pre-miRNA Information
pre-miRNA mmu-mir-122   
Genomic Coordinates chr18: 65248861 - 65248926
Synonyms Mirn122a, mmu-mir-122, Mir122a
Description Mus musculus miR-122 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-122-5p
Sequence 6| UGGAGUGUGACAAUGGUGUUUG |27
Evidence Experimental
Experiments Cloned
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Microarrays; Real-time quantitative RT-PCR analysis
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Liver tissue Microarrays; Real-time quantitative RT-PCR analysis
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Liver tissue Quantitative real-time reverse transcription PCR
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Quantitative real-time reverse transcription PCR
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Quantitative reverse transcription PCR
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data expression Increase Serum Quantitative reverse transcription PCR
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression . Blood Polymerase chain reaction
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Serum Quantitative polymerase chain reaction
BOL4H5 miR-122 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Higher Blood Polymerase chain reaction
Gene Information
Gene Symbol Iffo2   
Synonyms C79267
Description intermediate filament family orphan 2
Transcript NM_183148   
Expression
Putative miRNA Targets on Iffo2
3'UTR of Iffo2
(miRNA target sites are highlighted)
>Iffo2|NM_183148|3'UTR
   1 TGACGGAGGCCCGACGCTCCTGGTGGTCTTGGTGATGGGGTCCAGCCTCCTCTCCCCACTGAGCCGTGTGGGCTCCACTC
  81 CTCGACACAGACTTCTGTCCTCCCTTCTCCGGAGGCCCAGCGGGACCGCTGCTTCCTTCCTTCCTCCACCACCGACCCAT
 161 GGAATGGTGCTGTCGATTTTTCTATTGTCCCCACACACACCACAAACGCAGACTTTTGTGCGTCGATGCAGTGCAACTGT
 241 GCCTTCTCCCTTAAGCTGAGCCACTTTGAGCTCCAAAGAATTCTTCCTAGCAGGTGTTTTTTTAAATATAAAACTCTAAG
 321 GTGAGGGTGGGGCCTGGAGGCGTGGTAGCTTTTGGTTTTCTCCCTCCCACCTGCTCCTCTGATTGGACATGAGCTTTGCT
 401 CCCTCCCTCTGTCCCAAGATGACTTGCGGTGGTCTGCTTTCTCAAGGAAGTAGACTGTGTTACCTCCAGAGCTGGGCGAG
 481 GAGGAGTCGTCAATACTTTCTCACCCAGGGATAGAGTGGTGGACGGAAGTGGAGGGAGGGAAGACCAATTTTTTTCTTCT
 561 TCTTTTGGATCTAGTGGCGATGTATCGGGGAAAGGCACTGTGGGGGAAGGAAGAACCTCACTGTGTTTAAACTATGCAAA
 641 AAACAAAAACAAAAAACAAACAAACAAAAAAACCTAAAAGCAGCTTGCCTTATATCATTGGGGAAGGCAGGCCCTCTCTC
 721 AGACTTCTGGGAACTGGGAGAGAGGCCAAGGTTGGCATGAGTCCCTCATAGCCTCTGAGGTTCAGAGGTGGCTTTGGGGG
 801 TGGTCCCAGTCAGATTGCTGGTAAGGCCTGCCTGCATTCTGCAAGCCGGCCCACTGGACTGATGGTTTTCTTGGGGACCT
 881 CTGTGGGGTGGGGTGGGGTGGGTGGTGGTCTTTTATTTTCCTGATGACTTGATGTTCATTCCCGCCTCTCCAATCACCTG
