pre-miRNA Information | |
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pre-miRNA | mmu-mir-677 |
Genomic Coordinates | chr10: 128085286 - 128085363 |
Synonyms | Mirn677, mmu-mir-677, Mir677 |
Description | Mus musculus miR-677 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-677-5p |
Sequence | 6| UUCAGUGAUGAUUAGCUUCUGA |27 |
Evidence | Experimental |
Experiments | MPSS |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Ctdspl2 | ||||||||||||||||||||
Synonyms | D2Ertd485e | ||||||||||||||||||||
Description | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | ||||||||||||||||||||
Transcript | NM_212450 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Ctdspl2 | |||||||||||||||||||||
3'UTR of Ctdspl2 (miRNA target sites are highlighted) |
>Ctdspl2|NM_212450|3'UTR 1 GTTCAGAGACTTGTCATATCACTGAAGGGGGGGAGAGAATGCAGGACCCTTTTGGACTAAGACAAAAACATTGCCATTAC 81 TGTTGAAATTTTGCATTTTTGTACCCCGTCTTGCTTTCTTATCTTTGGTGCCCAATAATAATCAAGGGTTACAGAAAGAG 161 ACTCTCGGATTGAACACATACAGTGGGTAGGCTAAAACAGAAGCGTCTGTAGAGTAGACAGCTCCAGTGAGACTCTATGT 241 ATAGGACATCTGCAGCTCATAACGAATTCTGTTTCTGCCACCAGCAGTTTGACCTGTAGTTACACAGGATTTTATGATAA 321 TAACAGAGATGAAAGTGGACTTTCATTCTCTCTCTGTTTGGTGCTCTCAGTGGGTTTGTAGCCACTCTTCTGTTACTTCA 401 CTATTCTCATTTCAACAGGAATGGCCAGTAAAAGTTGTTTTATTTTTCCTGTTAAGGTTTATAACCTTTTTACATTTCTG 481 ACCTGTATTAGATTAGAATCTCATGATGCATTCCTTTTAGTTAAGGCGCTTCATAGTTTTCTGGAAATAGTCAATTTTTA 561 GTTTTTTTTTTAATTATACATTTGAATGGCCGTTTTCCTGCTTTGTCTGCCTGCATATTGTATATTTGTTTAAAAATATT 641 CTCTACTTTTAGTCCATGTTAAGTTTCATTTAAAAGATGCATTTATATTTTGTTCTGTAATATTCTACTGTAGGTGAAAT 721 CTTCAAAAATCAAGAGACTGGGTAGTTAAGAATATATGAATGACTAATATTCAAATGATTTGAATGAACCATTGTGATGA 801 CATGTATTCCAGATGGTAATATCTTGCAATGGCACACGTTTAATGGATAAAGGTATACCTCAGACTTCACTGTGCTCACT 881 AGCCTTTGAGGAGAACGAGTTCAGGCACCTGTTGGGCTTGATTCGGTTACTGCTGCCTTTGGGTTTTCTCCAGGAAGGAA 961 GTATTCAGCACAGTGACTCAGTATTTTTACTTTGCATGGGCTGGTAGTACCTCTGTTATGCTCCCAGTTACAATCAGTTT 1041 AAAGCTCTGTGTAACAGCTGTGGTACCTAACGGTGGCTATGCATAATCCTGTGGCACAGTACACTCCCGGGCCACCAGTG 1121 CAGTCAATGTGCTCATAGTGGTTTTCTATGCTATATGAAAATAAGTCGTCACGCCTTGGTTCTCTAATGCAGCTACCACA 1201 AGAGGTTGATATTTTTATAGTGGCGTGTAATCTCCTTTTCAGGAGGCTTTTTATGGAAGGTAGAATTTGTAAAAGTCAGT 1281 ATGCTTTGCCTCTCAACTGCATTAACATGCCGCAGGCTCAGACTGTTTTTGTGTAAAGGATGTCAAAGAACGGCACTTTT 1361 TCTAAAGAGAAGTTTGATATTTTGTATGCTTGTTAAGAAAGTACAGTATTGGAAATTAAAGGTGGACAATTGATAATTGA 1441 GGAGTATGTCAGTTAATTTTTTATGTATATTACCTGTTTACTTGTACAACTTATTGTACAAATTACATGCAGCTTCATTT 1521 