miRTarBase - #MIRT596427


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pre-miRNA Information
pre-miRNA mmu-mir-125a   
Genomic Coordinates chr17: 17830812 - 17830879
Description Mus musculus miR-125a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-125a-5p
Sequence 6| UCCCUGAGACCCUUUAACCUGUGA |29
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Hif1an   
Synonyms 2310046M24Rik, A830014H24Rik, FIH, FIH1
Description hypoxia-inducible factor 1, alpha subunit inhibitor
Transcript NM_176958   
Expression
Putative miRNA Targets on Hif1an
3'UTR of Hif1an
(miRNA target sites are highlighted)		 
>Hif1an|NM_176958|3'UTR
   1 CCTGCCAGAGGTCAAGGCCTCCTGTCAGGTGACTGCTATCCTGTCCACATGCTTCGTTGATGAGGACAGGACACTCCAAG
  81 CACTAGTATTGCACGCTGCACTTAATGGACTGGACTCTTGCCATGGCCCTGGAGGCAGGTGTCTGAGGCAAGGCAGGGTA
 161 GTTGACTCCACTCCCATTTGGAAAGGTTTCTCACCCTTGCCTCTTGAGCCCCAGAACCTTCCCTCTGCCCCCCTGAAGTC
 241 CTGCATTTAGTGTGTGGAGTCCCAGCTTCTGGTTGTAATCATGTCTGTGTTAGTCTGTTAACCTCAGGGTGTGTGTGTGT
 321 GTGTACATGTGTGCATATGCATGTGTGTATACACACACATGCATGTATCTGTTCCTTGTTCCCTCTTCCTGGGTCAGGAT
 401 GTCACTTCTGGCTCTCAGCTCCTGTCTCCTGAAGCCTCAGTGCCTCAGCCTGGGAGGAGAGATGCTCCTGTGTCCCTACA
 481 ACATCTGGGCTGTGGTGCCAGAATGACTCTGCACATGAGTCTGCCTTCTGCCAGTTTTTGCAGCATAGTCAGGCTACAAA
 561 CCAGGTGGCAATAACTGCTGGGGCCCTAATGGGGACATTGAGAAGGAGGCTTATCTTTGGGAGGTAGCCTTCTAGTGGAA
 641 GAGGATTAGATAAGATTCCAGTTGAGAACTACATGCTTAAGCCATACATAGAAGGAAAACTTGGGGACCTGAAACCAGGA
 721 TTGTGCATATGTCCAAATACAGGCATTTGCAGCCGTTCTCTTCAGTACCAGCTCCTGTCCCTGTGCTGCAATGAGGGATT
 801 CTAGCTCTGACTTTTTTGGGCTCGAGGGGTATGAACCTCTGCATGTGTGTGTACACATCTGCACACTTGTATGCATGTGT
 881 GATCACACTTGCCATCCTTCTTGCTTACTAAGGTTCTCAACTGCTAACATTGTCCAGTGTGGCAGTACAGCGTGAACCCC
 961 AGATACTGCCTGACTCAGCCTAGAGCTTTTACACTCGGATTTTAGCCATCCCGTCTTGGTCAGATCTTACTGCAGCCTAC
1041 CTAAAGCTGACTGGCTCAAGCCTCCCAGTCCTGTGTCTTTCCCTGTCTGAACCACATCCCTGCTCCTGCTGAGCTTCCTG
1121 GCTGAGTAGATGAAATGGGGTCAGACTTAGGCAGCTAACTCAATACCTTTCATCCACCTCAGGGCAAGGGGAAAAAAAAT
1201 GTCCTCTTGCCTCTTAGAGCCAGCGCCTCTGCCAGACCCAACAAAGCGTCGCATGTGAGCTGGAGTAGAGCTGGGAGAGC
1281 TTGGAGATAGAATTTACTTTTCTGTTGGTAGCTGTTTATGGGAGCCCTCCTCGGGGCTGCAGCTTATAGCTCTGTGTTAC
1361 ACAACACAGAGCGCAATCATTTGTATCTGTTAAGAGGGAATGGGGCCCCAGCAGCTTGGCAGAGTGGTGGCCCCGTGTCC
1441 ACTTACCTCAAGTCCCTTCCTTCTCTGTCAACCTTTTTTCTCTAAAATTGGAGTTGGAAGTCTGATTTTATTCTTTTCTT
