miRNA Infomation | |
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miRNA name | mmu-miR-1186a |
Gene Information | |
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Gene Symbol | Ubxn2a |
Synonyms | 6330407P03Rik, Ubxd4 |
Description | UBX domain protein 2A |
Transcript | NM_145441 |
Expression | |
Putative miRNA Targets on Ubxn2a | |
3'UTR of Ubxn2a (miRNA target sites are highlighted) |
>Ubxn2a|NM_145441|3'UTR 1 TAGTTTTTATTTTTGAGAGACTGAGAAAAATGATGGTTGCAAGTAGACATGCAGAGTGGGAGACAGAAGTCAATGTGACT 81 AAACTTGCGGTTTGAGGGCTTCTCAATCCCTTATGAGGGGGTTCAGTCGTCACAAGCTAGGAGAGTGACATGGCTCTAAG 161 CCAGGGTCAGTGCATTTTTCTCAACAGGCTATTCAGAAAAAAATACCTATTTTTCAAATATTAGTTAGCCAATATGACAT 241 TAAATAGCTGTGTCATTAATCTTAATGTGGTCTAAATTAGCAGAGTATTCAATTAGCTAAATCAGCATCAGCATTCAAAT 321 ATTATCTCCAAACAGCAGATATTTATATAAATGTTAGCTATCTCAGTTTTTAAATAGCAATACATCAAAATATTATCCAT 401 GCCATATTAAAAGCATCAATGTAGTTATTGCCCGTGCTTCATCCTCGGAGCTTTTCAGTTTCTACTTGTGATGGCAAAAG 481 ATACTCAAATACTCATTTGGCAACAGTATCCAAGATGTAGACTCTTCTCGGAATAAAATTGTGTAGCTTAGTATAATATC 561 AATACTAATCTATATACACAGTTTTCTATACCTTCTACATGTAATTTTATGGACTGGGAATGTAGTTCAGTGGTAGGGAT 641 TATTTGCCATACATACATGAGACTAGTTTAAATCCATCCCAGCACTACAAAAAAATCCTTTCAATTTGTAATGTAAAAGC 721 ACACACAAAAAAAATTCTTCAAAGCTGGGTGGTGGTAGTGGCAAAGCAGGCCTTTAGTTTAATCCTAGCACTTTGGAGGC 801 AGAGGCAGGAGGATCTCTGAGTTCAAGGACAGCCTGTCCTACAGAGCTAACTAACTTCCAGGGTTACACAGAGAAACCCT 881 GTCTAGAAAAAACTATAGAAAAGTTTTCAAATCTTTACTCATTTAAAAGGAACTTTGAAACTGCCCACAGGTGTATGCCC 961 TAGCTCTAGCTCACACCAAGCTGAGAGGAGAGGAGCCCAGGAGTTTGGTCAGCATAAGAGACATAGCAAAACCCTGTCTC 1041 TTGATAGTAACAACCTTCCCACCCGGAGACATAGATGGCTCAGCTGTTAAGAACACTGGCTGCGCCAGGCGGTGGTGGCG 1121 CACGCCTTTAATCCCAGCACTCGGGAGGCAGAGGCAGGTGGATTTGTGAGGCCAGTCTACAAAGTGAGTTCCAGGACAGC 1201 CAGGGCTACACAGAGAAACCCTCTCTCGAAAAACAAACAAAAAGCAAAACAAACAAACAAACAAACAAAAAAACACTGGC 1281 TGCCCTGGCTGTAGATCCAGGTTCAATTTCCAGCATACACATGGCAGTGCACAGCCATATGAAACTTCTGCTACAAGATA 1361 TCCAACTCCCTCTTCTGGCCTCTGTGGTCACTGCACTCAAGTTATACGTAGACATACACGCAGACAAAATATCATGCATA 1441 TTAAACTAATAATTTTCAACGAGTGGAAAGATTTATAGAGAAAGGTGGTGTTGTATTTCCTTTTCTCCAAAAATGTAATG 1521 TCTAACAATGAAGATAAAGATTCTCACCTG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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114 mmu-miR-1186a Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT579774 | Zfp568 | zinc finger protein 568 | ![]() |
1 | 1 | |||||||
MIRT580629 | Sycp2 | synaptonemal complex protein 2 | ![]() |
1 | 1 | |||||||
MIRT582212 | Nfatc3 | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 | ![]() |
1 | 1 | |||||||
MIRT582800 | Kcnmb2 | potassium large conductance calcium-activated channel, subfamily M, beta member 2 | ![]() |