pre-miRNA Information | |
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pre-miRNA | mmu-mir-186 |
Genomic Coordinates | chr3: 157544279 - 157544349 |
Synonyms | Mirn186, mmu-mir-186, Mir186 |
Description | Mus musculus miR-186 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-186-5p |
Sequence | 7| CAAAGAAUUCUCCUUUUGGGCU |28 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Fmnl2 | ||||||||||||||||||||
Synonyms | 5430425K04Rik, Man | ||||||||||||||||||||
Description | formin-like 2 | ||||||||||||||||||||
Transcript | NM_172409 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Fmnl2 | |||||||||||||||||||||
3'UTR of Fmnl2 (miRNA target sites are highlighted) |
>Fmnl2|NM_172409|3'UTR 1 GACGAAGTGTGAGACGGCGCTTCGATGATCAGAACCTGCGTTCTGTTAATGGTGCCGAAATAACAATGTGACTGGAGACC 81 ACCTTCATGAGAGGGTGTCCAAGAAACTGCCATTCCAGCCTTCACTACAGATGAAATACTCTCAAGGGCTCAGATTTAAC 161 AAACACATAGGAATTTTAAAGTGATGGGTTCTCTTTTTAACCCCTGTTAACAAGTGCCTAAAATTGGAAGTAACTTGCTC 241 AGATTAATCAAAGCAATAGGTTTGACTTAAATCTTTTTACATCAGTATGTTACTCAGTTTTTTAACCAAAATGTAAACTT 321 CATATTAAATTCATTATTTGCCATTTTGATTGTCCATTGTGGCCCACCCTGATTTCCTGGTAATCTGTAAATAACGGATG 401 TGTGTGCTATGGGTATCCTTTGCTGAGAGGTCTTCTAAGAAATTTTGTGTTCGAGCCATATTCACCAACTCCTAACAAGG 481 GACTGGAAACGGGAGATGGAAGCTGGCATACAATTACATCCTTCTTTAGTCTCAGCAAAGTACAAGCAGGATGCAACTGC 561 AGTGCCACTCCAAGTCATTCGATTTTATCCTATTTCATGTTGTTTCTGTGCAAGGCTGCCATGCACAAAGGCATTCACTT 641 GTATGACTTCAAGATGGCATAAAACATTGAAGACTTATTTGCAGAACTGTGTTAAGCTAGAGGCAGCTTTTAATAACGCA 721 AAGGTTTCTTAATTAGCACTAAAATTAATGTCTCAGTATTCTGATTTTTGAGGACCATTATGGGTGAATCCTTAAAATAG 801 AAATTGGTGCCTTGTTAGTCAGGGAGATTTTTACCACAAGCTCTATCAGTAAGCATTCAAAAATTACATGTATTAATGTA 881 ATGTTGGGAACCTGGCCTTATTCTCTTCTGACAATCGAAGGGTCCTTTTTTTTTTTTCTTCCCTTTGTAAATTATACTGA 961 TACAGTTGACATTAAGTTATCAGGGCTGAATTGCTTTATGCATTTCTTACTTATGGGAAATTCCCATTAAATTAACATTG 1041 AGATTAAGTTTAAATTATCCGCGATAGGGTTAAATGGTTGACTAAGTCACTCACCTTTACTTCCTCACTGACAAGGCATT 1121 TCCATCTTTCCCAAAGTCAAAGACTGGACTGAAGCTAAATTTGTACTTTTCATAATATATATTCTGCTTCTGGCTTACCT 1201 TGTTGGTACATCAGTATATTAATTGTAAAAATTATTGTATAGTATTTAACCACCAAATCTGTGTTCATGTGAACCCCTTG 1281 GTGAAGGCCCCCTTTTCATGGATGTGTAGTTATATGATCTTTAAAATGTACAGATATTTTGCTATAAGATTGGTGCAGTT 1361 TTTTATGGTTTTTACACTTCTCTTTAATTCCTACCTAAGCCTTTAGGTACTACTGTAAATATTGTTTTAAAATGCATCAG 1441 CCTATGCTACACAATCTGAATGTTACTTTAACTTATAGTTTGTTTTCTGAAATATATATATATTTAACTACAAGGACAGT 1521 TTAAAAGTCAGTTACCACATTTCACAGTAGTATGCCTATTTACAGATCCCTTTTAAACTGCCACTTGCTGTCACACTCAT 1601 AAATGTGTAGTTTAAAAAGAACATGCCAAGATTGTCGTCTTGTTGAGTCAATATCCATCTTGGTGAGTATATTAATTTGA 1681 TCATGATATCAGAAAAATATGTGGACCTCCTTCACACAAATCAGCTGCTTTCCAAAGGCGTGCATTTGCTTAAAGCAAAC 1761 TGCCCATTTCCCAGTGTACAAATGGACAATAATGTTGGCATATTCTTCTGTCTGTCTAGTAATGGCCCTGCTTCTTAGCA 1841 ATATTAGAAATGTTTTATAAAAGCAATCCATGTTACTTTTCTGGTCTTTTCATGCCATTTGAGCAAATAAACTATTTACA 1921 CTACTATTCGGTCATATGTTCTAATCCTTTGTATATTTTATCTGTTTTAGAAAAACTGCTCCCTCATATTCTTTATTAAA 2001 AAAAAAAGAGATATTGTCATCACCTACATATAAAGAAAGGCTCCCCTGATCTCTCTTCACCCCTTCTCTTTCAGCTGTTA 2081 CCTTGCCCCACTCTCTCTCCCAATAAACCTCAAGTGGAACTGTTAAAAAAAGTTGTGCTCCCAAGCCAAGAACACAAGCC 2161 TCTCCTCTCCTCTCCTGCCCAGTTCCCCAAGTTCTAATTAATTGCAATAGGACTTTTGACTTATTTAAAATGTCTTAAGG 2241 TATTACACATTTAGAATTTTTTGAATGTAACTAGAACAGTACAGCTCAAAGGATGATTTGGTTAGATTTAGAGATCATTT 2321 TATT Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) |
Disease | MIMAT0000215 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013594. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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46 mmu-miR-186-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577608 | Stxbp4 | syntaxin binding protein 4 | ![]() |
1 | 1 | |||||||
MIRT577884 | Qpct | glutaminyl-peptide cyclotransferase (glutaminyl cyclase) | ![]() |
1 | 1 | |||||||
