miRTarBase - #MIRT583267


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pre-miRNA Information
pre-miRNA mmu-mir-494   
Genomic Coordinates chr12: 109715318 - 109715402
Synonyms Mirn494, mmu-mir-494, Mir494
Description Mus musculus miR-494 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-494-3p
Sequence 50| UGAAACAUACACGGGAAACCUC |71
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Gmeb1   
Synonyms 1110050A04Rik, AI256615, AI481278
Description glucocorticoid modulatory element binding protein 1
Transcript NM_001122992   
Other Transcripts NM_020273   
Expression
Putative miRNA Targets on Gmeb1
3'UTR of Gmeb1
(miRNA target sites are highlighted)		 
>Gmeb1|NM_001122992|3'UTR
   1 TTGGGGACAGGGCCAAGAGCTGTGTTTTGGTTTGGAATTTTAATTATGTTTATTTTTATCATTGTCCCGCTCATTTCCAC
  81 ATAGAACTTTTTTTAAAAAAAAAACAAAAACAAACAAAAAAAAACCAAACTACAAAATCTCGTTGTAACTGCAAATGTTG
 161 GGTTCCTCCTACTTCCTCATTGACAACTGGACAGAACAAGCTGCCTTTCCAGAAGTTAGAAACAGGGCACCCAGGGTCTG
 241 AACCATCTTTCCCCAAGGAAGGTAATTGCTTTTAGGGGAAGTGTCAAAATATCCAGGAATCCTTTCCAGAATAGTCTGTC
 321 TGTGTATACACGCATGGTCTCACTCTTGTAAAGACGCATTGACCAGACCCTGGAACACAGATCTGACTCCAGAAGATGAC
 401 CAGCTCTGCTGTGGATACAGAAGCACGCTTGCCTCTGTGTCCTGGATATGATGGCCTCAGATGCTGGTGTGCAAAACTGA
 481 AAGAACAGGAGGTTGGCTCTGCTTAGGGTGGAAAGTAGTGTGATCAGCAGCTCATAGGGGGAGCCCTTTGACAGGGAGGG
 561 GCCGAGGAATGGTCTTCCAGAGGTGCATCTGATGCCCCTTGCGCTCTCTGAGGGTTGGGTACCATTTTCAATTTCAGAAG
 641 AGGACAGAGATTATAGAAAGACACAAAGCAATCAAAAGATTGTCACAGCTGTGCTTTTGGGATAGCTCACCTTGCCCCCA
 721 GCCTTGTCAAAGCCCTCACCCTCCTCGCCCAGGACTATCAGTCCATTCCTTTGCAGACTGTGATGTGGTATAAATTGTTC
 801 TAATTCTTGGACTGTGGCTGTCATGGAGGTGGGGCTCCAAGGCCATCATTTTTCGTTTCTTGACTCCAGGAATGGCAGAG
 881 TCCCTCGTGCAGACCAGCTGCTATTTTTGGTGGAGCCCTGCACGTAAGCATGCAAGTGTGTGTGTGTGTGTGTGTATGTG
 961 TGTGTGTGTGTGTGTGTGTGTGTGTGTGTACATGTTTCGGGTTTGGAACCAAAAGCAGTCATTTCCCTGGTGCTTCCTTT
1041 TCTTTTCCTTCCGTCTGCTGGACCCCATGCTCAGTAGCTTTTTGGCAGACAGCAGTGACAGGTGCCTGCCTGCCTTCATT
1121 CTCTTTGCCATTCTCCTCTTCTGATACCACAGATGTTTCTGTGAGATACCGAACTCATAAAATGGCTTAGGCTTGGCAGG
1201 GACAACTGGTAACACCTTTCCTGAGGTGTGGACTAGATGGCTCCTGAGTGAGCTGCACTTTCTGGGAAAGGGACATTGTA
1281 TTTGACATTGTAAGAAGTATGACAGGAGTGTCAGTAACGTCCAGGCGTGGGGCTTCTTCCTAAATGCTGTTTGTACATTC
1361 GGTACTACTAGGTCACTCTTTCTGCTGTGATCCCATGTCGTTGATTCTCTTCAGCGTTTGGGGGAGAGTAAGCAGTTTCT
