pre-miRNA Information | |
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pre-miRNA | mmu-mir-9-1 |
Genomic Coordinates | chr3: 88215598 - 88215686 |
Synonyms | Mirn9, Mirn9-1, mmu-mir-9-1, Mir9-1 |
Description | Mus musculus miR-9-1 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
pre-miRNA | mmu-mir-9-2 |
Genomic Coordinates | chr13: 83738814 - 83738885 |
Synonyms | Mirn9-2, mmu-mir-9-2, Mir9-2 |
Description | Mus musculus miR-9-2 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
pre-miRNA | mmu-mir-9-3 |
Genomic Coordinates | chr7: 79505264 - 79505353 |
Synonyms | Mirn9-3, mmu-mir-9-3, Mir9-3 |
Description | Mus musculus miR-9-3 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-9-5p |
Sequence | 16| UCUUUGGUUAUCUAGCUGUAUGA |38 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Biomarker Information |
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Gene Information | |||||||||||||||||||||
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Gene Symbol | Slc35g1 | ||||||||||||||||||||
Synonyms | AA590464, D330039I19Rik, Tmem20 | ||||||||||||||||||||
Description | solute carrier family 35, member G1 | ||||||||||||||||||||
Transcript | NM_175507 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Slc35g1 | |||||||||||||||||||||
3'UTR of Slc35g1 (miRNA target sites are highlighted) |
>Slc35g1|NM_175507|3'UTR 1 AGTGTCACTGCTGAAACCTGGTTTTTATTTTCAAGTGTGCTGTCACCTAGCTCAGACATCTTGCACACCCACACACATAC 81 CTGGAGAATCTTCATCACTCATTGGCTTTCTTTAATACCTTTCATAAAGTGCCATTTTTAAACATAGTGCGTTTTTAGTT 161 AAGAGTAGCTAGCTAGCCGGGCGTGTTGGCGCACGCCTTTAATCCCAGCACTCGGGAGGCAGAGGCAGGCGGATTTCTGA 241 GTTTGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACAGCCAAGGCTACACAGAGAAGCCCTGTCTCGAAAAACAAAA 321 ACAAAAAAGAGTAGCTAGCTAGGCTAGCCTCACAGTCTGGATAGCTTTTATCTTTGCTTTGGCTCCTTGGTTGGGTTACC 401 ATTGATGAGAAGGGAGCTCATTTGAGGAATTTCAGAAATTTTTATGAGTACAATTTTTAAAATTTATTTCTGACCCGGGA 481 TGTGGATGGGAGATCCTCTATTTTAGCAGTGCACATAAGAAGCTCAACGTTGACAATGCTGCTCTAGTTAGTACTGTGCT 561 AATCTGTTGATTGCAATATCATCCCACTTAGGATGCCAAAGCTGCAACTTGGTCTAGGTGCCTACCTACCCATAGGAGTA 641 TAAGCGAACCAGCCTTATTCTCAAGGATCTTAGAGATGATTACTACACTTTTAACTCATGTGTGCCTTTTCGTTTTGATG 721 CTGGGACTTTTTATATGTACTCTGAACAGAGCCTTCAGCTTGCCACATGTGGTTAGCAGTTCTCTCTTTCAGAATATTAA 801 CAACTCTGGCTATCATTTTGAATTTCAGTTGTCTCCTGTTTTATTGAAATTGCACTTTTTTTTTAACATTCCGAGATTTC 881 CAACCTTGAAATCATGAGAGCAAAATCTTGGCGTGATCAGTGTGTACATTCCCATCCTGAGGTGATTTCACTTCAGATGC 961 GGTGGTTTTTCTACAAATTCTCTTTGAATTCATAGTGTGATGCCAAATACAATTTTTTTCTCAGGATTGTACTAGGCTGG 1041 GCCATTATCAGATTGCCCAGATTCTACCGTTTTCATTTTCAAAACCCACAGTTCTAGAAGGTTCATCCCGCAGGCTCCCT 1121 TCGCATTAAACCAAATATTTATACCTTTACAGTACATGTCTGTTAATAAACGTACAGTCTTTTTCCATCTTGGAATGGTA 1201 TGTTATAATGCTTGTGGCATACGAAAAATGTAAAGACTTGTTACTCCATAGTTGATTGGTTTTCCCAGTCTTTTGCATAT 1281 ACGGAAAGAACACAGGTACAAGCCAGTCTTTGACACACAATCCTAGTGTGAACTTAGACAGTAGATTCTATCTGTGGAGC 1361 ACCAGCAGGCCAGTACTCCTCTGTGAAAGAGGAAAACTTGGTAGATTGGGAGTAAATGACCATGCGTCTTTGGGGCGCTT 1441 TGGATGCCTTTATGGTGAGGCCATTGTGGCTGCCACCTCTTACTTTGTCAGACACTGTCTACTGTTATCATTAGCTGCAG 