pre-miRNA Information
pre-miRNA mmu-mir-741   
Genomic Coordinates chrX: 66796805 - 66796875
Description Mus musculus miR-741 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-741-3p
Sequence 45| UGAGAGAUGCCAUUCUAUGUAGA |67
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Prkca   
Synonyms AI875142, Pkca
Description protein kinase C, alpha
Transcript NM_011101   
Expression
Putative miRNA Targets on Prkca
3'UTR of Prkca
(miRNA target sites are highlighted)
>Prkca|NM_011101|3'UTR
   1 AACTCAAAAATGAAAGATCAAATGCCTCCCCAGCCCCCAGCATCCCCAGCAGTGGGAAATGATCCTTAACCATAAAAATT
  81 TAAGGCTATGGCCTTGTATTTTGTTCCACACAGAGGCCTGGAAATTCTAGGGACATTAGTCAATACATGATCAACTTTTT
 161 TCCTCACCCCCCAACCAAAAGCATTATCTTAGTGGATGATGACATAAAGTACAGAGTATAGTTTAATTATGTAGAAGTCA
 241 TGTCAGCTACAAGTTGATTCTTCCTAAAAAAAATCAAAGCGACTTGGACCCTATTTTTTTTGTACGATTTGATATATTCT
 321 CCATACTTTCCATTTCTTGGATTTTCACTATCAGAATCGACCAGAGATAGTAAAGTGAACTCACCCTAACTCAAGGAAAC
 401 TCAAGGAAACACTTCCACCCAAGATGTCTTTGGAACAAAAGAACAGGAAGTCCAAAGAGAAAGCAAAGAGAGGTTGGGGG
 481 CTCATATATTCAAGACCACATAGCTTCTATTCTCCTTTTCAATGGAAACAGTCCCTAGACTCAGAGAGGGCAGGATGAAC
 561 CTGATCACTGTTCCCAGTCATCATAGCACAACCATAGTGCACAGTTTAAGAAGGAAAGAAAACTTCAGACAAATATTCAC
 641 TGAATCTACCATCTGTAATCCCCTGCTTGGTTGATAACAATCTCTATAACTCATTCTTTTTAAGAGGCCAAATCATCTAA
 721 GGACTTTGCTAAACAAGCATGTGAAATCATTTCAGATCAAGGATAAACCATGTGTACGTTCATTCTAATCTCTGGGAGAT
 801 GACTCTTCAATCCAGGGTGCCATCAGTAATCATGCCACTGTTCACGAGTGTTGTTAGCCAACCCCACACACACAATATTT
 881 TGCTACCTTTGTAGGTACCCTTCCTAAGAAGCTGAAATGTATGACCCCATCCCCCCCCCTTTTTTTACTATTTATTTAAT
 961 AAGCTGCAGTGTCGTTTATGGAAGTACAATGTATAGTAATTTAGTCAAAGTATTGACTAGCCTCAGTCCCTCTAGATTGA
1041 TTTTCCTCCTTTCTCTCGCCCCACATCCACTTAGAGATGAAAAAGAGCATAGTTTGGGTTCCCATTCTCAGTTCCTATTG
1121 AACGGCACATGTGGAACTGTAGGATCAAGATACTTTATGCTGATATCAACTCAAAGATGTTGTCTTGCTAGAAGGATTTT
1201 AATATGTTTTGCGAGTGCATCATGCAATGGATTTTGCATGTTTATAATAAACCTTAATAACGAGTTAATCTATATTATTG
1281 ATATAATTGTATCAACTATAAAGAGTATTATGATAATTTTTATAAGACACAATTGTGCTATATTTGTGACGCTCATGTTT
1361 CCAGTCTGCTTTAAGATTAAGTGTTAGCTTTATTCATTGCTGCTGGGCTCTCACCCGCTACTCCACACACTGGCACTCTA
