pre-miRNA Information | |
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pre-miRNA | mmu-mir-374b |
Genomic Coordinates | chrX: 103573060 - 103573154 |
Description | Mus musculus miR-374b stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-374b-5p |
Sequence | 22| AUAUAAUACAACCUGCUAAGUG |43 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Eea1 | ||||||||||||||||||||
Synonyms | A430109M19Rik, B230358H09Rik, ZFYVE2 | ||||||||||||||||||||
Description | early endosome antigen 1 | ||||||||||||||||||||
Transcript | NM_001001932 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Eea1 | |||||||||||||||||||||
3'UTR of Eea1 (miRNA target sites are highlighted) |
>Eea1|NM_001001932|3'UTR 1 CGGGTTATCACAACTTCAGAGTAGTATCACACTAACGTTAGACTTTTAATAAATTGATTTGGACTCTGGTTGCATACTAG 81 GCCAAATTGGAATTCGTATATTTTGGAATGTTACCAGTATCAAGTAAAACTCTTCTATTTTTGTGAGACTTGGGTTCATC 161 TTTAATTACTTTTTCCATTAAACCCCTAAAACAGCTTTCATGCCAAGGTCAGAATTAGCCAATGAAATGTAAATAATCTT 241 TGGACAGAAAATAGCAATGTATTTTTTTAAATATAATTTAATTATTCACAAATGATGACTACAATTCCTTAGCTTCTTCC 321 TCTCAGAGTAAATGTACAGAATGTCTGGACGGCTCCTATCATTTGTTGCGGTTTTGTTGCACAACGACACAGTGATTCTA 401 TTCTCTTGGTGGAGTCATGCACAGGAATGTAACACTTTCTGTTTTTTCCTCTATAGGTCTGTAGCTCAATTATGTTGTTG 481 TGTTATACATATTACTTGAGTGTTCTAAATGCAGTGTATGCTAAATGATGTGTTAACCATGAGTTTGCGTGTGGGTTTTG 561 TTTGGGCAGTATTGATTAAATTCTCAAGTAGATTTGATAAACTCCTATGTAAAATTTATGGTACTTCTGGGATTGTATTT 641 ATGAAATGAGTTAATTTGCATTTCTCTATCTTATTTCTGACACCCACACACTGTCCCCTAAAACATTGTATGTAACTTCC 721 CTTTCTGAGCTGGAGGGTGAGTAGTAGAGCCGTGTGGTGGCTTGGTCTTGGTTTTTGCTGGTGGAAAGTTTTCTGAAGTG 801 ATCTCACAGCGCAGCCTCACTCCCTCAATTTCAGCATCTTTAGGAAGTTTGCTTTCCAGCCTTCATAAATGTAGCTCAGC 881 CTCAGTGCAGTTGTGCTTGCAGTAGGGCCTTTGTAAAGATAGGAACGGACACTGCTAATGTCGCATCTGTACCTGTGAAG 961 ACTAAGTCAAGTGGTAAGGAAATAGTAGCCTTCTTCTCGGTACTTCCTCTAACCAAACAGGAAAGACTAAATACAGCGAC 1041 AGAAAGCTGGCGCCATGTCTCTGATGAGGGGCCCATATTAACTTGGGATCTTTTAACTTTGAAAAAATAGTGCTATGAGA 1121 TTACACAACCGCTACAGAGCAGAGTCCGTACAGCCCCACCTCCATATACCTAGGAGCTCCTAAATGATGATAAAAAGGAA 1201 AACACTGGCTGCTGCTCGACCCCTTAAAAGTCATTTGTCTACCAACCAATAAACTTGTTCTTAGAAAGCATCAGAAGACT 1281 GAACTTGCCACATACTAGTTTTTAAATTATCTTTCTGTAGAAGAAATATAAAGTTACACATCGAATCATTACAGTCATTT 1361 AGTGATAATAGCAGAGAAAGATAAGAGCTAATATTTCATTTGCAAGAAAGAATTTATATTACACACTGCTGTCAGGAGTA 1441 TGCTGGAGTCTTCATGTTTTTATGACATACTTACAACATTACACAAACAAGAGACTGACATGTAATTTTTAATCATTTAG 1521 CAAAGTTAAGCCCTGCTTTCAGTAATGACTAAGGACACTGATTACATCCCAGGACTTGGATAAGTATATCCTTGAGCTTA 1601 TATACTGAAGTGATACAATGGCTCTATATTAAAAATAATAGTTGGGTAATATAGACTGAGCTGTTTATGCTTTTTATATA 1681 ATTGTGAATCCTTTCCGGTAGTCCTAATTCTACCTTTTTGGTTTTTGCATATAAACACTTTGACTATGTTAAAAATGCAG 1761 ATATTCACAGCACTACTTTGTGAAAATTCTGGATTAAAATATTTGTTCATTTCATCCTTTAATTGAAGACACTGGAGACT 1841 TTCTTTTTGTGCATCCTCACTTCACAAAAAAATAGAAGTGGCTACAAAGAAAACCCGTATGTGTTTATGGTAGGTTTCCT 