pre-miRNA Information | |
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pre-miRNA | hsa-mir-6751 |
Genomic Coordinates | chr11: 65129916 - 65129978 |
Description | Homo sapiens miR-6751 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-6751-3p | ||||||||||||||||||||||||||||||
Sequence | 43| ACUGAGCCUCUCUCUCUCCAG |63 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Meta-analysis | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Map4 | ||||||||||||||||||||
Synonyms | AA407148, MAP-4, Mtap-4, Mtap4 | ||||||||||||||||||||
Description | microtubule-associated protein 4 | ||||||||||||||||||||
Transcript | NM_008633 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Map4 | |||||||||||||||||||||
3'UTR of Map4 (miRNA target sites are highlighted) |
>Map4|NM_008633|3'UTR 1 GACCTACAGGCTGACGTTCCGGGCAAATGCCAGGGCCCGCACCGACCATGGGGCTGACATTGTCTCCCGGCCTCCCCACT 81 TCCCTGGTGGCCCAAGCTTGGGGTCTCGAGCCCTGGGCTCCTTTTCCCGGGCTGTCTACTAGACTTGTAAGCTCTTGGGT 161 GCTGGGCAGCCCCTTTAGGCCTCCCTCCCTCCTGCCTCGCTTGCTCAAGGCAGCAGCAGCCCCACTCGCTGCCATTACAC 241 CTCCTTCCACCCCTTTCTGGGCCAACTCCAACTTCACTATCTCACCACTTCACCACTGCACCACGGAGAAAGTTGGGCGG 321 GGACGGGAGTCCAGTGGGATCTCTGTGGGATCTAGGGGTGAGGAGCTGGATTCCAGCCTTGGCTGTTTGGTTTTTTTGGA 401 CCAAACCCAAAAGAAACTGACAAACCTCTCTTCCCTGGCTCAACCTGGAGGGACTGGTAAAGGTGAACTCCACGTGGAGA 481 CCAGCACCGACTGAATCCCTGGAACCTAAACCACTCCTTGACCCCACGGGGTGGAAGCCACCATTTGGTGGTACCAGGCC 561 CTTTTGCTGCCTCACCTCAAGTTAGTCAAGGATCAGTCCTCCTTGTCCCCACGACTTATCGTACCTGAGTAGCTGCTGTC 641 TCACTTTTTTATTCTTTCCTCTCCCAATAACCTATGAACTGGTGGTGTAGTTTGCAGGCTGAAGCCATGTCTAAATGAGA 721 GTTCTTGGTAGGTGGTGAGGGAAGTGGGGAAGGAGATCCCGAGTCTCCACTGAGGAGGCTGTCAGATATTGGCGGGGGTT 801 GCCCTACTCTGGGCAGCTTGGGCCCTGCAGGAAGAAGTGAAGTCAGACAGCTAGGGTGGGTCAGTGTGGCTGATTGTGTT 881 GGTATTGTGTGTATGCTGCTTTTCTAACCAAGAGGCTGGTTTTGGCATCTATCTCATTCCCTGGGAATGCGGTGGTTAAA 961 TGTGTGATACAAAATCAGGGCTGGAGAAACAGAAATGAAGGTCAAAATCGCTGGCCTGTACCTACAGGCCATAGCACCCA 1041 AATCCTCATATCTAGGGGAGCCTGAAATGTCCAGAACGCTTGTGAACAGTGGGGAATCAGGTGTGAAAATTTAAAACTAA 1121 AATGCATGAGACTGAGGCCATCCAGTCTTCTGGTGTGGCGGGAGAGGTGGAGCCATGGTGGTGCAGCCATCCCAGCGTGG 1201 TCTGCTCATGGATGGGATGGTTGCAATGTTGAGAAAATCCCGGGAATTTTATCAACACAAGATTCTTATTGCACTTGTAT 1281 TTTTTGTATTAAAGTTTGCATGGTTTCTAATAAAGGATTCAAACCTAAGTTTGTATTGAAATGGCCTGGGAGTGTCTAAG 1361 GGCTCCTCTGATAGGGCATTTTCTGCTGGGCAGATTTGCCTCTCAGGAGGCTGGCCCAGACTTGGTCCCCTTGGCCCTCC 1441 TCCGAACAGACTCTGCCTTTGCTTGGGTACAGTTTGAGGAGGTAGAGGTCTTTACTCTCTCTCTGCCAAGGGAAGGTATC 1521 CCTGGGCTTGAAGGTCTTCTCCATTTATGAGGTAGCAGTTACTTTGTGATAATCTTGACACTGAATCCCTAGCTCTCTAA 