pre-miRNA Information | |
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pre-miRNA | mmu-mir-677 |
Genomic Coordinates | chr10: 128085286 - 128085363 |
Synonyms | Mirn677, mmu-mir-677, Mir677 |
Description | Mus musculus miR-677 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-677-5p |
Sequence | 6| UUCAGUGAUGAUUAGCUUCUGA |27 |
Evidence | Experimental |
Experiments | MPSS |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Tapt1 | ||||||||||||||||||||
Synonyms | 4932414K18Rik | ||||||||||||||||||||
Description | transmembrane anterior posterior transformation 1 | ||||||||||||||||||||
Transcript | NM_173764 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Tapt1 | |||||||||||||||||||||
3'UTR of Tapt1 (miRNA target sites are highlighted) |
>Tapt1|NM_173764|3'UTR 1 GTTTGTGACTAATGAGATGAAGATGTCAGGCCCCGGGCCACAAATTCTGGGTGCCAGGACACTTGCTAAAAATGGCACTT 81 AAATATTTATTTAAAAACTTAAATTATTAATGGCAAGCAAATCTTAGTATCTTTCTTCCAGTAATGTGGCCTTGCAGAAG 161 GGCAGATCACGGAGCAGCGGTGGCCTCTGGCCCTGACTCTGGATGCTGACACTTGAACACTTCCTCCTGCGTGGCCAACA 241 GCAGTGCTGCTTCCAGCACCTGGCCAAGCACTGCAGAAGCTCCTTTCCTTCGTCAGCCTGGGCTTCCAGATCGTCGGGTT 321 CTCCTCAAGGCCTCTTCAGGATAAGGACACACCTGGGAAACTGTGACGCTTCTACCATGAGTTCCCTTTCCAGCCTCAGA 401 CTGTCTCCACACACTCTTTCCAGACTTGACTCCATCTGCCAAAGCATTGACAAGTTGCTACATCTAAGTCCAGATGACGT 481 TCTTACCACCAGAGTCATCCTTGGCAATACATCTGAGCTAGTCAGAACAGAAGGCCACTTAACTACAACGTGGTGAATAG 561 CAGCGTCCTATGAGAAACAGTGAGCTCTTGGCCCAGTCATTTACTTTATAAAGGTCATGTGTCACTGAGAAATGCTTCCT 641 GCTGCCTCGGTTACTCAGGGCAGAGTGTGAGCTGTGTGACACGGGCCCAGTGACAATAAAAGGCACAGAGCAATGTCAAC 721 AGAGTAAAAGGCACAAGTGCAGTGTGACCTGGCTTTGCTTTAAGGCTAATTGCTTCATTGGTTATTCCAAGTTAAAGGAT 801 TTGGTGTTGAATTGGCGAATAGCCATTGCATAGCTGTTGCTAGTGCCAGGCTCGTTTGTTGGGTTTTGTTTTGGTTTGAG 881 TAACAGTTTTAAAGTATTCCCAGCAGATTGAGCAGTGTCACCTTGCTGGGCTTGTAAAATGCATTTGTCTGCCTGTGGGT 961 CTGTTCTGTGTGGGGAGGAAACCCTCACATGACCGACCGACCGTAAGTAGAGTGTTTGGGACACTGTAACTAGCAACCAA 1041 AAGGTGCTCTGGGGTTTTCATCTGAGATAAAGATGTTATTCCTGCTTCATTACTACCTATTAGCATCCCAGGACAAATTC 1121 TCGACACCCTACTTTATCTTAAGAGTCTGTTCTGCACTTCTCTTAGACAGAAAGTTGACCATTTCTGATCTGAACTGTCT 1201 AAAAGATGGTACTCTTAACTTCATTTCCTATGCTGTCTTCTGAAACTCAGCTCTCATGCAAATATTTGGGCACAGATGGC 1281 AAATTTTAAATGGTTTGCTGTATCCTGGATAAGTATAAAACTAGTTTGGATGCTTTGGCTTATGCATTTGAGATTCAGGA 1361 GGGTTTCTAATGTTTTGCACTAACAGAATCTAAAGATAGCTGTTGGAGATACTATATATTTATGCCTTGTAAAGCCAGGA 1441 AGCAATTTTAAGTTTAAAATGAACATTTTTATTCTTTTGTGTATGTTTTAGTGGGGCCCCACTTTTAAACTATTCTTTTT 1521 ACCGAAAGAGAGTGTCCATGGAAACCAGGAGCCGTGTGGAAAAAGCTTTGCCAAACGCAGCCCTGGTCAGAACAAGAGCA 1601 CGACCTAGGTGTATCTTTCTGTTCCGCTTGAGTTTTCTGTTTCCGCGCTGTTCTCTGAAGATTGCATTTCCTTTGCAGAT 1681 GCTCTTGGGAGTGTGGATGATACTCACTTCTGTCATAATGGCATTCAGTACTAATTTTATAAGTGCATCTTGTGTGAAAC 1761 TCAATAAATTCAATTTTATAATCTTTTTTAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) |
Disease | MIMAT0003451 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013581. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013585. RNA binding protein: AGO2. Condition:CD4+ T cells
"HITS-CLIP data was present in GSM1013586. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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44 mmu-miR-677-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT580133 | Ubap2l | ubiquitin-associated protein 2-like | ![]() |
1 | 1 | |||||||
MIRT582833 | Itgb3 | integrin beta 3 | ![]() |
1 | 4 | |||||||
MIRT583171 | Grik3 | glutamate receptor, ionotropic, kainate 3 | ![]() |