TCAAATGAATCCTTAAAATAAGGAAATCTTTTTAGGAAAACATTTAATTTTTGTATTTTTGATTTTAAAGGCATGAGTTG 1601 TCAGTTTTCAGTGTATTAATGAAGATTTTAACTTTTCATCAGGTTGAGTGTTTTCTTACTATATTATCTGTTGTGTATGT 1681 AGTTAGCATATTGTGTCACTGAACTGTTTAAAAATCTAGCATGTAGAGCAAGCCTGTTTTGTGGAAAATCCTTATTCATT 1761 AAAAAAAATAATCATGGCAGATTTTCTGCAAAAAAAAAAAAAGCAAAAGCATTTGCAATTCAGATTTTTTTTATTTAAAA 1841 AAAAAAGGTATTTTGCTTGCAGGAACAATACTACAGATTCATTTTAATGAGAATCTTCGAAATGTATTTATCTTTAGGGC 1921 ACCTGGGCATCTTTATGCTGTTTGTCTTATGTCTTTCTTGAAATAAAATGTAAATATGTTACCTTTACATATGCTCTTTC 2001 TCAAAATTGTGAACCTAGTTAATATCTTCTTGCCCCCATCATTTTTATGCTTATACAGCAAACCCCAAAACCTGTACAAG 2081 ATTGAATTTTTGACAAACATAATTGTTGACAATGTACTTGATCAGGAATTAAGTAAATACAGTCTCAAAGCCCTTCCCAC 2161 ATCTTAAAAGGGGAAACACTTATACCATAGTGCCTGTGGGCACTTTAATAATAAAAAAGCAGGCCTGTGCCAGGGGAATG 2241 AGCTCCTACTCAGCCAGTAGGTGAGTCAACAATACACTTTTGTAGAGAAATGTAACGTGGGAAAGTTTACATGGCCTGAG 2321 AGTTGAGACCAAATTAATAGATTATTTTTTTCTATTACTTTGAGTAATTCTAAAGTTGTTGATAACAAAGTTTAAAGAAG 2401 ATTATAAAGAAGTTTGCTGGCTTCTTTTCATTTTAATAGGTTTATCTTTCAATCATATCTTTTCTTTGTTGGTAACTGTA 2481 GAACGCTTCCTTTTAGTTAATCAGAGGTGTGTACTTTTTTAATTGCAATGTGCCCAGCCTGTCAGTGCACACAGCACACA 2561 TGACTATAGTAAATGCAGGGGCCATGGGTCCATGAAGCACACAGCAAGCTACCTGTGTACACATTACAACTCTTAAGGAC 2641 CTATTAAAATTGTGCTATTTCCAGTTATGAATGTTTGACTTTTAAGACATTCTTTTAAATATTTGTATCATTGTTAGAGA 2721 ATATTTGCTTGGTTGTATTTTTTAGACCCATGTAATATATGTAGTCCTGACCAGATTTATTACCATTTTTCTCTGGGTCC 2801 TAAAAGAGATCGATGACAATTCGTAACCAGAAATTGTTTTATATTTGCTAGTATGTATATTTATTTATCCAATGGCTTTA 2881 TTTGTTTCCCAAAATTGTTTTGGGACTTGTTGAAAGCATTGTGTAACTTCTATAAATGGCTATTTTCTTGTAACTGTCAG 2961 TGATATGGATGTGTACATTGTTTTTATATATATATACATATATATATCTATATATTTCTGGGTTTTTTGTTTTTTTGGTT 3041 TTTTAGGGTTTGACTTTTTTGTTTTTAAGTTACCTTTGCCAATGACTTTCTGTTAGCTTTTCCTTTCATTCAGCCTTCTA 3121 ACAGAGCTCATTTTTATTATGTTGTCAACTTTCCTGTAAGAGAGACTTCATCTCATCAGTGACGAAGGCATTCCATTATT 3201 CCTACAAGTCGTACAGCAAGCACAGACTCTTCACAAGGATCACAGCTCTTCCGTGTGTCAGTCACTTAAAGGACACTGAA 3281 GCCTTCACTCCTGTACTGATACGATGGTGTTATACACTACGTCACTAGCTAGTTAAGGTTTTCTGACCTGACTTCTCTTT 3361 GTCTTCCTAGGTATTTATTTGTTACCTCTTTAAATCTTGTATGTCTAAATTAACTTAGAATAGTTTCCCACCGAATAACT 3441 ATGCCAAGAACTAGGAAAGAATGTTTATTTTATTTCCCCTTATAGGGGAAGAGTGGACTGGGAACAAAAGTGTAAGGCCA 3521 AAAGGCCTTCGGTTATCAATCATTCACTTTCTTATTCCTCTCATGGGCTGTATTTGCCTAAAGGTTTGGGGGGAGGGGGC 3601 TGCTTTTTTTTCAGTGCTGATGTATTTGACTATGCCATTGCTTCTCATGTCTTCCCTTGAGTTGAAAGCCTGCTAGGACT 3681 TTGCATAAAATACCTAAAAGTTCTCAGAGTAAGAACCACAAAACTCAGTACCTTATATTCAAACGTTGCTTAAATTATTG 3761 AAATCTAAGTCACATTAGAATACATTTTCATATTCATATTTCTGTTATCTTGAATTGAAATTCCATTGTAAATCAATTTA 