pre-miRNA Information | |
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pre-miRNA | mmu-mir-374b |
Genomic Coordinates | chrX: 103573060 - 103573154 |
Description | Mus musculus miR-374b stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-374b-5p |
Sequence | 22| AUAUAAUACAACCUGCUAAGUG |43 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Frmpd4 | ||||||||||||||||||||
Synonyms | Gm196, PKAP1, Pdzd10, Pdzk10, Preso1, preso | ||||||||||||||||||||
Description | FERM and PDZ domain containing 4 | ||||||||||||||||||||
Transcript | NM_001033330 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Frmpd4 | |||||||||||||||||||||
3'UTR of Frmpd4 (miRNA target sites are highlighted) |
>Frmpd4|NM_001033330|3'UTR 1 CTTTGACAGAGCCTGGGAAGGAGAGACAAGGAGGCATGCCTTCAGCTTGGTCTCCACATCCTGAAGCTGATCCCATCCTG 81 CTACCATCAAATATTCACTTGGAATCAAAGGTGCCAAGCCCAAATCAAGACCCTAATGATTTCTCCCAAGGAATCCAGGC 161 ATTCGGAGAGGCTGTGAGCTGGTGGCCAGCAGATCTGAGAGGGGGGAGCCCCAGGACACCCCCCAGCCAGAGGGCTCTCA 241 GACATAGCAGCAGAATCCTCTCAGGACCCGTAGGTTTGGAGACCTTCCAAGAGAGAACCAAGGGTGTAGTCAGCTTGAAG 321 TATCCAGGTATCACAGAAGCACAGGAGGTCAGTTCAGAAAGACGAGCAGAACTCCCTCTGGGGAAGAAGCTCACCAAAAG 401 TTTTTCCCAAAGCTCAATGCACTTTATCTCTGAGGGAAAGTTTCACAAAAGGTCCCCCATGTCTCATAAAGACTCAAAGG 481 TGTATAGGACCCTACCCTTACGGAAGCTGGAAAGCAGCAACTGGAGATGTCGAGGACCCTTCAGCTACTGTTTTCTAAAC 561 CAAGGACAGGATGAAGATGGGGATGAGGATGAAGAGGAAGGAGAGGCCACCCTTCAGGTCTCTTGTCTCTATCGACCACA 641 GATAACCCAAGCCATGTCGGAACCAGGTAACTCATCCCTGGTTGTTGGACTGCAGAAGCAAGGGGAAGAACTGTCCAGAG 721 GGACAGCTCTGAAGGTCTGGACAGAAGACCCAGATGGCCCAGATGACTTGGACTTCAGCAGTCTGGCTTTTGATGCCCGG 801 ATTGCAAGAATAAATGCCCTAAAGGCAAACACATATGGAATGCCCGATGGGTTTCTCGAAGCCCAAAATGATGCCAATGA 881 GCTGCTCTGCCTTGTGAGGGCAACCAAGGCAAGGAAGGAGGAGTCACGCCCTGAAACATATGACCTTACACTTTCTCAGT 961 ACAAGCAACTGTTATCCATTGAGTCCAGACAGTTGGGAAGTGCCTGTAGGAAAATGGCAATGGCCGAGAAAAGCCCAGAA 1041 GAGATGCTCCTAGCTATGAGTTCCAGTTTTCAAGTGCTCTGTTGCCTAACAGAAGCTTGCATGCGGTTAGTGAAAGTCGT 1121 GAACACTGAAACACAGCGGCAAGAAATTGTAGCAAAGATTGATGAAGTGGTCATAAACTATATTTGTCTCCTGAAAGCTG 1201 CTGAGGCAGCCACTGGCAAGACCACTGGGGATCCTAATATTGGACTATCGATGCGACATTCAACCACCATGGCCGCTCTT 1281 GTAAGCACACTAACACGTTCTCTCAAGATGCTTTTAAATAAATAAATATGGAAGTCACATCATAATCTATCTTTGCAAAG 1361 CCATACATGAACTTTTCTTTACTTTCTGTGTACAATGAACAGATGTCTCCTTTCTTCTCTCTGTATATTTTGTTCTTTTA 1441 TATAAAATAGGAGATAGAAGTTACATTGATGAAATGTTGAAAAGTCTCAATCAGATATATTCTGTTTATATTATACAAAT 1521 ATACATGTAGAAGGAATATATGAGAAAATGATGACATTTGACTATTTTTCATGTAGTCAAAACTCTAAGCATATGATATG 1601 AAATTTTAAATTCTACATTGTTAGAGGAAAACAATGAATCCTATCCCCTTTCCTTCCAAATGGATACTTGGAGACCCTAT 1681 CATTCATATTTAGAAGAAAAGCCAAAAGAAACAGAATAGAAAAGAAATCAAAATGTATATAAAATAGTTCCCGTGTTTTA 1761 AAATCATAATTTTTAAACATTGGAAGTAGCAAAAATATATTTAAAATTCAAGAAGCTAATATGAATTACTAGAAAATATA 1841 TAATAAATTAACTTTTTGCTCATAGTGTTTTGTTATTGGATGCTTTCTTCCAAGAATCCCCACATATTCAATTTTGGTTT 1921 ATGCTATTTGGGCTACAGATTGGCAGGGGTGGGCAGATTCCATTGTGTCAGCATAAATGCTTTTTATAGTATTTCTAGAC 2001 TTAAAAAGTTCCCCCAAATAAAAGAACAGGGGAAATTATGGGCAGGATCCTAGGCAATAACTAAAGGTATAGGTTGTCTA 