pre-miRNA Information | |
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pre-miRNA | mmu-mir-186 |
Genomic Coordinates | chr3: 157544279 - 157544349 |
Synonyms | Mirn186, mmu-mir-186, Mir186 |
Description | Mus musculus miR-186 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-186-5p |
Sequence | 7| CAAAGAAUUCUCCUUUUGGGCU |28 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Lrig2 | ||||||||||||||||||||
Synonyms | 4632419I10Rik, BB096938, LIG-2 | ||||||||||||||||||||
Description | leucine-rich repeats and immunoglobulin-like domains 2 | ||||||||||||||||||||
Transcript | NM_001025067 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Lrig2 | |||||||||||||||||||||
3'UTR of Lrig2 (miRNA target sites are highlighted) |
>Lrig2|NM_001025067|3'UTR 1 AGCCCGTTGAGGAGGAAGTCTGAGCAAAGACTCAAGTTAGTTATTTACTACCTCAGAATTGAGAAGAAAAGTCAGTATTT 81 GTATTTCTCTTTGCTTCAAGTTACATCTGACCACATCAGCGTAGCTCTGGTGTTTGGGCTTACACCTGGCAAAGAGAAGG 161 TAGTGGCTGACAGAAGTGTACCACAGAAATGTGTACCACGTTGAAAGTGCACAGCCCTGGCAGAAGACAACATGGGCAGG 241 TGTCCTTCCTGATCCCCACCGGGATGTGCCCAGGCATGCACTGCCTGTCATGAAGAGTCATTGCTGCTTAGCCTACTGGA 321 TTGTTCCAGTCCTCAGAATGGTCCTGAGAAAGCGTCTCTACTTTGATATCCTACTTTGCTTGGAAAAGCACAGGGCAGAG 401 ATATCTTCTGAGCTTTCCTAAGTATAACAAGGATTCTCCAGTGGTGTTGAGCAGAGAAGAGCTGCTGAGGCTTTGATATT 481 CAAGGTCTTTAGCTAGAATCTAAGTTTCACCAACTGGTAGTACCAGATCAAAGGCTTTTGTATTCTTTGTGTGTGTGTGT 561 GTGGTGGGTTTGTTTTGTCTGTATAACTGGGGATGTCATTGTAAATATATGTGCATTCATAAATAATTTTTCTACTCATT 641 GACCTTGTGTGTTGGATACAGTGTAAATATTTTTGATATGCCCAAATTATATATAATGTCTGTCTGGTTACTGTATGGGC 721 AGCGGCTTCTCCAGATCACAGATTTTATATAACTTAGTGTAGTGAGGTCTGCAAACTCTGTTTAAAGTTCTAGAATTGTG 801 TGTTACCACGTGTATGTATAAAGGCAGGGTACTTAGTGATTGTGTGCTCATAGACTCAGTCTTGGTATAATTAACTGCCT 881 GCTTCATGCCTGAAGTTCTGTGCATCTTGTACTTACTGTCTCTTTACAAGTGCCAGGTGATCCTCTTGTCTTGCTCTTCC 961 AGAGCCCAGCAGTGTTGCCACAGCCCTGTGAGCACAGAAGATGACTTATTTCAGCAAAATACTTTGATGACAAGGAAACC 1041 AAAGATTGGCCTTTTTTATGTTTACTCTGTTTTCAGTCTCCTTCACGAATGTAGCATATTAAGAAGGGAAGTGTGCTCTT 1121 GGGAGTAGATCACACAAAAGTTCCTGTACTCTGTCAATTTAGTGTGGTTCTGTCTTTATACAAGTATTATTTAAGCCAAA 1201 CAGCTTTCTGAATTTTTGATAGCAAAAAGCTTTATGTAAACAAAGAATGTTAACACTAATGAAATGTCATGTGCTTTCAG 1281 TCTGTCCTATGAGTATAATACCAGCTTCCTGCTCTCAACTTTTAAAGGTGTCTATTTATAAGTAACTGTATATATACAGA 1361 GTTCCAAACTCACAGCTTCTTAGCTTTTTGTCAGAAAGTTCAGGTGAATTTCTGACATTTTTTTCCCATGCTTTTTTTTT 1441 CAAACCTAAGTTTTCTTCCTCAGACAGCAGCACTGTTTGCTTTTGAAACTTTCGCTTTTTATTTAAACATGTTTTCTTCA 1521 TTTCCACTTTGAACATTTAAAATGTATAGTGCTCTCATCTGTTTAGACTGTATGCCTTCTTTTAGGCTGTATTCCAGGTT 1601 TTTTACTGGTATGACAAGGCATTAAGAGCCTGCTCCCTTGGCACTGCTCGTGCTGGCTGTGTGTCTGAGTCTTACTGATA 1681 GAAAGAGACTGTTTATTAGCTGCTCTAAGCTGCTCTCCAGTTCCCGCCAGGAACCAAAGAGGATTGTGCCACTTGAGTGA 1761 AGAGCTGCCTTTGTGAACTGTTAGCTAGATCAAGGGTGATGCTGCTCCATCTAACTTGAGCTGTATTTATCTTGCCAATA 1841 CAAGACTTAACGGTCTAAGACATGCTCAGGGGAGGAAAAAATGTTCTGCTTCTAAACACTGTCAGTAAACAAAAAACTCA 1921 CATCCGAATTGGAAAAGTTGTCTTTTGTCTGGAAGCTGCTGCTCACAGGAGGCTCAGGATGGAGGTATACAGCAGCTCAT 2001 TTATAGCTGGCCATCCCACTTTGTCTGTGGTCAGAGTTCTGTGCCCTCACGGAGAGCCCAGGGTAGTCAGGGTAGAGAGC 2081 