pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Gene Information
Gene Symbol Tpgs2   
Synonyms 5730437P09Rik, 5730494M16Rik, AI666318, Pgs2
Description tubulin polyglutamylase complex subunit 2
Transcript NM_001004361   
Other Transcripts NM_001142697 , NM_001142698   
Expression
Putative miRNA Targets on Tpgs2
3'UTR of Tpgs2
(miRNA target sites are highlighted)
>Tpgs2|NM_001004361|3'UTR
   1 GCATTCTATCACCTCAGTAATATCCAGACACAGATGGCCCTGTGGCAGCGGCATTCTCCTGAGAGACCAAAGCCTTAGGC
  81 CTTTGTTTCCACTGTCATTAGCTAGGGGCTGGGACGATCACACTGAATTCTCCTCAGGAGTTCCTTCCTCTGTAGGTTGT
 161 GACAACCTCATCTCCAAAGCCAACGAAGACTTTCAGATGTACCTGAGCTTTCTTATGTCTGTACCCAATCCTTAACTTCT
 241 TAGCAGTAATTAGAGAGGTCACCCTCCCAAATAAACCCATGGTTTGACTCATGAAGCATCAGTATCGACTAGTTATGTGA
 321 CCATCTCAGTTAATGAAAATTGCACACCTTCAGTTGCATTCACCACACTTCAGCTATGCACCTGATGGTAGAGTCCATAT
 401 TGGACAGCACAGAAAGGGGAAGGTTTTTGTCACAGAAGTGTTTTGGACAACATTGCATGTGAACACGTTCATACTGTCCT
 481 TCAGATACAATAACGTAATGCCTTAGTTTCATACGCTTTATGTTTTGAGAAAACATTTTCAAAGACAGTCTTGTGTTCTT
 561 TACAACCTAGACCAGGAATGCTTAAAGGTGTGATCCCTAGACTTAGAATTGTGCACCAAAGTCACTGGTATCATGTGGGG
 641 ATAAGATGATTGGATTCCAGTTCTGATCTGCAAAATAAGAATTTCCAAGAAAAATTCCAGGTGTCAGGGTTTTCTTTTTA
 721 AGACAAGGTCTCACTATATAGTTTAGGCTGACCTATAGCTCACACACCCTATATAGCTTCCTGACACACACACACACACC
 801 CTGTCACTAACGTTTTAATTACAGATGTACAGTATCATGCGTAACATTGGATTTTTAGTCAATTTAACAGTACTTCTGAG
 881 TTTGAAACTTTCAGCTTAAGATCTCAGTGGTTTCAAACCACAAAGTTTCTTTGTAATTGGGTAAAGCACGTATAACTTTT
 961 TTGTTTTTTTTTTTTTGTTTTTTTTTTTTTGAAACAGGGTTTTTCTGTGTAGTCCTGGCTGTCCTGGAACTCATGGAGTT
1041 GTGGCTGCTAAATGACTTAGTGCATAGAGTTAGTTATCCTGTCCTTCCTTTGTAATGTGACCCTACGGTTGCTAATTATG
1121 ACCTTCCTGCTAGCAGCTGTGATCTCTTAAGTCGTTCATTTTTTGCTTGCAAGACACCAGTTGGGTTCTCACTTGTGCCT
1201 TTATACCTGTCCTTTCCTTGTGAGGTTCAGCTCTAGTCTGCCTCTACTCAAAGCTCAGTGAAGCTCCAACTCCCCTAGGT
1281 GAGCAGTGATTTTTTTGTGCTTCTCCAGAAAGCCATCCTAATCAATTCTGCATTAACCCAAATAAATGTGTCATATTTTA
1361 GGGCAATAAATTAGAATGAATGAGTAAAGTTGTGAAAATGTTTAACTTTAAAAATTGAGAAGACAATAATTGCCTTATTT
1441 TAGAGTCTGGATATCTTTCACTCATCTTACGGTCTGTGTCACAAAACCATCAAAATGAAATAGGTTACACATGAAGCCAT
1521 GAATGCCACTGGTCTTTTCTGCACCCAGAAACTATGTTGTACCCAGATACTACCTAACTGGATATCCCACCAATAACTGT
1601 CTTGATAAGGCTCTAAAAGACCAAAAAGTAACTCGTGAGACATGGTGGGATGTGAAACTTCTTACCCTGTATCTAGGAAA
1681 AGTTCTTCAACACCATTGATGCTGTTTCTTCAGATGTAAAATGAAAATTTATGGAAGGGCTATAAAACTATTAAATAATG
1761 CAAATGGAGTACACATGGAGATGCTTTCAGTAAGCAACAGCTTTTAAAATAGCATTCAGAAAGTCCATTTTCTCCCCATG
1841 AATTACCTAACCAACAGAACCAATTGCTTTACCAGATGATTTTTTGACAAAATTGATTATTTTAACACCTATCTTTACTG
1921 TCTATTTCAAAGCCATTAGCTTTCTTATAAAATCGCAAAGACATTTCATTCCTGAAGCAATTTGGTACTTTTGTGGTGTA
2001 GTTACCTCTCTGATAAAATGATTTCTAATCAAAACTAGAAATAGCTAAAGAATGGGGGATAACTGAAATTTAATTGGATG
2081 ACAGCCTCCCACAGCTTCTGTTAGACCTCCTGAGGAGAAGGATCAAGGCTCTCATTTTCCCAACTGACCACCCAGCCCTG
2161 TCACAGAGCTACCTACAAACCTGGCCCTTAGTGCATAGTTTGTTCTACTGTGTTTTCAGGACCTGATGGCTTAATACACA
2241 TAAGTTTACCCGTGTGTATTTCTGCAGGCCAGAAGTTCAATGTCAGTTTTATAGAGCCAAAATCTAGTTGTCACTGGGCC
2321 AGGACTTGGGAGGCTCCTATAGAGTCTGTCCCTGCTTCCTCCTGCAGATTGTTGTTTGGGTTCATATCACTTCAGTCCTG
2401 TTGCTTTCACTTCGTCTTCTCTTTCTCCAAATCTCTTCTGACTGTCCTTTATAAGGACACTTATGATTGGATTTGAGGCA
2481 TGTCGGACACTACAGGATGATCTTCTCACACCTGCAAGGAATCCTTACAAAGGAATTGTACATTTCAGAGATTAGAACCG
2561 GAGGCCCCAGAGATGTTGAGTCAATGTATTACAGTAGTGTTTGCTACTTCACCATTTCAAGGGACTGTGGATATAAATGA
2641 TTGTTTTGAAGGCCATAACGGATCTATAAGCCACTTTAGAGCTGGGAAACTAAGCTGCCGTTTGTACCCCTGCTCATCTT
2721 CTCTACATTGTGTTCAACAATGAACCTTGAAGAAAATAAAACCCAGGTCTCCAGCCTTCCCCAGCCCCGTGCATGCGCAT