 961 CCAGGTTCCATGGTTGTAATTTCTCTGTGAGAAAGTATGAACAGGCCAGGCCTGCTACCTACTCTGTCCTCCACAGTACC
1041 GTCTTGGTCCTCCGTTGTCCCTCTGGCTGGGGGGAAAAAGCCTTGTTGGGGGGGGGGGAGTGGCATGGCTGCTGGCAGGC
1121 TGGCAATGACTGGAGAGAAGCCTCAAGTGAGGACCGTCCTCATTCATACATGCTTTCCATACCCATCTGTCTGGACGCTG
1201 AGCCAGTGATTCCCCAAGGCTCCCCTGGGGCCTGAGGTAAGGGGCCATAAGATAGAGCATCCGTCTATCAGAGAGCAGCT
1281 GGCGACTTGCCTAGCAACAATCAGGTTTTGTTTTTATTTCTTTCCTTATTTTGGGGTCCACTCTAGTGGTTTTGATGGCC
1361 TATGTTGTTTTTATTGACCCAGTGGGTTCCTCTGGAGTTCAAAGGAACAAAATGTCCCCAGGGATCAGAACCCATGGCCC
1441 TCTGAGGCCTGGGTGGTAAAGGGCAGAGGACTCTGGAACCATAGTGGTACCCGAGCCTCCTCTTTATCCCTCTGTTTCTC
1521 TCTAGGTGGTTCCATTATCTGTTTTGCACTTAGAGCCAGTGTACATAGTAGGCTTATGTATGGATAGAGAGGAGAGAGGA
1601 TGTGTTTGTTGGTGGCTTGTAACTTATCAGAACTTGGTGGCCTTTCTTACGTGTGTCTTCCATGATGTGGGGAGGGGTTT
1681 CCCATTGGTCCCTGTGCAGGTACTTGGAGGGACAATTGTTTGGGAAAAGACACAGCCCCTGTCCTCACTATTCTCTTCCC
1761 CTTTCTCACCAATCCTTCTTTTAAAGGTTACAGGGTTCATACACTTCTGGTTATTATTATTGTGTGTTATTGATATTATT
1841 GTTTTGGTTTTATTTTATTCTATGTTATTTTTTTAACCAAAGGTTATCAGAGCCAGATGGGCCTGGACCTTAGCTGCTGT
1921 AAAGATTTCCGTTTCTGTGAGGGCAGGAGGAGGGTTGCCCTCATGGGTCCTTGACTGAGGTTGGGGACCGTTTCCATCCA
2001 GCGGTAAAGCGGTAGAGTCTGGTAGTCAGGTGGGCAGAGCAGAAGCCAGCCCTTGATCGTTCTTCATGGAGGTGGTGGGC
2081 TGACATGTATCTCTAGCGTTAAGACAGGAAGCAACAGCGTAAACGTTTGAGGGGATGGCTGTGTACACAGCTACTGTGTA
2161 GTTGCTGGTCTCTGGTGTTATTTAACTTTCCCACCTGTATACATAGGTCATTTGTCTGGTGTGCATGAGAAAAGCAGACT
2241 CCTTTGGGTTCCCTCCTGCTGACTTTCAAAGTCTGCTTTCCCCTGGGAGGTGGAGCTCTGAGGCAGGAGGATGAGTGGAG
2321 AGGAGCAAGGGTGTGGTAGGCATGTTTCCTGGCTTGGTCTGGGCTCTGGGCCTGGCCTCCTCTTAGTGTTTGGTTTGTTC
2401 GTTTCGTAGTTCGTTGCCAGTGGGTCCTGCTTGTGCTCACTGTGAGCCCACAGCTTGCCCAGAAAGACCCCACCCCTCAC
2481 TGGGGCCGCCTCTCACTGGGGCAGCGCCTGCCCTGTCTGGACGAACTTGTCCACCCGTGTAAACATGTACATATGTTCTC
2561 TTGACTTTTCTATGTCTGAGCCCCGTGTCATATTGACACGGGGGGGCTCAGGGCTTCTCAGATGGGCTCCCCGTGTTGCC
2641 CCTGGCCATGCTCCTAGTTTGGGGGTCACATACACAGGCACAGCAGGGAGACAGCATCCTTTCAGGTTCCTGGTTGGTCG
2721 TGAAACACACACACACACACACACACACACACACACACACACACACACACTCCACTAAGACTCCAAAGGAGAAAGATGGG
2801 GAAGAGGTTTTGTCTTCCCGTTGGCAGTGTGTCTGGAAGGCATGAACACTTTGGACTCTGTTTTAGGGGTAGAACTCAGA
2881 TGTCCTATGAAGAGTCAAACCACTTTGACTTTAGGGTGGGAGGAGAGGGGATGGGTTAGGGGTAAGATGAGGTGTAACTT
2961 AAGCTAAATGTATTCTATTTATGAAGCAAGAGACTGTATTTTTATGAAAGGAAAAGGTTTTTAATCTAGGGTAGGCAGTC
3041 ATGGTGGCCCAGCATTTTGCTGTGGATAAGATACCGCCATGTTCATTGACTCCGGTGTACAATCAACAGTAAACCCCTCT
3121 CCTCAGCTTGCCCTCCGTCCTCACTGAACGTCCGCACACAGCTGGGGCGGGAGTTTGTTGTTTCTTCTTCCCCGGCCCTC
3201 AGCTCCTTAGAAGTCTTGGAAGGGAGTGGGGAGGGAGGGTGGAATGCAGAAAACTGAGGTGGGGGAGAGGTAGGTTCTAA