1601 GCACACACAAAGAATTGCTGGGACCTGTGGAAAAAAGACTGCCTGAGCTGGGGAGTGGCTTTCTTCCCAAGCTGTCAGAA 1681 CTAAGCTTGGAGCCTGCATTGTCTGTATTTTGCAGCAATAGGGGCCCACGGAGCTGGGAAGGACACAGTGGGGACCAGGG 1761 TAGTGATGACTGAGCGTATACAGGTACTTGCTACCCTCCTTGATGTTGATCTTAGGGCCTTGAAGATGCTAAGGAAATTG 1841 ACAAGAAACAAGTCCATTGGCCAAGGATTAGAGAAAGGAAGGTAACCCAAGCTCTGTAGGTAGCTCCCTGGAAGGATCCC 1921 ACGAGCCAGAGAACCTGAGAAGGCTGGTCTAGCAGCTTGGGACCACAGGCCATGTGATGTGCATACTTCAAAATGTTTGG 2001 GAATAAGGTCCTTCTGTATTTTATAGTTTGCTCATGGCTTAGCCATTACCCATGTCTGTAATTGTTGTACTGATTTAAAC 2081 AATAAAGCTGCCTGACATCCCACCATGTT Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HUVEC |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP聽 data was present in GSM1013111. RNA binding protein: AGO. Condition:HUVEC-replicate-2
... - Balakrishnan I; Yang X; Brown J; et al., 2014, Stem cells (Dayton, Ohio). |
Article |
- Balakrishnan I; Yang X; Brown J; et al. - Stem cells (Dayton, Ohio), 2014
Regulation of hematopoietic stem cell proliferation, lineage commitment, and differentiation in adult vertebrates requires extrinsic signals provided by cells in the marrow microenvironment (ME) located within the bone marrow. Both secreted and cell-surface bound factors critical to this regulation have been identified, yet control of their expression by cells within the ME has not been addressed. Herein we hypothesize that microRNAs (miRNAs) contribute to their controlled expression. MiRNAs are small noncoding RNAs that bind to target mRNAs and downregulate gene expression by either initiating mRNA degradation or preventing peptide translation. Testing the role of miRNAs in downregulating gene expression has been difficult since conventional techniques used to define miRNA-mRNA interactions are indirect and have high false-positive and negative rates. In this report, a genome-wide biochemical technique (high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation or HITS-CLIP) was used to generate unbiased genome-wide maps of miRNA-mRNA interactions in two critical cellular components of the marrow ME: marrow stromal cells and bone marrow endothelial cells. Analysis of these datasets identified miRNAs as direct regulators of JAG1, WNT5A, MMP2, and VEGFA; four factors that are important to ME function. Our results show the feasibility and utility of unbiased genome-wide biochemical techniques in dissecting the role of miRNAs in regulation of complex tissues such as the marrow ME.
