pre-miRNA Information | |
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pre-miRNA | hsa-mir-1185-1 |
Genomic Coordinates | chr14: 101042977 - 101043062 |
Synonyms | MIRN1185-1, hsa-mir-1185-1, MIR1185-1 |
Description | Homo sapiens miR-1185-1 stem-loop |
Comment | This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-1185-1-3p | ||||||||||||||||||||||||||||||
Sequence | 53| AUAUACAGGGGGAGACUCUUAU |74 | ||||||||||||||||||||||||||||||
Evidence | Not_experimental | ||||||||||||||||||||||||||||||
Experiments | |||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Gene Information | |||||||||||||||||||||
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Gene Symbol | Pxdn | ||||||||||||||||||||
Synonyms | 2310075M15Rik, C85409, E330004E07, VPO1, mKIAA0230 | ||||||||||||||||||||
Description | peroxidasin | ||||||||||||||||||||
Transcript | NM_181395 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Pxdn | |||||||||||||||||||||
3'UTR of Pxdn (miRNA target sites are highlighted) |
>Pxdn|NM_181395|3'UTR 1 TGTTCCCGAGCTTAGCTCCTCGAAGCTGGTCCACAGAATACTTGTGAGCCTAGATGACAACATGGGGAGCTTCAGACCAC 81 AGGACAAGTTGGGATCTCAGACATTTCAGGACCTCTGCTGTGCCATCGCAGAAGCAGCCGGGGCTGCTTCACACCCTGTG 161 TTTGTAGAAGGAAATTGAGCAGGCGGGAGTGGGTGCAGGCTCTGGCCCTCACTTCATGTTAGACTTCTCAGGTTTATATT 241 TAAGTGTTTTTAAATGGAAAATTGGTGCTACTATTAAATCACACAGTTGAGACATGGGTTTCGAAATTGCTTCGGCCTGA 321 TGATGCCACTTCTGTTTAAGCGAGGCAGAAGGTCTTTGACAGGCTTCATTTAAACAGAAGCATTTGGCAAATGGAACAGG 401 ATCTTATAAAATAATATCCTGGGCCAAAATCCCTACAGGGATACTAGGGCTTTCTCCCACTGCTCCCTCATGTCTGCCAT 481 CTTCCCCTTCAGGGCCCTTCAGCGTCTAATAACAATACCAACACAAACCTGCACCTTGCGACCATGTCCACCCTTCTACA 561 CAGGACTGTCACATTATCAAGCCACAGTTAGAAATAATCTTGTTTCCACTTAGAAAATGTGTAAATACTGCCTTGCTGTA 641 AATTGAATGTGAAATCCTTTGGTCCTATGCCATGTTGAGTGACCCGAATAGCCCCTTGCATCGGCAGGATGGTCTGCAGC 721 CACCACCTGCCTTGGTTCCTGGCCATGGTGTAGGGAGGGTGATGGTCTGCAGCCACCACCTGCCTTGGTTCCTGGCCATG 801 GTGTAGGGAGGGTGATTCACTCTCCAGGTCCTTTGAATAGGTGACAGACAGGCAGAGCCTGAATGTCAGGAAATTCCATT 881 GTATGAATGCTTTAAAGGAAAACGTTCCCTATACCTCATTATTTTTTATTGCATGATGTTTTATAAAAATTTGCCCATTT 961 TAGATGTTAGAAAAATTATTTCCACTATGCAAATTTCTTTTTAATTCAGTGAAAAGCAACTGTTATACCTCATAGTCTCT 1041 TGTTTTTAATTGACCAAAATATTCCATTCTATTCTCACAAGGTTCTGAGGTCTCTGCCTGAAAAAGCAAGTCTCACCCTA 1121 TAGACACTGATGTGCCCAGCACTACGTGCCAGCCATTGTGGGAACACAAGAGGGTCACCTGCCCAAGGGCTAGGGAGGAA 1201 GACCTCAAGAACACAGAGGAGGTGGAAAAGGACAAAATAGGTGCCATTTTAGGGAGACCATGGTCAGATAGGGGGATGCT 1281 CAGTTCCTTGCAGCCTCGGGCGGGCTTATGTTGGCACTAAGGCCATTGTGGAGTGTACTTATATGATCCCTATGCTGATA 1361 GGATTACCTTCCTAGACATAGCTAGACGCAAAGCCACATGTGTAAGGCTGCTGAGCAAAGACAGCATCCCAGCATGGGTG 1441 