pre-miRNA Information | |
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pre-miRNA | mmu-mir-122 |
Genomic Coordinates | chr18: 65248861 - 65248926 |
Synonyms | Mirn122a, mmu-mir-122, Mir122a |
Description | Mus musculus miR-122 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-122-5p |
Sequence | 6| UGGAGUGUGACAAUGGUGUUUG |27 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Biomarker Information |
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Gene Information | |||||||||||||||||||||
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Gene Symbol | Tmem206 | ||||||||||||||||||||
Synonyms | 2310028N02Rik, AI118576 | ||||||||||||||||||||
Description | transmembrane protein 206 | ||||||||||||||||||||
Transcript | NM_025864 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Tmem206 | |||||||||||||||||||||
3'UTR of Tmem206 (miRNA target sites are highlighted) |
>Tmem206|NM_025864|3'UTR 1 AGCGCCCGTGCCACGGCACTCCGACAGAGCGAGACACCAGCAATCCTGAACTCACTTGAAGGGACCCTGCAGGGAAGGAC 81 AGTCCCGTCCATCGCACTGGAGGCTCAAACCCGGCCCGGGAGGGAAACGCCCAGTGAATAACCTGAAACTTATTTAAGTA 161 CTTAAATTATTAACGGACATCTTGCAGAGCTGCCTAGTGCCTTGGAGAGGTTCCTCCTATTTGGTCACTAAATAGTTAAG 241 GCTTCTTCTTTCCCTTAGGGCTTTTTTTCTTTAAAGCGGACTGATGTGCCCTGTACGCAGAATTCCTTTTAGACCATCTA 321 CTGTTACTTAACAAGAACTTGTTAGAGCCTAGATTTGACTTTTTTGTTTTTCCTTAAATGTAGCCCCGCTGTAATCACTG 401 TGTAGACCAGGCCTTCCTCGTGCCTTCCCATTGCTGAGACTAAGAGCCTACATCACTCCCCGCAAGCTTTACACGAGACC 481 TTAAAGGCTACTAGAAACTTGTGATTGTATTTCTGATGTGCTAGAAGTGCTAGCAGAGGTATATACAGTAGGCACCTACT 561 TAGTGTATCTTGATTTCATTAACAGGTAAATAAGGTTGGGCAAGCACAAAAGGGATGGGAGTGAATACCCAGTAAGCCAG 641 CGGGCAGCAACGCTGGACGCTGATGCTGTATGGCCAGCAAACCCAGAAGGTAGTGTAAGTCTGGACCGCAGCATAATGGC 721 TCTGACTCAGCACACATCACTGCCAACAGGGAGGTAAGCTGTGCACTGTCCACAGGTGGCCAAGAGGGATGGCCACACCA 801 CATGAGCTAGTCCCTGCGTCCTACAGAAACACACACCTAAAAGGGTGGCCTTTAGGGCTTTGATAAACAGCACCTCTACA 881 TAAAACCAAAAACTCTATAATAGAGTTCCACATGTGGCCAGAGGTAACATTGAAGAACTTGTAATTATGCCTTAGGGAAT 961 CGGAAGGGAAATACTCACAGGTATAAGGAGGACATTTTTGTCTCTAAATTAGCAGCAAGAAACTGTTTTGCCCAAATCCC 1041 TAGAAATAAACTTGTACTGTGAAATATTCCTGCTACCTTTGTCTCACATATATACAAGAATTTAGATTTTTAGCCTAAAA 1121 CTTTTATTATAAAACACCATTTTAGCACAAATGCCAAGCATAAAGCATCAGTGACATTAAAAATATGTGAAGGACAGAAA 1201 GTCGAGGGGCAGGGGTGCAGTCCAGTCACAGGATGTGTGCTTACCACGCAGGGCCCTTAAAGTTCACAGTTGCATAGCAC 1281 TTCAGTAGTTAAATATCTGCCTCAGTGAACACTAAAGCTTTATTTTCCTGTATTGTGAAAGCTGAGCTGCTTTTAATTTT 1361 GCTTTAGATAACTAGGAAGTAATTTTTGCCTATTCATAGAATAAAAACCCGACTTCCACTTTCTGGAAAGGCAACCCTGT 1441 GTTTTGTTTTGTTTTTTTTTAAGATTTATTTATTTATTATATGTAAGTACACTGTAGCTGTCTTCAGACACTCCAGAAGA 1521 GGGCATCAGATCTTGTTACAGATGGTTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCCTGACCTTCGGAAGAGCAG 1601 TCGGGTACTCTTACCCACTGAGCCATCTCACCAGCCCGCAACCCTGTGTTTTGTGTGGGTCGCCCAGGGCTATTCTGCAG 1681 AGGCCTAAAGGGAGCAGCCTCATTGGACTGCAACAATGGCCCTCCCTGGGATGCCCACTGCTTGAAAAGAGAGCAAAAAT 1761 TACAGGCCACTGTATTACAAGGGAGTTTGTCCAGAGGTCATGGAGGCTGCTGTCACAGCAACAAAAAACCCCTGTGACCC 1841 TTCTAAACTGGTGTTTAGTTGAAACCATGTTACAGTCTCCCTGCCTTTCCCAGAACTGCTACTGCCATGGATTCTGAGAT 1921 TTCCCGTTTTAGTTAAAACTAGCTTTAATGTTAAACTGTCCTAGAACACGGAGGGACAAGAAGCTTGGGATTTTATGAAA 2001 AGATCGGTTAGATGGCTAGACTCCTAATCCCTGGACCACAAGCAACCTAATTCTAATTAGAGTACATCCGTAAGTTATAA 2081 TTCTCTAATATAAATATCTTCCAGAGACAAAAGAGCAAATGACATAAGGCAAAATACAAACATAGACTTTATTAAATGCT 2161 GCTCAATCCTCAGTAAAGATCTCTCATTATAAAACAGTTTTCCATACAACTGCAAGGCAAGAGGCTGGAATGGTACTGGT 