pre-miRNA Information | |
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pre-miRNA | mmu-mir-374b |
Genomic Coordinates | chrX: 103573060 - 103573154 |
Description | Mus musculus miR-374b stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-374b-5p |
Sequence | 22| AUAUAAUACAACCUGCUAAGUG |43 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Npr3 | ||||||||||||||||||||
Synonyms | ANP-C, ANPR-C, EF-2, NPR-C, lgj, stri | ||||||||||||||||||||
Description | natriuretic peptide receptor 3 | ||||||||||||||||||||
Transcript | NM_001039181 | ||||||||||||||||||||
Other Transcripts | NM_008728 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Npr3 | |||||||||||||||||||||
3'UTR of Npr3 (miRNA target sites are highlighted) |
>Npr3|NM_001039181|3'UTR 1 AAGAGATGCCCCTCTCGCTTCGTCTACTTGAGATTCCTTAAAGAGATAGATGGAAGGACAGACATCAACGGAGCAGAAAG 81 GGCGTTCTCGGAGAAGTCATTCTTTTAAGCAGTAGTCATTTCATTTTACATTTTCTTTAGAAGCTCAGGAATGATTGTTA 161 ATCACTATCTGCCTTCTGGCCTCTCATCTCATGGCAAACTAATATAATGAAACAACGCAATGCTGTTAAGTGTTCTGGCT 241 GCTGGAGGGGCATCAGAGGAGATTTATGTCTTGAAAGTCTGCTGCGTCCATATCTTGATTGCTTTGGGGGCAGTTCACAC 321 GAGGATAGAAAAATGTGGCTTTTCTGAAATGAAATGTTTCGTAGCTAGGATAAAACAATTTTTACAAGGAGAATATTCTT 401 GGAAAGAATTTAACACCCAATAAGAGGACAATGGAATGAAAGAAATCTCCAGGCTGGGAATGCAGTGCCCCTCTCTCTGG 481 AACTGGGGGACAGGTTTGTGGTTGATGAAGGCTGCGTCCAACGTCCACATTCAGGTCTGAATTCATATCTCAAGAAAGGA 561 TCCTCCCTGTCTCTTTTAGTGTCTCATCAGAGCTACTCTGGAAAACTGTAAATATTAGTGAGCAAGGAGGATTTATATAA 641 GAAAATTGAGTCTAAAATGCTTCTTATACGATGTAAAAAAAGTCCTACTTCACACTAACATTTTATTTTTAAGTATTTTA 721 ATCTTATATTTTGGTATTAGAAATGTGTCTATTTTTTCATTTTGAAGATTAAATTTCACTTATATTTTAAGAGCACGGAG 801 GAGGTGTGTGACAAATCTGTGGAGAGGGAGGAACGGTTCTCGTTTTCTCTGCTGTCCTCTGTCCCTTGGCTGTCTCTAGT 881 CTAACTGCTAGTCTGGCTGAAGATGTACAGAAGTCTGTTCAGCTTACAAACTCTGAAGGAATACGTTGATGTTAAGCCGT 961 TGTTCATTTTCAACTGTTTTAAATGGATGTTATTGGAGGGCTACATTCTTTCTAACTATGGTCAAATGATGCCCTTCAAA 1041 ACCAGTAGACTTAAGTGGAGTCTATAAAGAAACACAACCCCTTTCCCTCAAGAATAAGCAGACAGTGAGAATTTGACAGC 1121 AAGACACAGTGGTGATACGTTTAAAAAAAAACTGCATGCAATTTATCAAAATTTGAGGTGATGATTTTAATTTAAAAAGG 1201 GAATGTTGATATCTGCTGTGTCCCTTTAACCTTATAGAGTTTTGCAGCCACCACAAATGATGCATAGCTTGGACAGTGAG 1281 CTAGGACAGACAAGGGCATCGTGGCTAAGACTGAGCCAGCCTTTGCTGGGTATCCTCTTTGCACTCAATCCTGGGTGCAG 1361 AGGTTTCAATTCTGGTTCCGACTTTATCATTTGAGGAGAGAACAAGGGTACCGTCTTGTAATTTTGCCTTTCTTGGTAAC 1441 ATTCTGAGCATCTGAAACCCAGCTTAAAGGGGGGAAATTAAATAATTTCTTGGAGGTCCTATCCATCCAGGTTAACTGTG 1521 GAGGAGTCCAAGCAAGCTTAGCAAGCTCTGGAAGCTGGCTTCCCAGGGAAGGAGTGGACCACACCTCATTCTCTCAGTGG 1601 AGTCAAAGTGAATGGGCTGCACCTGTGTGGGGCTCAGGAAACGGGATGCAAACCGCATGATAAAATGAATTAGCTTCTGA 1681 ACAACTGAAGGGGGTGTGGTAGGAGGTATGTCGTGGTTCTGCCTGTGGGATATTGAGGGAAAAGTGCTGACTTAAAAAAA 