miRTarBase - #MIRT579405


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pre-miRNA Information
pre-miRNA mmu-mir-410   
Genomic Coordinates chr12: 109743715 - 109743795
Synonyms Mirn410, mmu-mir-410, Mir410
Description Mus musculus miR-410 stem-loop
Comment Seitz et al. predicted a cluster of 40 miRNAs in the imprinted human 14q32 domain, and confirmed the expression of a subset by Northern blot or primer extension in mouse .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-410-3p
Sequence 50| AAUAUAACACAGAUGGCCUGU |70
Evidence Experimental
Experiments Northern
Putative Targets

Gene Information
Gene Symbol Akna   
Synonyms AI597013
Description AT-hook transcription factor
Transcript NM_001045514   
Expression
Putative miRNA Targets on Akna
3'UTR of Akna
(miRNA target sites are highlighted)		 
>Akna|NM_001045514|3'UTR
   1 CTCCCTGGAGACTCTGAGACTAAGTAGGCAGGCAGCCGCTGTTGTTTCCCAGTCAACAGTCTCCTGGTACCACTGATGGC
  81 TGGAAGATGTCACGTTCCCCTCCCCAGGAGTGCCACCTGATTCATGTGGCGTATTTAAAATGGAGAGACATTGGCCTAGT
 161 CAGGAGTGGATGAATGTCTGGGGGCCAACTCTGTCTAACAGGTGTAGTGATCATGGCTCCCTCTGTCGAGTCAGAGTCGC
 241 TGAGACTCCTCCTCGTCCCCCTCCTGCCCATGTGCTTCTGCAGCTAATAATGTGGCTCTTACTGGACAGAATGTCTTTAC
 321 ACTGGGGAGCTAACTTGGGCTTGGACCTGTCTCAGAAGGCCAGAGAGGAAAAGAAAAGTCTAGGGTCTCTGAAGCATTTT
 401 GGACACTGCCTGTGATAGCTACTCTGAGGCAGGCGTTGTCAGGGAGAAGAACTAGTTAGGGATTTTGTTCCTAGTAACTA
 481 GTGGGCAGGGGTAGTACTTGGGGACCCATTAATGTCTTGGGGCTGAGGCCTCAGCTGACGCACGCCCAGCTCTTCTGTGG
 561 TTACAGAAGTTTTTCCCATGAGCTCATGGAGTAGAAGCTGCTCATGTAGGCCAGGAAGCACCCAGCAGCCTCAGACATAC
 641 CCACTATGTCTTTGGCATCCACTTAGGACCAAGCTACCTTGCCAGGCCCTGGCCTGAGGCTGATAGACCAGGCCGGTACC
 721 CGTTTCCCTGTCCCATAGCAGAGTGACCTCAACATTTCTGGGATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
 801 GTGTGTGTTATCACAGATTGTTTATATATTTGAGGCATTTTTTAAAAATCTATTTTTGTTATAAAACAAATGAAGGAAAA
 881 TAAATAATGAACTTAAGAACGGGCAAAGAAATCCCCAAAGCTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uguccGGUAGACACAAUAUaa 5'
               |:||:| |||||||  
Target 5' aaaatCTATTTTTGTTATAaa 3'
 845 - 865 144.00 -8.50
2 
miRNA  3' ugUCCGGUAGACA-CAAUAUaa 5'
            || :| ||||| |||| |  
Target 5' ccAGCTCTTCTGTGGTTACAga 3'
 546 - 567 115.00 -10.35
3 
miRNA  3' ugUCCGGUAGACACAAUAUAa 5'
            |||| : |  ||||:| | 
Target 5' gcAGGCAGCCGCTGTTGTTTc 3'
 28 - 48 111.00 -13.24
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions C2C12
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes ...

- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell.

