miRTarBase - #MIRT593956


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miRNA Infomation
miRNA namemmu-miR-1186b

Gene Information
Gene Symbol Cpm   
Synonyms 1110060I01Rik, 5730456K23Rik, AA589379, E030045M14Rik
Description carboxypeptidase M
Transcript NM_027468   
Expression
Putative miRNA Targets on Cpm
3'UTR of Cpm
(miRNA target sites are highlighted)		 
>Cpm|NM_027468|3'UTR
   1 AGCAAGGTGTGAAACTCGACTTCCGGGAATCAGGGATTGGTTACTCCCGGTTATGGCAACCCTCCCTCCTGTGGGACTGC
  81 GATTGGGACAGACTCCACTGTTTTCCTTAAGAAGAAAACCGGATGTTTCCAAACCTGGCCTAGAGCGACCTGTAACGACC
 161 AAATCCATCTTCAGTCTGGATAAAGTGGAGGTCACTGCTTAGCTCATGCTGCCCACACAAACGCCACCCCGAAGGAGTCC
 241 CAAACACTTGTAAGAAAGTTCAGAAGCAAAACAGATATCCCTACAAGAAAAACAATTTGTCTACGGAGAGCCACGTGGAT
 321 CAGAGCCGCAAGGACGGGCACTTTCTGGTCACTTGCTGTGTTACGACCTTTCGTGTTATTTGTAGAGAGCTGATATTGTC
 401 TATAAGTGGTTCTCCCCAAAGGAAGAAATTTCTAGATAACGGGACTAAGAGCATTTACTCTTGCCAATGGTCTAAGGCCA
 481 AATGAGAGAAAATGGACAAACATGTCTGATGTGGGTACAGATGCAGTGGCCTCTGTCTCCCGTGCCTTTGCCCTTGCCCC
 561 CTGCACCTGATGCCACAGTCCTACGAAGATGACCCCTCCTGTATAACCCCAGTCCCTTGCCTGAGCCTCAGATGCAACTC
 641 CAGCTGCTCACCAGACACACCCACCTGACTACGATGCCTAGGAACTGCAGTTCATCCGGTTGACTGTTGAGACGCCATGC
 721 AAGGCTGTTCGATTCCCATATCCAGTCACTGGAAGCTGCTGTATACAGCCTCTCCAGGCCAGTTAGCGTCCCTCCGCCGC
 801 TGACCCAGCTGCTGCTCATGGGTATTTTCGCCAAGTCCGTCTTCCACACAGAACCTGGGGAGCTGGGCTGCCCAAAGCTC
 881 TCCTGCTCCCTAAACACAACACAGTAAGTGCTCTCGGTCCCAGGTCTGGATTCTGATTGTGTCACGTCTTGTTTCCTGCT
 961 CAGTAAAACTCCATTCCATGGGGGGTTAAGAGCACTGACTGCTCTTCCAGAGGTCCTGAGGTCAATTCCCAGCCACCACA
1041 TGGTGGCTCACAGCCATCTGTAATGGGATCCGAGGCTGCCTTCTGGTGTGTCTGAAGACAGCAACCATGTAGTCATACAC
1121 GTAAAATAAATAAATTTTTTAAAAGGAAGAATTCCAAGCATCGTCTTCAACGGGGAAGCCCATGGAGTTCCAGGTGGTCA
1201 AGTTCAAGGCCGATCCTTCAAAGAAGTTCCTTTGACTAGTGACTTTACAGCATCGTGGTGTGGAACTGCTCTGTGCTGGC
1281 CTTCTCTAGCACGCCATGAGCTCTTTAAGACAAGGATCTGCTTGAGAAATAATTTCTCAGAGTCTAGCCAAAAAACAGGA
1361 AATAAATGGATGGGGAAGTGTCTCAGCTACCGCTACAGACCTTTCCAGAACGCTAAGGATCTGAGTAATTTTGTGTAAAT
1441 GCGTTTTATGTTTGGCAACATTCAGCTTACTAGTACACACACACACACATACACACTTTTCACGTGTATGTCAAAGAACA
1521 AAATCCAAAGATAAATGCAAATGGGTGAGCTGTGAGGCTTGAGGGAAAGGCATTAGCTGTTAGCCAATCTGCCTTCTAGA
1601 CCAGAAAACAAATTCTTACAGTTCGAAGTAAAGTGTCCCCTGTAAAAGTAACTTTATTCTAACATTAGAAGAAGAGAAAG
1681 CTGGGCGTGTTGGCGCACACCTTTAATCCCAACACTCAGAAGGCAGAGGTGGGCGGATGTCTTCGTTTACACAGACAGAC
1761 CCTGTCTCAAAAGTAAATAAATTAAAAGAAAAAAAAAAGGATAAATATCAAACAGGAACATTAACAGTAACTCCGAGGTG
1841 CAGGTTTCTAAGTGACATGCATTTCCCACAGGAAGTAAGAACATGCGGGGTTTGACAGGCGATGAAGGCTTGAGACTCTA
1921 AAGAGATACGTGGGCACCCTGGTGCCCTTTCTTGGTGCCAAACCTAATCTATATTTTAATATCAATAGTCTGCATAGCTT
