pre-miRNA Information | |
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pre-miRNA | mmu-mir-466h |
Genomic Coordinates | chr2: 10514891 - 10514971 |
Description | Mus musculus miR-466h stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-466h-5p |
Sequence | 11| UGUGUGCAUGUGCUUGUGUGUA |32 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Tet2 | ||||||||||||||||||||
Synonyms | Ayu17-449, E130014J05Rik, mKIAA1546 | ||||||||||||||||||||
Description | tet methylcytosine dioxygenase 2 | ||||||||||||||||||||
Transcript | NM_001040400 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Tet2 | |||||||||||||||||||||
3'UTR of Tet2 (miRNA target sites are highlighted) |
>Tet2|NM_001040400|3'UTR 1 CGCTGGCCATTAGGCCAGACCACCAAGGACGACCTGTGAGCAGTATGTCTTTCATGGCATGGGCCGTAGGGACAGGTCAC 81 AGCATCTGTGACAAATGCAGTGTGTGTTTGTGTGTATGTTTATTGGGGGGGGGCTGTCAGCTCACCAGCAAAATAGTTTA 161 TTTTATCATTATATTTAATCTCTCCCGTGGTCCATGGTGGCATTCAGGAAGAGCATCCTATGCAAGGGCACAGTGGGAAG 241 GAAGCGCTGGACATTTGTCTTGAAAACCACTGGTTCTCTTATTGGCTGAGGTCATGCGTGTGCCATGCCCCTCAGCACTC 321 TACACGTAACTGCTTCTAGTACTCAGCGTGTGTAACCGTGGGACACAGCGCTGTAGTAGAGCAGTTGCAGGATCATCTGG 401 TGCTGACGTATGATGTACTGAAGAAATACTGGAACTAAGACTTTTTAACATGCAGGTTTTTTACTGTAATCTTAATAACT 481 TATTTATCAAAGTAGCTACAGAAAGCTTAAGTGAATAATGGCAAAACACTGAATCTGTTTGGGTGTTAACATTAAATGGT 561 GCTACAAATGGTGTTTTTAATAGCTGAAAAATCAATGCCTTCTATCATCTAGCCAGTGTGGTCGAGGGCCCTGGAGGCAC 641 TGGGGTACCTCTGATTTTACATTTCTATCTTAATTATTCAGCTTAGTTTTTAAAATGTGGACATTTCAAAGGCCTCTGGA 721 TTGTAGTTATCCACCGATGTCCTTGTAGGACTATAATGTATAGATATGCACACTTACACATGTGTACTGAAATATTTTAA 801 GTTGTGTCTTAGAAAAGCACTTTGCCTACCTAAGCTTTGGCAACTTGGGCAATGCTAAGGTACTAAAACATAAAAACAAA 881 ACAAAAAAAAGTTTACTTTCATTTAGGATTAAAAGTGGTTTTGTTTTGTTTCCTTTTAAGGAAACATTTGCTTTGCTCTT 961 AGCCACTATCGGCTGATGAGCAGTATCAGGCCTGTTACAATCCAAACCGAAGCTGAATGGATATGCTAGTCCACAGAAAA 1041 CAAATAACAGTTTTTGGTGCTCACCTTACTTGCTATCCTGTAAAACGGTGGTAGGGCAAGCTCATCCCTCCTGCGTATAC 1121 AGCTTAAGAACGTCTGTTAATTGCAGGTGATAATTAGCCTTGGTGCTGCAGACAGAGCAAAGCTTGCCCACTTAAGTCCA 1201 TGTTGTCCCACACACAGACCTGTATGTTCTTCAGAACAGCAGGCTGCCTTTGTGTTCATTACATGCTTTGTGGTGTCTTT 1281 TCTTAGCTAAGTGTTATATATACCAGGAAGGTTGAGTGGACTGAAACCCGCAGAAGTTGAGAAGACATGGTTAAGTCCAT 1361 AGGACTCTACTGGTTACAGAGCAACCAACAAAAACCGAAAGAGAATAGGCAGCTGGTTTATGGTGATTTTAAACATTAAT 1441 TTGTATTAAAAGGTAAAAAAGAGTTGTATAGTAAATTAAATTGTAAAACAACCTTTTTTAATGCAATGCTTTAGTATTTT 1521 AGTACTGTAAAAAATTAAATATATACATATGTGTATATATATATTATATATATATATATAATATATGAGATTGAAGAAAA 1601 ATTCACATCACGATGGTGCTACCCAGATTGCTCCACATAGATCTTAATGTGAGCTAAGAATCCATTCAAAGTTGGAGTGG 1681 TGTTCCTACTTGTCGTCATACCTCAACACTAGCTAGGCAATGGGATACTGAGCTAACAGTGGAGGCTTAGAGCATTGTAG 1761 ACCACCATTTTTCTTTTTTTTTTTTTTTTTAAATCTTTGTATTAAGACATACCATTTTTAAATACTTGATTTCTTAGCAA 