1441 GGTTTCTTTAATTATATTGTTTACTATGTTAGGGAAAATATAGAGACTCTCGAGGTGACTTTATAGGTCAAAAAAGCATA
1521 CAGCTTAGGAGCTGGAGGATTTATTATTATTATTAAAAGTAAAATTTTGGCTTTTGTTTAAAAAAAAAAAATAGAGAAGG
1601 ATGCCTGTCTAAATCTGTCTTCCTGCCTGCAGGTTTTGAAAACCCTGTAAGCAACCAAAAGTTGCACCTTCCATCTCTTA
1681 GACGGCCATGTGTCACCAGGGAAGCAAGCCCTCAGGGATCACTCTGAAGACCCTGAAGAGTGCGGCTTCTGAACTCTATT
1761 CAGATTTGTTTCAGCTTTAAAACTGGACTTTTCTTTTCAGACTCTTTAGTTAGGCTGGGGACAGAACTGAATTGGTAAAG
1841 TGGTCACCTAGCGTTCATGAAACCCTGGGCTCAGTCTCCAGCCAGAAGTAAACTGGGCATGGGGCCACATATCTGATCCT
1921 AACACTTGGGAAATAGAGACGGGAGACTTAGAAATTCAAGGTCATACATACCAAGTTCAAGACCAACCTGGGATATATGA
2001 AATAGTGTCTCAAAAAATTTTTGTTTAGGACAAGCTTTTGGTGAAAGAAGGAATTTATTCCTGCCTTCCTTACACTTTGT
2081 TAATACATAGGAATTTTTATTACATTTATTTATCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGATGGTG
2161 AGCTTGCTACGGTATGTATGTGAAGATCAGAGAACAACCTGCAGGAGTCTGTTCTCGCCTTCCACCATGTGGGTCCTGGG
2241 AATTGAACTCAGGTTGCCAGGCTTGGTGGTAAGCACCCTCATCCATTGAGCCATCTTGCCTGCTCTAAAAGTTTCGGTCT
2321 TCAGACCAAAACTGTTACTTGAACCTAGAAAGCCACATCGCATCCCTGTTGTGTCCTTTAGGTCATTTCTCTTTTCCAGA
2401 GATGGGCAGACCAATTCAGGACACGGGAGGCACCCTAGAGAATAGAGGCAGGCTCCTTCAGGTCCTGCCTTTTTGCTCTT
2481 CACAGCTGTTGTGTCATTAAAGGTTGTGTGAGCAGCATGCTTCCAAAGTCAGATTTCCTTCTTGAGACAGAGCCTGTTTA
2561 CTTAAAACAGATTACATGAGCTTTGCTGTTTTCCTGGTCTTCCAATTGCTGTCATTGCTAGCTGCAGTGGTACTTGGAGA
2641 GATGAGATCTCTCACAGACCTGGTCTAGATTATTTTAGGTGGGGTGATACACATGCAAGCTTCTGATGTGTGAATAGGCA
2721 GTTGCAATGAAATTACTCCTCAGGCTGACTTGATGGTAGCTATCTTTTCTCTAGCCATTCATTAAATAAACATTTGTAAG
2801 TACTGTCTATGTATAAGTACTAAACGCCAACTGATTGCGTCACCTAAGCCCCAGTAAGTACCATGAAGATGCAGGTTTTG
2881 TGCTAGACACTGATCTTGCAGACAAGACAATTCCTGTTCTTAAGAAGTTCATACCCAGACATCTTTGCAGTTAACCACAC
2961 TTTTTGTTTGTTTGGTTTGTTTTTTGAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACTCTCACTATGTAGCC
3041 AGGCTGACTGGAACTCACAGAGATCTGTTTGCCTCTGTCTTCCAAGTGCTGGGATTAAAGGTGTGCACCACCACTGCCAT
3121 AGTGAATAGTCAACCGTATTTTAATGTCATTGGTTTCTTTTGTGATCCTGTTTTATCTTAAATATTGGGAAGGACTCTGA
3201 GTCTTTAGTTCCTAGGTTTCAACAGGCAAAGTCACAGAGGTGAAGCCACCCCTGGTGAGATTTTACCTTAGGTTGAGGTG
3281 ACTGTAGCTATGGTCTTTTTTTTTTTTTTTAAAGATTTATTTATTTATTATATGTAAGTACACTGTAGCTGTCTTCAGAC
3361 ACTCCAGAAGAGGGAGTCAGATCTTGTTACAGATGGCTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCTGGACCTT
3441 CGGAAGAACAGTCGGGTGCTCTTACCCACTGAGCCATCTCACCAGCCCCAGCTATGGTCTTTTGGCCTGGAGTTAAGCAC