MIRT578137 | Noc3l | NOC3 like DNA replication regulator | ![]() |
1 | 1 | |||||||
MIRT578249 | Mnat1 | menage a trois 1 | ![]() |
1 | 1 | |||||||
MIRT579147 | Ces2g | carboxylesterase 2G | ![]() |
1 | 1 | |||||||
MIRT579219 | Ccdc138 | coiled-coil domain containing 138 | ![]() |
1 | 1 | |||||||
MIRT579578 | 4933427D06Rik | RIKEN cDNA 4933427D06 gene | ![]() |
1 | 1 | |||||||
MIRT580348 | Tmem33 | transmembrane protein 33 | ![]() |
1 | 1 | |||||||
MIRT580592 | Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1 | ![]() |
1 | 1 | |||||||
MIRT580668 | Stk32a | serine/threonine kinase 32A | ![]() |
1 | 1 | |||||||
MIRT580744 | Srek1 | splicing regulatory glutamine/lysine-rich protein 1 | ![]() |
1 | 1 | |||||||
MIRT580779 | Sp6 | trans-acting transcription factor 6 | ![]() |
1 | 1 | |||||||
MIRT580847 | Sltm | SAFB-like, transcription modulator | ![]() |
1 | 1 | |||||||
MIRT580944 | Slc26a5 | solute carrier family 26, member 5 | ![]() |
1 | 1 | |||||||
MIRT581214 | Samd4 | sterile alpha motif domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT581276 | Rprd2 | regulation of nuclear pre-mRNA domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT581520 | Ptprb | protein tyrosine phosphatase, receptor type, B | ![]() |
1 | 1 | |||||||
MIRT582203 | Nfia | nuclear factor I/A | ![]() |
1 | 1 | |||||||
MIRT582893 | Ildr2 | immunoglobulin-like domain containing receptor 2 | ![]() |
1 | 1 | |||||||
MIRT582996 | Id4 | inhibitor of DNA binding 4 | ![]() |
1 | 1 | |||||||
MIRT583079 | Hnrnpa3 | heterogeneous nuclear ribonucleoprotein A3 | ![]() |
1 | 1 | |||||||
MIRT583125 | Heca | hdc homolog, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT583739 | Epm2aip1 | EPM2A (laforin) interacting protein 1 | ![]() |
1 | 1 | |||||||
MIRT584127 | Crispld2 | cysteine-rich secretory protein LCCL domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT584166 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT584531 | C230081A13Rik | pseudopodium-enriched atypical kinase 1 | ![]() |
1 | 1 | |||||||
MIRT584646 | Bach2 | BTB and CNC homology, basic leucine zipper transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT587978 | Armc1 | armadillo repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT588832 | Sp1 | trans-acting transcription factor 1 | ![]() |
1 | 2 | |||||||
MIRT590758 | Acbd5 | acyl-Coenzyme A binding domain containing 5 | ![]() |
1 | 1 | |||||||
MIRT593146 | Mmp12 | matrix metallopeptidase 12 | ![]() |
1 | 4 | |||||||
MIRT593495 | Gjc3 | gap junction protein, gamma 3 | ![]() |
1 | 1 | |||||||
MIRT594880 | Lrig2 | leucine-rich repeats and immunoglobulin-like domains 2 | ![]() |
1 | 1 | |||||||
MIRT594898 | Ifi204 | interferon activated gene 204 | ![]() |
1 | 1 | |||||||
MIRT594932 | Gdi2 | guanosine diphosphate (GDP) dissociation inhibitor 2 | ![]() |
1 | 1 | |||||||
MIRT594945 | Fmnl2 | formin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595197 | Emc3 | ER membrane protein complex subunit 3 | ![]() |
1 | 1 | |||||||
MIRT595343 | Frmd4a | FERM domain containing 4A | ![]() |
1 | 1 | |||||||
MIRT595402 | Arsk | arylsulfatase K | ![]() |
1 | 1 | |||||||
MIRT595430 | A630033H20Rik | RIKEN cDNA A630033H20 gene | ![]() |
1 | 1 | |||||||
MIRT595947 | Nelfa | negative elongation factor complex member A, Whsc2 | ![]() |
1 | 1 | |||||||
MIRT596153 | Opn5 | opsin 5 | ![]() |
1 | 1 | |||||||
MIRT601390 | Utp23 | UTP23 small subunit processome component | ![]() |
1 | 1 | |||||||
MIRT602153 | Intu | inturned planar cell polarity protein | ![]() |
1 | 1 | |||||||
MIRT602577 | Colec12 | collectin sub-family member 12 | ![]() |
1 | 1 | |||||||
MIRT604817 | Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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