1761 AAAAGTAGGCCAGAAAGGCAAACTTTAAAATGCTAATCCAGGAGGCGCGTTTGTGGAGCACAACTCAGGAAGGCTGCAGC 1841 TGATGGTCAGGGACTCACATAATGAAGACAGATGGGCAGACTGCATCCACCCCAGTTCTCAGAACCAGAGGGCTGCTTGT 1921 TTCTCTCTTACATTTTCAATGATGTTTTCCCTGTGTTTCAGAGATACTCATTTTTTAATGTTTTTTTTTTTTGAACCTGT 2001 GTGTTAATTGCAGGAGGGTGACAGTGGGAAAAGTTCTCTACCTGGCTATATTCTTTGGGTATGAATATGTCTAATCCTTT 2081 CTTGAATTTGTATAGTTTCCCCTTGAATGTCAGCATAGTTACAACAGTATTTTTTATTTCTGCTCCAGCTAGAGGAATTG 2161 TTCCAAGGTTAATAGTGGATCCCCAGATTAGATGTTAAAGAATAGATTAGATGTTTAAAAAATAAATAGGCAGGGTGAAT 2241 CGTGAAGTCCCTGGAGTCATTTCCTACAATTTTAAAGCAATTCTTATTATATTATTATATTATTATTAATATTATTAAGG 2321 TTGATTGCTCATTTACATGCCTGCTGTATAGTTTGTCTTTCTTGAATGTCTTTACATGGCTAGACAAGGTGGCCCATGTC 2401 TTCAATTCCAGCACTTGGGAGGCAGAAGCAGGAGGATATCAGTGAGTTTAGGGCCAGGATGGTCTCCATAGTGAGTTTCA 2481 GATCAGCTGTAGTTACACAGTTAGACCTTGTCTCAGAAAAAAATAAATCATTATATGAGTAGCCAAAATGTCATTAAGTT 2561 TTAAAAACACCACCAAGTTGGGAAACCTTTGCTGACAGTATAGATGTCTGTTCCATGGTGGCTCTGGGTTAAAAACTCTT 2641 GGTATTGTATTGTAGAACTTAAATTCTTAACTGCTAAGCAACAACTTTGACAATTAGTCATTCATAATCTGCCAGTAGTC 2721 ATCTATTATATAATTAACAAAATGGAACTTTAGTTCTTAAGCCATTCTATAAATTTTTACTCTTAAGTCCAATGATCAAG 2801 GTTTCAAAGGGGGGGCATTTCATTAGTGTTTTTTATATCTTGTCAAATATAAGTTCATACACAAGCTAAACTAAGCGTAT 2881 ACTTATGGTGATGGAAATAAACACAAGTTTTATAGCCAATATTATTGTCTTAGATCTGGGAGAGAAGCTGAACTCAGAAA 2961 CAAAACTTTCTGGGTAGAGTCATATCTGTTCCCAACACAAACAGAGGTTTCACACGGAATCCGTCAACATGTATTGTTTT 3041 GAAGAGCCATTGGCGTGTCTTTTCCTGAACCACAGACAGAATTCCACATGTCTTGAAATAGTTGTTTACATTTCAGAATT 3121 CATGGAGGAGAGGGAGAATCCTATGGAATGAGAACAGATGCCCCACCCCCACTTCCTTTTTCTCTTGAATGAAAAGCTTT 3201 GGAATGCCAAGTCACTTCCCCTTGCTTACAGGCATCCTGTGCCTTTGCTCCTGGCACATCTACCTTCTGTGTCCCTAACT 3281 TACCTCTTTTCTTCTAGTTGGGACTGATTGTCAGGGTCTAAGACATGCAGTGGGACGTGGAAAGGGAGGCCTTGTGTATC 3361 TCAGAGAGTGGTTTCAGAAGCTGTTTCTAGTGATGCCATTGCTTTCTTGAAACAGAGCTACTCGTGCAGGTGTTTTAGAT 3441 GCGTCACAAGTGCGCGCGCGCACACACACACACACACACACACACACACACACACGAAAAAAGAGAATGAAAGAATAGCA 3521 TTTATAAATTGGAAAACACTAGGGTCTGTGTTTGTTGAGACACAAAGAGCTCAGATCCCTAATAGGTGCAACTACAAAGG 3601 CAAATGCCAATTGAACTTTGGCCCACTACCTATTTGTGTAGTTATACCCTACAGGTCTTTAGAAGAAGGCTGGTAATGAG 3681 CTGAATTTTTCCTTTAGTGGAAAAAACAGAAACTGTCTAGAAATACAGGATGCTTTAGGGGCAGCATAGAAGTAGGGAGA 3761 ACGAGCCAGAGGCACTGGAGGGATCTGTCTATTTTTCAGTTGGTCTTTAGAACAGAATAATGAACAGTTTAGACCTTCTT 3841 CAAAAGCCAGTCTCCACAAGAAGTGCTGGACATGCCCAGAGAGAAGAACCAGGAGCTTATGTCTCTCAAAGTGACAGAGA 3921 GAAGAAGTTTGCAGCTGACACGGGCTCAACTGTTCTTCATAGAGCTCCACCTGCTATCCATCACATTTCTATGGGTGTGC 4001 TAGCACCTTTCCCATGCAGGTGGAAACTTGTGAGGAGGCCTCCTCATTTACTCAGAGAAAAAAGACAAAATCGCACCGCT 4081 GTGAGGAGGTAGCTGGCTTCTACTCAGAAGCCTGACAGCAACTTGACCATGCATGTCCTTGGACAGTTTACATCTGTGAT 4161 