3521 AAAAGATCAAGCACTTACTCAGCTTGGGGTCTGAATGGCTTCCGCTAATCTGAGGCAGTTCTCTGCATACCCTAGTTGCC
3601 CTTGAACTTGGCTATGTAGAGTAGCCTGGCTTTGAGCTCATAAAGGTCCATCTGCCTCTGCCTCCTAAGCATTGGGATTA
3681 AAGCTATCACACTTGGCTCTTGCTACTCCTCAGTTTCTAGGCTTCCAAAGAGTGGTGCTGCATGCGTGCCTGGGGCCCCG
3761 GCCCCAGAGGGCAGGGGCAAGAAGAGAGAAAGCTTCAAGATCCTGTCTCACAAACCAGAAATTTAGGCTTCCACATCCCA
3841 AACCCAAAGTTACTCTACTTTTGTTTGTGTCGCTCCCCCCTCCCCCATGGACAATAGACATTCAAGATTCAAACCCACTT
3921 TGGTGTGTCGTTCCCTCACCTGCCATAGCAGGAGAGAGAACTAATATAGATGAATAGCAGGTGATTCTTTTAATGTTGCT
4001 GGTTTGTCCCATTTCATGAGAGACACTATAGATAAGTATATATGGGGAGTACTGATTTTATTTACAAAAAAAAAAAATGT
4081 ACATTTAGTGTGCTTGTGTGTGTGTGGCATGCCGGAGTACATGGTGTCTTTATCAATGAACAGCTTTCAGGATTCAGTTC
4161 TCGCCTTCCACTGTGTGGGTCCCAGGGGTCAAATTCAGTTTGCCAGGCTTGGCAAGCAAGCACCTCTACTCACTGAGCTA
4241 TCTTGCTGGCCCAATGAGATTTTTTCTTTTTCATGTATTTATTTTAGTTTATAATTGTTCTTGCAAGTATGTATGTGCAC
4321 CTCACCTCTCACGCATGCCTGGTATCTGACGTGGTTGGTCGGAGAACATTTCTGATCCCCTGGAACTGGTGTTAGAGATG
4401 GTGTCTGCTACCATGTGGGCGCTGGAAATCCAACCCAGGTTCTCTGAATGAATACATGCTCTCAACTGAGCTGTCTCTTC
4481 GGGTGATATTATAAATAACAAAACTGTTGTGAAATATGGAGTCATTGAGTCAGAACTGACCCATAATGGAGGACTATCTA
4561 GGAGATGGAAAAGAATCCTTCCCTCAACCCTCCCCAAAAAAGGTTGAATTCTGAAATTAAGCACAAAGTGGTGGTGGCAC
4641 ACATCTTTGATCCCAGCACGTAGGAGCCAGTTGGATCTCTGAGTTCAAGGCCAGACTTGTCTCGAGGACAGCCAAGGCTA
4721 CACAGAGAAATCACATCTTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cucCA-AAGGGCACA--UACAAAGu 5'
             || | : :||||  ||||||| 
Target 5' tgtGTGTGTGTGTGTACATGTTTCg 3'
 975 - 999 153.00 -13.40
2 
miRNA  3' cucCAAAGGGCACAUACAAAGu 5'
             | | ||   | ||||||| 
Target 5' tctGATACCACAG-ATGTTTCt 3'
 1140 - 1160 142.00 -8.40
3 
miRNA  3' cuCCAAAGGGCACA----UACAAAGu 5'
            ||||||:: |||     |||||: 
Target 5' ttGGTTTCTTTTGTGATCCTGTTTTa 3'
 3150 - 3175 122.00 -14.30
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Brain (Mouse neocortex)
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_BrainB_130_50. RNA binding protein: AGO. Condition:Brain B 2A8 P13 130 KD HITS-CLIP data was present in Chi_BrainC_130_50. RNA binding protein: AGO. Condition:Brain C 2A8 P13 130 KD ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cucCA-AAGGGCACAUACAAAgu 5'
             || | : :||||:||| |  
Target 5' -auGUGUGUGUGUGUGUGUGUgu 3'
 		1 - 22
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Liver