LinkOut: [PMID: 24038734]
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CLIP-seq Support 1 for dataset GSM1013111 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HUVEC / HUVEC-replicate-2 |
Location of target site | ENST00000383737.4 | 3UTR | UGUGAUGUGUACUCCGCAGCUGUUUGGGGUGGGACAUUUCUGUACUUCUCGAUUUGCUUAUGGCUCAGCCAUUACCUGUGUCAGUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 24038734 / GSE41272 |
CLIP-seq Viewer | Link |
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT130738 | GATAD2B | GATA zinc finger domain containing 2B | ![]() |
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2 | 4 | ||||||
MIRT134924 | CCND2 | cyclin D2 | ![]() |
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2 | 2 | ||||||
MIRT273034 | ZBTB18 | zinc finger and BTB domain containing 18 | ![]() |
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2 | 2 | ||||||
MIRT276645 | KPNA3 | karyopherin subunit alpha 3 | ![]() |
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2 | 6 | ||||||
MIRT446531 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ![]() |
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2 | 2 | ||||||
MIRT456268 | TDRKH | tudor and KH domain containing | ![]() |
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2 | 12 | ||||||
MIRT494454 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 2 | ||||||
MIRT494965 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT496689 | KREMEN1 | kringle containing transmembrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT496697 | RGS11 | regulator of G protein signaling 11 | ![]() |
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2 | 2 | ||||||
MIRT504376 | IRF4 | interferon regulatory factor 4 | ![]() |
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2 | 6 | ||||||
MIRT510980 | PFN2 | profilin 2 | ![]() |
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2 | 6 | ||||||
MIRT512548 | MFN2 | mitofusin 2 | ![]() |
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2 | 6 | ||||||
MIRT513639 | TP53INP2 | tumor protein p53 inducible nuclear protein 2 | ![]() |
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2 | 2 | ||||||
MIRT514016 | CAMSAP1 | calmodulin regulated spectrin associated protein 1 | ![]() |
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2 | 4 | ||||||
MIRT514074 | MTRNR2L6 | MT-RNR2-like 6 | ![]() |
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2 | 2 | ||||||
MIRT515300 | C15orf38-AP3S2 | C15orf38-AP3S2 readthrough | ![]() |
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2 | 4 | ||||||
MIRT517285 | AP3S2 | adaptor related protein complex 3 sigma 2 subunit | ![]() |
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2 | 4 | ||||||
MIRT519075 | KCNK6 | potassium two pore domain channel subfamily K member 6 | ![]() |
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2 | 2 | ||||||
MIRT520779 | TCF23 | transcription factor 23 | ![]() |
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2 | 2 | ||||||
MIRT522485 | MFSD9 | major facilitator superfamily domain containing 9 | ![]() |
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2 | 2 | ||||||
MIRT528856 | PKP1 | plakophilin 1 | ![]() |
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2 | 2 | ||||||
MIRT529081 | PATE2 | prostate and testis expressed 2 | ![]() |
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2 | 2 | ||||||
MIRT531209 | PLA2G4D | phospholipase A2 group IVD | ![]() |
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2 | 2 | ||||||
MIRT533988 | TAB3 | TGF-beta activated kinase 1 and MAP3K7 binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT537024 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ![]() |
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2 | 2 | ||||||
MIRT537498 | FAM168B | family with sequence similarity 168 member B | ![]() |
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2 | 2 | ||||||
MIRT553125 | UBE2Z | ubiquitin conjugating enzyme E2 Z | ![]() |
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2 | 2 | ||||||
MIRT555591 | PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase type 1 gamma | ![]() |
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2 | 2 | ||||||
MIRT556370 | LUZP1 | leucine zipper protein 1 | ![]() |
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2 | 2 | ||||||
MIRT569745 | C2orf71 | chromosome 2 open reading frame 71 | ![]() |
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2 | 2 | ||||||
MIRT570149 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | ![]() |
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2 | 2 | ||||||
MIRT571243 | FADS6 | fatty acid desaturase 6 | ![]() |
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2 | 2 | ||||||
MIRT573065 | TRIB1 | tribbles pseudokinase 1 | ![]() |
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2 | 2 | ||||||
MIRT575533 | Map4 | microtubule-associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT575777 | Tnfrsf10b | tumor necrosis factor receptor superfamily, member 10b | ![]() |
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2 | 2 | ||||||