1841 GTATAACTTGAATCTCAAACTTTTTGTTCTAAAAATTCAGGGATATTTCAGCTCATTCTCCTTATGCTAACATGTCATCT 1921 GTTTATGCAAAGTTGTCGGTTAATATATTCGCTTTCAGAGGATTGCAATCCCTCGTAGTTTGCTTGTATATGTACTGATA 2001 ACTGAAAACTAATTTTATAAATTTTGTCACCTTTCAATTGTAAATTTTGGAGAGTTGGCATTCAGCAGAGTAAAAAGTGT 2081 AAAATAGGAAGCCCTGAGCTGGCAGAGGGAGATGGGGGGTACAAGACATCGCCGGTAATGGCTTCTGATCTAGTGACGAG 2161 GACAGCTTTGGACTGCAGCTGGACAGTCCTAGAAGCTGGTGGTGTGCTGTGCAATAGGACTGTTGTTACATTGTGGCCTA 2241 AATACAGTGTTGCTTACTAGCTTTGCAAATAGCTTTGCGTCAGTGGAGACCTTTGTAATTTACCATCAGTCACATTTGTC 2321 ACTAAAAACTTTCAGAATGTCTGCCTTGCACACACACACACACACACACACACACACAAAAACAAAAACCACAAGGTTTC 2401 CAAACCATGATGTTGAGTCCACATCAGGTTCCTGCAAGGTGTGCTTGGCAATTTTTTTTTTTTTTTTTTGAGCCAGCCAT 2481 CCCTAAGGAATATTTGCTTTACATGTCACCCACTGTCATTTGTCAAACTGCTGGCCAACAGGAGTAGTAAGTGTGGTTTG 2561 AGAGGATGGGTGGTGTAGGGAGGAAGGCAGTGACATCCCACCTCTGTCCATTAGATCAAGTGGGAGGCAGATCTGTGATT 2641 TGCTTCTATAGGAACAGCTTGACTACATAGCCATACTCGATACAAGTGCTTCTGCTTGGTGTCAACATTACTTGAATGAA 2721 TTTTTCATCTTGATTGACGCACAGTGATGTATAGTTCACTTTACAAGGTAGTTTGGTTAACTTGTTAGGGTTTTTTTTTT 2801 TTTTTTGGTTTTGTTTTTTGTTTTTTTGCAGTTTGACACTAAGATAATGAACTTCTGTGTGCATTTTTCTATGCTTTATT 2881 TTTTAATGTAGCTTACTTCCTGAGATTTTGGCTTTGTTTATACAATCTGAGGGTGGTTATAAATACTGTAAGTATTGTAA 2961 TGTTATGAATGCAGTTTATTTTAAAGCTGTTTATTATATCATTCCTGATAACGCCATGTGAGTGTTTTTAATAAAATTTA 3041 TATTTATTTAATGCACTCAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | C2C12 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1385342. RNA binding protein: 聽AGO2. Condition:C2C12_GM_Ago2_CLIP-Seq_myoblast
... - Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al., 2014, Cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Zhang X; Zuo X; Yang B; Li Z; Xue Y; Zhou et al. - Cell, 2014
MicroRNAs are well known to mediate translational repression and mRNA degradation in the cytoplasm. Various microRNAs have also been detected in membrane-compartmentalized organelles, but the functional significance has remained elusive. Here, we report that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. We show that this positive effect requires specific miR:mRNA base-pairing and Ago2, but not its functional partner GW182, which is excluded from the mitochondria. We provide evidence for the direct action of Ago2 in mitochondrial translation by crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq), functional rescue with mitochondria-targeted Ago2, and selective inhibition of the microRNA machinery in the cytoplasm. These findings unveil a positive function of microRNA in mitochondrial translation and suggest a highly coordinated myogenic program via miR-1-mediated translational stimulation in the mitochondria and repression in the cytoplasm.