2001 TTTAACCGCTTCTAAATTTGGAAATAGCATGAGTATCTTGATCATTTTATTTAAATAAGCATTAACTTATATCCCAGAAG
2081 GCGCGTATTAATAGTTCAAAAAGGGATCTGGGTATATTACATTTGAAGTATATATATAAGACGAAGCCAGGTGTGGTGGT
2161 GAACTATTATCCCAGCGCTTGGGAGGCTGAGGCAAGATCGACACAGCTCAAGGCTAGCCTGGACTAGCCATCTTAGAAAA
2241 GCAAAACCAGTAAGATATGTAAGAGCAAACTTGGTTCGCCATCAGCTGGTGTTCTGAGTTCTGACTGGTTGACCCTTTCC
2321 TAAGATTCCGTGAAAGGAAATGAGCTGTTCGCTGAGCTGCTCATGGGCCTAACCGGAGACTTGGTACTGAAACAACTTGC
2401 AAGTGCCCGTGTCTTACCAGAGACTGTGCCAGGGCTTTGCACAGGGCCATTGAGCCACAGCTACGTCTTTATTTTGTTAC
2481 TTTTTGTTCAGACACAGCATTTCACTAAGCTGTGTAGCCTGCACTTGGAACTCATAGTAAGCCAAACTGGCTTTGGATCT
2561 GCCTGCCGTAGACGCTGGAGTAGCTATTACAGACCTGGTCCGCTGTGTCCATATTCAGGTTACATTACTTAAATCAGAAA
2641 TATATATCAAAACCCAGTGTAAAAATCACTAAAACAGGGTGAGGGGTGTAGCTCAGTGACAGTGTACTTAGCATATGCAA
2721 AGGCTTGGGTCTAATCTCCATTAACTACCCCCAAGACAAAACATAACCAGGAAATTATTCTGTTGCCCTCTGCCAGGTAG
2801 AGAAAGCAGAAGGAATACTTGGGTCTGTAACTGTTTTGAAAGCAATATACCTTACTAAAGGTGACCTGAAAACGGAAATG
2881 CTGGTTACCAAAAACCACGTCCTTTTCAAGGAAACTTTCACAAAGTGCCTAGTTTACATGCGTGCCCATTTTTGAATTGA
2961 GATGGTAAAATCCTAGCACCCAGGCAGCAGAGGCAGGTGGATCTCTGTGAGTTCAAGGCCAGTCTTTTCTACAGAGTTCT
3041 GGGACCGCCAGGGCTACGCAGAAAAACCCCCGTTTCAAACAAGCAAAAACAGTCCCAGTTTTCTCAGACTCTGCCTGTAC
3121 TAAAATGGTATTAACATCAGATCTGCTTTCCAATGTATGAGCTGAAGCTGGGTTGAGACGTATCTGTTTCTAGGAAAAAT
3201 ATACAAAGCCATATAGCACACTTATTTTCCTATTGCAACAGGAGTTTCATTCTCAGTCTCGGAGGGGGCATCTAGTGAAG
3281 GTTTGTGAGCTCAATTCTGCCTTCCTGGTGACCTCAGGTACGGGAGAGAATGATGCTGGATTAGGTGAAGAGCATCGGGT
3361 TCTTGGTGCCTACAACAGATTCTTCACCGAGTTTGTTCTAGACTTGCATCACTAATAAGATGCTGTACTGTGTCTCACAG
3441 GCCGTTTAATCAAACCTTAAGCTCACAAGCCAACCCACAGCTCTGTGCGAGAGACTTCATGCGGGTTTTTGTTTAACAAG
3521 CTTCTAAGTGATTCCTGCCATTAAAAGCACAGAAGCAGAAGCTATTAAAGGTGCCCAGGTTGAGTGGTGGCAGTGCTGGA
3601 CCACGCCTTTAATCCCAGTACTCCAGAGGCAGAGGCAGAGGGGACTCTGAGTTCAAATCCAGCCTGCCTGGTCTACACAG
3681 TGAGTTCCAAGACAGCCAGGGCTACACAGAAAAATAAATAAATTCTCAGATTATCTAAGATTACAACGTTTGCTTGGGAG
3761 GGACCATGACTACCTCTGAGCTTATTTTATTTACATTATCTGATTATCAATAAAGAATATTCATATAGTGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions CD4+ T cells (C57BL/6)
Disease MIMAT0015644
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM1013598. RNA binding protein: AGO2. Condition:CD4+ T cells ...

- Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell.

Article - Loeb GB; Khan AA; Canner D; Hiatt JB; et al.
- Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
CLIP-seq Support 1 for dataset GSM1013598
Method / RBP HITS-CLIP / AGO2
Cell line / Condition CD4+ T cells (C57BL/6) / CD4+ T cells, WT, biological rep12