1521 ACTTGAGGGGCTATTGCTCTCTCCCACACTCCTCACAGCTCTTCTGGAGGAAGGGACTGGTCTCCTGGATCTTACATTTA 1601 GCTATGAAAGGATCTTCTCCAGTAGTTCCTAAGAGGAACTTTGAGTTTGGTGGTTTTAAATCACCTTAGCCACCTGACAT 1681 CCTACATATGTACTTAGCTGAATCACCTCAGTTGCATTTGACCCCGCATAGATCTGCCAATGGTGCCGTTCTACCAACAT 1761 CCTAGAAAACACAGAGTCAGCAGACTCTTAGTACTCTGGAGGGGTCTTAGAGGGCATCCTGAGGGATGACGGGAGGGAGG 1841 GCTGCAATAGCTGGTTTCCATAGCAGCCTCCTCTTACTGAGTTCCACTCCTGGAGTACCACCAAACTTACACAATAGAAG 1921 AGTGTCTGGGATAGTGGAAGATAACCCCTTTGGAAATACATTATATTTCAACTGTGTCTTAAGTACATGGATGTCAGGAT 2001 ATGTGGCTGACATTGGAGACAATGTTTCTTATACCAACCTTTACAGGGTATGATTTTTAAACAATGTTCAAGTGGTATAC 2081 AAGGCTATGTATTGTAACAATTACGGGGGTTTATGTATTTTCCAAAGATTGTAGTTTCTATATCTTGCAAAGGGAAATAT 2161 TTTTTTCCTAATGTGTTTTTATTTTGTAAGTAATAAAATCATAAAAGAAAGATGTTGGGTTTTACAACT Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | C2C12 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes
... - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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526 mmu-miR-9-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT000453 | Stmn1 | stathmin 1 | ![]() |
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4 | 1 | ||||
MIRT001913 | Foxg1 | forkhead box G1 | ![]() |
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2 | 1 | ||||||
MIRT003796 | Runx1 | runt related transcription factor 1 | ![]() |
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3 | 1 | |||||
MIRT005601 | Sirt1 | sirtuin 1 | ![]() |
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4 | 1 | ||||
MIRT005793 | Hes1 | hairy and enhancer of split 1 (Drosophila) | ![]() |
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3 | 2 | |||||
MIRT006708 | Zfp521 | zinc finger protein 521 | ![]() |
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3 | 1 | |||||
MIRT015114 | Fmnl2 | formin-like 2 | ![]() |
1 | 1 | |||||||
MIRT015115 | Pdhx | pyruvate dehydrogenase complex, component X | ![]() |
1 | 1 | |||||||
MIRT015116 | Srcin1 | SRC kinase signaling inhibitor 1 | ![]() |
1 | 1 | |||||||
MIRT015117 | Sufu | suppressor of fused homolog (Drosophila) | ![]() |
1 | 1 | |||||||
MIRT015118 | Lsamp | limbic system-associated membrane protein | ![]() |
1 | 1 | |||||||
MIRT015119 | Bptf | bromodomain PHD finger transcription factor | ![]() |
1 | 1 | |||||||
MIRT015120 | Tor1aip2 | torsin A interacting protein 2 | ![]() |
1 | 1 | |||||||
MIRT015121 | Tspan7 | tetraspanin 7 | ![]() |
1 | 1 | |||||||
MIRT015122 | Ror1 | receptor tyrosine kinase-like orphan receptor 1 | ![]() |
1 | 1 | |||||||
MIRT015123 | Atp1b1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | ![]() |
1 | 1 | |||||||
MIRT015124 | Clock | circadian locomotor output cycles kaput | ![]() |
1 | 1 | |||||||
MIRT015125 | Zbtb34 | zinc finger and BTB domain containing 34 | ![]() |
1 | 1 | |||||||
MIRT015126 | Cdan1 | congenital dyserythropoietic anemia, type I (human) | ![]() |
1 | 1 | |||||||