2801 TCTCCTTCACCCCCAATTCCTTTTGAGTAAGTTACTTGTTAAAATAAATCCTTAAGGTTCAAAACAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cacACGAGAGACCAGUUGGUAg 5'
             | | :| || ||||| || 
Target 5' ctcTACATTGTGTTCAACAATg 3'
2721 - 2742 127.00 -9.90
2
miRNA  3' caCACGAGAGACCAGUUGGuag 5'
            |||:|||:|   |||||   
Target 5' ttGTGTTCTTT--ACAACCtag 3'
551 - 570 124.00 -15.32
3
miRNA  3' caCACG-AGAGACCAGUUGGUAg 5'
            |||| ||||  |  |:|||| 
Target 5' ttGTGCTTCTCCAGAAAGCCATc 3'
1295 - 1317 120.00 -19.40
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hMSC
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP聽 data was present in GSM1013116. RNA binding protein: AGO. Condition:hMSC-replicate-5 ...

- Balakrishnan I; Yang X; Brown J; et al., 2014, Stem cells (Dayton, Ohio).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' caCACG-AGAGAC-CAGUUgguag 5'
            |||: | | ||  |:||     
Target 5' guGUGUGUGUGUGUUUUAA----- 3'
18 - 36
Article - Balakrishnan I; Yang X; Brown J; et al.
- Stem cells (Dayton, Ohio), 2014
Regulation of hematopoietic stem cell proliferation, lineage commitment, and differentiation in adult vertebrates requires extrinsic signals provided by cells in the marrow microenvironment (ME) located within the bone marrow. Both secreted and cell-surface bound factors critical to this regulation have been identified, yet control of their expression by cells within the ME has not been addressed. Herein we hypothesize that microRNAs (miRNAs) contribute to their controlled expression. MiRNAs are small noncoding RNAs that bind to target mRNAs and downregulate gene expression by either initiating mRNA degradation or preventing peptide translation. Testing the role of miRNAs in downregulating gene expression has been difficult since conventional techniques used to define miRNA-mRNA interactions are indirect and have high false-positive and negative rates. In this report, a genome-wide biochemical technique (high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation or HITS-CLIP) was used to generate unbiased genome-wide maps of miRNA-mRNA interactions in two critical cellular components of the marrow ME: marrow stromal cells and bone marrow endothelial cells. Analysis of these datasets identified miRNAs as direct regulators of JAG1, WNT5A, MMP2, and VEGFA; four factors that are important to ME function. Our results show the feasibility and utility of unbiased genome-wide biochemical techniques in dissecting the role of miRNAs in regulation of complex tissues such as the marrow ME.
LinkOut: [PMID: 24038734]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' caCACG-AGAGAC-CAGUUgguag 5'
            |||: | | ||  |:||     
Target 5' guGUGUGUGUGUGUUUUAA----- 3'
18 - 36
Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1015448
Method / RBP HITS-CLIP / AGO2
Cell line / Condition BCBL-1 / BCBL-1 mRNA
Location of target site ENST00000334295.4 | 3UTR | AAACGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22927820 / GSE41357
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000334295.4 | 3UTR | AAACGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUUAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1013116
Method / RBP HITS-CLIP  / AGO
Cell line / Condition hMSC / hMSC-replicate-5
Location of target site ENST00000334295.4 | 3UTR | UGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24038734 / GSE41272
CLIP-seq Viewer Link
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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