pre-miRNA Information | |
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pre-miRNA | mmu-mir-122 |
Genomic Coordinates | chr18: 65248861 - 65248926 |
Synonyms | Mirn122a, mmu-mir-122, Mir122a |
Description | Mus musculus miR-122 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-122-5p |
Sequence | 6| UGGAGUGUGACAAUGGUGUUUG |27 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Biomarker Information |
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Gene Information | |||||||||||||||||||||
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Gene Symbol | March5 | ||||||||||||||||||||
Synonyms | 1810015H18Rik, 2310008I22Rik, 2700055A20Rik, 5730499H23Rik, E130202O05Rik, MARCH-V, MITOL, Marchv, Rnf153 | ||||||||||||||||||||
Description | membrane-associated ring finger (C3HC4) 5 | ||||||||||||||||||||
Transcript | NM_027314 | ||||||||||||||||||||
Other Transcripts | NM_001164336 , NM_001164337 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on March5 | |||||||||||||||||||||
3'UTR of March5 (miRNA target sites are highlighted) |
>March5|NM_027314|3'UTR 1 AACTGACTTCTGGTTGTTCTGAGGCCTCTCATCCTGACGAGTCTGTTGTGTTCTGATTCCATCATTAATGCGCTAGTGGA 81 GACTTGTGACGCTGCTCCTATATTCTAAGAGATACAATAAAGCACGCAGGGCCGGGGCAAGCCGCCCAGTAATCACGGAC 161 CTAAGGACACGCGTCAGCTCTGTCATTTGTATGTTCTACTTTTATGGCAGTCGGCTAAACCATTATTTTAGCATGGGAAA 241 CCTGAGTTTGTTCATATTTTTCCAGACAAGAATGTAAAGATAAAACTGTACAAACATTAAAAGTGGACATGTTTTATTCT 321 GACGCCTCTTTTGTATATACTCAGTTCAGTGTTTTCTTAGGAATAGCAACTCGATGAAGGAACTGTGAGGGCTTTTCTCA 401 TTGGTGTAATTGATTGTATGCTACAAAGGAGCCTCTGTTAACAGGAGGAAGTGTAAACTAGTTCTGAATAAATAACAAAC 481 CCAGAAATGTATGTCAGCATTGAAGTGATTATCTGAACAAAAGAGATTTTGTTTTCTTTTCCTAAACCCATGTGACATCT 561 CAGATGTGAAGGGTCAGTTTCCAGGGCTTCCAAAGCACTTTTTCACTATTAAACTTTATTTATGCAATGTTGACATCTCA 641 TAGTTCATAGTGTACTTTTGACTCGTAGTCGTCCTGTGTGTGTGGTGTGAGGGTGTGTGTGTGAGCGGGGAAGGGGACTT 721 CAGAAAGAAGGTAGGAGGGAGGGAAGCAGAGGATAGTGATAGGGAAATGAGGTGGAAGGCCCTTTTATCACTTAGTATGT 801 TTTTAAATTTGTATTTCTACAAATTAGAACTACTGATTCATAGGTTAAGCAGAGAACAACTTGCAAAAAATGATAATAAA 881 ATTATTGGGTTTCTGTTGATTCCGTTATTCAGATATTTGTTAACTGGCTCCCACTTACCTAGTCACTGTGCAGGTGCTAT 961 GGGATAGAGTTGGGGAACTTGTTCAGAGAGTCTGCAGTCTAATAGAACAAGCACTGATTGAACCCAAGGGAGCTCTTGAA 1041 TATCAGTGAGGTAATTATGGAGTATTGATCAGGGTCATTGGTTTCCACTTTATCTGTTTATAGGATAGCCAATACTGTTT 1121 TTAGGGTATCTTGTTTTTGAATCAGGGTCTCTAGCATAGCTAACCTCAGACTTCCTGTGTATCTGAAGGTGGCCTTGAGC 1201 TCCTGATCCCTGAGCCTCCTAACTACAGGTGAGCACCACAACACCTGCTTTTCTAACTTAATGCTGTGGATTGAACCTAG 1281 GGCCTTACACATGCTAGGTATACACTACATCACCAGCCCTCCTTTTAGATTTTAGTTGTCATATTAAGGGGGCGATCTCC 1361 TTACTAGTCATTGTTTAACTAGTTTTATATTCATTGTTCAAAAGCAATTATTTAGGTCATGTTTAATAGTGACCATTACA 1441 ATGTTCAGCAATCTGATTAGAATGAAAAATTTTTTTTAAAGATTTATTTATTTATTATATGTAAGTACACTGTAGCTGTC 1521 TTCAGACACTCCAGAAGAGGGAGTCAGATCTCATTATGGGTGGTTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCC 1601 GGACCTTCGGAAGAACAGTCGGGTGCTCTTACCCGCTGAGCCATCTCACCAGCCCCTAGAATGAAAATTTTTAAAGTTTA 1681 AAAAATAATGCTGTTCACAGTATATGATGCATGATAATGCTCCCCCTTTCTGCGAAATGGATACTTCTCTTTAGAAGTGT 1761 AACAAATATAGATTGAGCTGTGTTAGATTGTAAATAAATATTTTAGTAAAGACTGGTATCTTTCTCTAGGTTGGTTATCT 1841 CAGTTTTGAGTTTTACGGTGTCTGTGGGAATGACTCTTTTGAACATCCAGAGTTGTAATTATCTAGGGTATAAGGGGCAA 1921 TTTGACTGAGTTAACCTTAACACTGCTGTTATTCTGTAGAGAAAATGTGAACCCTGATTATATATAAAAATAACTAAGAT 