3841 GTCTTTTAGAAAGTTTATTCTAGCATATGGTTTTAATATTAGTATTTTAAGATAATATAGTTGACTACCAAACCTACCTG 3921 CTAATCAGAATTTCACTGAGGAGCTTTTAAACTGCACAGCATCCTGAAGCCTGGGAAGCCACCTCGTCTATACAGCAGGC 4001 TTGGAGAGTTCTGTGTTTTTAAAGCTTTCCCAGTGATTTAAATAGATAACTTTGGTATATCCTGTTTTAAATAATGTGGT 4081 TTGAGAATAGGTTGCAAAATTTGACCAGCCATATTTCCCTGTCTCTCTGTCTCTGTCTCTCTTTCTCTCTCTGGTAGTTT 4161 TTTTTTTTTTTTTTTTTTAAGTGCTGGGATCATATTTCACAGAACGTATTCAAATTCGTGGAGGAATAATGAAGATTGAG 4241 GCTACTGCTCATTGCCAGTTTTGTCATTCATACTTTTAAATTAAGAGTTTGCATTTATAGAACTCTGAATAGCTGATCAT 4321 TTACATAGCTGAAGGACATGTCCCTGAATGAGACCATTATATATATTAACTAAAATATTTCACTATTTTTTTATTTTATA 4401 AATCTTTGTAGAAATAAGCAATGAAATGCTACTTTCATCTTTTGAACTGGGATTTTTCAAGGTTGTGTCCTTTTGGCATT 4481 AAGGTAGGGGGGAGTTAATATTCTCTCTACTTATTTCCACATGAATCAATATGAAGTCGTGGACATTTAAAAATCTCAAT 4561 TTAATTTCTACTTATTTACTATGCAGTATAGCCGTGAACAAGTAATGTAGATTTAGTTTTCTCATCTTCAAATGCCCTGA 4641 TTACCCTACCTCACAGGGTTGTTGTGGGGATAAATAAAACTTTTATGGAAGTACTTTC Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) |
Disease | MIMAT0003451 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013581. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013582. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013589. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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44 mmu-miR-677-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT580133 | Ubap2l | ubiquitin-associated protein 2-like | ![]() |
1 | 1 | |||||||
MIRT582833 | Itgb3 | integrin beta 3 | ![]() |
1 | 4 | |||||||
MIRT583171 | Grik3 | glutamate receptor, ionotropic, kainate 3 | ![]() |
1 | 3 | |||||||
MIRT583782 | Elovl7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | ![]() |
1 | 2 | |||||||
MIRT585951 | Sin3a | transcriptional regulator, SIN3A (yeast) | ![]() |
1 | 1 | |||||||
MIRT589768 | Iws1 | IWS1, SUPT6 interacting protein | ![]() |
1 | 1 | |||||||
MIRT591164 | Mup19 | major urinary protein 19 | ![]() |
1 | 1 | |||||||
MIRT591170 | Mup12 | major urinary protein 12 | ![]() |
1 | 1 | |||||||
MIRT591176 | Mup10 | major urinary protein 10 | ![]() |
1 | 1 | |||||||
MIRT591807 | Mup14 | major urinary protein 14 | ![]() |
1 | 1 | |||||||
MIRT592567 | Mup17 | major urinary protein 17 | ![]() |
1 | 1 | |||||||
MIRT592608 | Mup11 | major urinary protein 11 | ![]() |
1 | 1 | |||||||
MIRT593180 | Clasp1 | CLIP associating protein 1 | ![]() |
1 | 1 | |||||||
MIRT594028 | 5430427O19Rik | RIKEN cDNA 5430427O19 gene | ![]() |
1 | 1 | |||||||