TTTCATGTACGCGAAGGAACCTGGCTTTTTTCTCAGCATATGGATTTTTCCGATGTTTCCTGCAGGCCTATGGAATGAAA 4241 ATACTCCTCCAAAGGACACTGAGTTGGAGGTTGTTCAAATATCGCATTAACCACTAATGTTAATTCATCCCAAATGCAGA 4321 GCATTTCCCAAATGCTGATGCTGGTGTTTCTGTTTTAAGTCACTTCAAAGGTAATCAAAAGGATTTCAGTGGGAGCTGAC 4401 TCTCAGAGGTAAAAATAAATATGTTACAAAAACTCTTTGGTCTATCAGGTATCATACGATTCCTAGTGGAGAGATTTGAA 4481 CCAAGTAGACCTCAGAGTTAATAAAACATGTTCCATTTCTTTGATTCATATTTAAAGGCATAAATTTATATGCACAGGAC 4561 CAGGAGGTCCATTTCCCCAAGTGTGAATCATAATAGGATACCGAGTTCATTTTTACTTTCTAGAATAAAGCTGTCATAGT 4641 CTCTACTTATTATTGGGGAGAGAAAGAGTTATTTCTCCAGAGAAAGAGGAAACCATGGCTTTTGATGGACTATCTCATTC 4721 ATTACTCAGTGCCTGTGTCTGAACGTGTTCAATATGGTGTAGCATAGAAGACAGCAAGGAAGTGCTCTCAATTGGCCAAA 4801 ATCGGAGCCTTCTTCCCTGGGCATTGCTGAAACCAAGGGGCTGTGAGCTAAGCATGGCAGAAGGCCAGTCCCTCAGCCTG 4881 TGTCTTTTGAGCCATTTTGTTCATGGATAATTTAAATATGACCACAAAACAATAAAAACGTACCATGAATCTGGTAGAAG 4961 AGTCAAAGCTGCACCAGCTACATATAGCTTCCTATTCTAATGTAAGTAGAACTGTCTGCATATAATGTGATTTAATTTAT 5041 TGTTGTTCTGTGTAGAAAGTGAGGACTCATGACTGTGGATAAAGCCCTGTTTTGTATAATATATATATATATATATATAT 5121 ATTTTTTTTTTCTGGTGCAAAATTGGTCATTTAAGCAATCTACTTCATTTGGTGTTTGGATAGAAATGTGCGCGTGTTCT 5201 TGTAAAGGTTTCTATTCAGCAAGAATACCACATAGCCCAAATATAACAGTATGTTCTCATTAAACGTATACTCTACAGAA 5281 A Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | C2C12 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes
... - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell. |
Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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76 mmu-miR-374b-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT418787 | Map2 | microtubule-associated protein 2 | ![]() |
1 | 1 | |||||||
MIRT577252 | Zfp84 | zinc finger protein 84 | ![]() |
1 | 1 | |||||||
MIRT577346 | Zfp11 | zinc finger protein 11 | ![]() |
1 | 1 | |||||||
MIRT577582 | Tcf21 | transcription factor 21 | ![]() |
1 | 1 | |||||||
MIRT577695 | Slc35d2 | solute carrier family 35, member D2 | ![]() |
1 | 1 | |||||||
MIRT577869 | Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | ![]() |
1 | 1 | |||||||
MIRT577940 | Ppp6r1 | protein phosphatase 6, regulatory subunit 1 | ![]() |
1 | 1 | |||||||
MIRT577949 | Pou4f2 | POU domain, class 4, transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT578202 | Nadsyn1 | NAD synthetase 1 | ![]() |
1 | 1 | |||||||
MIRT578468 | Impg2 | interphotoreceptor matrix proteoglycan 2 | ![]() |
1 | 1 | |||||||
MIRT578587 | Hist1h1d | histone cluster 1, H1d | ![]() |
1 | 1 | |||||||
MIRT579056 | Cradd | CASP2 and RIPK1 domain containing adaptor with death domain | ![]() |
1 | 1 | |||||||
MIRT579823 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 2 | |||||||
