pre-miRNA Information | |
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pre-miRNA | mmu-mir-122 |
Genomic Coordinates | chr18: 65248861 - 65248926 |
Synonyms | Mirn122a, mmu-mir-122, Mir122a |
Description | Mus musculus miR-122 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-122-5p |
Sequence | 6| UGGAGUGUGACAAUGGUGUUUG |27 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Biomarker Information |
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Gene Information | |||||||||||||||||||||
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Gene Symbol | Iffo2 | ||||||||||||||||||||
Synonyms | C79267 | ||||||||||||||||||||
Description | intermediate filament family orphan 2 | ||||||||||||||||||||
Transcript | NM_183148 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Iffo2 | |||||||||||||||||||||
3'UTR of Iffo2 (miRNA target sites are highlighted) |
>Iffo2|NM_183148|3'UTR 1 TGACGGAGGCCCGACGCTCCTGGTGGTCTTGGTGATGGGGTCCAGCCTCCTCTCCCCACTGAGCCGTGTGGGCTCCACTC 81 CTCGACACAGACTTCTGTCCTCCCTTCTCCGGAGGCCCAGCGGGACCGCTGCTTCCTTCCTTCCTCCACCACCGACCCAT 161 GGAATGGTGCTGTCGATTTTTCTATTGTCCCCACACACACCACAAACGCAGACTTTTGTGCGTCGATGCAGTGCAACTGT 241 GCCTTCTCCCTTAAGCTGAGCCACTTTGAGCTCCAAAGAATTCTTCCTAGCAGGTGTTTTTTTAAATATAAAACTCTAAG 321 GTGAGGGTGGGGCCTGGAGGCGTGGTAGCTTTTGGTTTTCTCCCTCCCACCTGCTCCTCTGATTGGACATGAGCTTTGCT 401 CCCTCCCTCTGTCCCAAGATGACTTGCGGTGGTCTGCTTTCTCAAGGAAGTAGACTGTGTTACCTCCAGAGCTGGGCGAG 481 GAGGAGTCGTCAATACTTTCTCACCCAGGGATAGAGTGGTGGACGGAAGTGGAGGGAGGGAAGACCAATTTTTTTCTTCT 561 TCTTTTGGATCTAGTGGCGATGTATCGGGGAAAGGCACTGTGGGGGAAGGAAGAACCTCACTGTGTTTAAACTATGCAAA 641 AAACAAAAACAAAAAACAAACAAACAAAAAAACCTAAAAGCAGCTTGCCTTATATCATTGGGGAAGGCAGGCCCTCTCTC 721 AGACTTCTGGGAACTGGGAGAGAGGCCAAGGTTGGCATGAGTCCCTCATAGCCTCTGAGGTTCAGAGGTGGCTTTGGGGG 801 TGGTCCCAGTCAGATTGCTGGTAAGGCCTGCCTGCATTCTGCAAGCCGGCCCACTGGACTGATGGTTTTCTTGGGGACCT 881 CTGTGGGGTGGGGTGGGGTGGGTGGTGGTCTTTTATTTTCCTGATGACTTGATGTTCATTCCCGCCTCTCCAATCACCTG 961 CCAGGTTCCATGGTTGTAATTTCTCTGTGAGAAAGTATGAACAGGCCAGGCCTGCTACCTACTCTGTCCTCCACAGTACC 1041 GTCTTGGTCCTCCGTTGTCCCTCTGGCTGGGGGGAAAAAGCCTTGTTGGGGGGGGGGGAGTGGCATGGCTGCTGGCAGGC 1121 TGGCAATGACTGGAGAGAAGCCTCAAGTGAGGACCGTCCTCATTCATACATGCTTTCCATACCCATCTGTCTGGACGCTG 