TGTTCACGGTGGATTCACCACGTTGCATATGTAAAGTGGTCCCCTTGGCTTACCCTTCACTTTGCTCATGAGATTCAGAA 1521 GCTGGTGGTCCAGCAGGGGTGAGCATTTGTGAAATAGTAAGCTGAACTTAGTGGTGAGATTTCAGAACAGACTTCTGTGA 1601 AGTAAGAGATGTAACCATGCATCTAAAATCAGATGGCCGTGTAACTGCTCGGGCATAGAAATGGTGGGAGAACCTGTCCT 1681 GGGTACCTGGCATTTCACATGAGCCCAGGGATATGTCTTGTGCCAAGGCACACAAGTGTCCATGGACTTGGACAGGTGCC 1761 AAGGGTTTTTGTCTCTGTTCCTATGTGGGAGGCTGGCTGTGATTTACATTAATTTCTGTATTTCAAACGAAGATGTCTGC 1841 AGATCTCCATTTTGATGTTACAGCCTCATTGCCCAGGCAGTGGGCAGTGCCCAGACACCCTTTCTGACTAGCCACTGCAT 1921 TGGGCTTCTGTGATTCAAAGTAGTGTATATATTTATTTACTTCTCTGACTGTGGCCAACAGCCAAATGCCATTTTATGTT 2001 CCTTGTATTCAGTCCATTACCAAAGAGGTGTTTGCACTTTGTAATGATACCTTTCAGTTCAAATAAAAGGACCACATCGT 2081 TAAGTGGAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HS5 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP聽 data was present in GSM1013108. RNA binding protein: AGO. Condition:HS5-replicate-3
... - Balakrishnan I; Yang X; Brown J; et al., 2014, Stem cells (Dayton, Ohio). |
Article |
- Balakrishnan I; Yang X; Brown J; et al. - Stem cells (Dayton, Ohio), 2014
Regulation of hematopoietic stem cell proliferation, lineage commitment, and differentiation in adult vertebrates requires extrinsic signals provided by cells in the marrow microenvironment (ME) located within the bone marrow. Both secreted and cell-surface bound factors critical to this regulation have been identified, yet control of their expression by cells within the ME has not been addressed. Herein we hypothesize that microRNAs (miRNAs) contribute to their controlled expression. MiRNAs are small noncoding RNAs that bind to target mRNAs and downregulate gene expression by either initiating mRNA degradation or preventing peptide translation. Testing the role of miRNAs in downregulating gene expression has been difficult since conventional techniques used to define miRNA-mRNA interactions are indirect and have high false-positive and negative rates. In this report, a genome-wide biochemical technique (high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation or HITS-CLIP) was used to generate unbiased genome-wide maps of miRNA-mRNA interactions in two critical cellular components of the marrow ME: marrow stromal cells and bone marrow endothelial cells. Analysis of these datasets identified miRNAs as direct regulators of JAG1, WNT5A, MMP2, and VEGFA; four factors that are important to ME function. Our results show the feasibility and utility of unbiased genome-wide biochemical techniques in dissecting the role of miRNAs in regulation of complex tissues such as the marrow ME.