Location of target site NM_027468 | 3UTR | CCCAACACUCAGAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23142080 / GSE41285
CLIP-seq Viewer Link
86 mmu-miR-1186b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT576999 Mark2 MAP/microtubule affinity regulating kinase 2 2 2
MIRT585120 Zfp935 zinc finger protein 935 2 2
MIRT586283 Prc1 protein regulator of cytokinesis 1 2 4
MIRT586381 Pbld1 phenazine biosynthesis-like protein domain containing 1 2 2
MIRT586708 Loxl2 lysyl oxidase-like 2 2 4
MIRT587092 Gla galactosidase, alpha 2 4
MIRT587538 Cxcr2 chemokine (C-X-C motif) receptor 2 2 2
MIRT589503 Myo1e myosin IE 2 4
MIRT589590 Magt1 magnesium transporter 1 2 2
MIRT590954 Stxbp2 syntaxin binding protein 2 2 2
MIRT591055 Rab11fip1 RAB11 family interacting protein 1 (class I) 2 2
MIRT591076 Polr2l polymerase (RNA) II (DNA directed) polypeptide L 2 2
MIRT591337 Gm10778 predicted gene 10778 2 2
MIRT592001 Wdr34 WD repeat domain 34 2 4
MIRT592296 Foxr1 forkhead box R1 2 4
MIRT593950 Cpne1 copine I 2 2
MIRT593956 Cpm carboxypeptidase M 2 2
MIRT595194 Tmtc3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT595287 Mef2c myocyte enhancer factor 2C 2 2
MIRT596506 Zfp933 zinc finger protein 933 2 2
MIRT596786 Ubxn2a UBX domain protein 2A 2 2
MIRT597061 Tcea1 transcription elongation factor A (SII) 1 2 2
MIRT597101 Taf1a TATA-box binding protein associated factor, RNA polymerase I, A 2 2
MIRT597153 Stxbp4 syntaxin binding protein 4 2 2
MIRT597459 Rhag Rhesus blood group-associated A glycoprotein 2 2
MIRT597814 Pla2g2d phospholipase A2, group IID 2 2
MIRT597836 Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha 2 2
MIRT598087 Nek7 NIMA (never in mitosis gene a)-related expressed kinase 7 2 2
MIRT598275 Med16 mediator complex subunit 16 2 2
MIRT598705 Haus2 HAUS augmin-like complex, subunit 2 2 2
MIRT598887 Glrx2 glutaredoxin 2 (thioltransferase) 2 2
MIRT598959 Gemin8 gem nuclear organelle associated protein 8 2 2
MIRT599390 Clmn calmin 2 2
MIRT599417 Chek2 checkpoint kinase 2 2 2
MIRT599571 Btc betacellulin, epidermal growth factor family member 2 2
MIRT599852 Adarb1 adenosine deaminase, RNA-specific, B1 2 2
MIRT599903 Acat1 acetyl-Coenzyme A acetyltransferase 1 2 2
MIRT599922 A830018L16Rik RIKEN cDNA A830018L16 gene 2 2
MIRT599998 4930579G24Rik RIKEN cDNA 4930579G24 gene 2 2
MIRT600123 Zfyve27 zinc finger, FYVE domain containing 27 2 2
MIRT600437 Samd8 sterile alpha motif domain containing 8 2 2
MIRT600468 Rbm4 RNA binding motif protein 4 2 2
MIRT600872 Gabpb2 GA repeat binding protein, beta 2 2 2