1521 TGCCACCTTTTAGTCCCCTTCCCTGTAGATTTGACCTCCCGTGTTCAAGCTGTGGGTCTTAGCCCTGAAGCTCAGCTTAC
1601 AGCGCCCCATGGACTGAACAGATGCAGGCGAATGCTTGTGCACCCGTGTGCGTTTAGGGGCGGGAGCTCTAGCCCCCACT
1681 CTGGGCTCTGCAGTGTGGTTGCGCAGACTTGGTACCTTCTTGAGTATGGCTCTTTAAATACAGCCCGTGCTGGGCAGTGT
1761 GATCGCGGCAAACGCATGCCTCCATCTCTTTTGGGAACGAGGGATGCAGCAGAAGAGGGAGGCAGAGTGGTATTAGTTTG
1841 GCCACCGTGGCGGATTTTCATTCTCCGCAGATCTATGGTCCTGGCTCTGCCCTCAAAGGTGTCTGGGATGTGTGGCAGGG
1921 AGTCTGGATCTGCTCGGTTGACCCTTCAGTATAACTCTGCTCTCACAGGTCTGACCTAGGGTGGCTGAGGGCAGCGAGAG
2001 AGAAGGTGAGCTTAGGCACCATCACAGGATTGGCCCTGATGCTGGGATGATGTCATGGCTGTTCCTGGTCTTAGACACCT
2081 GATGTGTACCTGTTGTTTCTAGCTCTGTCCCTCACAGTGCTGCGTGGTAGTCAAGAGCAAACCTAATGCCATTTAGCTAT
2161 AAACCCACTACTCCCTGCTCCTCCATTTCTTCCAAATGCTGTTGGTTCTCTACCTCACCTCAAGCCTTGTTCCCTAGAGA
2241 GTGTGCAGGTAGACTCAGGCAAGAGGGTGTGGAAGGGTGAAAGGCTTTGGGGGTTCAGCTAGAGACATGGAAAAGCTGCC
2321 TAGAAAGCCATCTTAACAAGCTAAGGGTTCTGGGAAGAAGCAGAAGAGTGAGCTTCGGCCCTGCGGGGGAAAGGGGTGCT
2401 GTAGGTCCTGTAGCTCCTCTCACCACACCTCTGCATGCTGAGAGGAAGCTCTGGTAACCCGATTCATATTCTGCTGGGCC
2481 ACTTCCTCCTGGGGATGGCAAGCAGGGACTCACCTAGGCTAGGGTCTCAACCCTAGGGCTGTTGAGGCTCCAGTTGTACT
2561 TGCAGCAGAGCAGGCATCACTATTGTGTACCCATTCTAGCCAACAGCCTGGGAGTCAGACGTGCCAAGGAAGGTGGAGAC
2641 CTGGGCTTGTCCAGGGGTCAGCCATCTTGCAGGCTCTCGTGTTTATACCAGCAGTACAGTGAAAACTACTGTTTTGTGAA
2721 GTCAAATATTTGCTGGGGGGTTAGAGTTATGGGGTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGATGCCCAGGAT
2801 GCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAAATTACAAGGTTTTTACCAACGCGAACAGTTGGGGGAAGT
2881 CGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGGATGAAGGAAAAGAAATTTGACAATTAGGA
2961 ATGAGCCATCATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGCTCCTTACTATTGGGCCAACCTAGTATGGGGAG
3041 ACACTCCCTATTTCTGACCCCAGAATCTTGTGGGCCAGGTACCCTTTTGGAGTTCCCACAAGTGTGGGTGGAGTTTGTAT
3121 GCCTTCATAGACTGGAGTCCAGGCCCAGCTTGAGGTGGGTTTGCAAACAGACATCTTTCTGCCTGAGCCCTCGCAGTTGA
3201 AGGTAGGTAGGCTGGTTACTGCGTGTGCTCAGTTACAGGAAGGATCTCTGTAGTAGTCAGCACTGTTGCGCCCCACCTGT
3281 GACAGGGATCTGTCACTTCGAAGCACTTGAGCTTGTGTGGGAAGCCTGAGCTTCATCAAACCCCAGACACTGGTGGAAGT
3361 TGGAAAGGAAACCGTATGAAGAGTAGCAGAGCCTAGGTATGTGCAAGGAGGGGTGTGAGGAAGAGCTGGTCCAGCACAGG
3441 CTGTCTGGGAGGAGACTCGGCCTCTCAGCAGCGTTGTCTTACTCTGGATCAGCGAGCCATTGCTGTGGGGAACACTGAGG
3521 TTCCTGGCTCAGTGACCCAGTGATGTGGCTATTGAAAAATGGAGAGTCCAGCGTAGATCTTCCAGTGTTTGCAAGTTACC