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in ERR266281. RNA binding protein: AGO2. Condition:A_Liver partial hapatectomy 48h HITS-CLIP data was present in ERR266286. RNA binding protein: AGO2. Condition:A_Liver partial hapatectomy 1h HITS-CLIP data was present in ERR266287. RNA binding protein: AGO2. Condition:B_Liver partial hapatectomy 36h HITS-CLIP data was present in ERR266292. RNA binding protein: AGO2. Condition:B_Liver partial hapatectomy 48h HITS-CLIP data was present in ERR266293. RNA binding protein: AGO2. Condition:A_Liver partial hapatectomy 36h HITS-CLIP data was present in ERR266295. RNA binding protein: AGO2. Condition:B_Liver partial hapatectomy 1h HITS-CLIP data was present in ERR266298. RNA binding protein: AGO2. Condition:A_Untreated HITS-CLIP data was present in ERR266300. RNA binding protein: AGO2. Condition:B_Untreated ...

- Schug J; McKenna LB; Walton G; Hand N; et al., 2013, BMC genomics.

Article - Schug J; McKenna LB; Walton G; Hand N; et al.
- BMC genomics, 2013
BACKGROUND: Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. RESULTS: miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. miRNA recruitment to the RISC did not correlate with changes in overall miRNA expression for these dynamically recruited miRNAs, emphasizing the necessity to determine miRNA recruitment to the RISC in order to fully assess the impact of miRNA regulation. We incorporated RNA-seq quantification of total mRNA to identify expression-weighted Ago footprints, and developed a microRNA regulatory element (MRE) prediction algorithm that represents a greater than 20-fold refinement over computational methods alone. These high confidence MREs were used to generate candidate 'competing endogenous RNA' (ceRNA) networks. CONCLUSION: HITS-CLIP analysis provide novel insights into global miRNA:mRNA relationships in the regenerating liver.
LinkOut: [PMID: 23597149]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions C2C12
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1385342. RNA binding protein: 聽AGO2. Condition:C2C12_GM_Ago2_CLIP-Seq_myoblast HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes ...

- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell.

Article - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al.
- Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
42 mmu-miR-494-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005687 Hsf2 heat shock factor 2 1 1
MIRT006622 Pten phosphatase and tensin homolog 1 1
MIRT006623 Rock1 Rho-associated coiled-coil containing protein kinase 1 1 1
MIRT006624 Camk2b calcium/calmodulin-dependent protein kinase II beta 1 1
MIRT006625 Fgfr2 fibroblast growth factor receptor 2 1 1
MIRT006626 Lif LIF, interleukin 6 family cytokine 1 1
MIRT578347 Lsm12 LSM12 homolog 1 2
MIRT578906 Ephx3 epoxide hydrolase 3 1 3
MIRT579711 Zhx2 zinc fingers and homeoboxes 2 1 1
MIRT580333 Tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 1 1
MIRT582377 Msrb3 methionine sulfoxide reductase B3 1 2
MIRT582618 Lrch1 leucine-rich repeats and calponin homology (CH) domain containing 1 1 1
MIRT583235 Gopc golgi associated PDZ and coiled-coil motif containing 1 1
MIRT583267 Gmeb1 glucocorticoid modulatory element binding protein 1 1 3
MIRT583415 Fyttd1 forty-two-three domain containing 1 1 1
MIRT583463 Foxk1 forkhead box K1 1 1
MIRT583788 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 1 1
MIRT583876 Dusp7 dual specificity phosphatase 7 1 1
MIRT584114 Csmd1 CUB and Sushi multiple domains 1 1 3
MIRT584936 Ado 2-aminoethanethiol (cysteamine) dioxygenase 1 1
MIRT585324 Zdbf2 zinc finger, DBF-type containing 2 1 1
MIRT585542 Tpte transmembrane phosphatase with tensin homology 1 1
MIRT586337 Pex13 peroxisomal biogenesis factor 13 1 2
MIRT587029 Gmip Gem-interacting protein 1 2
MIRT588763 Stxbp5 syntaxin binding protein 5 (tomosyn) 1 2
MIRT589348 Ostf1 osteoclast stimulating factor 1 1 1
MIRT589540 Mkrn3 makorin, ring finger protein, 3 1 1
MIRT590075 Faf1 Fas-associated factor 1 1 1
MIRT590633 Arl5a ADP-ribosylation factor-like 5A 1 1
MIRT592898 Otx1 orthodenticle homeobox 1 1 2
MIRT595129 Magee2 melanoma antigen, family E, 2 1 1
MIRT595134 Lrrc4c leucine rich repeat containing 4C 1 1
MIRT595443 9030617O03Rik D-glutamate cyclase 1 1
MIRT595554 Ubr3 ubiquitin protein ligase E3 component n-recognin 3 1 1
MIRT595634 Atrn attractin 1 1
MIRT595916 Syne2 spectrin repeat containing, nuclear envelope 2 1 1
MIRT597960 Olig3 oligodendrocyte transcription factor 3 1 1
MIRT604095 Dpm1 dolichol-phosphate (beta-D) mannosyltransferase 1 1 1
MIRT605674 Itsn1 intersectin 1 (SH3 domain protein 1A) 1 1
MIRT731455 Fgfr2 fibroblast growth factor receptor 2 4 1
MIRT731456 Rock1 Rho-associated coiled-coil containing protein kinase 1 4 1
MIRT736998 Rnf41 ring finger protein 41 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-494 Vincristine approved 5978 Quantitative real-time PCR Hep-2 cells 23780424 2013 down-regualted
miR-494 Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 down-regualted
miR-494 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-494 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray Pancreatic Cancer PANC-1 cells 19407485 2009 up-regulated
miR-494 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Microarray Pancreatic Cancer PANC-1 cells 19407485 2009 up-regulated
miR-494 Trichostatin A (TSA) NULL 444732 Microarray Pancreatic Cancer PANC-1 cells 19407485 2009 up-regulated
miR-494 Bio-Oss NULL NULL Microarray osteoblast-like cell line (MG63) 20224834 2010 up-regulated
miR-494 Dihydrotestosterone(DHT) NULL 10635 Microarray prostate cancer 20945501 2011 up-regulated
miR-494 All-trans-retinoic acid (ATRA) approved 444795 Microarray acute myeloid leukemia (AML) cell line HL-60 21518431 2011 up-regulated
miR-494 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 up-regulated
miR-494 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 up-regulated
miR-494 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-494 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-494 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-494 Acetaminophen approved 1983 Microarray rat liver 17965554 2007 down-regulated
miR-494 Carbon tetrachloride NULL 5943 Microarray rat liver 17965554 2007 down-regulated
miR-494 Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
mmu-miR-494-3p Fluorouracil 3385 NSC19893 approved sensitive Low Colon Cancer tissue and cell line (SW480)

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