MIRT601116 Bri3bp Bri3 binding protein 2 2
MIRT601328 Zfp689 zinc finger protein 689 2 2
MIRT601448 Tprkb Tp53rk binding protein 2 2
MIRT601451 Tns4 tensin 4 2 2
MIRT601483 Tmod1 tropomodulin 1 2 2
MIRT601536 Tet1 tet methylcytosine dioxygenase 1 2 2
MIRT601857 Pkd2 polycystic kidney disease 2 2 2
MIRT601946 Nwd1 NACHT and WD repeat domain containing 1 2 2
MIRT602015 Mpp7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 2 2
MIRT602020 Moap1 modulator of apoptosis 1 2 2
MIRT602190 Hyal1 hyaluronoglucosaminidase 1 2 2
MIRT602217 Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2 2
MIRT602370 Fbxl3 F-box and leucine-rich repeat protein 3 2 2
MIRT602416 F2r coagulation factor II (thrombin) receptor 2 2
MIRT602429 Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 2 2
MIRT602495 Dkc1 dyskeratosis congenita 1, dyskerin 2 2
MIRT602566 Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2 2
MIRT602668 Car5b carbonic anhydrase 5b, mitochondrial 2 2
MIRT602688 Camk4 calcium/calmodulin-dependent protein kinase IV 2 2
MIRT602852 Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 2 2
MIRT602997 Pdzd2 PDZ domain containing 2 2 2
MIRT603145 Ubxn8 UBX domain protein 8 2 2
MIRT603436 Rpl7l1 ribosomal protein L7-like 1 2 2
MIRT603456 Rhbdl2 rhomboid, veinlet-like 2 (Drosophila) 2 2
MIRT603635 Pbxip1 pre B cell leukemia transcription factor interacting protein 1 2 2
MIRT603725 Mrpl51 mitochondrial ribosomal protein L51 2 2
MIRT603750 Mfsd2b major facilitator superfamily domain containing 2B 2 2
MIRT603819 Kif5b kinesin family member 5B 2 2
MIRT603907 Hpgds hematopoietic prostaglandin D synthase 2 2
MIRT603918 Hltf helicase-like transcription factor 2 2
MIRT603975 Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type 2 2
MIRT604114 Diap2 diaphanous related formin 2 2 2
MIRT604187 Cxcl11 chemokine (C-X-C motif) ligand 11 2 2
MIRT604294 Ccdc36 coiled-coil domain containing 36 2 2
MIRT604400 Aida axin interactor, dorsalization associated 2 2
MIRT604629 Syt11 synaptotagmin XI 2 2
MIRT604707 Scml4 sex comb on midleg-like 4 (Drosophila) 2 2
MIRT604967 Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT605165 C030039L03Rik zinc finger protein 607B 2 2
MIRT605198 B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 2 2
MIRT605619 Mpv17 MpV17 mitochondrial inner membrane protein 2 2
MIRT606468 Tcaim T cell activation inhibitor, mitochondrial 1 1
MIRT606659 Lsm11 U7 snRNP-specific Sm-like protein LSM11 2 2

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