LinkOut: [PMID: 25083871]
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CLIP-seq Support 1 for dataset GSM4656407 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | mouse liver / e185 |
Location of target site | NM_001040400 | 3UTR | GCACACUUACACAUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE153876 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1385342 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | C2C12 / C2C12_GM_Ago2_CLIP-Seq_myoblast |
Location of target site | NM_001040400 | 3UTR | CAGAAUGUCUGCCUUGCACACACACACACACACACACACA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 25083871 / GSE57596 |
CLIP-seq Viewer | Link |
87 mmu-miR-466h-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577339 | Zfp157 | zinc finger protein 157 | ![]() |
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2 | 2 | ||||||
MIRT577488 | Tns4 | tensin 4 | ![]() |
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2 | 6 | ||||||
MIRT578067 | Oxsm | 3-oxoacyl-ACP synthase, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT578343 | Ltf | lactotransferrin | ![]() |
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2 | 2 | ||||||
MIRT578743 | Gm4841 | predicted gene 4841 | ![]() |
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2 | 4 | ||||||
MIRT578822 | Fermt1 | fermitin family member 1 | ![]() |
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2 | 2 | ||||||
MIRT579127 | Chrnd | cholinergic receptor, nicotinic, delta polypeptide | ![]() |
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2 | 2 | ||||||
MIRT579135 | Chrna1 | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) | ![]() |
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2 | 2 | ||||||
MIRT579305 | BC021785 | major facilitator superfamily domain containing 4B5 | ![]() |
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2 | 4 | ||||||
MIRT579417 | Agtrap | angiotensin II, type I receptor-associated protein | ![]() |
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2 | 2 | ||||||
MIRT579732 | Zfp92 | zinc finger protein 92 | ![]() |
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2 | 4 | ||||||
MIRT579978 | Wrn | Werner syndrome RecQ like helicase | ![]() |
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2 | 4 | ||||||
MIRT581035 | Sim1 | single-minded homolog 1 (Drosophila) | ![]() |
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2 | 4 | ||||||
MIRT581532 | Pten | phosphatase and tensin homolog | ![]() |
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2 | 2 | ||||||
MIRT582312 | Nab1 | Ngfi-A binding protein 1 | ![]() |
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2 | 4 | ||||||
MIRT582843 | Itga9 | integrin alpha 9 | ![]() |
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2 | 4 | ||||||
MIRT582976 | Igf2 | insulin-like growth factor 2 | ![]() |
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2 | 4 | ||||||
MIRT583470 | Foxk1 | forkhead box K1 | ![]() |
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2 | 4 | ||||||
MIRT584662 | B4galt6 | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 | ![]() |
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2 | 4 | ||||||
MIRT585220 | Zfp488 | zinc finger protein 488 | ![]() |
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2 | 4 | ||||||
MIRT585299 | Zfp26 | zinc finger protein 26 | ![]() |
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2 | 2 | ||||||
MIRT585311 | Zfp248 | zinc finger protein 248 | ![]() |
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2 | 4 | ||||||
MIRT585835 | Slc6a17 | solute carrier family 6 (neurotransmitter transporter), member 17 | ![]() |
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2 | 4 | ||||||
MIRT586077 | Rhobtb1 | Rho-related BTB domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT586329 | Pgm5 | phosphoglucomutase 5 | ![]() |
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2 | 4 | ||||||
MIRT587381 | Dzip3 | DAZ interacting protein 3, zinc finger | ![]() |
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2 | 2 | ||||||
MIRT587611 | Cml2 | N-acetyltransferase 8 (GCN5-related) family member 2 | ![]() |
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2 | 2 | ||||||
MIRT587631 | Clec7a | C-type lectin domain family 7, member a | ![]() |
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2 | 8 | ||||||
MIRT587725 | Cd28 | CD28 antigen | ![]() |
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2 | 2 | ||||||
MIRT587758 | Cd200r1 | CD200 receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT588012 | Akap7 | A kinase (PRKA) anchor protein 7 | ![]() |
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2 | 2 | ||||||
MIRT588296 | 1700019G17Rik | N-acetyltransferase 8 (GCN5-related) family member 4 | ![]() |
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2 | 2 | ||||||
MIRT588555 | Uhrf1bp1l | UHRF1 (ICBP90) binding protein 1-like | ![]() |
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2 | 2 | ||||||
MIRT588689 | Tet2 | tet methylcytosine dioxygenase 2 | ![]() |
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2 | 2 | ||||||
MIRT588893 | Slc1a2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | ![]() |
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2 | 4 | ||||||
MIRT589021 | Rnf11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT589101 | Rasal2 | RAS protein activator like 2 | ![]() |
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2 | 4 | ||||||
MIRT590106 | Etv3 | ets variant 3 | ![]() |
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2 | 2 | ||||||
MIRT590170 | Elovl6 | ELOVL family member 6, elongation of long chain fatty acids (yeast) | ![]() |
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2 | 4 | ||||||
MIRT590929 | Tacr2 | tachykinin receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT591061 | Ptpre | protein tyrosine phosphatase, receptor type, E | ![]() |
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2 | 4 | ||||||
MIRT591144 | Nsun3 | NOL1/NOP2/Sun domain family member 3 | ![]() |