2001 CTACAGCTGTAATTATGAAATTGGCTTCCATCATTGCCAGTGTGAAAATATATATATTCTGACATTTCCTGGATACTCCT 2081 GTTAAGTTGAGCAGCTTTTACACAGCCACAAGCCCTCAGCTCCCTGTGTACTACTTTAATTTCCGGGGTGGTGGTGGGGG 2161 GTGGGGAGCTGCTTGGATCGATCTATTGGCATCAAGGCCCGTGAAGGCAGAGGTTTATAGAGCTATGGGGAGGGAGCCAC 2241 ACTTGTCTGCAGTCCAGAGTGAACACTAGCCCTGCTGCATTTGAACACCACATGACAGGCCTCCCTGGAACCACAAATCA 2321 AAAGACATGGGCAGACTGAAAGCTGAATAGGTTACGTTGAGCTCCCATCAAGTTTTAGTAGCTGTAGTGTATAACCTTGG 2401 CCAGGTGGCTATTCAGCCACAGTTACGTTCATCTCTAAAATGCAAGTCACACCTAGACACTTTCTAGGATTTGGTTGAGA 2481 AAAGACAGGTACTTTCGGCCTCAGTAGCTCCTAAAGGTGGTCGTCCCATCTAGGACAGGGCAGTAACCAAGGGTAGGGCC 2561 CTCGAGGACAGAGCCAGCACAGACTTGAGGATTTGTGAGTATGCTGTTCTCCGATTTTCTTTCTTTTTCTTCCTTCCTTC 2641 CTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTCTTTTTGTCCTAGAAATGTCACATTTAAACCTTTTTTTAA 2721 AAAAATTAGAATTCAGTGATTAGTAAAATTCTATTGTAGAAGTTAACTCCATCTAAGTTGGCTGAAAATGTTCATTACTT 2801 ACCAAATGGTTGAAGAATATATAATTAAGTGGCTTCATTAGTCACTGCCTTGCTAATTTTGCTGTATTTTTTTTTCTAAT 2881 TCCTTGTTTTTAATATAGAAAACTCAATACTGGCTGAAATAGGTTGAATAAACAATTTTTATGCTCTCTAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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86 mmu-miR-122-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT003075 | Tmem50b | transmembrane protein 50B | ![]() |
1 | 1 | |||||||
MIRT003076 | Lass6 | ceramide synthase 6 | ![]() |
1 | 1 | |||||||
MIRT003077 | Gpx7 | glutathione peroxidase 7 | ![]() |
1 | 1 | |||||||
MIRT003113 | Tgfbr1 | transforming growth factor, beta receptor I | ![]() |
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3 | 1 | |||||
MIRT003114 | Sbk1 | SH3-binding kinase 1 | ![]() |
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3 | 1 | |||||
MIRT003117 | Hist1h1c | histone cluster 1, H1c | ![]() |
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3 | 1 | |||||
MIRT003118 | Ddc | dopa decarboxylase | ![]() |
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2 | 1 | ||||||
MIRT003120 | Rell1 | RELT-like 1 | ![]() |
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3 | 1 | |||||
MIRT003121 | Bach1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | ![]() |
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2 | 1 | ||||||
MIRT003122 | Apob | apolipoprotein B | ![]() |
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2 | 1 | ||||||
MIRT003123 | P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | ![]() |
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2 | 1 | ||||||
MIRT003124 | Ccng1 | cyclin G1 | ![]() |
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2 | 1 | ||||||
MIRT003125 | Slc7a1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | ![]() |
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3 | 3 | |||||
MIRT003126 | Gys1 | glycogen synthase 1, muscle | ![]() |
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2 | 2 | ||||||
MIRT003127 | Slc35a4 | solute carrier family 35, member A4 | ![]() |
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2 | 2 | ||||||
MIRT003128 | Hfe2 | hemochromatosis type 2 (juvenile) | ![]() |
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3 | 3 | |||||
MIRT003129 | Tmed3 | transmembrane p24 trafficking protein 3 | ![]() |
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2 | 2 | ||||||