1201 AGCCAGTGATTCCCCAAGGCTCCCCTGGGGCCTGAGGTAAGGGGCCATAAGATAGAGCATCCGTCTATCAGAGAGCAGCT 1281 GGCGACTTGCCTAGCAACAATCAGGTTTTGTTTTTATTTCTTTCCTTATTTTGGGGTCCACTCTAGTGGTTTTGATGGCC 1361 TATGTTGTTTTTATTGACCCAGTGGGTTCCTCTGGAGTTCAAAGGAACAAAATGTCCCCAGGGATCAGAACCCATGGCCC 1441 TCTGAGGCCTGGGTGGTAAAGGGCAGAGGACTCTGGAACCATAGTGGTACCCGAGCCTCCTCTTTATCCCTCTGTTTCTC 1521 TCTAGGTGGTTCCATTATCTGTTTTGCACTTAGAGCCAGTGTACATAGTAGGCTTATGTATGGATAGAGAGGAGAGAGGA 1601 TGTGTTTGTTGGTGGCTTGTAACTTATCAGAACTTGGTGGCCTTTCTTACGTGTGTCTTCCATGATGTGGGGAGGGGTTT 1681 CCCATTGGTCCCTGTGCAGGTACTTGGAGGGACAATTGTTTGGGAAAAGACACAGCCCCTGTCCTCACTATTCTCTTCCC 1761 CTTTCTCACCAATCCTTCTTTTAAAGGTTACAGGGTTCATACACTTCTGGTTATTATTATTGTGTGTTATTGATATTATT 1841 GTTTTGGTTTTATTTTATTCTATGTTATTTTTTTAACCAAAGGTTATCAGAGCCAGATGGGCCTGGACCTTAGCTGCTGT 1921 AAAGATTTCCGTTTCTGTGAGGGCAGGAGGAGGGTTGCCCTCATGGGTCCTTGACTGAGGTTGGGGACCGTTTCCATCCA 2001 GCGGTAAAGCGGTAGAGTCTGGTAGTCAGGTGGGCAGAGCAGAAGCCAGCCCTTGATCGTTCTTCATGGAGGTGGTGGGC 2081 TGACATGTATCTCTAGCGTTAAGACAGGAAGCAACAGCGTAAACGTTTGAGGGGATGGCTGTGTACACAGCTACTGTGTA 2161 GTTGCTGGTCTCTGGTGTTATTTAACTTTCCCACCTGTATACATAGGTCATTTGTCTGGTGTGCATGAGAAAAGCAGACT 2241 CCTTTGGGTTCCCTCCTGCTGACTTTCAAAGTCTGCTTTCCCCTGGGAGGTGGAGCTCTGAGGCAGGAGGATGAGTGGAG 2321 AGGAGCAAGGGTGTGGTAGGCATGTTTCCTGGCTTGGTCTGGGCTCTGGGCCTGGCCTCCTCTTAGTGTTTGGTTTGTTC 2401 GTTTCGTAGTTCGTTGCCAGTGGGTCCTGCTTGTGCTCACTGTGAGCCCACAGCTTGCCCAGAAAGACCCCACCCCTCAC 2481 TGGGGCCGCCTCTCACTGGGGCAGCGCCTGCCCTGTCTGGACGAACTTGTCCACCCGTGTAAACATGTACATATGTTCTC 2561 TTGACTTTTCTATGTCTGAGCCCCGTGTCATATTGACACGGGGGGGCTCAGGGCTTCTCAGATGGGCTCCCCGTGTTGCC 2641 CCTGGCCATGCTCCTAGTTTGGGGGTCACATACACAGGCACAGCAGGGAGACAGCATCCTTTCAGGTTCCTGGTTGGTCG 2721 TGAAACACACACACACACACACACACACACACACACACACACACACACACTCCACTAAGACTCCAAAGGAGAAAGATGGG 2801 GAAGAGGTTTTGTCTTCCCGTTGGCAGTGTGTCTGGAAGGCATGAACACTTTGGACTCTGTTTTAGGGGTAGAACTCAGA 2881 TGTCCTATGAAGAGTCAAACCACTTTGACTTTAGGGTGGGAGGAGAGGGGATGGGTTAGGGGTAAGATGAGGTGTAACTT 2961 AAGCTAAATGTATTCTATTTATGAAGCAAGAGACTGTATTTTTATGAAAGGAAAAGGTTTTTAATCTAGGGTAGGCAGTC 3041 ATGGTGGCCCAGCATTTTGCTGTGGATAAGATACCGCCATGTTCATTGACTCCGGTGTACAATCAACAGTAAACCCCTCT 3121 CCTCAGCTTGCCCTCCGTCCTCACTGAACGTCCGCACACAGCTGGGGCGGGAGTTTGTTGTTTCTTCTTCCCCGGCCCTC 