AGGCCTTGACCTGGTCCTCTAGAAACACCTTACCCAAGATATCGCCTCCAAGCTCCAGCTGTGGCCCTTCTGCTGCGGTG 2161 TCCATTGGATCTCCTGAGAATTGGGGAGATGTTGACCTGCCTGCGCTTCCAGATCCCTGGCTGGCCTGAGTAACTGATTA 2241 GGAACCCATTTACAGACGAGAAGAGCCTGCCTCTGCTCCTGAAATAACAACAGAAGATTCTTACCCTAGAGAATTTGGTT 2321 TCACGTTTGACCATAGGACTAGTGTCTGCTTAGTTAACAAAATAATCTTCTCTGTGTTCACAACTAAAAACATGAAATTA 2401 TGGCATCATTTTTCTGAAAAACAAAACCAATCCTACATTTCAGATACAAATGTCAGTGACAAACAATTTAAGTATATGTT 2481 GTATTATACATCTTTACTCTTGATTTTAATTTTTTTATTTTTAGCAGCCACTGGCCTTGAACTCTCTTGTCTCTCCCTCC 2561 CAAATGTGGAGACTAGATATATCTGGCTAGATTGATTTTTGTTCTTGCCTATAGAGCCAGCTGGAGTGGTATTGGTATTA 2641 CAGTGTTCAGTTTATATTTTACCAAGTGTGTGAGGATGGCCTTTTCTCATAACACACTACAGGAGTAAGGAGTAGTAACA 2721 GGGAAATGTGGCTGTTTCCCTCAGGACTGGGATTCAACCATCAGGTTCCTGAATGCCCGGTACATGTCCTCCCACTCAAC 2801 TCAGGCCCTGTATTTGTTCTCCTTAAGTGAGATATAGTTCATCTTTGGGCCTTTTTTCCAGGCTTTTGGCATTCCTAGGT 2881 ATTAAACCTATAGCTTCCTATATACCAGGCAAGTGTTCTACCTCTAAGCTGCAGCCTCAGCTGAACTGTTGTTCAAATTA 2961 ATGGGTGGTTATAAGAACAATGGGGCCATGAATAGTTGAGCTGTTTGCTTCTGTTAGATCTCTTTCCCAGTCCAGTGTGG 3041 AGGTATGCTCCCATCTACTTTCAGCTTTTTGTTTGGAACATGGTTAAATATACAGCAGTTAGTCTAGATTTCCTCTCCTC 3121 TCCTCTCCTCTCTGCTCCTTTCCTTTCCTTTCCCCCTTTTTTTTTTTTTTTTTTTGGACATCTGTCTGGTTCATTGGCAG 3201 AAGTACCAAGTTCCTGAGGTAAGGCTGTATTGGGGACATCTGAAAATGGAAGAATTACTTGCAGGATTGTGAGAAGGTGG 3281 GAGGTGAAAGGGTTGGTGTATGATGTCCTAGGAGTCAAGCCCAGGCAAGTGCTCTCAAGGCCGGTGTGCTGTAAGTTAGG 3361 GTTTGGATCCTCTCCCTCTCATTTGTATATTGTTTCCTCGAAGTCCTGATAATCAGGTGAAGAGCAGCGTGGCTTGTCTG 3441 CGCATGTTGTTGGGTGTGAAGTGATCTTGTAGCACCTGTAACTGTTTTCAAAGAGGAGCTGATCTTCAGGTGGCCAAGTG 3521 TCCTTGAAGTATTACCTGGCTGCTGGAGACGCCTCTTCACCCCTGCCTGACTTATACTCCCTGCCACCCTCTGTTCTCTT 3601 GCCCATTAGAGGGTGTCAGGCTGAGCAGCCCTGGTGTAAGGCGCCTCTAAAGGGAAGTACAAGCCAAGTGGTCTCATGTG 3681 GCTGTTTCCTGGTATCCTTTATATTTTCTCACATAAGAATGTATATTTTACAGAGCATGTGTTCGTCCTGTCTACTGTAA 3761 TGTCAATAAAGCTAAGACATTAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) | ||||||
Disease | MIMAT0000215 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013594. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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46 mmu-miR-186-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577608 | Stxbp4 | syntaxin binding protein 4 | ![]() |
1 | 1 | |||||||
MIRT577884 | Qpct | glutaminyl-peptide cyclotransferase (glutaminyl cyclase) | ![]() |
1 | 1 | |||||||
MIRT578137 | Noc3l | NOC3 like DNA replication regulator | ![]() |
1 | 1 | |||||||
MIRT578249 | Mnat1 | menage a trois 1 | ![]() |
1 | 1 | |||||||
MIRT579147 | Ces2g | carboxylesterase 2G | ![]() |
1 | 1 | |||||||
MIRT579219 | Ccdc138 | coiled-coil domain containing 138 | ![]() |
1 | 1 | |||||||
MIRT579578 | 4933427D06Rik | RIKEN cDNA 4933427D06 gene | ![]() |
1 | 1 | |||||||
MIRT580348 | Tmem33 | transmembrane protein 33 | ![]() |
1 | 1 | |||||||
MIRT580592 | Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1 | ![]() |
1 | 1 | |||||||
MIRT580668 | Stk32a | serine/threonine kinase 32A | ![]() |
1 | 1 | |||||||
MIRT580744 | Srek1 | splicing regulatory glutamine/lysine-rich protein 1 | ![]() |
1 | 1 | |||||||