1 | 3 | |||||||
MIRT583782 | Elovl7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | ![]() |
1 | 2 | |||||||
MIRT585951 | Sin3a | transcriptional regulator, SIN3A (yeast) | ![]() |
1 | 1 | |||||||
MIRT589768 | Iws1 | IWS1, SUPT6 interacting protein | ![]() |
1 | 1 | |||||||
MIRT591164 | Mup19 | major urinary protein 19 | ![]() |
1 | 1 | |||||||
MIRT591170 | Mup12 | major urinary protein 12 | ![]() |
1 | 1 | |||||||
MIRT591176 | Mup10 | major urinary protein 10 | ![]() |
1 | 1 | |||||||
MIRT591807 | Mup14 | major urinary protein 14 | ![]() |
1 | 1 | |||||||
MIRT592567 | Mup17 | major urinary protein 17 | ![]() |
1 | 1 | |||||||
MIRT592608 | Mup11 | major urinary protein 11 | ![]() |
1 | 1 | |||||||
MIRT593180 | Clasp1 | CLIP associating protein 1 | ![]() |
1 | 1 | |||||||
MIRT594028 | 5430427O19Rik | RIKEN cDNA 5430427O19 gene | ![]() |
1 | 1 | |||||||
MIRT595083 | Zfp516 | zinc finger protein 516 | ![]() |
1 | 1 | |||||||
MIRT595535 | Fign | fidgetin | ![]() |
1 | 1 | |||||||
MIRT595555 | Ubr3 | ubiquitin protein ligase E3 component n-recognin 3 | ![]() |
1 | 1 | |||||||
MIRT595557 | Tcte1 | t-complex-associated testis expressed 1 | ![]() |
1 | 1 | |||||||
MIRT595562 | Sptbn1 | spectrin beta, non-erythrocytic 1 | ![]() |
1 | 1 | |||||||
MIRT595569 | Nrsn1 | neurensin 1 | ![]() |
1 | 1 | |||||||
MIRT595571 | Mtf1 | metal response element binding transcription factor 1 | ![]() |
1 | 1 | |||||||
MIRT595579 | Josd1 | Josephin domain containing 1 | ![]() |
1 | 1 | |||||||
MIRT595580 | Fam101b | refilin B | ![]() |
1 | 1 | |||||||
MIRT595587 | 4930444A02Rik | protein-O-mannose kinase | ![]() |
1 | 1 | |||||||
MIRT595593 | Ago1 | argonaute RISC catalytic subunit 1 | ![]() |
1 | 1 | |||||||
MIRT595602 | Nbl1 | neuroblastoma, suppression of tumorigenicity 1 | ![]() |
1 | 1 | |||||||
MIRT595604 | March8 | membrane-associated ring finger (C3HC4) 8 | ![]() |
1 | 1 | |||||||
MIRT595625 | Nol7 | nucleolar protein 7 | ![]() |
1 | 1 | |||||||
MIRT595629 | Gnptg | N-acetylglucosamine-1-phosphotransferase, gamma subunit | ![]() |
1 | 1 | |||||||
MIRT595633 | Ednra | endothelin receptor type A | ![]() |
1 | 1 | |||||||
MIRT595649 | B3galt5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | ![]() |
1 | 1 | |||||||
MIRT595667 | Rxrb | retinoid X receptor beta | ![]() |
1 | 1 | |||||||
MIRT595743 | Ctdspl2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | ![]() |
1 | 1 | |||||||
MIRT595789 | Fignl2 | fidgetin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595880 | Gid4 | GID complex subunit 4, VID24 homolog | ![]() |
1 | 1 | |||||||
MIRT595909 | Tapt1 | transmembrane anterior posterior transformation 1 | ![]() |
1 | 1 | |||||||
MIRT595919 | Trim9 | tripartite motif-containing 9 | ![]() |
1 | 1 | |||||||
MIRT595925 | Efr3a | EFR3 homolog A | ![]() |
1 | 1 | |||||||
MIRT595937 | Acmsd | amino carboxymuconate semialdehyde decarboxylase | ![]() |
1 | 1 | |||||||
MIRT595943 | B3gnt5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | ![]() |
1 | 1 | |||||||
MIRT596004 | Disp2 | dispatched RND tramsporter family member 2 | ![]() |
1 | 1 | |||||||
MIRT596008 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596167 | Ms4a15 | membrane-spanning 4-domains, subfamily A, member 15 | ![]() |
1 | 1 | |||||||
MIRT597273 | Slc25a33 | solute carrier family 25, member 33 | ![]() |
1 | 1 |