2081 ATTACATAAAATAAATGGAATTAGTAATGCCAAAATTAAATTGTTTGATGAAAAGAGAGATCTGCTTTGACTCAATGTCA 2161 AAATACATAAACCGAAGGCATTATTTCCTTCCAACTCAACCATGAAGCTTACTATTTCCTTTCAAGAACACCTAGTAAAG 2241 TGTTTGTAGAATTACACAAAAGCAGATTTAATGAGCACAAAAAGTGCAGACCCAGCAATGTAAATCAGAGCGCACCCCAG 2321 CACCTGGGAAGCACAGCTCAGCCTTCAACTCTTAGTCCTCAGCTCCATGAAGGGCTTCCTGTTGCCCCTCTCTGACAGGA 2401 GCATGGCTAGCAACAAAACGTGGAAAGACAGCCTACTACTGGGACAAAATTTCAAATCTAGAGTGTTCCAGAAAATCAAG 2481 TAGAGATGACTACTCTCATAATTGAAACCATGATTCAAAAGGTAGTATTTACCTAATGAGTACTTCATTTGGCAGATAGA 2561 AATACAAAATCTGACAGAAACATGGCAAATTTGACTATTTTAAGTGAAACTAAGGGAATACAAAGGTGTGTTCTGAACTG 2641 TCATCACTCAAATTATATCTTTGGGTCAAAACAAAAGAAGGCAAACTCTTCAATCATAAGTTAAATTGATATGTACATAT 2721 GTAGTTTCTGGATCACTCTGTAGTCAAGCTCCCCAATTCCTATTTCTGTAAATGGCTTAGAATAAGAGTAGTATAGCAAG 2801 AATCAATATTTCCCATTTTGTAGCCTGCCATGCAGGAGACCTAGCAAGGTCTACAGTTGCTATTTCTCTCTGGTCAGCCA 2881 TTCATTCCACAGAGACTCAGCAAATGCAACACCACAGATTTACAGATTGTAACCAATGAAAGGAGTTCAGATATACGTTG 2961 TTATAAATAATGTTTGATTAAATAATAAAACATTATTTCATTACAATTCTAAATATTTGGTGTTTTGCTGTTGAGAGACA 3041 TTAGTGGTGTTTACTGTGGAAAATCTTAGCAAATATTCTGTGTACTATAATACAAACAATAATAGGATGTGTGCTCTGTG 3121 TCAGACAATGTGCTAAACATTATTATCACATGTATTATCTCATTTAATCATGTCTATGATCTCTTGGTTTGGACACTATC 3201 ATTAGTTCCTTCTGGAGGCATTATGGTTTACTAGTTATGAAATGTGGGGCTTGGGATCAGAAACATCTTGATTTAAATTT 3281 TGGTCCTGCCATTCCCTAGCCCTTTCATCTTGGGAAAGCTATCTTTTCTTTTTCAGTCTTGATTTCCTTATTGTGAAATG 3361 GACTTCAATCATGAGATCTATTTCCATAGGGTTTTCACAAGTTTTAAGTAAAATTGTGTATTGTAAAGTTCTTACCACAA 3441 TATCTGATGGAGAATAAGTATTCAATGTTAGATATTATAATTATCATAATTGTTGTGTTAAACATATTGCCCAAGATACT 3521 GTGTGGAGGATGTTTGTTTTCGATGCATACTGTATCCTGATTGTGTGCAGAACACATTTGTGTGTAGTGCATACTCTGAA 3601 AAGAAGCATACAGGGAAATGATGGTCTGTTTTCAAATTGCAAATCTAGCTAGAACAACTTCCTACTCCATTGTGGTTCTT 3681 TGAGAAGCCTCAGGGAAATAGCTCTGGGTCTTTCTAGCCAATCTCTAATTTCCTGTGACTACTCCAGTAAGTTTCTGTTC 3761 TCCTAAAGCAAGTCTTTACTATTCAAAAATCTCAAAAGGCCCCCTCACCTTCATTAAGCATGGGGCTCCTAACTGGAGTT 3841 CATGTCCATTAGAGTATAGGAAGAACATACTAGAATGATACTTGTGTTTATTTTTATCTAGTTTTTTTATGTTTGTGTAT 3921 GTTTTATAATGGCATAATAGTACAGTGGTACATGTACATAATTTTAAATAAATAAATAAACAAATAAACAAG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | C2C12 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes
... - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell. |
Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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76 mmu-miR-374b-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT418787 | Map2 | microtubule-associated protein 2 | ![]() |
1 | 1 | |||||||
MIRT577252 | Zfp84 | zinc finger protein 84 | ![]() |
1 | 1 | |||||||
MIRT577346 | Zfp11 | zinc finger protein 11 | ![]() |
1 | 1 | |||||||
MIRT577582 | Tcf21 | transcription factor 21 | ![]() |
1 | 1 | |||||||
MIRT577695 | Slc35d2 | solute carrier family 35, member D2 | ![]() |
1 | 1 | |||||||
MIRT577869 | Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | ![]() |
1 | 1 | |||||||