Article - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al.
- Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
154 mmu-miR-410-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT411453 Timp3 tissue inhibitor of metalloproteinase 3 1 1
MIRT429039 Nfib nuclear factor I/B 1 1
MIRT577363 Zbed6 zinc finger, BED type containing 6 1 1
MIRT577415 Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 1 1
MIRT577447 Ttc17 tetratricopeptide repeat domain 17 1 1
MIRT577509 Tmem100 transmembrane protein 100 1 1
MIRT577583 Tcf21 transcription factor 21 1 1
MIRT577727 Slc12a8 solute carrier family 12 (potassium/chloride transporters), member 8 1 1
MIRT577749 Shh sonic hedgehog 1 1
MIRT577866 Rassf5 Ras association (RalGDS/AF-6) domain family member 5 1 1
MIRT577939 Ppp6r1 protein phosphatase 6, regulatory subunit 1 1 1
MIRT577946 Pou4f2 POU domain, class 4, transcription factor 2 1 1
MIRT577955 Pm20d2 peptidase M20 domain containing 2 1 1
MIRT578018 Pfkl phosphofructokinase, liver, B-type 1 2
MIRT578052 Pcdhb17 protocadherin beta 17 1 1
MIRT578199 Nadsyn1 NAD synthetase 1 1 1
MIRT578517 Igfbp3 insulin-like growth factor binding protein 3 1 1
MIRT578557 Hopx HOP homeobox 1 1
MIRT578586 Hist1h1d histone cluster 1, H1d 1 1
MIRT578724 Gm8369 predicted gene 8369 1 1
MIRT578808 Folh1 folate hydrolase 1 1 1
MIRT578868 Fam151b family with sequence similarity 151, member B 1 1
MIRT579020 Ctxn3 cortexin 3 1 1
MIRT579049 Crp C-reactive protein, pentraxin-related 1 1
MIRT579405 Akna AT-hook transcription factor 1 1
MIRT579630 Mettl20 electron transfer flavoprotein beta subunit lysine methyltransferase 1 1
MIRT579670 1200011I18Rik GPALPP motifs containing 1 1 1
MIRT579703 Zmynd8 zinc finger, MYND-type containing 8 1 1
MIRT579745 Zfp644 zinc finger protein 644 1 1
MIRT579786 Zfp384 zinc finger protein 384 1 1
MIRT579807 Zfp148 zinc finger protein 148 1 1
MIRT579834 Zfand5 zinc finger, AN1-type domain 5 1 1
MIRT579839 Zer1 zyg-11 related, cell cycle regulator 1 1
MIRT579858 Zc3hav1l zinc finger CCCH-type, antiviral 1-like 1 1
MIRT579995 Wnt3 wingless-type MMTV integration site family, member 3 1 1
MIRT580002 Wnt11 wingless-type MMTV integration site family, member 11 1 1
MIRT580021 Whsc1l1 nuclear receptor binding SET domain protein 3 1 1
MIRT580090 Usp6nl USP6 N-terminal like 1 1
MIRT580211 Ttc39b tetratricopeptide repeat domain 39B 1 1
MIRT580239 Trps1 transcriptional repressor GATA binding 1 1 1
MIRT580243 Trpc7 transient receptor potential cation channel, subfamily C, member 7 1 1
MIRT580411 Tmem161b transmembrane protein 161B 1 1
MIRT580506 Tfam transcription factor A, mitochondrial 1 1
MIRT580533 Tead3 TEA domain family member 3 1 1
MIRT580554 Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box 1 1
MIRT580568 Tbx4 T-box 4 1 1
MIRT580612 Syp synaptophysin 1 1
MIRT580665 Strbp spermatid perinuclear RNA binding protein 1 1
MIRT580793 Snx27 sorting nexin family member 27 1 1
MIRT580819 Smurf2 SMAD specific E3 ubiquitin protein ligase 2 1 1
MIRT580868 Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 1 1
MIRT580880 Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 1 1
MIRT580920 Slc35a1 solute carrier family 35 (CMP-sialic acid transporter), member 1 1 1
MIRT581144 Senp3 SUMO/sentrin specific peptidase 3 1 1
MIRT581245 Rufy2 RUN and FYVE domain-containing 2 1 1
MIRT581261 Rragb Ras-related GTP binding B 1 1
MIRT581293 Rnf166 ring finger protein 166 1 1
MIRT581352 Ret ret proto-oncogene 1 1
MIRT581388 Rbms3 RNA binding motif, single stranded interacting protein 1 1
MIRT581422 Rasal2 RAS protein activator like 2 1 1
MIRT581453 Ranbp10 RAN binding protein 10 1 1
MIRT581541 Pten phosphatase and tensin homolog 1 1
MIRT581573 Prrx1 paired related homeobox 1 1 1
MIRT581589 Lzts3 leucine zipper, putative tumor suppressor family member 3 1 1
MIRT581665 Ppp4r2 protein phosphatase 4, regulatory subunit 2 1 1
MIRT581738 Plxnc1 plexin C1 1 1
MIRT581791 Plaur plasminogen activator, urokinase receptor 1 1
MIRT581820 Pkib protein kinase inhibitor beta, cAMP dependent, testis specific 1 1
MIRT581893 Phf17 jade family PHD finger 1 1 1
MIRT581982 Pcsk5 proprotein convertase subtilisin/kexin type 5 1 1
MIRT582003 Pcdh20 protocadherin 20 1 1
MIRT582052 Osbp oxysterol binding protein 1 1
MIRT582100 Nupl2 nucleoporin like 2 1 1
MIRT582149 Nol7 nucleolar protein 7 1 1
MIRT582156 Nln neurolysin (metallopeptidase M3 family) 1 1
MIRT582256 Nckap5l NCK-associated protein 5-like 1 1