LinkOut: [PMID: 24038734]
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CLIP-seq Support 1 for dataset GSM1013108 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HS5 / HS5-replicate-3 |
Location of target site | ENST00000252804.4 | 3UTR | UCACCACACGUCAGCAUCUAAUCCCAAGACAAACAUUCCCGCUGCUCGAAGCAGCUGUAUAGCCUGUGACUCUCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 24038734 / GSE41272 |
CLIP-seq Viewer | Link |
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT066415 | TBK1 | TANK binding kinase 1 | ![]() |
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2 | 4 | ||||||
MIRT073567 | NR2F2 | nuclear receptor subfamily 2 group F member 2 | ![]() |
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2 | 2 | ||||||
MIRT074516 | USP1 | ubiquitin specific peptidase 1 | ![]() |
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2 | 4 | ||||||
MIRT080576 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | ![]() |
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2 | 6 | ||||||
MIRT086539 | HSPE1-MOB4 | HSPE1-MOB4 readthrough | ![]() |
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2 | 2 | ||||||
MIRT086547 | MOB4 | MOB family member 4, phocein | ![]() |
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2 | 2 | ||||||
MIRT088684 | EML4 | echinoderm microtubule associated protein like 4 | ![]() |
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2 | 4 | ||||||
MIRT090811 | MBNL1 | muscleblind like splicing regulator 1 | ![]() |
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2 | 4 | ||||||
MIRT095500 | PURA | purine rich element binding protein A | ![]() |
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2 | 2 | ||||||
MIRT109530 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 6 | ||||||
MIRT109807 | ZFX | zinc finger protein, X-linked | ![]() |
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2 | 2 | ||||||
MIRT117888 | ZBTB7A | zinc finger and BTB domain containing 7A | ![]() |
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2 | 2 | ||||||
MIRT120273 | GSK3B | glycogen synthase kinase 3 beta | ![]() |
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2 | 4 | ||||||
MIRT149892 | LDLR | low density lipoprotein receptor | ![]() |
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2 | 2 | ||||||
MIRT178475 | LCOR | ligand dependent nuclear receptor corepressor | ![]() |
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2 | 4 | ||||||
MIRT193445 | RORA | RAR related orphan receptor A | ![]() |
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2 | 2 | ||||||
MIRT198527 | DSG2 | desmoglein 2 | ![]() |
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2 | 2 | ||||||
MIRT226427 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 | ![]() |
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2 | 2 | ||||||
MIRT227669 | SET | SET nuclear proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT320405 | HOXA9 | homeobox A9 | ![]() |
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2 | 2 | ||||||
MIRT407774 | MRPL35 | mitochondrial ribosomal protein L35 | ![]() |
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2 | 2 | ||||||
MIRT439228 | ZMIZ1 | zinc finger MIZ-type containing 1 | ![]() |
1 | 1 | |||||||
MIRT439312 | VAT1L | vesicle amine transport 1 like | ![]() |
1 | 1 | |||||||
MIRT439421 | TMOD1 | tropomodulin 1 | ![]() |
1 | 1 | |||||||
MIRT439446 | TMEM104 | transmembrane protein 104 | ![]() |
1 | 1 | |||||||
MIRT439524 | STIM2 | stromal interaction molecule 2 | ![]() |
1 | 1 | |||||||
MIRT439612 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) | ![]() |
1 | 1 | |||||||
MIRT439997 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | ![]() |
1 | 1 | |||||||
MIRT440017 | PCSK1 | proprotein convertase subtilisin/kexin type 1 | ![]() |
1 | 1 | |||||||
MIRT440131 | NCOA4 | nuclear receptor coactivator 4 | ![]() |
1 | 1 | |||||||
MIRT440311 | LRRC1 | leucine rich repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT440475 | IAPP | islet amyloid polypeptide | ![]() |
1 | 1 | |||||||
MIRT440511 | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | ![]() |
1 | 1 | |||||||
MIRT440617 | FOXA2 | forkhead box A2 | ![]() |
1 | 1 | |||||||
MIRT440666 | FBXL16 | F-box and leucine rich repeat protein 16 | ![]() |
1 | 1 | |||||||
MIRT440705 | ERO1LB | endoplasmic reticulum oxidoreductase 1 beta | ![]() |
1 | 1 | |||||||
MIRT441007 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | ![]() |
1 | 1 | |||||||
MIRT441018 | CAND1 | cullin associated and neddylation dissociated 1 | ![]() |
1 | 1 | |||||||
MIRT441062 | C1orf43 | chromosome 1 open reading frame 43 | ![]() |
