pre-miRNA Information | |
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pre-miRNA | mmu-mir-677 |
Genomic Coordinates | chr10: 128085286 - 128085363 |
Synonyms | Mirn677, mmu-mir-677, Mir677 |
Description | Mus musculus miR-677 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-677-5p |
Sequence | 6| UUCAGUGAUGAUUAGCUUCUGA |27 |
Evidence | Experimental |
Experiments | MPSS |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | B3galt5 | ||||||||||||||||||||
Synonyms | 1190002B21Rik, AU045265, b3Galt-V | ||||||||||||||||||||
Description | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | ||||||||||||||||||||
Transcript | NM_001122993 | ||||||||||||||||||||
Other Transcripts | NM_033149 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on B3galt5 | |||||||||||||||||||||
3'UTR of B3galt5 (miRNA target sites are highlighted) |
>B3galt5|NM_001122993|3'UTR 1 GGGGACCCTGGGGGCGCCTAGGACAAACTTCTGATAACCTTTGGTGATGATTTGGGACGATCTGGGATGGTCTTGCTGGG 81 AACTGTCTCGGGTAGAGAGCCGATGAGGATGTTCTCAGAGCCACACGGGAAAGGGTATATACGAAAGCTGAGGAATGACT 161 TCTTCCCACTTGGCACCCGGAGCAATAACAGATCTCGTTTTTTTCAGGCCTTTGCGGGATGCCCTCAATGCTTGAGACAT 241 GCCCTTCATCCACCTGTTTCAGGGCTCAGCATACATTAGAAGCCCTGGGTAGGTTAAGAGCCAGCAGCCAGGGTCACTTA 321 CTCGTTCAAAGACTCACAGCCTGTAGACGAATCGGGAATGAGAATCAAGTGGTATCAGGATTCAATTGGTGGTCGATCCC 401 CAACTGGGTATCCCATGCCTTGGGAGAAGGTGGTGGTGGGAGAAATTGTGTGTGGGGGGATTCTTATAACTAAGTAGCAT 481 CCTTCAGTCCTTTTCTGGGGTCTCCTGCCCCTCACTTGTACTTTTTGAATGTTAAGGCTAGGATGAACCGGCTTCTCAGG 561 CCTTGCCTCTTGCTCAAATGATATAGCCGGGCACTGAGTTAATACAGATTAACCACTTGATACCCAAAGTGTCCTCAGTA 641 TGATTTTAGGAGACATGCATGCCTGCAGCCTCTGTAGCTCACTTCCATGCTAGAAGGAACCCGGTTTATAGGACCATAAA 721 AGTCAGGCTGACAAGCCGCTGCTGAGTCTTGCTGTGTAGACTGACTACTGCTAACATCCCGATGAGGGAGATGTCTCCAC 801 TGAGCCAGCACTACATTGGATGCACTATTAGTGACTATTTGCAGCCCTGGGGGCACTTCAGACCTCTAAGTTCAAACTCA 881 AGGGTAGCCAGGTACAGGCATGGTCTGTATGGATACCCGGGAGCTTTCCTGGGCCCTGGGCTGGGTCTGAGCTCCTGAGA 961 TACAGAGCCAGGAAGTAGGCCCAGTCTAGGGGCTCTTCCTGAATCTGTGGTCCTTACCGACCTCCCAGAATTTATCATGT 1041 AGTCGTAGACATGCTGAGTGTTGCCTTTTGGAATTTAACTTTCTATTCTCAGCTTAGTGTCCCTACCCCTGAAGGTTTTC 1121 AGAGCTGGGTAAAGACAGGGGACTTATGGCCATTCATCAGACAGGTAATCTTGCTGTGTGTCACAGGAATTATTGCTTTC 1201 CCACAGCTTTTTACTCTTCTAGATTTTACTATGTGCTTGGGGCAAAGACTGTGTAATTATAAATGTTGGAATATGCTCTC 1281 ACCTGAACTCAGGAAAACTTAACGGTCGGAACACCGTTAGGTTGGAGGAAGCTGGAAGCTGCCTCCGGGGCCTCATTTTC 1361 ACACTTGTTCCTGTCTCTCCTATGAATCTCTTCCACGACTCTTGGGGAAATTTCTTCTGTCTGTGACATCCTTCAAAATC 1441 ATGCAGCACCAAGTTCTGGACCCTCATTGAGAATATGTGAAATTCTGAACCAGGTAAAGAGAAAGGGTATTTGTTCCTGG 1521 GTGTGTACTATGGACTACATACACCATCCAAACCCAACCCAACCCTACATCTTCTTTGACAGAGGGGGAAGCCAAAGCTT 1601 GTAATCACGTGGTGGTGTTGCTATCTAGAGGGTGGGAGAGCTGGCATCGGCACCTAGCACCAGCCACCATGTGCTAGACC 1681 TTCCGTTTACTCATTCATTAGCCATATTGCTCTTTGCATCCGCACATCATGAACAAGGTCAAGGTTAGGTCTGCAGAGAG 1761 CAGACTGGATCGAGCATTCAGTGCTGAGAAGATGGTTGGGCGTAGGTATATGCACAGGGCACTGGAGCCTAAGCAGATGT 1841 GGTCACACTTACTGTTGCATTTAAGATGCCAGCACCCCTGGCAAGGGGCCATCCTTCATTCTTACAACCAGATTGGTTGT 1921 CCGCAGAGGCAGCTGAAGTGACTCAGTGACTCATCCAGCGTCGGAGACGTGGCACAGACACAATGCTCTGTCTTCTCCTT 2001 