3201 AGCTCCTTAGAAGTCTTGGAAGGGAGTGGGGAGGGAGGGTGGAATGCAGAAAACTGAGGTGGGGGAGAGGTAGGTTCTAA 3281 TTAGTCACCCCATCTCCCTTCTGGCCAGACCTGCTCCCATTCAGCTGTGTGGGGAGAGTAGGAGGGAGGTTCTGTGGGGT 3361 TGGGGGACACAGGACTTCTTAGGGGCATAGGGACTTACTATGTCTGAAGTCGTCAGGCAGCTGGAGCAGGCATAGAAGGG 3441 ACTCAGGACACTAAGAGCTCAGCCCTGTCTGTGTCTACTCCAGGCCAAGGTCGAGCTTGGTTGTGGATGAAGGACCAGGA 3521 CTCTGTAGGGTTTCATCAGACCTGGGTCCTCCCTCTGGGACTGACCTAGTGGGAGGAGTGGAGACGGGTCTGGGCAAAGC 3601 CATACACACTCTGGGAAAAGATTTCCAGGCTCAGCGTGGACTGTGTGTGAGTCTCAGGCAAACTCCTCACCTTATGACTT 3681 CCTTCCCAAGCTCTCGAGGACATGTGAATTCCCCACCATGACACGACCCCTTTCCACACACTGTAGCATCTACCTGGTTT 3761 TTAGTCCCACCCTACCCACCGTTGCTGTGTCTGTCAGCTGGGTCTGAAAATCACCGGGAGGGGTTTGTACTCATCAAAGA 3841 CTACTGACCCTACCAGAAAACCAACCTGTTTACTGTACTGTTGTAAATACTGTGCCCTTTATATCGTGTATATTGGCTTC 3921 TTTGGAATAAAGTAAAATGTCTTAGCACAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Liver |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in ERR266286. RNA binding protein: AGO2. Condition:A_Liver partial hapatectomy 1h
HITS-CLIP data was present in ERR266300. RNA binding protein: AGO2. Condition:B_Untreated
... - Schug J; McKenna LB; Walton G; Hand N; et al., 2013, BMC genomics. |
Article |
- Schug J; McKenna LB; Walton G; Hand N; et al. - BMC genomics, 2013
BACKGROUND: Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. RESULTS: miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. miRNA recruitment to the RISC did not correlate with changes in overall miRNA expression for these dynamically recruited miRNAs, emphasizing the necessity to determine miRNA recruitment to the RISC in order to fully assess the impact of miRNA regulation. We incorporated RNA-seq quantification of total mRNA to identify expression-weighted Ago footprints, and developed a microRNA regulatory element (MRE) prediction algorithm that represents a greater than 20-fold refinement over computational methods alone. These high confidence MREs were used to generate candidate 'competing endogenous RNA' (ceRNA) networks. CONCLUSION: HITS-CLIP analysis provide novel insights into global miRNA:mRNA relationships in the regenerating liver.
