pre-miRNA Information | |
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pre-miRNA | mmu-mir-677 |
Genomic Coordinates | chr10: 128085286 - 128085363 |
Synonyms | Mirn677, mmu-mir-677, Mir677 |
Description | Mus musculus miR-677 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-677-5p |
Sequence | 6| UUCAGUGAUGAUUAGCUUCUGA |27 |
Evidence | Experimental |
Experiments | MPSS |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Disp2 | ||||||||||||||||||||
Synonyms | AI840597, B230210L08Rik, DispB, mKIAA1742 | ||||||||||||||||||||
Description | dispatched RND tramsporter family member 2 | ||||||||||||||||||||
Transcript | NM_170593 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Disp2 | |||||||||||||||||||||
3'UTR of Disp2 (miRNA target sites are highlighted) |
>Disp2|NM_170593|3'UTR 1 GAGAGGCCAAGGAAGGCCAGACCAGGGTCCACAACCCTGTTGGTGAAGATAAGGCAGATGCCACACTAGCCTAGAGCCTG 81 AAGGTATTTCTCCCTATTGACATGATGTCTTACCCTCCAAGTATGGATTCTAAACCCTGCCAGATGTTCTAGCCTTGATC 161 TCTTTGCTACTTACCCCTGCATCTGGAGGATTCAGTGGGAGGGCCTTGCAAGGTAATACCAGGCTCTCCCTGTGACCAAC 241 TAAGGACTCATCTGTCCCCACAGTGCCAACAAGGACCCCTACTCTGGAAAGGAGGGAGGCCAGATGTGCAGTTCCAGGTA 321 TTGGGGAGGCTGATCAGCTGTCTCCCGGGTGACAAGAAGTTCAGTGACGCTAAGGTACTCCATCTTTGGGATCCAGTTGG 401 AGTATCTCACTGACTAGAAAAACCCTTAAGAACCTCCACAGCCTATTGAATCTCATCCCTTCTCATTGGCTCTTAATCGG 481 GACACTTCAGTTCTTGGGAAGCTTCTCTGGGCTGGAAGTGAACACGGGCCTCTGTCCTGCACTGTCCTGTTCTGCTCACA 561 CTCACCAGTGTGACTAGAAGCTCTCCAAAAGCAGGACAGAGGTGGATGACAAGAGAGAAGCAGGAGACAGGAAGGTCGGC 641 TTTGGAGTATCCCTAAATTCCAAGATTCCCCCATAGGACGCTGACTCCAGAATGTTCCCCTGTAAGTGAGCAGTAGTTAC 721 CCCTTACCATTGCCACACCTGCCAGTCTTCTTGGACCTTTGCAAAGTTACTCCACAGTGGCCTGCAGTTGGTCAAGACAC 801 TGAGAATGGTTGATTGATTGTCCCCCAAAGTCATGTCACTGGGTAGCAGCAGGATTCTCTCCTGACTCATGCTGCCACTA 881 TAGCTCCCTGTCTCCTCCTGAGTGTGAGCTTCAGGGCCCTGGGCCCCTGGCTGTCTTGGTCCTTTGCTTCTGGCAGTTAC 961 CCAGTCTCTTTGCTTGAGCCTCTCTTTGTGAGCCCTCCCTCCCCTTGGGGCCTCCACCTCCAGAAAGAGTTGTAGTCTGA 1041 GTAGACCGGAGAGTTCCTCATTTCCTTTGAGTTTCCCCGCTCTGAAACTCTCTGAGATGCCTACTAGCCATGGGCCTACC 1121 GGGTCACAGGCAGCCGAGCTGAAGCTTAGGCTTCAAGGATGTGCCTCTTTCATGGCTGAGGAGTACAGACAGGCTTTGCC 1201 AGAAGAGGTACGAAGGGACAGAAGAATGTGAACAGAATCTAGTTAAGACAAGAACACAAAGTTGCTCTTGTGGAGTTGTC 1281 CAGGACCCTGAAGTCTAGGTATCAGGTCCTCAGTTTCTGAAGACTAGGCCTCCCAGTAAGGTTGCTTGACGGTGTCACTG 1361 ATCAGTGGCAGAGTGCTCTCCTGACTCATCCTGCCACTATGGCTCCCTGTCTCCTCCTGACCAACTGCCTGCTTCAGGGC 1441 CATTAGCTTTCTCCACCCAAAGCACTCATGTGACACAGCTCAAGACACCAGGCACCATCTGCAAGTTTACTGAACACCTG 1521 