1441 TCAGATATATTAATTTTTTAATGTAGATGTAATTTTAAAAATGAATGGCTACTTTACACGTTTAACTAGGGTTTTACTAT
1521 ATATGTGTACATATGTATATATATATATATATATATTTGATTCTACCTACAAACCCCGGTTTTGTTTGTGGGGATTATTT
1601 TTTGAGATAAGACTCTGTTAACTTCTTCATGTTATCCTCTGTTCAAGTTCCTTTATCACCCCTTCTCTTGGGGACAGCTG
1681 AATATATTTAATTCCAGTATTCCTGATATGTTCATATATATGTGGCATTGTTACAGCACCTAGGCTGAATTGTGTGTGTG
1761 TGTGTGTCTGTCTGTCTGTCTGTCTGTCTGTCTGGTACTTTTCAGCCTATGTCTTTGGGGTCTCTAGGGATGAAGGGGTG
1841 AGAGAACTCCTTTCTGTGTGTGCATATGGACACCCAAAAATATGTAGTCTGTCTTTCTGCCCCAGAATAACTCACTGTGT
1921 ACTTCAGAACACACAGAATCCTTGAGACAAACTTTATCTCCATGCCTGTGTAGAGCCATCTCTGAAGCTGTTGCCAACAG
2001 ACTCTCTTCAGAGGCACATACTGTCTTAAAGCGGTTCCTAGAACATTCCGGTCTTTGAAGAGCATGCCTTTGTCCAAATG
2081 CCTCCTAATACAAGGTGTTTAGAAGAGGCAGGCTTCTGCAGCATAAAGGATAAGTGAAAAAGGAGTTCCTACCAGTCCTT
2161 AGAGAAGGCACCTCTATCGAAATCATCTCACAGCTAGGCTCTCCTCTTTGTTATTCTCCACCTATCTGCTTGACAGTCAC
2241 ATACCCTGCAACCCACCAAGAGTCTTTGAGATACGGAGCATAGGCTGTTCTGAAAATCCCTAATCAGAAGGAGATATGGA
2321 GTCGAGAGTGGGCCAAACCAGAAAAGAGCAGTTTCTTCTGCAATCTTTCATGAATTCTGGACTTCAGACCTCAAAAAGTG
2401 GGGAAGGGTGTCATATATGGATCTCAGAAGTCAAGTTCACCATCTTGGTAACCTAGCCTTATCAAAAACACTGTACTCAG
2481 TCCAACTGTAAAGGAACTGGCTTATCAATGAGCCTTGGAAGTGAAAGCATTGCTCTTCCCAGGTGGGACAGCAACAGGAA
2561 GCTGAACCTCTCAAAGTGGGGGAAACCACAGAGAAGGAGCACAGGGTTCGTAGACAATCCACCCTGAGGTGCCAAGCTGC
2641 CTGACTCTCATGCCAGTAGCAGGCTTGGGTTCTTCCTTAAACCGCCAGCATCCAGCTCCGAGTGATTCAACTTCTCTAGA
2721 AAATGTGTGCGGTTCCTTGGATGGCTTGTACGCTTAGAGAATACCCACCAACATTCTCACACTGGAGGAGGGAAATAACA
2801 GAGCCACAGACCAGCAATTGCCTAAGGAACAGAACACTGGAGAACAAACTTAGGAGAGATGATAAAAATTTAAGGACGTG
2881 TTCATGATGCTGCCTATTCTATACACTGCTGAGGGTTAAATTCAGATGAAGGCTAGTACTTTAAAGATCTGGACAGCAGA
2961 GACAACTTTTGCTACAAAACTAACTCACCTGGATAACCACTAGCAGCTGTTAGGCAGGATCAATTGATACTATTCTACAT
3041 CCTTGTCCCACTTCACAGACCTTGTATGAAACAGGGCTACAGGGAAACATCTGCCATTTGAACTGAAGCAACCAAGCAGG
3121 AGGCCAGAACCAGGAGGGTGCCTTGAAGGGTTTAATCCCCAGGGGCAGGGGTGGGAACTATTTAGAATGTACCTGCTCTC
3201 AGGCTGTGCCTGCATTGGCAGGGTCTGTGGAGGAGAACCTAGCACAATCCAAGTCTCCACAGGGACCCATCAGGCCGTGA
3281 CCCAGAAAATCCATTGAAATAATTTTGTATTATATTCCCCTGGAAGGTGGCCATTTCCCAGGAGCAGCTCTTCCCTGTTC