3601 TCACCACTCACCCCCATCCCTTCAAACGCCTAAGAATATTAGTCTGTACCAAGTAGTGGTCCTCACCATTAGTGTGTTCC
3681 TTAGACCCCAGCCCCCCCAAGGTTTGGAGGGGGCTCCTCTGTCTCCTTTCATAATGTGAACTTCTCAAGGATGGTGCTAT
3761 CTCAGTCCTTGGTAAGTTCCCTACCTCTGTTGTCTTTCATCCTTCAAAACTTGGTGCAGAATTTAGCAAGGGCTACCAGC
3841 AGTGACCCTCTGACCAGTTTTTCCTACATGGCCAGGGGTGGGGATGGGGATAGCTCAGGGTTGTAGAGGCCAGGCCTTTC
3921 CAGTTCCTGTTTCTCTTGGTGTCCTCTTGACCCATCTTTAAGAGGATCCTTGAGCTTTCTCCTAACTAGGCTCTCAGTGG
4001 CCTCTTTACCAAGGCTCTTTTCCTCAAAGACGCTCTCTGGCTCCAAGTGCTGGGCAGCCTGGCTGGAGGATCCCTCTCCA
4081 CAGGGTCTGTCCCTGCCCCTGCTTCACTTCTGACCTCAGGTAGCTCTGTTGCTGTGTCCCTGCTGAGTTGCTATGTCCGT
4161 CTGCTCTGTCCACTTACCATTCCTCAGTCTTTCCATGCTGGGCCGTTGTCTTACCATGGCCATCCTTCCTACCTTTTCTT
4241 CAGCCAGCTCTGTTTAATTATAGACCCATAGGGTCCTGACTGGAGCCCCATTGAGCACTTTGGGGACGTTTCTGGAGGAA
4321 CAGAGGCTCAGAAACTGGTGTCCTCAAGGCCCATGGGCCTGTGGTTAGCGAAGCCTCGGAGACAACTGGGGAGGAACTTG
4401 GAGAGGTGAAGGACTTGGTGAGAGACTTGGAGAAAGAGGCCAGGCTTGGGAAAGCAGGGTGGCAGGAGCGAGCTCTGTTT
4481 TCCATGAGTGTGTCCTTGTGCCTTAGGGTCCAGCAGTTCAGGTATGAGGGGCATTTTCTGAATGCCTCCTAATTTCTCTC
4561 AGGTCTTTGGCTCAGTGTCACCAAGTTTGACAGACCCCTTCGTTCCTGAGCTTGCTAGAAGGGAAGCAGCACGTTGAGTG
4641 GTGTGGTGTGGTGCGAGAGCGGAGGCCTCCCATGCAGAAGGCTGGGGTGGTGGACAAGAGAAAGGGCCCGGTGGTCAGCT
4721 TCTCACCGATGACTCTCCATGCCTCAAGAGACTGAGTATAGTAGTTGGTTCAAGAAGTTACTCTAAAACTGCCTGCCCTC
4801 TTCACCTAAAGTCTGTTCTCATTTCGGGGAGGAATGCAAGTCCTTAATTTTCAAGGGAAGACAGTCTAGTGTTTAAAAGC
4881 ATGTGTCTGGGGTCTGGTCCCTTTGGTACATTTCTAGCTTGCTACTTACCAGCTGGGTTTGACCTTGGTTGATTGATTGA
4961 ACCCGAGTCTCGGTTTCCTTTCCTATAATGACTTGTGGGGGTGGGGGTTTGAAAATATCTACCTCAGGGTTGCTGGATGA
5041 ACTGAAATAATGTCTGTAAAGCTTTAGCACAGTGCCTGGCAAGCACTTAATAAACGGCTGTGGTGGTGGTGGTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agugUCCAAUUUCCCA--GAGUCCCu 5'
              :|| | ::|| |  ||||||| 
Target 5' ggtgGGGAT-GGGGATAGCTCAGGGt 3'
 3877 - 3901 149.00 -21.60
2 
miRNA  3' agugucCAAUUUCCCAGAGUCCCu 5'
                |||||     ||||||| 
Target 5' tagtctGTTAA----CCTCAGGGt 3'
 291 - 310 148.00 -12.50
3 
miRNA  3' agugUCCAA--UUUCCCA----GAGUCCCu 5'
              :||||  |||   |    ||||||| 
Target 5' gtggGGGTTTGAAAATATCTACCTCAGGGt 3'
 5001 - 5030 148.00 -16.53
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions CD4+ T cells (C57BL/6)
Disease MIMAT0000135
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM1013576. RNA binding protein: AGO2. Condition:CD4+ T cells ...