MIRT015127 | Asb7 | ankyrin repeat and SOCS box-containing 7 | ![]() |
1 | 1 | |||||||
MIRT015128 | Nmt2 | N-myristoyltransferase 2 | ![]() |
1 | 1 | |||||||
MIRT015129 | Ccdc50 | coiled-coil domain containing 50 | ![]() |
1 | 1 | |||||||
MIRT015130 | Gzf1 | GDNF-inducible zinc finger protein 1 | ![]() |
1 | 1 | |||||||
MIRT015131 | Fads2 | fatty acid desaturase 2 | ![]() |
1 | 1 | |||||||
MIRT015132 | Arf2 | ADP-ribosylation factor 2 | ![]() |
1 | 1 | |||||||
MIRT015133 | Elovl2 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 | ![]() |
1 | 1 | |||||||
MIRT015134 | Ctgf | connective tissue growth factor | ![]() |
1 | 1 | |||||||
MIRT015135 | Myo5a | myosin VA | ![]() |
1 | 1 | |||||||
MIRT015136 | Plat | plasminogen activator, tissue | ![]() |
1 | 1 | |||||||
MIRT015137 | Akap9 | A kinase (PRKA) anchor protein (yotiao) 9 | ![]() |
1 | 1 | |||||||
MIRT015138 | Akt3 | thymoma viral proto-oncogene 3 | ![]() |
1 | 1 | |||||||
MIRT015139 | Prom1 | prominin 1 | ![]() |
1 | 1 | |||||||
MIRT015140 | Prrc2b | proline-rich coiled-coil 2B | ![]() |
1 | 1 | |||||||
MIRT015141 | Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | ![]() |
1 | 1 | |||||||
MIRT015142 | Scn8a | sodium channel, voltage-gated, type VIII, alpha | ![]() |
1 | 1 | |||||||
MIRT015143 | Fam63b | MINDY lysine 48 deubiquitinase 2 | ![]() |
1 | 1 | |||||||
MIRT015144 | Gtf3c4 | general transcription factor IIIC, polypeptide 4 | ![]() |
1 | 1 | |||||||
MIRT015145 | Chst11 | carbohydrate sulfotransferase 11 | ![]() |
1 | 1 | |||||||
MIRT015146 | Cplx2 | complexin 2 | ![]() |
1 | 1 | |||||||
MIRT015147 | B4galt5 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 | ![]() |
1 | 1 | |||||||
MIRT015148 | Rnf4 | ring finger protein 4 | ![]() |
1 | 1 | |||||||
MIRT015149 | Myo6 | myosin VI | ![]() |
1 | 1 | |||||||
MIRT015150 | Sidt2 | SID1 transmembrane family, member 2 | ![]() |
1 | 1 | |||||||
MIRT015151 | Fam115a | TRPM8 channel-associated factor 1 | ![]() |
1 | 1 | |||||||
MIRT015152 | Rpgrip1l | Rpgrip1-like | ![]() |
1 | 1 | |||||||
MIRT015153 | Nkrf | NF-kappaB repressing factor | ![]() |
1 | 1 | |||||||
MIRT015154 | Clstn1 | calsyntenin 1 | ![]() |
1 | 1 | |||||||
MIRT015155 | Paqr8 | progestin and adipoQ receptor family member VIII | ![]() |
1 | 1 | |||||||
MIRT015156 | Hdgfrp3 | HDGF like 3 | ![]() |
1 | 1 | |||||||
MIRT015157 | D3Bwg0562e | phospholipid phosphatase related 4 | ![]() |
1 | 1 | |||||||
MIRT015158 | Gjc3 | gap junction protein, gamma 3 | ![]() |
1 | 1 | |||||||
MIRT015159 | Larp4 | La ribonucleoprotein domain family, member 4 | ![]() |
1 | 1 | |||||||
MIRT015160 | March8 | membrane-associated ring finger (C3HC4) 8 | ![]() |
1 | 1 | |||||||
MIRT015161 | Spire1 | spire homolog 1 (Drosophila) | ![]() |
1 | 1 | |||||||
MIRT015162 | Cnrip1 | cannabinoid receptor interacting protein 1 | ![]() |
1 | 1 | |||||||
MIRT015163 | Slc30a10 | solute carrier family 30, member 10 | ![]() |
1 | 1 | |||||||
MIRT015164 | Tspan31 | tetraspanin 31 | ![]() |
1 | 1 | |||||||