MIRT003132 | Bckdk | branched chain ketoacid dehydrogenase kinase | ![]() |
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4 | 1 | ||||
MIRT003133 | Aldoa | aldolase A, fructose-bisphosphate | ![]() |
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4 | 7 | ||||
MIRT003134 | Ndrg3 | N-myc downstream regulated gene 3 | ![]() |
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4 | 2 | ||||
MIRT003135 | Cd320 | CD320 antigen | ![]() |
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4 | 1 | ||||
MIRT003724 | Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | ![]() |
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3 | 1 | |||||
MIRT003725 | Rcan1 | regulator of calcineurin 1 | ![]() |
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2 | 1 | ||||||
MIRT003726 | Gde1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 1 | ||||||
MIRT004536 | Ccrn4l | nocturnin | ![]() |
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4 | 1 | ||||
MIRT005975 | Klf6 | Kruppel-like factor 6 | ![]() |
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4 | 1 | ||||
MIRT005976 | B2m | beta-2 microglobulin | ![]() |
1 | 1 | |||||||
MIRT005977 | Afp | alpha fetoprotein | ![]() |
1 | 1 | |||||||
MIRT005978 | Ccl2 | chemokine (C-C motif) ligand 2 | ![]() |
1 | 1 | |||||||
MIRT005979 | Csf3r | colony stimulating factor 3 receptor (granulocyte) | ![]() |
1 | 1 | |||||||
MIRT005980 | Ctgf | connective tissue growth factor | ![]() |
1 | 1 | |||||||
MIRT005981 | Cxcl13 | chemokine (C-X-C motif) ligand 13 | ![]() |
1 | 1 | |||||||
MIRT005982 | Cyp2b13 | cytochrome P450, family 2, subfamily b, polypeptide 13 | ![]() |
1 | 1 | |||||||
MIRT005983 | Dbp | D site albumin promoter binding protein | ![]() |
1 | 1 | |||||||
MIRT005984 | Igf2 | insulin-like growth factor 2 | ![]() |
1 | 1 | |||||||
MIRT005985 | Il1b | interleukin 1 beta | ![]() |
1 | 1 | |||||||
MIRT005986 | Jun | jun proto-oncogene | ![]() |
1 | 1 | |||||||
MIRT005987 | Per1 | period circadian clock 1 | ![]() |
1 | 1 | |||||||
MIRT005988 | Alpl | alkaline phosphatase, liver/bone/kidney | ![]() |
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2 | 1 | ||||||
MIRT005989 | Cs | citrate synthase | ![]() |
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2 | 1 | ||||||
MIRT005990 | Prom1 | prominin 1 | ![]() |
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3 | 1 | |||||
MIRT005991 | Sox4 | SRY (sex determining region Y)-box 4 | ![]() |
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3 | 1 | |||||
MIRT013527 | Uros | uroporphyrinogen III synthase | ![]() |
1 | 1 | |||||||
MIRT013528 | Ppox | protoporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013529 | Urod | uroporphyrinogen decarboxylase | ![]() |
1 | 1 | |||||||
MIRT013530 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013531 | Fech | ferrochelatase | ![]() |
1 | 1 | |||||||
MIRT013532 | Hamp | hepcidin antimicrobial peptide | ![]() |
1 | 1 | |||||||
MIRT013533 | Tfr2 | transferrin receptor 2 | ![]() |
1 | 1 | |||||||
MIRT013534 | Smad4 | SMAD family member 4 | ![]() |
1 | 1 | |||||||
MIRT013535 | Smad7 | SMAD family member 7 | ![]() |
1 | 1 | |||||||
MIRT013536 | Bmpr1a | bone morphogenetic protein receptor, type 1A | ![]() |