- Loeb GB; Khan AA; Canner D; Hiatt JB; et al., 2012, Molecular cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aguguccaauuucccagAGUCCCu 5'
                           |||||| 
Target 5' -----------------UCAGGGu 3'
 		1 - 7
Article - Loeb GB; Khan AA; Canner D; Hiatt JB; et al.
- Molecular cell, 2012
MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a transcriptome-wide identification of the endogenous targets of a single miRNA-miR-155-in a genetically controlled manner. We found that approximately 40% of miR-155-dependent Argonaute binding occurs at sites without perfect seed matches. The majority of these noncanonical sites feature extensive complementarity to the miRNA seed with one mismatch. These noncanonical sites confer regulation of gene expression, albeit less potently than canonical sites. Thus, noncanonical miRNA binding sites are widespread, often contain seed-like motifs, and can regulate gene expression, generating a continuum of targeting and regulation.
LinkOut: [PMID: 23142080]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions liver tissue of C57BL/6
Disease MIMAT0000135
Tools used in this research TargetScan
Original Description (Extracted from the article) ... "FIH1 is a target of miR-125a-5p We then determined whether miR- 125a-5p influenced the expression of FIH1. Similar to the miR-NC ...

- Li G; Li J; Li C; Qi H; Dong P; Zheng J; Yu F, 2016, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Article - Li G; Li J; Li C; Qi H; Dong P; Zheng J; Yu F
- Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016
BACKGROUND/AIMS: Emerging evidence shows that microRNAs (miRNAs) play a crucial role in the regulation of activation, proliferation and apoptosis of hepatic stellate cells (HSCs). Previous studies have indicated that miR-125a-5p is correlated with hepatitis B virus replication and disease progression. However, little is known about the biological role and underlying mechanism of miR-125a-5p in liver fibrosis. METHODS: We analyzed the level of miR-125a-5p in carbon tetrachloride-induced liver fibrosis and activated HSCs. We analyzed the effects of miR-125a-5p down-regulation on HSC activation and proliferation. We also analyzed the binding of miR-125a-5p to the 3'-untranslated region of factor inhibiting hypoxia-inducible factor 1 (FIH1) mRNA. RESULTS: Up-regulation of miR-125a-5p was observed in the liver tissues of fibrotic mice and activated HSCs. Down-regulation of miR-125a-5p prevented the activation and proliferation of HSCs. FIH1, a negative modulator of hypoxia inducible factor 1, was confirmed to be a target of miR-125a-5p using the luciferase reporter assay. Further studies demonstrated that miR-125a-5p prompted the activation and proliferation of HSCs, at least in part, by down-regulating FIH1. CONCLUSION: Our findings shed new light on miRNAs as a promising therapeutic target in liver fibrosis.
