pre-miRNA Information | |
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pre-miRNA | mmu-mir-186 |
Genomic Coordinates | chr3: 157544279 - 157544349 |
Synonyms | Mirn186, mmu-mir-186, Mir186 |
Description | Mus musculus miR-186 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-186-5p |
Sequence | 7| CAAAGAAUUCUCCUUUUGGGCU |28 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Frmd4a | ||||||||||||||||||||
Synonyms | 2700017I06Rik, 5330420J21, AI594879, C230040M21Rik, Frmd4, Gm13190, mKIAA1294 | ||||||||||||||||||||
Description | FERM domain containing 4A | ||||||||||||||||||||
Transcript | NM_001177843 | ||||||||||||||||||||
Other Transcripts | NM_001177844 , NM_172475 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Frmd4a | |||||||||||||||||||||
3'UTR of Frmd4a (miRNA target sites are highlighted) |
>Frmd4a|NM_001177843|3'UTR 1 AGGAGCTACAGTGACAGCTGCTTCCTGGATTCCTCCCTCTATCCAGAGCTAGCTGATGTCCAATGGTACGGGCAGGAAAA 81 AGCCAAGCCCGGGACCCTCGTGTGAGCCGGCCAGGCTGGATGTGACCACCGCCACGCCATTCCAAGTCACCTCACTGCCT 161 CTCATTTGCCTTACCCAGATGCACTGTCACCTGCACCAGCTTCGGCCCTCAGCACTTTTCTTCTCCTGTCTCCACATCCC 241 TTTCACCCTCAAAAACCTGACTGAGGAGACATTCTGGAAGGTTCCGAACCCACTGTGTGTCCCCTGGCTCTCTTGCCCAG 321 AGAGCCAGACAACAATCCTCAATGGCACCTTGGTGGTTTCCGTCTGCCATGATACCCAGGCCACAAACTGTCAGGAAAGC 401 CAACACATGCAATTCCTGTAGAAGAGAACAAGAAAAAAGCTAGCCCTGCCTGCAGATACTGAAGCTGTTTCTGGCTGCCA 481 CCCTATAGGCCGGCCGAGTGCTTCTAGAGGAGAGTGCTCAGGGGATATCAGTTTACACCTGAAATAAATCTGCCATAGTG 561 AGACAGCCAGCAAGAGCTCCTAAGGGGACGTGTGAGAAAGAAGACTGGTGCTTCAGAGACGCATCAGAGGATCACAGTTG 641 GTTCTATGCTGCCAAAGATTAGACACATTCAACAATGAACAGATAGGAGGGGCCAAGAGGAACACACTTTTTCTGCAGCG 721 AAATTTCAATTCTAAACTGCTCCTACGCAGCACAAGTGAAAGTCAACCATCTTAGACCACGTCCTGTCGTGACCCTTCTC 801 CTGGAGCACTCCTGAGAGCTGGGAACAAACCCAACGGGACAGTGAAGATGAAGGAGGCTCGGCTGGCCTGGCAGACTCGG 881 ACTCTATCTGTCTGGACATGGGAGGAGCAGGGTACCATTAGGACTGCCCTATGCAGGGGCTTCAGCCTACGCCCCCAAAG 961 CTTCCTTCCTTTTGGGATGGGGAGGAAGCCAACGGTGACCATAGCCAAAAGCAGTTCTCTCGTTAAAACCACCAGTAAAA 1041 GTGTAACCTTTCTGTTTTGTACAAGGCCTTTCAGTTTTTGTTTTTGGGAAACCAAGGGAAAAAGCACATTGCAATCTACT 1121 CAAGTGTTTTACCGTTGTGGTTCATTTTATGTTTGTTAACACTTGTGTGCACTCGGACAGACCTCGCCTGTGTGTCGCTT 1201 AGTCAGAGAACTCACGTACGCCCTTAGGTAGGAAGACTTTTTACACACGTCTACCAGTTGGCAGGCAGAGCAGAGTTGCA 1281 ACAACTCAGCTCCCAAAGGGCCCAGACCCCTCCAGCAGTATCTGTGACCTCGATACACCACCTCCGTCCACAGATACCAA 1361 GAGGATAAAAGGCAAAAAACATAAAAGCACGCGTGCAAGCTGCTTGTTTACATGTGTTTTGAGCTATGCTTAACACACAA 1441 CCAAAAAGCCATCAATCTCCAAAGGCCTCAGAACCACTTCTATACTAACTAACCAGTGCACAGTCTTAGTGGGGCATGGC 1521 ACTAACGATGGCACAAGAGTCTCTGTGGAGGTAGTGTGGCTTGCAGGGGTTACCTTGTCATGACTTCCTGTGGGGAAGAC 1601 ATCTAGGACCAGGAGCCAGGGTGGGAAGAAAGCAAATCTAAAAGTTGGCTGTGGCATCAAAAGAAAAAAACTTCCTCATG 1681 TATTTAAATCCAAGAATAACAATAGACATTACCAGACTGGGAAGGTAAGAAATGAACAGCAGAAAGGACTGACCCTCACT 1761 TTGCAGTGGCTTGGAAACCTCTGGAAGTCAAGTGGGAGCATTCATCCCATGTGGCCTGAGGCCTTTTCTCTCCCATTCAA 