2241 AACAACAGTGTGAAAAATACCTGACCAGGTAAAAACAGACAAAGCTTCTACATAGTCAGCTCTGAGGACACCTGCTGCAG 2321 TTCCTTTAAATAAAGCCAGGCAGTGACAGCTAGCAGTCTGCATCACACTGTGGGAGGGACCCAGAGCTCCACCCTGCAGG 2401 CAGGCAGGCCTGGGGACTGGCAGGGTGAGGACTGGGAAGGCCCTGCCTCCAGCCTTGGAGGAGAGGAATGAAGGAGGTGA 2481 GCCTCGGGTCCACCCGTGGCCTGTGCTGCTCCGCACACGCTCCGGGGAGCCGCTGCTGAAGGGGGGATTTGGGAACATCA 2561 GAATTTTGGTTTACTTCCCCCCCCCAACTTTAATACTTTGTGCTTCAGAAGCCTGGAAATGTCAGATGTTGTAAAACCCA 2641 GAGTATGGCAGTGTCTTTAATGAGGCTGGGCTCTTGTCCCCTGCCCACACCTCTCTAGGAGAGGTGAGGGAAGGGCAACC 2721 CCTCCGCTTATCTTACGAGGCTCTTTCCTCAGATGTACTCAAGGTGTGCAGCACCAAGGTGTGCAGCACGGTGAAAACAC 2801 ATGATAAAGGAAGTGTGCAGAGGACGGCTTCATCTGTGTGTGCAGCACAACCGGGCTCAAGTCGCAACACACGCTTGCCA 2881 CTCCCACGATCACCTCACTCAACAGAGACAGTGACACAATCCATGATTAGACAGAGTTTACAATATACTGTGGCCGTGAT 2961 ACAGCACAGGGCTATGTTTTAGTCCATAATTCTTTCGCTTTTACGCTTGCCAGGAAAAACTGGCCTCCTAATTATATTAT 3041 ACTGATGAGGTCTGCTCTGAAGTTTTTATATATTC Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | mESCs |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM622570. RNA binding protein: AGO2. Condition:WT1A
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | C2C12 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes
... - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell. |
Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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86 mmu-miR-122-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT003075 | Tmem50b | transmembrane protein 50B | ![]() |
1 | 1 | |||||||
MIRT003076 | Lass6 | ceramide synthase 6 | ![]() |
1 | 1 | |||||||
MIRT003077 | Gpx7 | glutathione peroxidase 7 | ![]() |
1 | 1 | |||||||
MIRT003113 | Tgfbr1 | transforming growth factor, beta receptor I | ![]() |
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3 | 1 | |||||
MIRT003114 | Sbk1 | SH3-binding kinase 1 | ![]() |
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3 | 1 | |||||
MIRT003117 | Hist1h1c | histone cluster 1, H1c | ![]() |
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3 | 1 | |||||
MIRT003118 | Ddc | dopa decarboxylase | ![]() |
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2 | 1 | ||||||
MIRT003120 | Rell1 | RELT-like 1 | ![]() |
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3 | 1 | |||||
MIRT003121 | Bach1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | ![]() |
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2 | 1 | ||||||
MIRT003122 | Apob | apolipoprotein B | ![]() |
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2 | 1 | ||||||
MIRT003123 | P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | ![]() |
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2 | 1 | ||||||
MIRT003124 | Ccng1 | cyclin G1 | ![]() |
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2 | 1 | ||||||
MIRT003125 | Slc7a1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | ![]() |
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3 | 3 | |||||
MIRT003126 | Gys1 | glycogen synthase 1, muscle | ![]() |
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2 | 2 | ||||||
MIRT003127 | Slc35a4 | solute carrier family 35, member A4 | ![]() |
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2 | 2 | ||||||
MIRT003128 | Hfe2 | hemochromatosis type 2 (juvenile) | ![]() |
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3 | 3 | |||||