LinkOut: [PMID: 23597149]
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86 mmu-miR-122-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT003075 | Tmem50b | transmembrane protein 50B | ![]() |
1 | 1 | |||||||
MIRT003076 | Lass6 | ceramide synthase 6 | ![]() |
1 | 1 | |||||||
MIRT003077 | Gpx7 | glutathione peroxidase 7 | ![]() |
1 | 1 | |||||||
MIRT003113 | Tgfbr1 | transforming growth factor, beta receptor I | ![]() |
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3 | 1 | |||||
MIRT003114 | Sbk1 | SH3-binding kinase 1 | ![]() |
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3 | 1 | |||||
MIRT003117 | Hist1h1c | histone cluster 1, H1c | ![]() |
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3 | 1 | |||||
MIRT003118 | Ddc | dopa decarboxylase | ![]() |
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2 | 1 | ||||||
MIRT003120 | Rell1 | RELT-like 1 | ![]() |
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3 | 1 | |||||
MIRT003121 | Bach1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | ![]() |
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2 | 1 | ||||||
MIRT003122 | Apob | apolipoprotein B | ![]() |
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2 | 1 | ||||||
MIRT003123 | P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | ![]() |
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2 | 1 | ||||||
MIRT003124 | Ccng1 | cyclin G1 | ![]() |
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2 | 1 | ||||||
MIRT003125 | Slc7a1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | ![]() |
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3 | 3 | |||||
MIRT003126 | Gys1 | glycogen synthase 1, muscle | ![]() |
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2 | 2 | ||||||
MIRT003127 | Slc35a4 | solute carrier family 35, member A4 | ![]() |
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2 | 2 | ||||||
MIRT003128 | Hfe2 | hemochromatosis type 2 (juvenile) | ![]() |
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3 | 3 | |||||
MIRT003129 | Tmed3 | transmembrane p24 trafficking protein 3 | ![]() |
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2 | 2 | ||||||
MIRT003132 | Bckdk | branched chain ketoacid dehydrogenase kinase | ![]() |
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4 | 1 | ||||
MIRT003133 | Aldoa | aldolase A, fructose-bisphosphate | ![]() |
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4 | 7 | ||||
MIRT003134 | Ndrg3 | N-myc downstream regulated gene 3 | ![]() |
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4 | 2 | ||||
MIRT003135 | Cd320 | CD320 antigen | ![]() |
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4 | 1 | ||||
MIRT003724 | Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | ![]() |
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3 | 1 | |||||
MIRT003725 | Rcan1 | regulator of calcineurin 1 | ![]() |
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2 | 1 | ||||||
MIRT003726 | Gde1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 1 | ||||||
MIRT004536 | Ccrn4l | nocturnin | ![]() |
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4 | 1 | ||||
MIRT005975 | Klf6 | Kruppel-like factor 6 | ![]() |
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4 | 1 | ||||
MIRT005976 | B2m | beta-2 microglobulin | ![]() |
1 | 1 | |||||||
MIRT005977 | Afp | alpha fetoprotein | ![]() |
1 | 1 | |||||||
MIRT005978 | Ccl2 | chemokine (C-C motif) ligand 2 | ![]() |
1 | 1 | |||||||
MIRT005979 | Csf3r | colony stimulating factor 3 receptor (granulocyte) | ![]() |
1 | 1 | |||||||
MIRT005980 | Ctgf | connective tissue growth factor | ![]() |
1 | 1 | |||||||
MIRT005981 | Cxcl13 | chemokine (C-X-C motif) ligand 13 | ![]() |
1 | 1 | |||||||
MIRT005982 | Cyp2b13 | cytochrome P450, family 2, subfamily b, polypeptide 13 | ![]() |
1 | 1 | |||||||
MIRT005983 | Dbp | D site albumin promoter binding protein | ![]() |
1 | 1 | |||||||
MIRT005984 | Igf2 | insulin-like growth factor 2 | ![]() |
1 | 1 | |||||||
MIRT005985 | Il1b | interleukin 1 beta | ![]() |
1 | 1 | |||||||
MIRT005986 | Jun | jun proto-oncogene | ![]() |
1 | 1 | |||||||
MIRT005987 | Per1 | period circadian clock 1 | ![]() |
1 | 1 | |||||||
MIRT005988 | Alpl | alkaline phosphatase, liver/bone/kidney | ![]() |
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2 | 1 | ||||||