1841 GGCTGGGTACCCCAGAGCTGGGCATGGTTGGCGTGATGAGCCCAGCTTCCAGAAGCAGTACTCTTCCCAGACACTTGAGG 1921 GATAACCCTGTAGGGTGAGTGGGGACGGGATATGATGGTACAAAATGACCCTGGGGCTCCGTGGAGACGGGGCTACCTTT 2001 CTTGCTCCTAGTATGATAGTCGGAGCTACATAAAGCAGGTTTATTTGGGGACTATTTCTTCCTTCCTTAGCTAATGGAAA 2081 TGTGACACATTGTGCCCCATTTTCTTTCTTCCAAAAGGAGATGCCTGAATAATTTGCCTGAACAGAAAACGTCCAAAAGG 2161 AAACAAAGAACAAGACAAGGTTACATGGTTACAGGTTATAACAGAGACAGCAGTTTGAAAATTGATTCTGAAGTCCTTCG 2241 GATCTATGAGAGATGCAGAAAGAATCTAAATGTAATAGATTTGGGGAGCAGAGGGAAACGGAATGGGAGCTGTGAACACC 2321 ATCACGATAGTCTGGCAGTAAGGACAGAGATTTAAGTAAAACAGGTTTTACTGTTTAGCTGTGTTCGGTTAATACACTGT 2401 ACATAATATAATACGCATTAGTCCTTTGAGACTGACATAATAAATGGTCGCTGTGGTTGGTGATGAACGCTCTAGGTATT 2481 GTATCCAAGCACCTGCAGATTCTTTACACATCCCTGTTTCTTTTAAGGGAGATGAAGTCCCCAGTTTAAAGCCCCTATTG 2561 GATTCGTTGGATACATGTAAGAAATTGCTTGTTTCAGCCAGAAGACTATGTTGTGAGCCAGGTTGGTTTATTTTGTTATA 2641 TGCAGGTGAGTGTTGGAGTGTTCAAAGCCCAATTTGTTTTCATCCAGTATTAGTTTAGTTCTAAATATAGCAAGCCTCAC 2721 CCAGGTGCTATCAGATGACCAATTACTGCTTAGTTAACTAGGTGTAAAGTTTTACATATCCATTCATGTCAATAGTTTAT 2801 TACAAGTTGTGTAAAACGGACTCTAGTTTAATAATTGGGGGGGTGGTAAGATTAGGTTGCTCCTGAAACTGACTGTAGAG 2881 CATGTAAAATGATTTTACTGGATTCTGTTCAACTGTAATCAATGACAAAGATGTATGTTGTAGACAAAGTTGCAGAATTA 2961 AAAAAAAAAGGAAATCTGCTTTTAATTTATTCTTTTTGTATTAAGAATTTGTATAGTACCTTTACATTTTGCAGAACAGT 3041 GTTGTCAACACTTATTAAAGCATTTTCAAAATGAAAACAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) |
Disease | MIMAT0000215 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013593. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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46 mmu-miR-186-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577608 | Stxbp4 | syntaxin binding protein 4 | ![]() |
1 | 1 | |||||||
MIRT577884 | Qpct | glutaminyl-peptide cyclotransferase (glutaminyl cyclase) | ![]() |
1 | 1 | |||||||
MIRT578137 | Noc3l | NOC3 like DNA replication regulator | ![]() |
1 | 1 | |||||||
MIRT578249 | Mnat1 | menage a trois 1 | ![]() |
1 | 1 | |||||||
MIRT579147 | Ces2g | carboxylesterase 2G | ![]() |
1 | 1 | |||||||
MIRT579219 | Ccdc138 | coiled-coil domain containing 138 | ![]() |
1 | 1 | |||||||
MIRT579578 | 4933427D06Rik | RIKEN cDNA 4933427D06 gene | ![]() |
1 | 1 | |||||||
MIRT580348 | Tmem33 | transmembrane protein 33 | ![]() |
1 | 1 | |||||||
MIRT580592 | Tbl1xr1 | transducin (beta)-like 1X-linked receptor 1 | ![]() |
1 | 1 | |||||||
MIRT580668 | Stk32a | serine/threonine kinase 32A | ![]() |
1 | 1 | |||||||
MIRT580744 | Srek1 | splicing regulatory glutamine/lysine-rich protein 1 | ![]() |
1 | 1 | |||||||
MIRT580779 | Sp6 | trans-acting transcription factor 6 | ![]() |
1 | 1 | |||||||
MIRT580847 | Sltm | SAFB-like, transcription modulator | ![]() |
1 | 1 | |||||||
MIRT580944 | Slc26a5 | solute carrier family 26, member 5 | ![]() |