3281 TTAGTCACCCCATCTCCCTTCTGGCCAGACCTGCTCCCATTCAGCTGTGTGGGGAGAGTAGGAGGGAGGTTCTGTGGGGT
3361 TGGGGGACACAGGACTTCTTAGGGGCATAGGGACTTACTATGTCTGAAGTCGTCAGGCAGCTGGAGCAGGCATAGAAGGG
3441 ACTCAGGACACTAAGAGCTCAGCCCTGTCTGTGTCTACTCCAGGCCAAGGTCGAGCTTGGTTGTGGATGAAGGACCAGGA
3521 CTCTGTAGGGTTTCATCAGACCTGGGTCCTCCCTCTGGGACTGACCTAGTGGGAGGAGTGGAGACGGGTCTGGGCAAAGC
3601 CATACACACTCTGGGAAAAGATTTCCAGGCTCAGCGTGGACTGTGTGTGAGTCTCAGGCAAACTCCTCACCTTATGACTT
3681 CCTTCCCAAGCTCTCGAGGACATGTGAATTCCCCACCATGACACGACCCCTTTCCACACACTGTAGCATCTACCTGGTTT
3761 TTAGTCCCACCCTACCCACCGTTGCTGTGTCTGTCAGCTGGGTCTGAAAATCACCGGGAGGGGTTTGTACTCATCAAAGA
3841 CTACTGACCCTACCAGAAAACCAACCTGTTTACTGTACTGTTGTAAATACTGTGCCCTTTATATCGTGTATATTGGCTTC
3921 TTTGGAATAAAGTAAAATGTCTTAGCACAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guuUGUG-GUAACAGUGUGAGGu 5'
             |||| ||    |||||||| 
Target 5' cacACACACACACACACACTCCa 3'
2752 - 2774 155.00 -20.00
2
miRNA  3' guUUGUGGUAACAGUGUGAGGu 5'
            || :||||   |||||||: 
Target 5' gcAAAGCCAT--ACACACTCTg 3'
3594 - 3613 144.00 -16.60
3
miRNA  3' guuUGUGGUAACAGUGUGAGGu 5'
             |||  :||  :|||||:| 
Target 5' gttACAGGGTTCATACACTTCt 3'
1787 - 1808 139.00 -11.10
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Liver
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in ERR266286. RNA binding protein: AGO2. Condition:A_Liver partial hapatectomy 1h HITS-CLIP data was present in ERR266300. RNA binding protein: AGO2. Condition:B_Untreated ...

- Schug J; McKenna LB; Walton G; Hand N; et al., 2013, BMC genomics.

Article - Schug J; McKenna LB; Walton G; Hand N; et al.
- BMC genomics, 2013
BACKGROUND: Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. RESULTS: miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. miRNA recruitment to the RISC did not correlate with changes in overall miRNA expression for these dynamically recruited miRNAs, emphasizing the necessity to determine miRNA recruitment to the RISC in order to fully assess the impact of miRNA regulation. We incorporated RNA-seq quantification of total mRNA to identify expression-weighted Ago footprints, and developed a microRNA regulatory element (MRE) prediction algorithm that represents a greater than 20-fold refinement over computational methods alone. These high confidence MREs were used to generate candidate 'competing endogenous RNA' (ceRNA) networks. CONCLUSION: HITS-CLIP analysis provide novel insights into global miRNA:mRNA relationships in the regenerating liver.