1 | 1 | |||||||
MIRT441209 | ARCN1 | archain 1 | ![]() |
1 | 1 | |||||||
MIRT449461 | HAT1 | histone acetyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT467104 | SRI | sorcin | ![]() |
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2 | 2 | ||||||
MIRT468060 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
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2 | 10 | ||||||
MIRT468476 | SESN3 | sestrin 3 | ![]() |
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2 | 4 | ||||||
MIRT473533 | MAX | MYC associated factor X | ![]() |
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2 | 2 | ||||||
MIRT473852 | MAP2K4 | mitogen-activated protein kinase kinase 4 | ![]() |
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2 | 2 | ||||||
MIRT474711 | KIF13A | kinesin family member 13A | ![]() |
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2 | 6 | ||||||
MIRT481665 | ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | ![]() |
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2 | 2 | ||||||
MIRT485120 | SF3B3 | splicing factor 3b subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT493055 | MTFR1 | mitochondrial fission regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT504258 | C1orf147 | chromosome 1 open reading frame 147 | ![]() |
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2 | 4 | ||||||
MIRT504361 | ARID1B | AT-rich interaction domain 1B | ![]() |
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2 | 4 | ||||||
MIRT505748 | SENP1 | SUMO1/sentrin specific peptidase 1 | ![]() |
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2 | 8 | ||||||
MIRT506298 | PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | ![]() |
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2 | 6 | ||||||
MIRT508442 | ZNF608 | zinc finger protein 608 | ![]() |
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2 | 4 | ||||||
MIRT512782 | COL4A3BP | collagen type IV alpha 3 binding protein | ![]() |
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2 | 2 | ||||||
MIRT520447 | TSPAN2 | tetraspanin 2 | ![]() |
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2 | 4 | ||||||
MIRT522133 | NRBF2 | nuclear receptor binding factor 2 | ![]() |
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2 | 6 | ||||||
MIRT522395 | MYADM | myeloid associated differentiation marker | ![]() |
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2 | 4 | ||||||
MIRT523397 | GRIK3 | glutamate ionotropic receptor kainate type subunit 3 | ![]() |
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2 | 4 | ||||||
MIRT523938 | E2F8 | E2F transcription factor 8 | ![]() |
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2 | 4 | ||||||
MIRT524349 | CREB1 | cAMP responsive element binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT524711 | BRMS1L | breast cancer metastasis-suppressor 1 like | ![]() |
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2 | 4 | ||||||
MIRT525134 | ZNF256 | zinc finger protein 256 | ![]() |
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2 | 2 | ||||||
MIRT525710 | DCAF12L2 | DDB1 and CUL4 associated factor 12 like 2 | ![]() |
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2 | 2 | ||||||
MIRT531264 | PPIL3 | peptidylprolyl isomerase like 3 | ![]() |
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2 | 2 | ||||||
MIRT538844 | BTG1 | BTG anti-proliferation factor 1 | ![]() |
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2 | 2 | ||||||
MIRT541366 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
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2 | 2 | ||||||
MIRT542093 | KCNK10 | potassium two pore domain channel subfamily K member 10 | ![]() |
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2 | 6 | ||||||
MIRT543770 | RBM12B | RNA binding motif protein 12B | ![]() |
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2 | 4 | ||||||
MIRT543940 | NCOA7 | nuclear receptor coactivator 7 | ![]() |
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2 | 2 | ||||||
MIRT545150 | GABRG1 | gamma-aminobutyric acid type A receptor gamma1 subunit | ![]() |
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2 | 2 | ||||||
MIRT545842 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 4 | ||||||
MIRT548057 | GOLGA7 | golgin A7 | ![]() |
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2 | 2 | ||||||
MIRT549242 | ATXN1L | ataxin 1 like | ![]() |
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2 | 4 | ||||||
MIRT551829 | AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | ![]() |