MIRT595083 | Zfp516 | zinc finger protein 516 | ![]() |
1 | 1 | |||||||
MIRT595535 | Fign | fidgetin | ![]() |
1 | 1 | |||||||
MIRT595555 | Ubr3 | ubiquitin protein ligase E3 component n-recognin 3 | ![]() |
1 | 1 | |||||||
MIRT595557 | Tcte1 | t-complex-associated testis expressed 1 | ![]() |
1 | 1 | |||||||
MIRT595562 | Sptbn1 | spectrin beta, non-erythrocytic 1 | ![]() |
1 | 1 | |||||||
MIRT595569 | Nrsn1 | neurensin 1 | ![]() |
1 | 1 | |||||||
MIRT595571 | Mtf1 | metal response element binding transcription factor 1 | ![]() |
1 | 1 | |||||||
MIRT595579 | Josd1 | Josephin domain containing 1 | ![]() |
1 | 1 | |||||||
MIRT595580 | Fam101b | refilin B | ![]() |
1 | 1 | |||||||
MIRT595587 | 4930444A02Rik | protein-O-mannose kinase | ![]() |
1 | 1 | |||||||
MIRT595593 | Ago1 | argonaute RISC catalytic subunit 1 | ![]() |
1 | 1 | |||||||
MIRT595602 | Nbl1 | neuroblastoma, suppression of tumorigenicity 1 | ![]() |
1 | 1 | |||||||
MIRT595604 | March8 | membrane-associated ring finger (C3HC4) 8 | ![]() |
1 | 1 | |||||||
MIRT595625 | Nol7 | nucleolar protein 7 | ![]() |
1 | 1 | |||||||
MIRT595629 | Gnptg | N-acetylglucosamine-1-phosphotransferase, gamma subunit | ![]() |
1 | 1 | |||||||
MIRT595633 | Ednra | endothelin receptor type A | ![]() |
1 | 1 | |||||||
MIRT595649 | B3galt5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | ![]() |
1 | 1 | |||||||
MIRT595667 | Rxrb | retinoid X receptor beta | ![]() |
1 | 1 | |||||||
MIRT595743 | Ctdspl2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | ![]() |
1 | 1 | |||||||
MIRT595789 | Fignl2 | fidgetin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595880 | Gid4 | GID complex subunit 4, VID24 homolog | ![]() |
1 | 1 | |||||||
MIRT595909 | Tapt1 | transmembrane anterior posterior transformation 1 | ![]() |
1 | 1 | |||||||
MIRT595919 | Trim9 | tripartite motif-containing 9 | ![]() |
1 | 1 | |||||||
MIRT595925 | Efr3a | EFR3 homolog A | ![]() |
1 | 1 | |||||||
MIRT595937 | Acmsd | amino carboxymuconate semialdehyde decarboxylase | ![]() |
1 | 1 | |||||||
MIRT595943 | B3gnt5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | ![]() |
1 | 1 | |||||||
MIRT596004 | Disp2 | dispatched RND tramsporter family member 2 | ![]() |
1 | 1 | |||||||
MIRT596008 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596167 | Ms4a15 | membrane-spanning 4-domains, subfamily A, member 15 | ![]() |
1 | 1 | |||||||
MIRT597273 | Slc25a33 | solute carrier family 25, member 33 | ![]() |
1 | 1 |