MIRT579840 | Zer1 | zyg-11 related, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT579950 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT579992 | Wnt3 | wingless-type MMTV integration site family, member 3 | ![]() |
1 | 1 | |||||||
MIRT579997 | Wnt11 | wingless-type MMTV integration site family, member 11 | ![]() |
1 | 1 | |||||||
MIRT580191 | Ttll7 | tubulin tyrosine ligase-like family, member 7 | ![]() |
1 | 1 | |||||||
MIRT580256 | Trim2 | tripartite motif-containing 2 | ![]() |
1 | 1 | |||||||
MIRT580383 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT580415 | Tmem161b | transmembrane protein 161B | ![]() |
1 | 1 | |||||||
MIRT580534 | Tead3 | TEA domain family member 3 | ![]() |
1 | 1 | |||||||
MIRT580565 | Tbx4 | T-box 4 | ![]() |
1 | 1 | |||||||
MIRT580611 | Syp | synaptophysin | ![]() |
1 | 1 | |||||||
MIRT581171 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT581538 | Pten | phosphatase and tensin homolog | ![]() |
1 | 1 | |||||||
MIRT581571 | Prrx1 | paired related homeobox 1 | ![]() |
1 | 1 | |||||||
MIRT581741 | Plxnc1 | plexin C1 | ![]() |
1 | 1 | |||||||
MIRT581794 | Plaur | plasminogen activator, urokinase receptor | ![]() |
1 | 1 | |||||||
MIRT581822 | Pkib | protein kinase inhibitor beta, cAMP dependent, testis specific | ![]() |
1 | 1 | |||||||
MIRT581971 | Pdcd10 | programmed cell death 10 | ![]() |
1 | 1 | |||||||
MIRT582055 | Osbp | oxysterol binding protein | ![]() |
1 | 1 | |||||||
MIRT582142 | Npr3 | natriuretic peptide receptor 3 | ![]() |
1 | 1 | |||||||
MIRT582168 | Nkx2-2 | NK2 homeobox 2 | ![]() |
1 | 1 | |||||||
MIRT582469 | Mex3a | mex3 RNA binding family member A | ![]() |
1 | 1 | |||||||
MIRT582518 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT582589 | Lrrtm2 | leucine rich repeat transmembrane neuronal 2 | ![]() |
1 | 1 | |||||||
MIRT582667 | Lmtk2 | lemur tyrosine kinase 2 | ![]() |
1 | 1 | |||||||
MIRT583063 | Hoxa11 | homeobox A11 | ![]() |
1 | 1 | |||||||
MIRT583111 | Hexim1 | hexamethylene bis-acetamide inducible 1 | ![]() |
1 | 1 | |||||||
MIRT583233 | Gpc6 | glypican 6 | ![]() |
1 | 1 | |||||||
MIRT583395 | Fzd5 | frizzled class receptor 5 | ![]() |
1 | 1 | |||||||
MIRT583429 | Frmpd4 | FERM and PDZ domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT583613 | Fam46a | family with sequence similarity 46, member A | ![]() |
1 | 1 | |||||||
MIRT583848 | Eea1 | early endosome antigen 1 | ![]() |
1 | 1 | |||||||
MIRT584669 | B3gat1 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | ![]() |
1 | 1 | |||||||
MIRT584731 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | ![]() |