LinkOut: [PMID: 27074047]
CLIP-seq Support 1 for dataset GSM4656409
Method / RBP HITS-CLIP / AGO
Cell line / Condition mouse liver / Adult
Location of target site NM_176958 | 3UTR | AAUGACUUGUGGGGGUGGGGGUUUGAAAAUAUCUACCUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE153876
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4656410
Method / RBP HITS-CLIP / AGO
Cell line / Condition mouse liver / e185 rep2
Location of target site NM_176958 | 3UTR | GUGGGGGUGGGGGUUUGAAAAUAUCUACCUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE153876
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4751757
Method / RBP HITS-CLIP / AGO
Cell line / Condition adipose tissue / RNA sequencing of iBAT 2
Location of target site NM_176958 | 3UTR | CUCAGGGUUGUAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE142677
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4751757
Method / RBP HITS-CLIP / AGO
Cell line / Condition adipose tissue / RNA sequencing of iBAT 2
Location of target site NM_176958 | 3UTR | GUUGCUGGAUGAACUGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE142677
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4751759
Method / RBP HITS-CLIP / AGO
Cell line / Condition adipose tissue / RNA sequencing of iBAT 4
Location of target site NM_176958 | 3UTR | GUGUGUGUGUGUGUGUACAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE142677
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4751760
Method / RBP HITS-CLIP / AGO
Cell line / Condition adipose tissue / RNA sequencing of eWAT 1
Location of target site NM_176958 | 3UTR | GUUGCUGGAUGAACUGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE142677
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4751761
Method / RBP HITS-CLIP / AGO
Cell line / Condition adipose tissue / RNA sequencing of eWAT 2
Location of target site NM_176958 | 3UTR | GUUGCUGGAUGAACUGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE142677
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM4751763
Method / RBP HITS-CLIP / AGO
Cell line / Condition adipose tissue / RNA sequencing of eWAT 4
Location of target site NM_176958 | 3UTR | GUUGCUGGAUGAACUGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE142677
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1013576
Method / RBP HITS-CLIP / AGO2
Cell line / Condition CD4+ T cells (C57BL/6) / CD4+ T cells, 155KO, biological rep2
Location of target site NM_176958 | 3UTR | UCAGGGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23142080 / GSE41285
CLIP-seq Viewer Link
28 mmu-miR-125a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001716 Lin28a lin-28 homolog A (C. elegans) 1 1
MIRT005597 Trim71 tripartite motif-containing 71 4 3
MIRT006310 Cbx7 chromobox 7 2 1
MIRT006967 4632428N05Rik V-set immunoregulatory receptor 2 1
MIRT054177 Ptpn18 protein tyrosine phosphatase, non-receptor type 18 2 1
MIRT054178 Ptpn7 protein tyrosine phosphatase, non-receptor type 7 2 1
MIRT054179 Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 2 1
MIRT054180 Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 2 1
MIRT054570 Traf6 TNF receptor-associated factor 6 3 1
MIRT580227 Tspan12 tetraspanin 12 2 2
MIRT582368 Mtf1 metal response element binding transcription factor 1 2 2
MIRT582450 Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A 2 2
MIRT584884 Antxr2 anthrax toxin receptor 2 2 2
MIRT587193 Foxk1 forkhead box K1 2 2
MIRT588848 Snrnp40 small nuclear ribonucleoprotein 40 (U5) 2 2
MIRT591275 Lars2 leucyl-tRNA synthetase, mitochondrial 2 4
MIRT592914 Madd MAP-kinase activating death domain 2 2
MIRT594893 Il1rn interleukin 1 receptor antagonist 2 4
MIRT596427 Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 3 3
MIRT599142 Dqx1 DEAQ RNA-dependent ATPase 2 2
MIRT599717 Aph1c aph1 homolog C, gamma secretase subunit 2 2
MIRT600832 Gm14137 predicted gene 14137 2 2
MIRT604902 Jmy junction-mediating and regulatory protein 2 2
MIRT605441 Stat1 signal transducer and activator of transcription 1 2 2
MIRT606092 Wdr25 WD repeat domain 25 2 2
MIRT732537 Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 4 0
MIRT734700 VDR vitamin D receptor 2 0
MIRT734824 Sox11 SRY (sex determining region Y)-box 11 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-125a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-125a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 down-regulated
miR-125a Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 down-regualted
miR-125a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-125a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 up-regulated
miR-125a Enoxacin approved 3229 Quantitative real-time PCR HEK293 cells 18641635 2008 up-regulated
miR-125a 4-hydroxynonenal NULL 5283344 Microarray human leukemic HL-60 cell 19022373 2009 up-regulated
miR-125a Valproate approved 3121 Quantitative real-time PCR CD4+, CD25- T cells 20427269 2010 down-regulated
miR-125a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-125a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-125a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-125a 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
miR-125a-5p Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-125a-5p Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
miR-125a-5p Curcumin NULL 969516 Microarray HONE1 cells 24896104 2014 down-regulated
miR-125a-5p 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 down-regulated
miR-125a-5p Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-125a-5p Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-125a-5p Glucocorticoid NULL NULL TaqMan low-density array Eosinophilic esophagitis 22815788 2012 up-regulated
miR-125a-5p Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
mmu-miR-125a-5p Paclitaxel 36314 NSC125973 approved sensitive Low Colon Cancer tissue and cell line (HT-29)

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