TGGTGCACTGTCCACATCCCTTTCCATGGGCTTGCTTCTCTCAGAAGCTTGGGGCTGGTGCTACCCCAGGAGTCACCAGC 2081 ATCTCACTCTGCCTGCACGCTGCCACTTCTGACCTGGCTGTTGTCTTGAGTGTTGGTCTACTTCCTGGTTCTGCTTGACT 2161 TCCTGTGACTTGGCCCTGGGGTTATCCGTGGAATTCTCACAAACCTCCCATTTAGACTAGCCTTCTCACGAGGTCATGTG 2241 TGGCCAAGTCTGGCATATTGAGTTCAGTCCTTGAGATCTGTGTGGTTGAAGGAGAGAATTAATCTTTACAAGCCCGCAGT 2321 GGCACATATGTGCCTGCACACATGTGCATGCAAAACTGTAATAAGTAACATGTAAATGAGACAATTTTTGCAAAGACTCC 2401 TTCAAACAGTGACCTCTGAAGGTCTTTGCTTATTTTTATTTCTGTGTTGCTCTCCATGATGCAAATCCTTGTGTGTGAAC 2481 ACTGGCACAGGTGTAGTAGAAAAAAAAAACCCTCTCAGTTAGGATTATTTGCAAAATGCCTTAGTTTGGTTGGGAATTCA 2561 ATAGAAAATTTTGTCAGGGTCTTGCCCCAGGTCTGTCTAGTTCCCTACTTGTTAATTTAACTCCCAGGATAAGACCCTCA 2641 GAGCCGGCCTTAGACTGATCCTGGAGGTGAAGGGTGAAACCATCCAAGCTCAGAGTTGAGAAGGGCTGTGTAAGCCTGAC 2721 AGGAGCAAGTCAGAGTGAAGCAAAGTAACAATAGCAAAAGGTTTTAAGTCCATTAAAAGTAGCATTTTCTAATTACCAGG 2801 CATAACACTTTTAAATACAAGTAGAAAATGGATTTTGTGGCCAAATGTCATATACCTGCTTTTTTTGTGATATTGTTTTG 2881 TGGTTTTTGGTGCTGGGGATGGAGCCCTAATGCTTATCAGGGCTCCCCTACTGTGCCTCTCCAGCCCCCTGTTGAGTTGT 2961 TTTTCACCATGTGGTTTACTACCTCCTGCAGGGGTCTTGGGGATCAGAGCCTGGTGCCTCCAGTTCAGATGCTGTGCTGG 3041 GTATTTCTAACTGTTAACTCTGGAAGAGAGTTTTAATGAGAAATTATTTCTTCATTATTAATTGACGTAGAAAGATTCAG 3121 TTCATTGTGGGCGACACTATTCCCTAGGCAGGGTATACTAAACAGTACGAGAGGAGAAAGCCAGCCGAGGGCAAGCAAGG 3201 ATCCGTGTTTACCTCTCTGTTTGTGAGACTGTGGTGTGCTCATCTGCTTCATGTTCCTGCCTTGACTTCCCTGCAATAAC 3281 ACACTGCAACCTGGACTTGTGAGCCAAATAAACCCTCTCTTCCCCAAGTTGATTTTGTCACAGTAACAGAAGGGAAGCTA 3361 AACCAGATGCTCAGGTTGATACCTGCGGGCTCAGACCACCAGGCCCTTCTCACCCTGCCCTGGATGTCATCCAGTGCCAT 3441 CTCTCTGTCCCACACAGAGGGGAGCCCAGACGCTGCTTACATTCTGCTTCAGGGAAATATCAGAGGAGGAGAGCTGACTC 3521 ATTTCACATAAACAAACAAACAAAAACATGCCTCCTATGACTGCAAACAACTCATCTGCAGCTGCGGACACTTTGTGGTC 3601 AAATTTGATTTCCAAAAGGATTAAAAAATTAAGTGTCACTGAATGGAGTTTGGAATTGTCATTTGCCTGTATGAGGCTCT 3681 GATACTGTACTTGGGGAGCGGGTATATGTATTTATGATTTATTAATGATATTTATCTTTAATAAAAATTAAGTTATAAGC 3761 AGC Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) |
Disease | MIMAT0003451 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013581. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013582. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013585. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013588. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013589. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013590. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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44 mmu-miR-677-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT580133 | Ubap2l | ubiquitin-associated protein 2-like | ![]() |
1 | 1 | |||||||
MIRT582833 | Itgb3 | integrin beta 3 | ![]() |
1 | 4 | |||||||
MIRT583171 | Grik3 | glutamate receptor, ionotropic, kainate 3 | ![]() |
1 | 3 | |||||||
MIRT583782 | Elovl7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | ![]() |
1 | 2 | |||||||
MIRT585951 | Sin3a | transcriptional regulator, SIN3A (yeast) | ![]() |
1 | 1 | |||||||
MIRT589768 | Iws1 | IWS1, SUPT6 interacting protein | ![]() |
1 | 1 | |||||||