3361 CACCACAGGCCGGTGGGCTGCTAGCTCTGCCTTCAGTGTGGCATCTAAAGTTACCTGGTGCTTGGGTTGAATGGAAAGAG
3441 CTGGAGTATGCTGCCAGGTGCAGCCCCAGGAGTTAATGGGAGGCTTACCCCAGGCAGCAGCTAATTCAGAAGGCAGAAGA
3521 GAAGCCCCAGGAGCTAAACTGATTGCCCTTCACCCTCCTACCTCTGTGGCCTAGTTTGAGCTAGTAGCCTTTTCTTTAAT
3601 TTAGTCTTTTTTATTAGTAATTTGAGAAACTCAGGAGGCCCAGAGTTTTCCGGAAGCTTGGTCTGAGATGGTCACGTGAA
3681 AGATTACCAGAGGCCAGTATTAACCCTCAAATGTTGCTGCTCACAAGCTCCAGTTCTTAGCAAATAAATCATGGTGGCTT
3761 GCCAACCCCAAAAGAGCCACTCATCGATGTATCACAAAGAGGAGGAAGCAGAAGTCAACACCATTAAAGAGCAGGGTTTG
3841 AGTGCACCCAGGAAGACATGGAAGGTGGTGGAAAGGTTGTGTTAATCTGCATGGGCTTTCCACTGGGGGTCATTGTGCAA
3921 ATGGAAGTTACTGTTCATCAGCCTTCAAAGGTGTGGCTTTTTGCCAGATACAACCTTTTGTTCGTTCTCAGACTCTCCCA
4001 ACTGTAACAAGTCCTTTGCCCAGAGCCGAGCCAGCCAGCAGACCCTAGAAGCACTTAGTTCCATCTTTATCCCTCTGATA
4081 ATTATGGCTGCTGAGACTAGGTCCAGAAGTCACGAAAACAACCAACAACGACCTGCCAGCTTCTGCTCAGCAGAGAAAAA
4161 TAGGAAGGGTTTGTGCAGGGCTTTATTTTCTCAAACGCCTCCACAAGGCAACACCACCTGACAGTCATTTTCTCACCTTG
4241 GTCTTATGAAATCATCTATTTCTTGTGTGTACATGTCACGCTGTTTCCTGTTTGTTTACAACCCTAGAAGGGTAGGGTTA
4321 CCTGTCCCCATGCCACGGCTGAGCACATCAGTCACTCTCAGGAGATGCGTGCTGAGCCAGGGACCTGAAAGGATGCTGAC
4401 CATGGGGGGTTGGGGGGACAATAGCAAGGAAGGAGACAGGTCCTCTGGTTAGCAGTGGGTCCACACTAACATGACAGAGT
4481 GTTAGGAAACTGGTTTTAAAATTGTTTTCCATGAACTGCTGTTAACAAAATGTGCTGGACAGTCAACACCCCTGCCACAT
4561 CTCACTGGGCCAGCGTAGCAAATCTAGAAGAAGCAGATACTTTCTGCTGTCAGAATAATCCAGAAAATCAGGAAAGGGTG
4641 CTTGAGGCATGCACAGACACAGTGTTCTAGAAACGGTGTCTAATGCTGTCCCAGGGATGATACAGCAATGGTTAAAAAGT
4721 GTGGTTGGCTCAGCATTCGTGTGGTCAGGTGTCAGTCAATGAACAGAAGACACACCAGGTTGTTAAACAGCCTTACTGTG
4801 ACCCTCCTCAGAAGCCCACAAGTTCCAAAGACTTTTTTTAACCTAAAACAAGAAATTAACTTATTAACTCCAAGAGAGTA
4881 CCTGGGTATCCTGGGCTATTTGTACTTTTTTATAGAGGACTTTAATAACTCAATTCTTTTCAAGTGAGTTTTTAAAATAA
4961 TAAAAATTTCATAAATTTCCAATTCCATGCAACTTATAGGAGGATTTCACCCAGGTTGGATAGAGCACCCACGATCTGCA
5041 TTCCCACAGCGGGATTTTCCCGTGCTAGTGAGGTCTGGAGTCCACATTGGATTGGCTGGCATTTCCTAGCAGACACTAAA
5121 GATAGCTGTGCAAGGTTTAGCTATCGCTCAACTGTGGGGATGACGGCTTTATAGCTCCCCTTCCTGATACAGCCCCCGGA
5201 AAGGATTCTTGGGGATCTACAGGACCCCACTCTTCACTGTAAGAGTCAGAGCAGGAAGGGGGTGCTTCTTCAACTCTGGC