MIRT577940 | Ppp6r1 | protein phosphatase 6, regulatory subunit 1 | ![]() |
1 | 1 | |||||||
MIRT577949 | Pou4f2 | POU domain, class 4, transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT578202 | Nadsyn1 | NAD synthetase 1 | ![]() |
1 | 1 | |||||||
MIRT578468 | Impg2 | interphotoreceptor matrix proteoglycan 2 | ![]() |
1 | 1 | |||||||
MIRT578587 | Hist1h1d | histone cluster 1, H1d | ![]() |
1 | 1 | |||||||
MIRT579056 | Cradd | CASP2 and RIPK1 domain containing adaptor with death domain | ![]() |
1 | 1 | |||||||
MIRT579823 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 2 | |||||||
MIRT579840 | Zer1 | zyg-11 related, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT579950 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT579992 | Wnt3 | wingless-type MMTV integration site family, member 3 | ![]() |
1 | 1 | |||||||
MIRT579997 | Wnt11 | wingless-type MMTV integration site family, member 11 | ![]() |
1 | 1 | |||||||
MIRT580191 | Ttll7 | tubulin tyrosine ligase-like family, member 7 | ![]() |
1 | 1 | |||||||
MIRT580256 | Trim2 | tripartite motif-containing 2 | ![]() |
1 | 1 | |||||||
MIRT580383 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT580415 | Tmem161b | transmembrane protein 161B | ![]() |
1 | 1 | |||||||
MIRT580534 | Tead3 | TEA domain family member 3 | ![]() |
1 | 1 | |||||||
MIRT580565 | Tbx4 | T-box 4 | ![]() |
1 | 1 | |||||||
MIRT580611 | Syp | synaptophysin | ![]() |
1 | 1 | |||||||
MIRT581171 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT581538 | Pten | phosphatase and tensin homolog | ![]() |
1 | 1 | |||||||
MIRT581571 | Prrx1 | paired related homeobox 1 | ![]() |
1 | 1 | |||||||
MIRT581741 | Plxnc1 | plexin C1 | ![]() |
1 | 1 | |||||||
MIRT581794 | Plaur | plasminogen activator, urokinase receptor | ![]() |
1 | 1 | |||||||
MIRT581822 | Pkib | protein kinase inhibitor beta, cAMP dependent, testis specific | ![]() |
1 | 1 | |||||||
MIRT581971 | Pdcd10 | programmed cell death 10 | ![]() |
1 | 1 | |||||||
MIRT582055 | Osbp | oxysterol binding protein | ![]() |
1 | 1 | |||||||
MIRT582142 | Npr3 | natriuretic peptide receptor 3 | ![]() |
1 | 1 | |||||||
MIRT582168 | Nkx2-2 | NK2 homeobox 2 | ![]() |
1 | 1 | |||||||
MIRT582469 | Mex3a | mex3 RNA binding family member A | ![]() |
1 | 1 | |||||||
MIRT582518 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT582589 | Lrrtm2 | leucine rich repeat transmembrane neuronal 2 | ![]() |
1 | 1 | |||||||
MIRT582667 | Lmtk2 | lemur tyrosine kinase 2 | ![]() |
1 | 1 | |||||||
MIRT583063 | Hoxa11 | homeobox A11 | ![]() |
1 | 1 | |||||||
MIRT583111 | Hexim1 | hexamethylene bis-acetamide inducible 1 | ![]() |
1 | 1 | |||||||
MIRT583233 | Gpc6 | glypican 6 | ![]() |
1 | 1 | |||||||
MIRT583395 | Fzd5 | frizzled class receptor 5 | ![]() |
1 | 1 | |||||||
MIRT583429 | Frmpd4 | FERM and PDZ domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT583613 | Fam46a | family with sequence similarity 46, member A | ![]() |