1 | 1 | |||||||
MIRT584872 | Ap3m1 | adaptor-related protein complex 3, mu 1 subunit | ![]() |
1 | 1 | |||||||
MIRT585039 | Lrrc71 | leucine rich repeat containing 71 | ![]() |
1 | 1 | |||||||
MIRT585303 | Zfp248 | zinc finger protein 248 | ![]() |
1 | 3 | |||||||
MIRT585725 | T2 | brachyury 2 | ![]() |
1 | 1 | |||||||
MIRT585759 | St8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | ![]() |
1 | 1 | |||||||
MIRT585986 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 | |||||||
MIRT586181 | Ptprr | protein tyrosine phosphatase, receptor type, R | ![]() |
1 | 1 | |||||||
MIRT586738 | Lcn5 | lipocalin 5 | ![]() |
1 | 1 | |||||||
MIRT586778 | Jmjd4 | jumonji domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT587048 | Gm5531 | transmembrane epididymal protein 1B | ![]() |
1 | 1 | |||||||
MIRT587444 | Dimt1 | DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) | ![]() |
1 | 1 | |||||||
MIRT588190 | A130010J15Rik | RIKEN cDNA A130010J15 gene | ![]() |
1 | 1 | |||||||
MIRT588690 | Tet2 | tet methylcytosine dioxygenase 2 | ![]() |
1 | 1 | |||||||
MIRT589450 | Nck2 | non-catalytic region of tyrosine kinase adaptor protein 2 | ![]() |
1 | 1 | |||||||
MIRT590325 | Csgalnact2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | ![]() |
1 | 1 | |||||||
MIRT590458 | Car5b | carbonic anhydrase 5b, mitochondrial | ![]() |
1 | 1 | |||||||
MIRT590752 | Actr10 | ARP10 actin-related protein 10 | ![]() |
1 | 1 | |||||||
MIRT594398 | Ints6 | integrator complex subunit 6 | ![]() |
1 | 1 | |||||||
MIRT594639 | Mex3c | mex3 RNA binding family member C | ![]() |
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2 | 1 | ||||||
MIRT594870 | Man1a2 | mannosidase, alpha, class 1A, member 2 | ![]() |
1 | 1 | |||||||
MIRT595871 | Csmd1 | CUB and Sushi multiple domains 1 | ![]() |
1 | 1 | |||||||
MIRT596012 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596332 | Rpp14 | ribonuclease P 14 subunit | ![]() |
1 | 1 | |||||||
MIRT600146 | Zfp1 | zinc finger protein 1 | ![]() |
1 | 1 | |||||||
MIRT601141 | Bcl11b | B cell leukemia/lymphoma 11B | ![]() |
1 | 1 | |||||||
MIRT601571 | Sumf2 | sulfatase modifying factor 2 | ![]() |
1 | 1 | |||||||
MIRT605724 | Gmeb1 | glucocorticoid modulatory element binding protein 1 | ![]() |
1 | 1 | |||||||
MIRT731705 | Myf6 | myogenic factor 6 | ![]() |
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3 | 1 | |||||
MIRT735635 | Socs1 | suppressor of cytokine signaling 1 | ![]() |
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3 | 0 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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