MIRT616558 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 2 | ||||||
MIRT624851 | ABI2 | abl interactor 2 | ![]() |
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2 | 2 | ||||||
MIRT630078 | GRWD1 | glutamate rich WD repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT631479 | KLHL21 | kelch like family member 21 | ![]() |
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2 | 2 | ||||||
MIRT632173 | CCL22 | C-C motif chemokine ligand 22 | ![]() |
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2 | 2 | ||||||
MIRT638397 | QSOX2 | quiescin sulfhydryl oxidase 2 | ![]() |
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2 | 4 | ||||||
MIRT641192 | ISG20L2 | interferon stimulated exonuclease gene 20 like 2 | ![]() |
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2 | 2 | ||||||
MIRT642562 | TEX9 | testis expressed 9 | ![]() |
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2 | 2 | ||||||
MIRT642935 | KRTAP5-9 | keratin associated protein 5-9 | ![]() |
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2 | 2 | ||||||
MIRT649703 | ZNF175 | zinc finger protein 175 | ![]() |
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2 | 2 | ||||||
MIRT650437 | CPXM2 | carboxypeptidase X, M14 family member 2 | ![]() |
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2 | 2 | ||||||
MIRT652113 | TRUB2 | TruB pseudouridine synthase family member 2 | ![]() |
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2 | 2 | ||||||
MIRT652273 | TOMM20 | translocase of outer mitochondrial membrane 20 | ![]() |
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2 | 2 | ||||||
MIRT655215 | PFKM | phosphofructokinase, muscle | ![]() |
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2 | 2 | ||||||
MIRT682778 | ZNF852 | zinc finger protein 852 | ![]() |
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2 | 2 | ||||||
MIRT683001 | MUC20 | mucin 20, cell surface associated | ![]() |
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2 | 2 | ||||||
MIRT684320 | GTF3C4 | general transcription factor IIIC subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT689435 | CYB561 | cytochrome b561 | ![]() |
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2 | 2 | ||||||
MIRT693847 | ZNF107 | zinc finger protein 107 | ![]() |
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2 | 2 | ||||||
MIRT696715 | TAX1BP3 | Tax1 binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT698597 | TEX261 | testis expressed 261 | ![]() |
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2 | 2 | ||||||
MIRT699973 | RREB1 | ras responsive element binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT703310 | GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | ![]() |
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2 | 2 | ||||||
MIRT706796 | RAI1 | retinoic acid induced 1 | ![]() |
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2 | 2 | ||||||
MIRT709004 | CD109 | CD109 molecule | ![]() |
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2 | 2 | ||||||
MIRT709181 | TBC1D10B | TBC1 domain family member 10B | ![]() |
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2 | 2 | ||||||
MIRT709835 | PAQR7 | progestin and adipoQ receptor family member 7 | ![]() |
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2 | 2 | ||||||
MIRT711627 | CORO1C | coronin 1C | ![]() |
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2 | 2 | ||||||
MIRT712634 | RNF103-CHMP3 | RNF103-CHMP3 readthrough | ![]() |
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2 | 2 | ||||||
MIRT713694 | CYB5R4 | cytochrome b5 reductase 4 | ![]() |
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2 | 2 | ||||||
MIRT713752 | SLC9A8 | solute carrier family 9 member A8 | ![]() |
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2 | 2 | ||||||
MIRT714908 | CHMP3 | charged multivesicular body protein 3 | ![]() |
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2 | 2 | ||||||
MIRT716371 | CBLL1 | Cbl proto-oncogene like 1 | ![]() |
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2 | 2 | ||||||
MIRT718303 | XPOT | exportin for tRNA | ![]() |
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2 | 2 | ||||||
MIRT718713 | ANKRD18A | ankyrin repeat domain 18A | ![]() |
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2 | 2 | ||||||
MIRT718740 | ATP9A | ATPase phospholipid transporting 9A (putative) | ![]() |
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2 | 2 | ||||||
MIRT719441 | NPTX2 | neuronal pentraxin 2 | ![]() |
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2 | 2 | ||||||
MIRT720896 | OTUD4 | OTU deubiquitinase 4 | ![]() |
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2 | 2 | ||||||
MIRT722448 | RXFP4 | relaxin/insulin like family peptide receptor 4 | ![]() |
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2 | 2 | ||||||
MIRT723882 | VKORC1 | vitamin K epoxide reductase complex subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT724586 | SYNJ2BP | synaptojanin 2 binding protein | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||
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