5281 TCAAGTCCCCTCTGGTCTCTCAGTCTCTCGCATTTGATTAAAATGGAGAGATGCCCTCTAAGGATTCTGCCCACTGGGCA
5361 ATTCAAGCCTCCTACCCCGAGAAGAGACAGCGCTGAGTGTGCCTGGGCATCTGCGTCCATGCCCATGGATGTGAGTAGAC
5441 AGAACCCTACTTTTGAGAAAACGCCTATCCAGCCCACTTTGTAAGAACCCCCTTTTTCTAAACTATGACAAAAGGCGGCT
5521 TTGCACTTTCTGATCAAACAACACTGTCTTTTGTCTCCTGCTTAACTTTTAAGACTATTCTGTGACCGACGTTTGTAGAT
5601 TTTTTTTTTTGTTAATATTTTGCCTGGAAAAATGTGACTCTCTCCTTGGGAGGTTTAGTAGACTAATAAAAATTATACAT
5681 GAAGGTGGTTGCTATTTTGAGGCTAAAGGTTTTTCTAAGAATCGCCCTCGTATCCTGACCGTGAAGGCTTTTCAGGATAC
5761 CTTTTATAGACGATCAGATGCATTCGAGCTGTGTTTCCTACATGATTTCTGTTTTGTTTTATGAAGGACACGCCATGTTT
5841 AAATCTCTCATTGGAAAAAAAAAAAAAAAACACCATGCAAAACCCCAAATTGGTTTGGAGGAAGGAGTGAAGGTGGAGGC
5921 TGTTGCCCGAATGGGCCTTTACTGATGAGCCAGGGGCTGATCCACTGCTCGTTTGGTTACTGGGCAGGTGAGGTAGACAT
6001 GTAAATTACTGCCTAGCTTTCTTGGATTTGTGTAACCTCTACTCTCCGTTTGCATGATCCGCTCTGTTAGATGCATTCAT
6081 TGTAGTTCGGAAGCAAGCGTGTATGAATAAAGATACTGATCACTGCTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agaUGUAUCUUACCG---UAGAGAGu 5'
             ||| :  ||| :   ||||||| 
Target 5' aggACACGCCATGTTTAAATCTCTCa 3'
5825 - 5850 148.00 -11.40
2
miRNA  3' agAUGUAUCUUACCGUAGAGAgu 5'
            |:::||||  | |||||||  
Target 5' ccTGTGTAGA--GCCATCTCTga 3'
1965 - 1985 145.00 -17.70
3
miRNA  3' agAUGUAUCUUACCGUAGAGAgu 5'
            |||:|  | |   ||||||  
Target 5' tgTACGTTCATTCTAATCTCTgg 3'
773 - 795 133.00 -9.79
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions CD4+ T cells (C57BL/6)
Disease MIMAT0004236
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM1013581. RNA binding protein: AGO2. Condition:CD4+ T cells "HITS-CLIP data was present in GSM1013582. RNA binding protein: AGO2. Condition:CD4+ T cells "HITS-CLIP data was present in GSM1013593. RNA binding protein: AGO2. Condition:CD4+ T cells "HITS-CLIP data was present in GSM1013594. RNA binding protein: AGO2. Condition:CD4+ T cells "HITS-CLIP data was present in GSM1013595. RNA binding protein: AGO2. Condition:CD4+ T cells ...

- Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell.

Article - Loeb GB; Khan AA; Canner D; Hiatt JB; et al.
- Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
70 mmu-miR-741-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT577358 Zcchc9 zinc finger, CCHC domain containing 9 1 1
MIRT577968 Pla2g4f phospholipase A2, group IVF 1 1
MIRT578333 Lyrm7 LYR motif containing 7 1 1
MIRT580150 Ubap2 ubiquitin-associated protein 2 1 1
MIRT580536 Tcte1 t-complex-associated testis expressed 1 1 1
MIRT581216 S1pr3 sphingosine-1-phosphate receptor 3 1 1
MIRT581676 Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma 1 1
MIRT583764 Epas1 endothelial PAS domain protein 1 1 1
MIRT583808 Eif4e2 eukaryotic translation initiation factor 4E member 2 1 5
MIRT584890 Ank1 ankyrin 1, erythroid 1 1
MIRT587270 Fam161b family with sequence similarity 161, member B 1 1
MIRT587313 Epb4.1l5 erythrocyte membrane protein band 4.1 like 5 1 1
MIRT587704 Cd38 CD38 antigen 1 2
MIRT588808 Srgap3 SLIT-ROBO Rho GTPase activating protein 3 1 2
MIRT589434 Nhsl2 NHS-like 2 1 3
MIRT589731 Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 1 1
MIRT592014 Tyw3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 1 1
MIRT592469 Rpusd2 RNA pseudouridylate synthase domain containing 2 1 1
MIRT592881 Srd5a3 steroid 5 alpha-reductase 3 1 2
MIRT592882 Six2 sine oculis-related homeobox 2 1 2
MIRT592937 Bhlha15 basic helix-loop-helix family, member a15 1 3
MIRT593014 St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 1 2
MIRT593066 Ddr2 discoidin domain receptor family, member 2 1 1
MIRT593164 Fmo5 flavin containing monooxygenase 5 1 2
MIRT593184 Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 1 2
MIRT593252 Wfdc13 WAP four-disulfide core domain 13 1 2
MIRT593276 Prrx1 paired related homeobox 1 1 2
MIRT593280 Kynu kynureninase (L-kynurenine hydrolase) 1 3
MIRT593375 Nab2 Ngfi-A binding protein 2 1 2
MIRT594244 St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 1 1
MIRT594280 Prkca protein kinase C, alpha 1 1
MIRT594582 Zfhx3 zinc finger homeobox 3 1 1
MIRT596747 Vav1 vav 1 oncogene 1 1
MIRT597032 Thada thyroid adenoma associated 1 1
MIRT597262 Slc25a42 solute carrier family 25, member 42 1 1
MIRT597402 Rrm2b ribonucleotide reductase M2 B (TP53 inducible) 1 1
MIRT597467 Rgs20 regulator of G-protein signaling 20 1 1
MIRT598650 Iars isoleucine-tRNA synthetase 1 1
MIRT598979 Gadl1 glutamate decarboxylase-like 1 1 1
MIRT599097 Edem1 ER degradation enhancer, mannosidase alpha-like 1 1 1
MIRT599155 Dkk1 dickkopf WNT signaling pathway inhibitor 1 1 1
MIRT599398 Chst3 carbohydrate (chondroitin 6/keratan) sulfotransferase 3 1 1
MIRT599633 BC052040 cDNA sequence BC052040 1 1
MIRT599637 BC048403 cDNA sequence BC048403 1 1
MIRT599952 9330159F19Rik RIKEN cDNA 9330159F19 gene 1 1
MIRT600131 Zfp780b zinc finger protein 780B 1 1
MIRT600221 Trim67 tripartite motif-containing 67 1 1
MIRT600517 Prkce protein kinase C, epsilon 1 1
MIRT600603 Myo5a myosin VA 1 1
MIRT600626 Mrc2 mannose receptor, C type 2 1 1
MIRT600914 Faim2 Fas apoptotic inhibitory molecule 2 1 1
MIRT600973 Dlc1 deleted in liver cancer 1 1 1
MIRT601388 Vamp5 vesicle-associated membrane protein 5 1 1
MIRT601755 Rasgrp1 RAS guanyl releasing protein 1 1 1
MIRT601906 Padi2 peptidyl arginine deiminase, type II 1 1
MIRT601957 Nf2 neurofibromin 2 1 1
MIRT601985 Mylk4 myosin light chain kinase family, member 4 1 1
MIRT602477 Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 1 1
MIRT602478 Dmbx1 diencephalon/mesencephalon homeobox 1 1 1
MIRT602774 Armc2 armadillo repeat containing 2 1 1
MIRT602881 4931428F04Rik RIKEN cDNA 4931428F04 gene 1 1
MIRT602949 Xpo7 exportin 7 1 1
MIRT602996 Qk quaking 1 1
MIRT603591 Bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 1 1
MIRT603895 Ifi203 interferon activated gene 203 1 1
MIRT603911 Homez homeodomain leucine zipper-encoding gene 1 1
MIRT604573 Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 1 1
MIRT605235 Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) 1 1
MIRT605416 T2 brachyury 2 1 1
MIRT606761 Ncam1 neural cell adhesion molecule 1 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-741 (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 up-regulated

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