MIRT005989 | Cs | citrate synthase | ![]() |
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2 | 1 | ||||||
MIRT005990 | Prom1 | prominin 1 | ![]() |
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3 | 1 | |||||
MIRT005991 | Sox4 | SRY (sex determining region Y)-box 4 | ![]() |
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3 | 1 | |||||
MIRT013527 | Uros | uroporphyrinogen III synthase | ![]() |
1 | 1 | |||||||
MIRT013528 | Ppox | protoporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013529 | Urod | uroporphyrinogen decarboxylase | ![]() |
1 | 1 | |||||||
MIRT013530 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013531 | Fech | ferrochelatase | ![]() |
1 | 1 | |||||||
MIRT013532 | Hamp | hepcidin antimicrobial peptide | ![]() |
1 | 1 | |||||||
MIRT013533 | Tfr2 | transferrin receptor 2 | ![]() |
1 | 1 | |||||||
MIRT013534 | Smad4 | SMAD family member 4 | ![]() |
1 | 1 | |||||||
MIRT013535 | Smad7 | SMAD family member 7 | ![]() |
1 | 1 | |||||||
MIRT013536 | Bmpr1a | bone morphogenetic protein receptor, type 1A | ![]() |
1 | 1 | |||||||
MIRT013537 | Hba-a1 | hemoglobin alpha, adult chain 1 | ![]() |
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2 | 1 | ||||||
MIRT013538 | Hmbs | hydroxymethylbilane synthase | ![]() |
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2 | 1 | ||||||
MIRT013539 | Mir17 | microRNA 17 | ![]() |
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2 | 1 | ||||||
MIRT013540 | Alas2 | aminolevulinic acid synthase 2, erythroid | ![]() |
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2 | 1 | ||||||
MIRT013541 | Mir451 | microRNA 451a | ![]() |
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2 | 1 | ||||||
MIRT013542 | Tfrc | transferrin receptor | ![]() |
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2 | 1 | ||||||
MIRT013543 | Socs2 | suppressor of cytokine signaling 2 | ![]() |
1 | 1 | |||||||
MIRT013544 | Slc35g1 | solute carrier family 35, member G1 | ![]() |
1 | 1 | |||||||
MIRT013545 | Camk2b | calcium/calmodulin-dependent protein kinase II, beta | ![]() |
1 | 1 | |||||||
MIRT013546 | Irf6 | interferon regulatory factor 6 | ![]() |
1 | 1 | |||||||
MIRT013547 | Rbl2 | RB transcriptional corepressor like 2 | ![]() |
1 | 1 | |||||||
MIRT013548 | Hfe | hemochromatosis | ![]() |
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2 | 1 | ||||||
MIRT013549 | Ccnd1 | cyclin D1 | ![]() |
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2 | 1 | ||||||
MIRT054338 | Pkm | pyruvate kinase, muscle | ![]() |
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3 | 1 | |||||
MIRT054339 | Tfdp2 | transcription factor Dp 2 | ![]() |
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3 | 1 | |||||
MIRT054340 | E2f1 | E2F transcription factor 1 | ![]() |
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3 | 1 | |||||
MIRT579817 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 1 | |||||||
MIRT580378 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT581166 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT582514 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT586941 | H2-T24 | histocompatibility 2, T region locus 24 | ![]() |
1 | 2 | |||||||
MIRT591859 | Iffo2 | intermediate filament family orphan 2 | ![]() |
1 | 1 | |||||||
MIRT592160 | Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | ![]() |
1 | 1 | |||||||
MIRT592189 | Nanog | Nanog homeobox | ![]() |
1 | 2 | |||||||
MIRT592792 | Cdh12 | cadherin 12 | ![]() |
1 | 1 | |||||||
MIRT597026 | Thap1 | THAP domain containing, apoptosis associated protein 1 | ![]() |
1 | 1 | |||||||
MIRT597210 | Snhg11 | small nucleolar RNA host gene 11 | ![]() |
1 | 1 | |||||||
MIRT601300 | Zfp949 | zinc finger protein 949 | ![]() |
1 | 1 | |||||||
MIRT602608 | Chrna1 | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) | ![]() |
1 | 1 | |||||||
MIRT602960 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT603391 | Sgol2 | shugoshin 2A | ![]() |
1 | 1 | |||||||
MIRT604008 | Ggps1 | geranylgeranyl diphosphate synthase 1 | ![]() |
1 | 1 | |||||||
MIRT605553 | Ppp1r16b | protein phosphatase 1, regulatory (inhibitor) subunit 16B | ![]() |
1 | 1 | |||||||
MIRT606204 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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