MIRT003129 | Tmed3 | transmembrane p24 trafficking protein 3 | ![]() |
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2 | 2 | ||||||
MIRT003132 | Bckdk | branched chain ketoacid dehydrogenase kinase | ![]() |
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4 | 1 | ||||
MIRT003133 | Aldoa | aldolase A, fructose-bisphosphate | ![]() |
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4 | 7 | ||||
MIRT003134 | Ndrg3 | N-myc downstream regulated gene 3 | ![]() |
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4 | 2 | ||||
MIRT003135 | Cd320 | CD320 antigen | ![]() |
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4 | 1 | ||||
MIRT003724 | Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | ![]() |
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3 | 1 | |||||
MIRT003725 | Rcan1 | regulator of calcineurin 1 | ![]() |
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2 | 1 | ||||||
MIRT003726 | Gde1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 1 | ||||||
MIRT004536 | Ccrn4l | nocturnin | ![]() |
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4 | 1 | ||||
MIRT005975 | Klf6 | Kruppel-like factor 6 | ![]() |
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4 | 1 | ||||
MIRT005976 | B2m | beta-2 microglobulin | ![]() |
1 | 1 | |||||||
MIRT005977 | Afp | alpha fetoprotein | ![]() |
1 | 1 | |||||||
MIRT005978 | Ccl2 | chemokine (C-C motif) ligand 2 | ![]() |
1 | 1 | |||||||
MIRT005979 | Csf3r | colony stimulating factor 3 receptor (granulocyte) | ![]() |
1 | 1 | |||||||
MIRT005980 | Ctgf | connective tissue growth factor | ![]() |
1 | 1 | |||||||
MIRT005981 | Cxcl13 | chemokine (C-X-C motif) ligand 13 | ![]() |
1 | 1 | |||||||
MIRT005982 | Cyp2b13 | cytochrome P450, family 2, subfamily b, polypeptide 13 | ![]() |
1 | 1 | |||||||
MIRT005983 | Dbp | D site albumin promoter binding protein | ![]() |
1 | 1 | |||||||
MIRT005984 | Igf2 | insulin-like growth factor 2 | ![]() |
1 | 1 | |||||||
MIRT005985 | Il1b | interleukin 1 beta | ![]() |
1 | 1 | |||||||
MIRT005986 | Jun | jun proto-oncogene | ![]() |
1 | 1 | |||||||
MIRT005987 | Per1 | period circadian clock 1 | ![]() |
1 | 1 | |||||||
MIRT005988 | Alpl | alkaline phosphatase, liver/bone/kidney | ![]() |
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2 | 1 | ||||||
MIRT005989 | Cs | citrate synthase | ![]() |
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2 | 1 | ||||||
MIRT005990 | Prom1 | prominin 1 | ![]() |
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3 | 1 | |||||
MIRT005991 | Sox4 | SRY (sex determining region Y)-box 4 | ![]() |
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3 | 1 | |||||
MIRT013527 | Uros | uroporphyrinogen III synthase | ![]() |
1 | 1 | |||||||
MIRT013528 | Ppox | protoporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013529 | Urod | uroporphyrinogen decarboxylase | ![]() |
1 | 1 | |||||||
MIRT013530 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013531 | Fech | ferrochelatase | ![]() |
1 | 1 | |||||||
MIRT013532 | Hamp | hepcidin antimicrobial peptide | ![]() |
1 | 1 | |||||||
MIRT013533 | Tfr2 | transferrin receptor 2 | ![]() |
1 | 1 | |||||||
MIRT013534 | Smad4 | SMAD family member 4 | ![]() |
1 | 1 | |||||||
MIRT013535 | Smad7 | SMAD family member 7 | ![]() |