MIRT582373 Map1a microtubule-associated protein 1 A 1 1
MIRT582410 Mpped2 metallophosphoesterase domain containing 2 1 1
MIRT582442 Mgea5 meningioma expressed antigen 5 (hyaluronidase) 1 1
MIRT582587 Lrrtm2 leucine rich repeat transmembrane neuronal 2 1 1
MIRT582671 Lin54 lin-54 homolog (C. elegans) 1 1
MIRT582719 Larp1 La ribonucleoprotein domain family, member 1 1 1
MIRT582727 L3mbtl4 l(3)mbt-like 4 (Drosophila) 1 2
MIRT582764 Klf12 Kruppel-like factor 12 1 1
MIRT582858 Ism1 isthmin 1, angiogenesis inhibitor 1 1
MIRT582943 Ikzf5 IKAROS family zinc finger 5 1 1
MIRT582999 Id2 inhibitor of DNA binding 2 1 1
MIRT583061 Hoxa11 homeobox A11 1 1
MIRT583100 Hiat1 major facilitator superfamily domain containing 14A 1 1
MIRT583108 Hexim1 hexamethylene bis-acetamide inducible 1 1 1
MIRT583136 Has2 hyaluronan synthase 2 1 1
MIRT583187 Grhl3 grainyhead-like 3 (Drosophila) 1 1
MIRT583231 Gpc6 glypican 6 1 1
MIRT583391 Fzd5 frizzled class receptor 5 1 1
MIRT583411 Fzd1 frizzled class receptor 1 1 1
MIRT583425 Fsd1l fibronectin type III and SPRY domain containing 1-like 1 1
MIRT583527 Fgf16 fibroblast growth factor 16 1 1
MIRT583544 Fbxl20 F-box and leucine-rich repeat protein 20 1 1
MIRT583611 Fam46a family with sequence similarity 46, member A 1 1
MIRT583738 Erc1 ELKS/RAB6-interacting/CAST family member 1 1 3
MIRT583770 Ep300 E1A binding protein p300 1 1
MIRT583797 Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 1 1
MIRT583817 Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha 1 1
MIRT583953 Dlx3 distal-less homeobox 3 1 1
MIRT584138 Crebzf CREB/ATF bZIP transcription factor 1 1
MIRT584210 Cops7b COP9 signalosome subunit 7B 1 1
MIRT584435 Ccdc90b coiled-coil domain containing 90B 1 1
MIRT584453 Cbx3 chromobox 3 1 1
MIRT584467 Casc4 cancer susceptibility candidate 4 1 1
MIRT584506 Calm1 calmodulin 1 1 1
MIRT584735 Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 1 1
MIRT584809 Arl15 ADP-ribosylation factor-like 15 1 1
MIRT584849 Arhgap11a Rho GTPase activating protein 11A 1 1
MIRT584997 Ndnf neuron-derived neurotrophic factor 1 1
MIRT585041 Lrrc71 leucine rich repeat containing 71 1 1
MIRT585730 Synpr synaptoporin 1 1
MIRT585764 Sri sorcin 1 1
MIRT586097 Reep5 receptor accessory protein 5 1 1
MIRT586120 Rccd1 RCC1 domain containing 1 1 1
MIRT587442 Dimt1 DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 1 1
MIRT587533 Cxxc5 CXXC finger 5 1 1
MIRT588362 Zfp518b zinc finger protein 518B 1 1
MIRT588472 Wwtr1 WW domain containing transcription regulator 1 1 1
MIRT588619 Trak2 trafficking protein, kinesin binding 2 1 1
MIRT588696 Tet2 tet methylcytosine dioxygenase 2 1 1
MIRT588844 Sort1 sortilin 1 1 1
MIRT588974 Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 1 1
MIRT589264 Plau plasminogen activator, urokinase 1 1
MIRT589381 Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 1 1
MIRT589449 Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 1 1
MIRT589536 Mllt3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 1 1
MIRT590500 Cacnb2 calcium channel, voltage-dependent, beta 2 subunit 1 1
MIRT590676 Anln anillin, actin binding protein 1 3
MIRT590761 Acbd5 acyl-Coenzyme A binding domain containing 5 1 1
MIRT590795 4921524J17Rik RIKEN cDNA 4921524J17 gene 1 1
MIRT593050 Nf2 neurofibromin 2 1 1
MIRT594246 Sox11 SRY (sex determining region Y)-box 11 1 1
MIRT594396 Ints6 integrator complex subunit 6 1 1
MIRT594712 Zwint ZW10 interactor 1 1
MIRT594774 Tex12 testis expressed gene 12 1 1
MIRT594790 Slitrk2 SLIT and NTRK-like family, member 2 1 1
MIRT595122 Mex3b mex3 RNA binding family member B 1 1
MIRT595538 Etv3 ets variant 3 1 1
MIRT595682 Rnf6 ring finger protein (C3H2C3 type) 6 1 1
MIRT595833 Tmem56 transmembrane protein 56 1 1
MIRT595896 Cd69 CD69 antigen 1 1
MIRT595962 Znrf1 zinc and ring finger 1 1 1
MIRT595979 Ocrl OCRL, inositol polyphosphate-5-phosphatase 1 1
MIRT596009 Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 1 1
MIRT596190 Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 1 1
MIRT603671 Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 1 1
MIRT735076 Hmgb1 high mobility group box 1 3 0
MIRT755744 Nos2 nitric oxide synthase 2, inducible 1 1
MIRT755745 Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-410 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-410 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated

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