MIRT591164 | Mup19 | major urinary protein 19 | ![]() |
1 | 1 | |||||||
MIRT591170 | Mup12 | major urinary protein 12 | ![]() |
1 | 1 | |||||||
MIRT591176 | Mup10 | major urinary protein 10 | ![]() |
1 | 1 | |||||||
MIRT591807 | Mup14 | major urinary protein 14 | ![]() |
1 | 1 | |||||||
MIRT592567 | Mup17 | major urinary protein 17 | ![]() |
1 | 1 | |||||||
MIRT592608 | Mup11 | major urinary protein 11 | ![]() |
1 | 1 | |||||||
MIRT593180 | Clasp1 | CLIP associating protein 1 | ![]() |
1 | 1 | |||||||
MIRT594028 | 5430427O19Rik | RIKEN cDNA 5430427O19 gene | ![]() |
1 | 1 | |||||||
MIRT595083 | Zfp516 | zinc finger protein 516 | ![]() |
1 | 1 | |||||||
MIRT595535 | Fign | fidgetin | ![]() |
1 | 1 | |||||||
MIRT595555 | Ubr3 | ubiquitin protein ligase E3 component n-recognin 3 | ![]() |
1 | 1 | |||||||
MIRT595557 | Tcte1 | t-complex-associated testis expressed 1 | ![]() |
1 | 1 | |||||||
MIRT595562 | Sptbn1 | spectrin beta, non-erythrocytic 1 | ![]() |
1 | 1 | |||||||
MIRT595569 | Nrsn1 | neurensin 1 | ![]() |
1 | 1 | |||||||
MIRT595571 | Mtf1 | metal response element binding transcription factor 1 | ![]() |
1 | 1 | |||||||
MIRT595579 | Josd1 | Josephin domain containing 1 | ![]() |
1 | 1 | |||||||
MIRT595580 | Fam101b | refilin B | ![]() |
1 | 1 | |||||||
MIRT595587 | 4930444A02Rik | protein-O-mannose kinase | ![]() |
1 | 1 | |||||||
MIRT595593 | Ago1 | argonaute RISC catalytic subunit 1 | ![]() |
1 | 1 | |||||||
MIRT595602 | Nbl1 | neuroblastoma, suppression of tumorigenicity 1 | ![]() |
1 | 1 | |||||||
MIRT595604 | March8 | membrane-associated ring finger (C3HC4) 8 | ![]() |
1 | 1 | |||||||
MIRT595625 | Nol7 | nucleolar protein 7 | ![]() |
1 | 1 | |||||||
MIRT595629 | Gnptg | N-acetylglucosamine-1-phosphotransferase, gamma subunit | ![]() |
1 | 1 | |||||||
MIRT595633 | Ednra | endothelin receptor type A | ![]() |
1 | 1 | |||||||
MIRT595649 | B3galt5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | ![]() |
1 | 1 | |||||||
MIRT595667 | Rxrb | retinoid X receptor beta | ![]() |
1 | 1 | |||||||
MIRT595743 | Ctdspl2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | ![]() |
1 | 1 | |||||||
MIRT595789 | Fignl2 | fidgetin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595880 | Gid4 | GID complex subunit 4, VID24 homolog | ![]() |
1 | 1 | |||||||
MIRT595909 | Tapt1 | transmembrane anterior posterior transformation 1 | ![]() |
1 | 1 | |||||||
MIRT595919 | Trim9 | tripartite motif-containing 9 | ![]() |
1 | 1 | |||||||
MIRT595925 | Efr3a | EFR3 homolog A | ![]() |
1 | 1 | |||||||
MIRT595937 | Acmsd | amino carboxymuconate semialdehyde decarboxylase | ![]() |
1 | 1 | |||||||
MIRT595943 | B3gnt5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | ![]() |
1 | 1 | |||||||
MIRT596004 | Disp2 | dispatched RND tramsporter family member 2 | ![]() |
1 | 1 | |||||||
MIRT596008 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596167 | Ms4a15 | membrane-spanning 4-domains, subfamily A, member 15 | ![]() |
1 | 1 | |||||||
MIRT597273 | Slc25a33 | solute carrier family 25, member 33 | ![]() |
1 | 1 |