1921 GTTCCCCCAATAATCTTATGCCACAGGTCCCAAATAATGTCCCTATCACACGCCACTTTACTGATGACACAATGAAGCCA 2001 AACAAACCACCGTTCCTCTTAACTATTACCAATTCAGAATGGACTGGACACAGAAATGTAAGATTTTTTTTTTCTCGTTT 2081 AATGAAAAAGTCTTGTGAATTCTTTTTGGCTGTACACTTAGCTGTTTGCTAGTAGTATTGTACTGTCAGTGGGCTGGAGC 2161 TGCCGCATACAGAGTCCCAGGTCTTGGCTATCATGCACAGTTGGCATCAGGTGTTGGCAAACTGCACACCCCAGCACAGA 2241 AATGGGAGCTGAAATGAGGTTGTGCTGGGTTGTGCACAGTAAACTGTATGTAGAGAGTGTCTGTAGTAGGCAGCAGGGGA 2321 AGCTGCTGATACAGGACTTACTTGTTTTGAAGAAAGGAAAGAAGGAGACAAACACACAAACCTCAGTGCAGTGTACAAAT 2401 AAACATTTTGTTCAACTACCTCTTAAAGTGGAGTTAGCTAGTGTAATGGTTTCCTTATAGTAATAGTCAATAGCAACTGC 2481 CAAATTTACGTTCCCATGCCTCTTAAAAGGTCTTCATGATTACTTTCTATAGCTTTGAGGTCCTTCCTTGTGGCTACTTT 2561 TTTACTCTTGCATTTGCATAAGATATTACCCTCTAAGTGGAAGGCAAATGACAGCCGTATATTTTGATATTTGTGACCTG 2641 TTTAATTATAGCAGTTTTTTTAATGCACTTTGGCTATAAAAACTATGGGTAACTTGATCTATAAGATTTAAATGTGCCAT 2721 CAATTTAGTATTCCTAGACATAAGCTTGATGAATGATCTTCTATAATTATAATGTGCCACATTTTTCTGTGTCTTAATTG 2801 CCCTTTGCCTGAATTTCAATGATCAAAATGTTATTGTTGCACATGTGAATACTGTGTATAAAACTTCCTAAATTTATGTA 2881 AAGTTGTATAATATAGAATAAAGAAATCCCACTGTGTTCTCTCTGTAAGAAGTAATGAACTTACTGTAACATGGTCCAGC 2961 CACAAGTCTGACATTTTATGCTCTCTGAAGTGGATCATATATCCATAGCCTCTGTACATACTTTTGCATGAGTATTTTCT 3041 CTGTTAGTTTTTGGGTTCATTATTTATATTGTGTTTACTACTTGTGATCATGTAGTTGTGCCTTATTTTTGTGAAAGAGT 3121 TTAGCTCAGTAAATACTGTAATTTCTAATCCCAGTGATTAGAAAGTTACCGATTATAAATAAATAACTGATAAATTATAA 3201 GACAGCATTTAAATCTGTATAAAGAACAATGGAAGGATCCTTACTGAATTGCCACTTCTGTTTTTTAATATGTTAAAGAT 3281 GATATTAAAGACCATTTCTTTCTAGTAGATGTTA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | C2C12 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1385343. RNA binding protein: 聽AGO2. Condition:C2C12_DM_Ago2_CLIP-Seq_myotubes
... - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell. |
Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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76 mmu-miR-374b-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT418787 | Map2 | microtubule-associated protein 2 | ![]() |
1 | 1 | |||||||
MIRT577252 | Zfp84 | zinc finger protein 84 | ![]() |
1 | 1 | |||||||
MIRT577346 | Zfp11 | zinc finger protein 11 | ![]() |
1 | 1 | |||||||
MIRT577582 | Tcf21 | transcription factor 21 | ![]() |
1 | 1 | |||||||
MIRT577695 | Slc35d2 | solute carrier family 35, member D2 | ![]() |
1 | 1 | |||||||
MIRT577869 | Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | ![]() |
1 | 1 | |||||||
MIRT577940 | Ppp6r1 | protein phosphatase 6, regulatory subunit 1 | ![]() |
1 | 1 | |||||||
MIRT577949 | Pou4f2 | POU domain, class 4, transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT578202 | Nadsyn1 | NAD synthetase 1 | ![]() |
1 | 1 | |||||||
MIRT578468 | Impg2 | interphotoreceptor matrix proteoglycan 2 | ![]() |