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2 | 2 | ||||||
MIRT591210 | Mdm2 | transformed mouse 3T3 cell double minute 2 | ![]() |
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2 | 2 | ||||||
MIRT591429 | Car10 | carbonic anhydrase 10 | ![]() |
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2 | 4 | ||||||
MIRT591502 | Acot2 | acyl-CoA thioesterase 2 | ![]() |
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2 | 4 | ||||||
MIRT591557 | Zfp449 | zinc finger protein 449 | ![]() |
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2 | 2 | ||||||
MIRT591632 | Ubtf | upstream binding transcription factor, RNA polymerase I | ![]() |
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2 | 4 | ||||||
MIRT591952 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
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2 | 2 | ||||||
MIRT591973 | Ap1ar | adaptor-related protein complex 1 associated regulatory protein | ![]() |
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2 | 2 | ||||||
MIRT592040 | Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | ![]() |
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2 | 2 | ||||||
MIRT592091 | Smo | smoothened, frizzled class receptor | ![]() |
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2 | 2 | ||||||
MIRT592109 | Slc25a12 | solute carrier family 25 (mitochondrial carrier, Aralar), member 12 | ![]() |
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2 | 2 | ||||||
MIRT592174 | Oxtr | oxytocin receptor | ![]() |
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2 | 2 | ||||||
MIRT592217 | Map3k7 | mitogen-activated protein kinase kinase kinase 7 | ![]() |
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2 | 2 | ||||||
MIRT592224 | Magee2 | melanoma antigen, family E, 2 | ![]() |
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2 | 6 | ||||||
MIRT592250 | Lcp2 | lymphocyte cytosolic protein 2 | ![]() |
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2 | 4 | ||||||
MIRT592267 | Kcnj16 | potassium inwardly-rectifying channel, subfamily J, member 16 | ![]() |
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2 | 2 | ||||||
MIRT592390 | Trp53i11 | transformation related protein 53 inducible protein 11 | ![]() |
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2 | 6 | ||||||
MIRT592420 | Stxbp5l | syntaxin binding protein 5-like | ![]() |
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2 | 2 | ||||||
MIRT592441 | Snx12 | sorting nexin 12 | ![]() |
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2 | 2 | ||||||
MIRT592515 | Npr3 | natriuretic peptide receptor 3 | ![]() |
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2 | 2 | ||||||
MIRT592626 | Mbnl3 | muscleblind like splicing factor 3 | ![]() |
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2 | 4 | ||||||
MIRT592703 | Gfra2 | glial cell line derived neurotrophic factor family receptor alpha 2 | ![]() |
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2 | 2 | ||||||
MIRT592746 | Epas1 | endothelial PAS domain protein 1 | ![]() |
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2 | 2 | ||||||
MIRT592765 | Dmd | dystrophin, muscular dystrophy | ![]() |
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2 | 4 | ||||||
MIRT592843 | Akap2 | A kinase (PRKA) anchor protein 2 | ![]() |
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2 | 2 | ||||||
MIRT592989 | Cacna2d2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT593003 | Bend4 | BEN domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT593228 | Fndc3a | fibronectin type III domain containing 3A | ![]() |
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2 | 2 | ||||||
MIRT593415 | Neurod2 | neurogenic differentiation 2 | ![]() |
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2 | 4 | ||||||
MIRT593453 | Rab11fip1 | RAB11 family interacting protein 1 (class I) | ![]() |
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2 | 2 | ||||||
MIRT593482 | Havcr2 | hepatitis A virus cellular receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT593517 | Csf2ra | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | ![]() |
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2 | 2 | ||||||
MIRT594037 | 2810006K23Rik | RIKEN cDNA 2810006K23 gene | ![]() |
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2 | 2 | ||||||
MIRT594129 | Fam104a | family with sequence similarity 104, member A | ![]() |
1 | 1 | |||||||
MIRT595670 | Rxrb | retinoid X receptor beta | ![]() |
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2 | 2 | ||||||
MIRT595701 | Fndc7 | fibronectin type III domain containing 7 | ![]() |
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2 | 2 | ||||||
MIRT596268 | Bnc2 | basonuclin 2 | ![]() |
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2 | 2 | ||||||
MIRT596281 | Slc6a8 | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | ![]() |
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2 | 2 | ||||||
MIRT598763 | Gpr68 | G protein-coupled receptor 68 | ![]() |
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2 | 2 | ||||||
MIRT601111 | Btrc | beta-transducin repeat containing protein | ![]() |
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2 | 2 | ||||||
MIRT601202 | Arhgef9 | CDC42 guanine nucleotide exchange factor (GEF) 9 | ![]() |
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2 | 2 | ||||||
MIRT603151 | Ubxn8 | UBX domain protein 8 | ![]() |
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2 | 2 | ||||||
MIRT603192 | Trim65 | tripartite motif-containing 65 | ![]() |
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2 | 2 | ||||||
MIRT604581 | Trim71 | tripartite motif-containing 71 | ![]() |
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2 | 2 | ||||||
MIRT605447 | St18 | suppression of tumorigenicity 18 | ![]() |
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2 | 2 | ||||||
MIRT605591 | Ncam1 | neural cell adhesion molecule 1 | ![]() |
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2 | 2 |