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2 | 2 | ||||||
MIRT552484 | ZNF136 | zinc finger protein 136 | ![]() |
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2 | 2 | ||||||
MIRT553663 | TGFBR2 | transforming growth factor beta receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT554988 | RAB39B | RAB39B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT555760 | PCTP | phosphatidylcholine transfer protein | ![]() |
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2 | 2 | ||||||
MIRT556923 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | ![]() |
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2 | 4 | ||||||
MIRT564991 | WNK1 | WNK lysine deficient protein kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT566458 | PGGT1B | protein geranylgeranyltransferase type I subunit beta | ![]() |
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2 | 2 | ||||||
MIRT566538 | PANK3 | pantothenate kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT567732 | DLX2 | distal-less homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT570081 | KANSL1L | KAT8 regulatory NSL complex subunit 1 like | ![]() |
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2 | 2 | ||||||
MIRT571735 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT573529 | MDM2 | MDM2 proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT574459 | RPS16 | ribosomal protein S16 | ![]() |
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2 | 2 | ||||||
MIRT574992 | Phka1 | phosphorylase kinase alpha 1 | ![]() |
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2 | 3 | ||||||
MIRT576349 | Pxdn | peroxidasin | ![]() |
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2 | 2 | ||||||
MIRT610196 | CD99 | CD99 molecule (Xg blood group) | ![]() |
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2 | 4 | ||||||
MIRT612920 | GPRIN3 | GPRIN family member 3 | ![]() |
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2 | 2 | ||||||
MIRT615021 | DUSP6 | dual specificity phosphatase 6 | ![]() |
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2 | 2 | ||||||
MIRT623573 | IRS1 | insulin receptor substrate 1 | ![]() |
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2 | 2 | ||||||
MIRT624437 | CASD1 | CAS1 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT628714 | ZNF585A | zinc finger protein 585A | ![]() |
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2 | 2 | ||||||
MIRT639565 | PCK1 | phosphoenolpyruvate carboxykinase 1 | ![]() |
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2 | 4 | ||||||
MIRT641485 | POLA2 | DNA polymerase alpha 2, accessory subunit | ![]() |
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2 | 2 | ||||||
MIRT641657 | PAPOLG | poly(A) polymerase gamma | ![]() |
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2 | 2 | ||||||
MIRT642210 | RUVBL2 | RuvB like AAA ATPase 2 | ![]() |
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2 | 2 | ||||||
MIRT653010 | STX7 | syntaxin 7 | ![]() |
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2 | 2 | ||||||
MIRT656130 | MSH6 | mutS homolog 6 | ![]() |
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2 | 2 | ||||||
MIRT656893 | KIAA2018 | upstream transcription factor family member 3 | ![]() |
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2 | 2 | ||||||
MIRT660130 | BRPF3 | bromodomain and PHD finger containing 3 | ![]() |
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2 | 2 | ||||||
MIRT660855 | AFAP1 | actin filament associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT676843 | PHKA1 | phosphorylase kinase regulatory subunit alpha 1 | ![]() |
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2 | 3 | ||||||
MIRT681473 | DIP2A | disco interacting protein 2 homolog A | ![]() |
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2 | 2 | ||||||
MIRT682253 | RS1 | retinoschisin 1 | ![]() |
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2 | 2 | ||||||
MIRT694296 | COPB2 | coatomer protein complex subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT694401 | ALDH1A3 | aldehyde dehydrogenase 1 family member A3 | ![]() |
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2 | 2 | ||||||
MIRT705277 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT720833 | C1orf52 | chromosome 1 open reading frame 52 | ![]() |
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2 | 2 | ||||||
MIRT735713 | SIRT1 | sirtuin 1 | ![]() |
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2 | 0 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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