1 | 1 | |||||||
MIRT578587 | Hist1h1d | histone cluster 1, H1d | ![]() |
1 | 1 | |||||||
MIRT579056 | Cradd | CASP2 and RIPK1 domain containing adaptor with death domain | ![]() |
1 | 1 | |||||||
MIRT579823 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 2 | |||||||
MIRT579840 | Zer1 | zyg-11 related, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT579950 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT579992 | Wnt3 | wingless-type MMTV integration site family, member 3 | ![]() |
1 | 1 | |||||||
MIRT579997 | Wnt11 | wingless-type MMTV integration site family, member 11 | ![]() |
1 | 1 | |||||||
MIRT580191 | Ttll7 | tubulin tyrosine ligase-like family, member 7 | ![]() |
1 | 1 | |||||||
MIRT580256 | Trim2 | tripartite motif-containing 2 | ![]() |
1 | 1 | |||||||
MIRT580383 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT580415 | Tmem161b | transmembrane protein 161B | ![]() |
1 | 1 | |||||||
MIRT580534 | Tead3 | TEA domain family member 3 | ![]() |
1 | 1 | |||||||
MIRT580565 | Tbx4 | T-box 4 | ![]() |
1 | 1 | |||||||
MIRT580611 | Syp | synaptophysin | ![]() |
1 | 1 | |||||||
MIRT581171 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT581538 | Pten | phosphatase and tensin homolog | ![]() |
1 | 1 | |||||||
MIRT581571 | Prrx1 | paired related homeobox 1 | ![]() |
1 | 1 | |||||||
MIRT581741 | Plxnc1 | plexin C1 | ![]() |
1 | 1 | |||||||
MIRT581794 | Plaur | plasminogen activator, urokinase receptor | ![]() |
1 | 1 | |||||||
MIRT581822 | Pkib | protein kinase inhibitor beta, cAMP dependent, testis specific | ![]() |
1 | 1 | |||||||
MIRT581971 | Pdcd10 | programmed cell death 10 | ![]() |
1 | 1 | |||||||
MIRT582055 | Osbp | oxysterol binding protein | ![]() |
1 | 1 | |||||||
MIRT582142 | Npr3 | natriuretic peptide receptor 3 | ![]() |
1 | 1 | |||||||
MIRT582168 | Nkx2-2 | NK2 homeobox 2 | ![]() |
1 | 1 | |||||||
MIRT582469 | Mex3a | mex3 RNA binding family member A | ![]() |
1 | 1 | |||||||
MIRT582518 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT582589 | Lrrtm2 | leucine rich repeat transmembrane neuronal 2 | ![]() |
1 | 1 | |||||||
MIRT582667 | Lmtk2 | lemur tyrosine kinase 2 | ![]() |
1 | 1 | |||||||
MIRT583063 | Hoxa11 | homeobox A11 | ![]() |
1 | 1 | |||||||
MIRT583111 | Hexim1 | hexamethylene bis-acetamide inducible 1 | ![]() |
1 | 1 | |||||||
MIRT583233 | Gpc6 | glypican 6 | ![]() |
1 | 1 | |||||||
MIRT583395 | Fzd5 | frizzled class receptor 5 | ![]() |
1 | 1 | |||||||
MIRT583429 | Frmpd4 | FERM and PDZ domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT583613 | Fam46a | family with sequence similarity 46, member A | ![]() |
1 | 1 | |||||||
MIRT583848 | Eea1 | early endosome antigen 1 | ![]() |
1 | 1 | |||||||
MIRT584669 | B3gat1 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | ![]() |