MIRT580779 | Sp6 | trans-acting transcription factor 6 | ![]() |
1 | 1 | |||||||
MIRT580847 | Sltm | SAFB-like, transcription modulator | ![]() |
1 | 1 | |||||||
MIRT580944 | Slc26a5 | solute carrier family 26, member 5 | ![]() |
1 | 1 | |||||||
MIRT581214 | Samd4 | sterile alpha motif domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT581276 | Rprd2 | regulation of nuclear pre-mRNA domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT581520 | Ptprb | protein tyrosine phosphatase, receptor type, B | ![]() |
1 | 1 | |||||||
MIRT582203 | Nfia | nuclear factor I/A | ![]() |
1 | 1 | |||||||
MIRT582893 | Ildr2 | immunoglobulin-like domain containing receptor 2 | ![]() |
1 | 1 | |||||||
MIRT582996 | Id4 | inhibitor of DNA binding 4 | ![]() |
1 | 1 | |||||||
MIRT583079 | Hnrnpa3 | heterogeneous nuclear ribonucleoprotein A3 | ![]() |
1 | 1 | |||||||
MIRT583125 | Heca | hdc homolog, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT583739 | Epm2aip1 | EPM2A (laforin) interacting protein 1 | ![]() |
1 | 1 | |||||||
MIRT584127 | Crispld2 | cysteine-rich secretory protein LCCL domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT584166 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT584531 | C230081A13Rik | pseudopodium-enriched atypical kinase 1 | ![]() |
1 | 1 | |||||||
MIRT584646 | Bach2 | BTB and CNC homology, basic leucine zipper transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT587978 | Armc1 | armadillo repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT588832 | Sp1 | trans-acting transcription factor 1 | ![]() |
1 | 2 | |||||||
MIRT590758 | Acbd5 | acyl-Coenzyme A binding domain containing 5 | ![]() |
1 | 1 | |||||||
MIRT593146 | Mmp12 | matrix metallopeptidase 12 | ![]() |
1 | 4 | |||||||
MIRT593495 | Gjc3 | gap junction protein, gamma 3 | ![]() |
1 | 1 | |||||||
MIRT594880 | Lrig2 | leucine-rich repeats and immunoglobulin-like domains 2 | ![]() |
1 | 1 | |||||||
MIRT594898 | Ifi204 | interferon activated gene 204 | ![]() |
1 | 1 | |||||||
MIRT594932 | Gdi2 | guanosine diphosphate (GDP) dissociation inhibitor 2 | ![]() |
1 | 1 | |||||||
MIRT594945 | Fmnl2 | formin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595197 | Emc3 | ER membrane protein complex subunit 3 | ![]() |
1 | 1 | |||||||
MIRT595343 | Frmd4a | FERM domain containing 4A | ![]() |
1 | 1 | |||||||
MIRT595402 | Arsk | arylsulfatase K | ![]() |
1 | 1 | |||||||
MIRT595430 | A630033H20Rik | RIKEN cDNA A630033H20 gene | ![]() |
1 | 1 | |||||||
MIRT595947 | Nelfa | negative elongation factor complex member A, Whsc2 | ![]() |
1 | 1 | |||||||
MIRT596153 | Opn5 | opsin 5 | ![]() |
1 | 1 | |||||||
MIRT601390 | Utp23 | UTP23 small subunit processome component | ![]() |
1 | 1 | |||||||
MIRT602153 | Intu | inturned planar cell polarity protein | ![]() |
1 | 1 | |||||||
MIRT602577 | Colec12 | collectin sub-family member 12 | ![]() |
1 | 1 | |||||||
MIRT604817 | Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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