LinkOut: [PMID: 23597149]
86 mmu-miR-122-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT003075 Tmem50b transmembrane protein 50B 1 1
MIRT003076 Lass6 ceramide synthase 6 1 1
MIRT003077 Gpx7 glutathione peroxidase 7 1 1
MIRT003113 Tgfbr1 transforming growth factor, beta receptor I 3 1
MIRT003114 Sbk1 SH3-binding kinase 1 3 1
MIRT003117 Hist1h1c histone cluster 1, H1c 3 1
MIRT003118 Ddc dopa decarboxylase 2 1
MIRT003120 Rell1 RELT-like 1 3 1
MIRT003121 Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 2 1
MIRT003122 Apob apolipoprotein B 2 1
MIRT003123 P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide 2 1
MIRT003124 Ccng1 cyclin G1 2 1
MIRT003125 Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 3 3
MIRT003126 Gys1 glycogen synthase 1, muscle 2 2
MIRT003127 Slc35a4 solute carrier family 35, member A4 2 2
MIRT003128 Hfe2 hemochromatosis type 2 (juvenile) 3 3
MIRT003129 Tmed3 transmembrane p24 trafficking protein 3 2 2
MIRT003132 Bckdk branched chain ketoacid dehydrogenase kinase 4 1
MIRT003133 Aldoa aldolase A, fructose-bisphosphate 4 7
MIRT003134 Ndrg3 N-myc downstream regulated gene 3 4 2
MIRT003135 Cd320 CD320 antigen 4 1
MIRT003724 Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 3 1
MIRT003725 Rcan1 regulator of calcineurin 1 2 1
MIRT003726 Gde1 glycerophosphodiester phosphodiesterase 1 2 1
MIRT004536 Ccrn4l nocturnin 4 1
MIRT005975 Klf6 Kruppel-like factor 6 4 1
MIRT005976 B2m beta-2 microglobulin 1 1
MIRT005977 Afp alpha fetoprotein 1 1
MIRT005978 Ccl2 chemokine (C-C motif) ligand 2 1 1
MIRT005979 Csf3r colony stimulating factor 3 receptor (granulocyte) 1 1
MIRT005980 Ctgf connective tissue growth factor 1 1
MIRT005981 Cxcl13 chemokine (C-X-C motif) ligand 13 1 1
MIRT005982 Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 1 1
MIRT005983 Dbp D site albumin promoter binding protein 1 1
MIRT005984 Igf2 insulin-like growth factor 2 1 1
MIRT005985 Il1b interleukin 1 beta 1 1
MIRT005986 Jun jun proto-oncogene 1 1
MIRT005987 Per1 period circadian clock 1 1 1
MIRT005988 Alpl alkaline phosphatase, liver/bone/kidney 2 1
MIRT005989 Cs citrate synthase 2 1
MIRT005990 Prom1 prominin 1 3 1
MIRT005991 Sox4 SRY (sex determining region Y)-box 4 3 1
MIRT013527 Uros uroporphyrinogen III synthase 1 1
MIRT013528 Ppox protoporphyrinogen oxidase 1 1
MIRT013529 Urod uroporphyrinogen decarboxylase 1 1
MIRT013530 Cpox coproporphyrinogen oxidase 1 1
MIRT013531 Fech ferrochelatase 1 1
MIRT013532 Hamp hepcidin antimicrobial peptide 1 1
MIRT013533 Tfr2 transferrin receptor 2 1 1
MIRT013534 Smad4 SMAD family member 4 1 1
MIRT013535 Smad7 SMAD family member 7 1 1
MIRT013536 Bmpr1a bone morphogenetic protein receptor, type 1A 1 1
MIRT013537 Hba-a1 hemoglobin alpha, adult chain 1 2 1
MIRT013538 Hmbs hydroxymethylbilane synthase 2 1
MIRT013539 Mir17 microRNA 17 2 1
MIRT013540 Alas2 aminolevulinic acid synthase 2, erythroid 2 1
MIRT013541 Mir451 microRNA 451a 2 1
MIRT013542 Tfrc transferrin receptor 2 1
MIRT013543 Socs2 suppressor of cytokine signaling 2 1 1
MIRT013544 Slc35g1 solute carrier family 35, member G1 1 1
MIRT013545 Camk2b calcium/calmodulin-dependent protein kinase II, beta 1 1
MIRT013546 Irf6 interferon regulatory factor 6 1 1
MIRT013547 Rbl2 RB transcriptional corepressor like 2 1 1
MIRT013548 Hfe hemochromatosis 2 1
MIRT013549 Ccnd1 cyclin D1 2 1
MIRT054338 Pkm pyruvate kinase, muscle 3 1
MIRT054339 Tfdp2 transcription factor Dp 2 3 1