1 | 1 | |||||||
MIRT013536 | Bmpr1a | bone morphogenetic protein receptor, type 1A | ![]() |
1 | 1 | |||||||
MIRT013537 | Hba-a1 | hemoglobin alpha, adult chain 1 | ![]() |
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2 | 1 | ||||||
MIRT013538 | Hmbs | hydroxymethylbilane synthase | ![]() |
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2 | 1 | ||||||
MIRT013539 | Mir17 | microRNA 17 | ![]() |
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2 | 1 | ||||||
MIRT013540 | Alas2 | aminolevulinic acid synthase 2, erythroid | ![]() |
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2 | 1 | ||||||
MIRT013541 | Mir451 | microRNA 451a | ![]() |
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2 | 1 | ||||||
MIRT013542 | Tfrc | transferrin receptor | ![]() |
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2 | 1 | ||||||
MIRT013543 | Socs2 | suppressor of cytokine signaling 2 | ![]() |
1 | 1 | |||||||
MIRT013544 | Slc35g1 | solute carrier family 35, member G1 | ![]() |
1 | 1 | |||||||
MIRT013545 | Camk2b | calcium/calmodulin-dependent protein kinase II, beta | ![]() |
1 | 1 | |||||||
MIRT013546 | Irf6 | interferon regulatory factor 6 | ![]() |
1 | 1 | |||||||
MIRT013547 | Rbl2 | RB transcriptional corepressor like 2 | ![]() |
1 | 1 | |||||||
MIRT013548 | Hfe | hemochromatosis | ![]() |
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2 | 1 | ||||||
MIRT013549 | Ccnd1 | cyclin D1 | ![]() |
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2 | 1 | ||||||
MIRT054338 | Pkm | pyruvate kinase, muscle | ![]() |
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3 | 1 | |||||
MIRT054339 | Tfdp2 | transcription factor Dp 2 | ![]() |
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3 | 1 | |||||
MIRT054340 | E2f1 | E2F transcription factor 1 | ![]() |
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3 | 1 | |||||
MIRT579817 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 1 | |||||||
MIRT580378 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT581166 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT582514 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT586941 | H2-T24 | histocompatibility 2, T region locus 24 | ![]() |
1 | 2 | |||||||
MIRT591859 | Iffo2 | intermediate filament family orphan 2 | ![]() |
1 | 1 | |||||||
MIRT592160 | Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | ![]() |
1 | 1 | |||||||
MIRT592189 | Nanog | Nanog homeobox | ![]() |
1 | 2 | |||||||
MIRT592792 | Cdh12 | cadherin 12 | ![]() |
1 | 1 | |||||||
MIRT597026 | Thap1 | THAP domain containing, apoptosis associated protein 1 | ![]() |
1 | 1 | |||||||
MIRT597210 | Snhg11 | small nucleolar RNA host gene 11 | ![]() |
1 | 1 | |||||||
MIRT601300 | Zfp949 | zinc finger protein 949 | ![]() |
1 | 1 | |||||||
MIRT602608 | Chrna1 | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) | ![]() |
1 | 1 | |||||||
MIRT602960 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT603391 | Sgol2 | shugoshin 2A | ![]() |
1 | 1 | |||||||
MIRT604008 | Ggps1 | geranylgeranyl diphosphate synthase 1 | ![]() |
1 | 1 | |||||||
MIRT605553 | Ppp1r16b | protein phosphatase 1, regulatory (inhibitor) subunit 16B | ![]() |
1 | 1 | |||||||
MIRT606204 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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