CATTGGAAAGGGTGTTGTAAGGGAGAGAGACATGGAACGGAGAACTGGCCTCCTGCTGGGAAGCAGGCATTAGTGGGTCA 1601 GGGTTACTGCCGAGCTCAGGTGCCCAGCAATAGGTGACCGGGAAGATCTCGTGGAGAGGGATGGGTTTGAGCTGGGCTTC 1681 AGAAGATCAAGCAGATCAGACAGGAGGGAGCTTGGTGATCCAACTCCAAGGGTCCCCTAAGGACTGTTCTTTCAATAAGC 1761 TCCTGTGTCTAAAACTCCTGCTCCGAGGGGTGTGAGTTTAGGGGTGCTGCTAGCTCAGCTTCCCTTTCTAGTGCAGATCT 1841 CCAGGGGTCTCCAGGTCCCTGGGAATATCCATAGATCTTGGCATGAAGACCACCAATCTAGGCCATTTTATATAGGAGTA 1921 TCAGAAAGGAGTTTTCCAGTGCCAAACAATCTAAGGCAAGGCTAGAGGCAAGCCAGAGGACACTTTTGTTTTATTTTGTT 2001 GAGTTCCTGTGTTATTGAGACCTATCTCCCACCCCAAGTAGCCCAGGACAAGTGGAGCAGAAACTCAGATGAGAACATAA 2081 GAATGTGGGAAAGACAGAAGACAGTTTTCCCTCAGTATCCATGGAGAACTGGTTCCAGCACACCCCGCACCTTCCAGCAT 2161 ACTAAAATCTGAGGATGCTCAAGTCCCTCGTGTAGAATGGTGTAGTATTTGCATATAATGATGCATATTCTCCTATATTT 2241 AAATCGTCTCTAGAGTACTTATAATGCCTAATATGATGTAAATGCTATGTCAGTCCTTACACCGTGTTGTTGTAATAATG 2321 ACAAGAAAAATAATATGTGTGTGGTGAGT Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | CD4+ T cells (C57BL/6) | ||||||
Disease | MIMAT0003451 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM1013582. RNA binding protein: AGO2. Condition:CD4+ T cells
... - Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Loeb GB; Khan AA; Canner D; Hiatt JB; et al. - Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
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44 mmu-miR-677-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT580133 | Ubap2l | ubiquitin-associated protein 2-like | ![]() |
1 | 1 | |||||||
MIRT582833 | Itgb3 | integrin beta 3 | ![]() |
1 | 4 | |||||||
MIRT583171 | Grik3 | glutamate receptor, ionotropic, kainate 3 | ![]() |
1 | 3 | |||||||
MIRT583782 | Elovl7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | ![]() |
1 | 2 | |||||||
MIRT585951 | Sin3a | transcriptional regulator, SIN3A (yeast) | ![]() |
1 | 1 | |||||||
MIRT589768 | Iws1 | IWS1, SUPT6 interacting protein | ![]() |
1 | 1 | |||||||
MIRT591164 | Mup19 | major urinary protein 19 | ![]() |
1 | 1 | |||||||
MIRT591170 | Mup12 | major urinary protein 12 | ![]() |
1 | 1 | |||||||
MIRT591176 | Mup10 | major urinary protein 10 | ![]() |
1 | 1 | |||||||
MIRT591807 | Mup14 | major urinary protein 14 | ![]() |
1 | 1 | |||||||
MIRT592567 | Mup17 | major urinary protein 17 | ![]() |
1 | 1 | |||||||
MIRT592608 | Mup11 | major urinary protein 11 | ![]() |
1 | 1 | |||||||
MIRT593180 | Clasp1 | CLIP associating protein 1 | ![]() |
1 | 1 | |||||||
MIRT594028 | 5430427O19Rik | RIKEN cDNA 5430427O19 gene | ![]() |
1 | 1 | |||||||