1 | 1 | |||||||
MIRT583848 | Eea1 | early endosome antigen 1 | ![]() |
1 | 1 | |||||||
MIRT584669 | B3gat1 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | ![]() |
1 | 1 | |||||||
MIRT584731 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | ![]() |
1 | 1 | |||||||
MIRT584872 | Ap3m1 | adaptor-related protein complex 3, mu 1 subunit | ![]() |
1 | 1 | |||||||
MIRT585039 | Lrrc71 | leucine rich repeat containing 71 | ![]() |
1 | 1 | |||||||
MIRT585303 | Zfp248 | zinc finger protein 248 | ![]() |
1 | 3 | |||||||
MIRT585725 | T2 | brachyury 2 | ![]() |
1 | 1 | |||||||
MIRT585759 | St8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | ![]() |
1 | 1 | |||||||
MIRT585986 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 | |||||||
MIRT586181 | Ptprr | protein tyrosine phosphatase, receptor type, R | ![]() |
1 | 1 | |||||||
MIRT586738 | Lcn5 | lipocalin 5 | ![]() |
1 | 1 | |||||||
MIRT586778 | Jmjd4 | jumonji domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT587048 | Gm5531 | transmembrane epididymal protein 1B | ![]() |
1 | 1 | |||||||
MIRT587444 | Dimt1 | DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) | ![]() |
1 | 1 | |||||||
MIRT588190 | A130010J15Rik | RIKEN cDNA A130010J15 gene | ![]() |
1 | 1 | |||||||
MIRT588690 | Tet2 | tet methylcytosine dioxygenase 2 | ![]() |
1 | 1 | |||||||
MIRT589450 | Nck2 | non-catalytic region of tyrosine kinase adaptor protein 2 | ![]() |
1 | 1 | |||||||
MIRT590325 | Csgalnact2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | ![]() |
1 | 1 | |||||||
MIRT590458 | Car5b | carbonic anhydrase 5b, mitochondrial | ![]() |
1 | 1 | |||||||
MIRT590752 | Actr10 | ARP10 actin-related protein 10 | ![]() |
1 | 1 | |||||||
MIRT594398 | Ints6 | integrator complex subunit 6 | ![]() |
1 | 1 | |||||||
MIRT594639 | Mex3c | mex3 RNA binding family member C | ![]() |
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2 | 1 | ||||||
MIRT594870 | Man1a2 | mannosidase, alpha, class 1A, member 2 | ![]() |
1 | 1 | |||||||
MIRT595871 | Csmd1 | CUB and Sushi multiple domains 1 | ![]() |
1 | 1 | |||||||
MIRT596012 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596332 | Rpp14 | ribonuclease P 14 subunit | ![]() |
1 | 1 | |||||||
MIRT600146 | Zfp1 | zinc finger protein 1 | ![]() |
1 | 1 | |||||||
MIRT601141 | Bcl11b | B cell leukemia/lymphoma 11B | ![]() |
1 | 1 | |||||||
MIRT601571 | Sumf2 | sulfatase modifying factor 2 | ![]() |
1 | 1 | |||||||
MIRT605724 | Gmeb1 | glucocorticoid modulatory element binding protein 1 | ![]() |
1 | 1 | |||||||
MIRT731705 | Myf6 | myogenic factor 6 | ![]() |
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3 | 1 | |||||
MIRT735635 | Socs1 | suppressor of cytokine signaling 1 | ![]() |
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3 | 0 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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