MIRT054340 E2f1 E2F transcription factor 1 3 1
MIRT579817 Zfp113 zinc finger protein 113 1 1
MIRT580378 Tmem206 transmembrane protein 206 1 2
MIRT581166 Sec23ip Sec23 interacting protein 1 1
MIRT582514 March5 membrane-associated ring finger (C3HC4) 5 1 2
MIRT586941 H2-T24 histocompatibility 2, T region locus 24 1 2
MIRT591859 Iffo2 intermediate filament family orphan 2 1 1
MIRT592160 Paxip1 PAX interacting (with transcription-activation domain) protein 1 1 1
MIRT592189 Nanog Nanog homeobox 1 2
MIRT592792 Cdh12 cadherin 12 1 1
MIRT597026 Thap1 THAP domain containing, apoptosis associated protein 1 1 1
MIRT597210 Snhg11 small nucleolar RNA host gene 11 1 1
MIRT601300 Zfp949 zinc finger protein 949 1 1
MIRT602608 Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) 1 1
MIRT602960 Xpo7 exportin 7 1 1
MIRT603391 Sgol2 shugoshin 2A 1 1
MIRT604008 Ggps1 geranylgeranyl diphosphate synthase 1 1 1
MIRT605553 Ppp1r16b protein phosphatase 1, regulatory (inhibitor) subunit 16B 1 1
MIRT606204 Sfxn4 sideroflexin 4 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-122 Quercetin NULL 5280343 Quantitative real-time PCR liver 22402395 2012 up-regulated
miR-122 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Quantitative real-time PCR thymus 23024791 2012 up-regulated
miR-122 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-122 Streptozotocin (STZ) NULL 29327 Microarray streptozotocin (STZ)-induced type 1 diabetic mice 19372595 2009 down-regulated
miR-122 Streptozotocin (STZ) NULL 29327 Quantitative real-time PCR streptozotocin (STZ)-induced type 1 diabetic mice 19372595 2009 down-regulated
miR-122 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-122 Benzo(a)pyrene NULL 2336 Microarray Adult male B6C3F1 mice 21569818 2011 down-regulated
miR-122 Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-122 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-122 Bortezomib approved 387447 Quantitative real-time PCR SeAx and MyLa2000 cells 22235305 2012 up-regulated
miR-122 Doxorubicin approved 31703 Quantitative real-time PCR SeAx and MyLa2000 cells 22235305 2012 up-regulated
miR-122 MG132 NULL 462382 Quantitative real-time PCR SeAx and MyLa2000 cells 22235305 2012 up-regulated
miR-122 Microcystin-LR (MC-LR) NULL 445434 Quantitative real-time PCR WRL-68 Cells 22265967 2012 down-regulated
miR-122 Furan NULL 8029 Quantitative real-time PCR liver 22079235 2011 down-regulated
miR-122 Proanthocyanidins approved 108065 Quantitative real-time PCR liver cells 23922812 2013 down-regualted
miR-122 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 down-regulated
miR-122 Dexamethasone approved 5743 Quantitative real-time PCR adrenals and granulosa cells 24205079 2014 down-regulated
miR-122 Proanthocyanidins approved 108065 Quantitative real-time PCR postprandial lipemia and liver 24445039 2014 down-regulated
miR-122 Aristolochic acid NULL 2236 Microarray kidney 25106556 2014 down-regualted
miR-122 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-122 Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
mmu-miR-122-5p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma tissue and cell line
mmu-miR-122-5p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma tissue and cell line
mmu-miR-122-5p Fluorouracil 3385 NSC19893 approved sensitive Low Colon Cancer tissue and cell line (HCT-116, HCT-29)

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