1 | 1 | |||||||
MIRT013537 | Hba-a1 | hemoglobin alpha, adult chain 1 | ![]() |
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2 | 1 | ||||||
MIRT013538 | Hmbs | hydroxymethylbilane synthase | ![]() |
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2 | 1 | ||||||
MIRT013539 | Mir17 | microRNA 17 | ![]() |
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2 | 1 | ||||||
MIRT013540 | Alas2 | aminolevulinic acid synthase 2, erythroid | ![]() |
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2 | 1 | ||||||
MIRT013541 | Mir451 | microRNA 451a | ![]() |
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2 | 1 | ||||||
MIRT013542 | Tfrc | transferrin receptor | ![]() |
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2 | 1 | ||||||
MIRT013543 | Socs2 | suppressor of cytokine signaling 2 | ![]() |
1 | 1 | |||||||
MIRT013544 | Slc35g1 | solute carrier family 35, member G1 | ![]() |
1 | 1 | |||||||
MIRT013545 | Camk2b | calcium/calmodulin-dependent protein kinase II, beta | ![]() |
1 | 1 | |||||||
MIRT013546 | Irf6 | interferon regulatory factor 6 | ![]() |
1 | 1 | |||||||
MIRT013547 | Rbl2 | RB transcriptional corepressor like 2 | ![]() |
1 | 1 | |||||||
MIRT013548 | Hfe | hemochromatosis | ![]() |
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2 | 1 | ||||||
MIRT013549 | Ccnd1 | cyclin D1 | ![]() |
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2 | 1 | ||||||
MIRT054338 | Pkm | pyruvate kinase, muscle | ![]() |
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3 | 1 | |||||
MIRT054339 | Tfdp2 | transcription factor Dp 2 | ![]() |
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3 | 1 | |||||
MIRT054340 | E2f1 | E2F transcription factor 1 | ![]() |
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3 | 1 | |||||
MIRT579817 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 1 | |||||||
MIRT580378 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT581166 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT582514 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT586941 | H2-T24 | histocompatibility 2, T region locus 24 | ![]() |
1 | 2 | |||||||
MIRT591859 | Iffo2 | intermediate filament family orphan 2 | ![]() |
1 | 1 | |||||||
MIRT592160 | Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | ![]() |
1 | 1 | |||||||
MIRT592189 | Nanog | Nanog homeobox | ![]() |
1 | 2 | |||||||
MIRT592792 | Cdh12 | cadherin 12 | ![]() |
1 | 1 | |||||||
MIRT597026 | Thap1 | THAP domain containing, apoptosis associated protein 1 | ![]() |
1 | 1 | |||||||
MIRT597210 | Snhg11 | small nucleolar RNA host gene 11 | ![]() |
1 | 1 | |||||||
MIRT601300 | Zfp949 | zinc finger protein 949 | ![]() |
1 | 1 | |||||||
MIRT602608 | Chrna1 | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) | ![]() |
1 | 1 | |||||||
MIRT602960 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT603391 | Sgol2 | shugoshin 2A | ![]() |
1 | 1 | |||||||
MIRT604008 | Ggps1 | geranylgeranyl diphosphate synthase 1 | ![]() |
1 | 1 | |||||||
MIRT605553 | Ppp1r16b | protein phosphatase 1, regulatory (inhibitor) subunit 16B | ![]() |
1 | 1 | |||||||
MIRT606204 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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