MIRT595083 | Zfp516 | zinc finger protein 516 | ![]() |
1 | 1 | |||||||
MIRT595535 | Fign | fidgetin | ![]() |
1 | 1 | |||||||
MIRT595555 | Ubr3 | ubiquitin protein ligase E3 component n-recognin 3 | ![]() |
1 | 1 | |||||||
MIRT595557 | Tcte1 | t-complex-associated testis expressed 1 | ![]() |
1 | 1 | |||||||
MIRT595562 | Sptbn1 | spectrin beta, non-erythrocytic 1 | ![]() |
1 | 1 | |||||||
MIRT595569 | Nrsn1 | neurensin 1 | ![]() |
1 | 1 | |||||||
MIRT595571 | Mtf1 | metal response element binding transcription factor 1 | ![]() |
1 | 1 | |||||||
MIRT595579 | Josd1 | Josephin domain containing 1 | ![]() |
1 | 1 | |||||||
MIRT595580 | Fam101b | refilin B | ![]() |
1 | 1 | |||||||
MIRT595587 | 4930444A02Rik | protein-O-mannose kinase | ![]() |
1 | 1 | |||||||
MIRT595593 | Ago1 | argonaute RISC catalytic subunit 1 | ![]() |
1 | 1 | |||||||
MIRT595602 | Nbl1 | neuroblastoma, suppression of tumorigenicity 1 | ![]() |
1 | 1 | |||||||
MIRT595604 | March8 | membrane-associated ring finger (C3HC4) 8 | ![]() |
1 | 1 | |||||||
MIRT595625 | Nol7 | nucleolar protein 7 | ![]() |
1 | 1 | |||||||
MIRT595629 | Gnptg | N-acetylglucosamine-1-phosphotransferase, gamma subunit | ![]() |
1 | 1 | |||||||
MIRT595633 | Ednra | endothelin receptor type A | ![]() |
1 | 1 | |||||||
MIRT595649 | B3galt5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | ![]() |
1 | 1 | |||||||
MIRT595667 | Rxrb | retinoid X receptor beta | ![]() |
1 | 1 | |||||||
MIRT595743 | Ctdspl2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | ![]() |
1 | 1 | |||||||
MIRT595789 | Fignl2 | fidgetin-like 2 | ![]() |
1 | 1 | |||||||
MIRT595880 | Gid4 | GID complex subunit 4, VID24 homolog | ![]() |
1 | 1 | |||||||
MIRT595909 | Tapt1 | transmembrane anterior posterior transformation 1 | ![]() |
1 | 1 | |||||||
MIRT595919 | Trim9 | tripartite motif-containing 9 | ![]() |
1 | 1 | |||||||
MIRT595925 | Efr3a | EFR3 homolog A | ![]() |
1 | 1 | |||||||
MIRT595937 | Acmsd | amino carboxymuconate semialdehyde decarboxylase | ![]() |
1 | 1 | |||||||
MIRT595943 | B3gnt5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | ![]() |
1 | 1 | |||||||
MIRT596004 | Disp2 | dispatched RND tramsporter family member 2 | ![]() |
1 | 1 | |||||||
MIRT596008 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596167 | Ms4a15 | membrane-spanning 4-domains, subfamily A, member 15 | ![]() |
1 | 1 | |||||||
MIRT597273 | Slc25a33 | solute carrier family 25, member 33 | ![]() |
1 | 1 |