIP1L DAZ interacting zinc finger protein 1 like 2 2
MIRT647702 NADSYN1 NAD synthetase 1 2 2
MIRT648082 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648547 TMEM169 transmembrane protein 169 2 2
MIRT648690 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT649747 GNB5 G protein subunit beta 5 2 2
MIRT650154 ZNF426 zinc finger protein 426 2 2
MIRT650450 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650943 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT651544 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT652304 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT652890 SYVN1 synoviolin 1 2 2
MIRT654222 RNF19B ring finger protein 19B 2 2
MIRT654676 PSMB5 proteasome subunit beta 5 2 2
MIRT658249 FAXC failed axon connections homolog 2 2
MIRT658363 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT659622 CELF1 CUGBP Elav-like family member 1 2 2
MIRT660171 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660634 ANKRD52 ankyrin repeat domain 52 2 2
MIRT662428 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT662984 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT663939 ZNF554 zinc finger protein 554 2 2
MIRT666960 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT667945 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT668847 CYCS cytochrome c, somatic 2 2
MIRT671792 RGS17 regulator of G protein signaling 17 2 2
MIRT672382 RPL37 ribosomal protein L37 2 2
MIRT673516 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT674716 FAM73A mitoguardin 1 2 2
MIRT676352 KLF8 Kruppel like factor 8 2 2
MIRT677820 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT678440 PDE4C phosphodiesterase 4C 2 2
MIRT678499 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT679243 LRP10 LDL receptor related protein 10 2 2
MIRT693607 SLC39A1 solute carrier family 39 member 1 2 2
MIRT695927 ZNF174 zinc finger protein 174 2 2
MIRT697987 TSPAN6 tetraspanin 6 2 2
MIRT700821 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701350 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT702348 KLHL7 kelch like family member 7 2 2
MIRT703387 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703883 ERBB2IP erbb2 interacting protein 2 2
MIRT708237 PPP1R26 protein phosphatase 1 regulatory subunit 26 2 2
MIRT708629 NUDT18 nudix hydrolase 18 2 2
MIRT708990 CABP4 calcium binding protein 4 2 2
MIRT709804 FOXE1 forkhead box E1 2 2
MIRT710203 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT710248 VAMP1 vesicle associated membrane protein 1 2 2
MIRT710281 FGF1 fibroblast growth factor 1 2 2
MIRT712992 IRGQ immunity related GTPase Q 2 2
MIRT713887 MOB3A MOB kinase activator 3A 2 2
MIRT715600 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT715639 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715686 FRK fyn related Src family tyrosine kinase 2 2
MIRT717053 WIZ widely interspaced zinc finger motifs 2 2
MIRT717611 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT721539 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722096 SUSD1 sushi domain containing 1 2 2
MIRT722435 HRNR hornerin 2 2
MIRT722855 NEGR1 neuronal growth regulator 1 2 2
MIRT724621 SNAP25 synaptosome associated protein 25 2 2
MIRT724777 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6819 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6819-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6819-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6819-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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