1 | 1 | |||||||
MIRT584731 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | ![]() |
1 | 1 | |||||||
MIRT584872 | Ap3m1 | adaptor-related protein complex 3, mu 1 subunit | ![]() |
1 | 1 | |||||||
MIRT585039 | Lrrc71 | leucine rich repeat containing 71 | ![]() |
1 | 1 | |||||||
MIRT585303 | Zfp248 | zinc finger protein 248 | ![]() |
1 | 3 | |||||||
MIRT585725 | T2 | brachyury 2 | ![]() |
1 | 1 | |||||||
MIRT585759 | St8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | ![]() |
1 | 1 | |||||||
MIRT585986 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 | |||||||
MIRT586181 | Ptprr | protein tyrosine phosphatase, receptor type, R | ![]() |
1 | 1 | |||||||
MIRT586738 | Lcn5 | lipocalin 5 | ![]() |
1 | 1 | |||||||
MIRT586778 | Jmjd4 | jumonji domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT587048 | Gm5531 | transmembrane epididymal protein 1B | ![]() |
1 | 1 | |||||||
MIRT587444 | Dimt1 | DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) | ![]() |
1 | 1 | |||||||
MIRT588190 | A130010J15Rik | RIKEN cDNA A130010J15 gene | ![]() |
1 | 1 | |||||||
MIRT588690 | Tet2 | tet methylcytosine dioxygenase 2 | ![]() |
1 | 1 | |||||||
MIRT589450 | Nck2 | non-catalytic region of tyrosine kinase adaptor protein 2 | ![]() |
1 | 1 | |||||||
MIRT590325 | Csgalnact2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | ![]() |
1 | 1 | |||||||
MIRT590458 | Car5b | carbonic anhydrase 5b, mitochondrial | ![]() |
1 | 1 | |||||||
MIRT590752 | Actr10 | ARP10 actin-related protein 10 | ![]() |
1 | 1 | |||||||
MIRT594398 | Ints6 | integrator complex subunit 6 | ![]() |
1 | 1 | |||||||
MIRT594639 | Mex3c | mex3 RNA binding family member C | ![]() |
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2 | 1 | ||||||
MIRT594870 | Man1a2 | mannosidase, alpha, class 1A, member 2 | ![]() |
1 | 1 | |||||||
MIRT595871 | Csmd1 | CUB and Sushi multiple domains 1 | ![]() |
1 | 1 | |||||||
MIRT596012 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596332 | Rpp14 | ribonuclease P 14 subunit | ![]() |
1 | 1 | |||||||
MIRT600146 | Zfp1 | zinc finger protein 1 | ![]() |
1 | 1 | |||||||
MIRT601141 | Bcl11b | B cell leukemia/lymphoma 11B | ![]() |
1 | 1 | |||||||
MIRT601571 | Sumf2 | sulfatase modifying factor 2 | ![]() |
1 | 1 | |||||||
MIRT605724 | Gmeb1 | glucocorticoid modulatory element binding protein 1 | ![]() |
1 | 1 | |||||||
MIRT731705 | Myf6 | myogenic factor 6 | ![]() |
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3 | 1 | |||||
MIRT735635 | Socs1 | suppressor of cytokine signaling 1 | ![]() |
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3 | 0 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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