miRNA Infomation
miRNA namemmu-miR-1186a

Gene Information
Gene Symbol Ubxn2a   
Synonyms 6330407P03Rik, Ubxd4
Description UBX domain protein 2A
Transcript NM_145441   
Expression
Putative miRNA Targets on Ubxn2a
3'UTR of Ubxn2a
(miRNA target sites are highlighted)
>Ubxn2a|NM_145441|3'UTR
   1 TAGTTTTTATTTTTGAGAGACTGAGAAAAATGATGGTTGCAAGTAGACATGCAGAGTGGGAGACAGAAGTCAATGTGACT
  81 AAACTTGCGGTTTGAGGGCTTCTCAATCCCTTATGAGGGGGTTCAGTCGTCACAAGCTAGGAGAGTGACATGGCTCTAAG
 161 CCAGGGTCAGTGCATTTTTCTCAACAGGCTATTCAGAAAAAAATACCTATTTTTCAAATATTAGTTAGCCAATATGACAT
 241 TAAATAGCTGTGTCATTAATCTTAATGTGGTCTAAATTAGCAGAGTATTCAATTAGCTAAATCAGCATCAGCATTCAAAT
 321 ATTATCTCCAAACAGCAGATATTTATATAAATGTTAGCTATCTCAGTTTTTAAATAGCAATACATCAAAATATTATCCAT
 401 GCCATATTAAAAGCATCAATGTAGTTATTGCCCGTGCTTCATCCTCGGAGCTTTTCAGTTTCTACTTGTGATGGCAAAAG
 481 ATACTCAAATACTCATTTGGCAACAGTATCCAAGATGTAGACTCTTCTCGGAATAAAATTGTGTAGCTTAGTATAATATC
 561 AATACTAATCTATATACACAGTTTTCTATACCTTCTACATGTAATTTTATGGACTGGGAATGTAGTTCAGTGGTAGGGAT
 641 TATTTGCCATACATACATGAGACTAGTTTAAATCCATCCCAGCACTACAAAAAAATCCTTTCAATTTGTAATGTAAAAGC
 721 ACACACAAAAAAAATTCTTCAAAGCTGGGTGGTGGTAGTGGCAAAGCAGGCCTTTAGTTTAATCCTAGCACTTTGGAGGC
 801 AGAGGCAGGAGGATCTCTGAGTTCAAGGACAGCCTGTCCTACAGAGCTAACTAACTTCCAGGGTTACACAGAGAAACCCT
 881 GTCTAGAAAAAACTATAGAAAAGTTTTCAAATCTTTACTCATTTAAAAGGAACTTTGAAACTGCCCACAGGTGTATGCCC
 961 TAGCTCTAGCTCACACCAAGCTGAGAGGAGAGGAGCCCAGGAGTTTGGTCAGCATAAGAGACATAGCAAAACCCTGTCTC
1041 TTGATAGTAACAACCTTCCCACCCGGAGACATAGATGGCTCAGCTGTTAAGAACACTGGCTGCGCCAGGCGGTGGTGGCG
1121 CACGCCTTTAATCCCAGCACTCGGGAGGCAGAGGCAGGTGGATTTGTGAGGCCAGTCTACAAAGTGAGTTCCAGGACAGC
1201 CAGGGCTACACAGAGAAACCCTCTCTCGAAAAACAAACAAAAAGCAAAACAAACAAACAAACAAACAAAAAAACACTGGC
1281 TGCCCTGGCTGTAGATCCAGGTTCAATTTCCAGCATACACATGGCAGTGCACAGCCATATGAAACTTCTGCTACAAGATA
1361 TCCAACTCCCTCTTCTGGCCTCTGTGGTCACTGCACTCAAGTTATACGTAGACATACACGCAGACAAAATATCATGCATA
1441 TTAAACTAATAATTTTCAACGAGTGGAAAGATTTATAGAGAAAGGTGGTGTTGTATTTCCTTTTCTCCAAAAATGTAATG
1521 TCTAACAATGAAGATAAAGATTCTCACCTG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Leung AK; Young AG; Bhutkar A; Zheng GX; et al.
- Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
114 mmu-miR-1186a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT579774 Zfp568 zinc finger protein 568 1 1
MIRT580629 Sycp2 synaptonemal complex protein 2 1 1
MIRT582212 Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 1 1
MIRT582800 Kcnmb2 potassium large conductance calcium-activated channel, subfamily M, beta member 2