1 | 1 | |||||||
MIRT581214 | Samd4 | sterile alpha motif domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT581276 | Rprd2 | regulation of nuclear pre-mRNA domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT581520 | Ptprb | protein tyrosine phosphatase, receptor type, B | ![]() |
1 | 1 | |||||||
MIRT582203 | Nfia | nuclear factor I/A | ![]() |
1 | 1 | |||||||
MIRT582893 | Ildr2 | immunoglobulin-like domain containing receptor 2 | ![]() |
1 | 1 | |||||||
MIRT582996 | Id4 | inhibitor of DNA binding 4 | ![]() |
1 | 1 | |||||||
MIRT583079 | Hnrnpa3 | heterogeneous nuclear ribonucleoprotein A3 | ![]() |
1 | 1 | |||||||
MIRT583125 | Heca | hdc homolog, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT583739 | Epm2aip1 | EPM2A (laforin) interacting protein 1 | ![]() |
1 | 1 | |||||||
MIRT584127 | Crispld2 | cysteine-rich secretory protein LCCL domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT584166 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT584531 | C230081A13Rik | pseudopodium-enriched atypical kinase 1 | ![]() |
1 | 1 | |||||||
MIRT584646 | Bach2 | BTB and CNC homology, basic leucine zipper transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT587978 | Armc1 | armadillo repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT588832 | Sp1 | trans-acting transcription factor 1 | ![]() |
1 | 2 | |||||||
MIRT590758 | Acbd5 | acyl-Coenzyme A binding domain containing 5 | ![]() |
1 | 1 | |||||||
MIRT593146 | Mmp12 | matrix metallopeptidase 12 | ![]() |
1 | 4 | |||||||
MIRT593495 | Gjc3 | gap junction protein, gamma 3 | ![]() |
1 | 1 | |||||||
MIRT594880 | Lrig2 | leucine-rich repeats and immunoglobulin-like domains 2 | ![]() |
1 | 1 | |||||||
MIRT594898 | Ifi204 | interferon activated gene 204 | ![]() |
1 | 1 | |||||||
MIRT594932 | Gdi2 | guanosine diphosphate (GDP) dissociation inhibitor 2 | ![]() |
1 | 1 | |||||||
MIRT594945 | Fmnl2 | formin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595197 | Emc3 | ER membrane protein complex subunit 3 | ![]() |
1 | 1 | |||||||
MIRT595343 | Frmd4a | FERM domain containing 4A | ![]() |
1 | 1 | |||||||
MIRT595402 | Arsk | arylsulfatase K | ![]() |
1 | 1 | |||||||
MIRT595430 | A630033H20Rik | RIKEN cDNA A630033H20 gene | ![]() |
1 | 1 | |||||||
MIRT595947 | Nelfa | negative elongation factor complex member A, Whsc2 | ![]() |
1 | 1 | |||||||
MIRT596153 | Opn5 | opsin 5 | ![]() |
1 | 1 | |||||||
MIRT601390 | Utp23 | UTP23 small subunit processome component | ![]() |
1 | 1 | |||||||
MIRT602153 | Intu | inturned planar cell polarity protein | ![]() |
1 | 1 | |||||||
MIRT602577 | Colec12 | collectin sub-family member 12 | ![]() |
1 | 1 | |||||||
MIRT604817 | Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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