pre-miRNA Information | |
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pre-miRNA | mmu-mir-741 |
Genomic Coordinates | chrX: 66796805 - 66796875 |
Description | Mus musculus miR-741 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-741-3p |
Sequence | 45| UGAGAGAUGCCAUUCUAUGUAGA |67 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Zfp780b | ||||||||||||||||||||
Synonyms | B230208L21Rik | ||||||||||||||||||||
Description | zinc finger protein 780B | ||||||||||||||||||||
Transcript | NM_001081021 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Zfp780b | |||||||||||||||||||||
3'UTR of Zfp780b (miRNA target sites are highlighted) |
>Zfp780b|NM_001081021|3'UTR 1 AATCCATATTGATAAGAATCCTCATGAATGTAGTGAATGTGGGAAGTACTTTACACATGGCAGAGATGTTAAAGTACATC 81 AAAGCATTCACACTGGTGACAAACTCACAGTGTTAAGAACGTGGGAAGACTTAGTTGAATATGAAACTTGTTTTGACATT 161 ATACATACATTAATAAGAAGTCATGATGTAAGGAAAATGAAAGGCCTACAGTAAATTCTAAGCTAGCGAGCTGTATATCA 241 GAGAATTTCTACTGATGAGAAATTCTATGAATATGAGTAAGGTGGCAAAATGTTAAGATTTAGTTCAGCCTTCATGCACA 321 GTGGCAAGTTCATATCGGTAATCAACCCTATCGCTGTAAAGAATGTGCCAAGAGCTCTAATTGGAACTTAGATCTTCAAA 401 ATCAAGGAAGCCATGCTGGCTTCAAATACAGTGAATACAAGGAATGTGGGGACATTTATAGAATTAGCTGTTAAAGCTCA 481 TCAGAGAGTCCCTGTAGGTCTGAAATCCTGTGACGATGAAGACTCAGGAAAAGCCTTTATTGCAAATGGGTGAGCTTATA 561 CAGCCTGAGAAAATCCATACTCTCCAGGAGGCCTGCGAGTGTAGGCAAGGAGGACAAGCCAGTGGATGAAAATGTGACTG 641 GACACCAGAGAACTCATATTGGGAAGGTTGTGACTTAAAAGAATGTGGGAACTTTAATCTGTCCTGGGAATTGGTCAACA 721 TCAAAAGAATTCATGTACTGTTGCTGCCAAGAAACCCTTTGGAATGGGTATGTGGAAAGTCGGTTGTTCAGAGAAGATAC 801 TCTGTTGCGAATGTCTTTTATTGTCAGAAATACAATGTAGTAATCATGATTTACTCTCATCTTGCTAGTTGTATAAACTT 881 AACTCACTCATTAGTCACCAAGGGCTGTCAACTAAGGGGGAGCAGTTACTGCAACTGTGTTTGCCGGAGATGCTCCCCAC 961 CCCCCATGGTTCCTGAGATGGTGGAGCACATGTTTACTTTTTGCATAATTTGTTAATGGCCAGCACAGGACCAGCCAAAG 1041 TTATGGCAACAGAGTTATAATAGAAAATAAAGTCCTTGACAATATTGGTCAGTGCCCATGTTCTATAATACAGCTTTTAC 1121 ATAGTTCTAGTTTCATGAGCATTAGCATAACTGACATGGAAGCCTGATTGCACTGTAGATAGTTTAGGAAAGTCTCATGC 1201 TTTTACCCACTGTTAAGTTTTAAATAACTTTATTCTGAATACTTGTAATGGATGGTTAGGAACTTGAAAGTATTTGAATT 1281 GTGAGTCCATTTCTTAAGTATTTGTGTGTAAAGTTTTAAAACAATCATTGATGAATAAGAACTTTCTAAAAAGAGTAAAA 1361 ACTATAAAAAGTTCAAAAGTTAAAATCCTATTATTTGTGCCCTCTCCACACATGAAGATAAACTATATTTGTGATAGGAC 1441 AAGAAAGTTTTTGGATCTTCAATCTCTCTCTCTCTCTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGTT 1521 TTTTGAGACAGGGTTTCTTTGTATAGCCCTGGCTGTCCTGGAACTCACTTTGTAGACCAGGCTGGCCTCGAACTCAGAAG 1601 TCCGCCTGCCTCTGCCTCCGGAGTGCTGGGATTAAAGGCGTGTACATCCTCGCCCAGCCAATCTCTTATTTCTGAGAACA 1681 TTTTAACTTCAACTAGAATTTGATTCCCTCGATGGAGAATCTCATGGTATATCCAATTCTACTAGAGGTCAAATTGCCTC 1761 TGATAATTTATTGTGACTTCTTTTTAAACCTCCCACTCCAGCTATCTGTTTATCTTCATACTATTAAACTGCCTGCTTGG 1841 GCAAAAGCTCCCCCTGCAGCTGCTGAGCAAGATAATAGAATGTGGGTTTGTTCTAAATGCTTGGGATTATACTCCGGTCC 1921 CAAATACCTGAATGTACTCAGAGCTGGCTGGAATAAAGCCTTTCATTTGGCTCTACACTGTGTCTGAGTGGGCATCTCTA 2001 GTGAGCAACCTGTAACACCTTTACAAAATAGCCAGAGTGAAACTACTTATAAAAAAATATATGTGTGTTGTGGCCAGTCA 2081 GCAGCTCGCAACGAACGGTTCTACTGAGATGGCAACTCGGGCTGAAAGAGAAGAACTAGACGGGCGGAAGAAAGAACGAA 2161 GCCAAGTCAAAAGTCTGATCAAAGCTCCATTTTTACTGTTGCAACACTCAGTTATGAAGGAAGGGGGAGGGGACCCGATT 2241 CCCGCCAAATAATCTCGGATCCAGTAGCAGGGTGAGCACGTGATGGCTTCAGAACAGCAAGGCGGCAGGTTCTAGCAGTG 2321 GGCATGGCAGAACGAATGAGCAGGAAGCTCCACCCCAGAACAAGCAGGTTTCAGGCTGGGGGAGGGGAGACTACATATGT 2401 GCAATTTTTCATCCATGTTGAAAGCTTGGAATATTCAATACACATCTGTATCCTCACCTAGATTGAAAATTGTCAACAAT 2481 TTACAAGGTTGATCCTGTTTTTCTGTGTATATAGGTTTGGGGATGCACCATTAATATGTTTTAGAACTGAATATGGCAAA 2561 GCATATCTGAATCCTAGTTATTATAAAGATGAATTAGGAGAATCAAGAGTTGGAGGCAAGGGGCTGGAGAGATGGCTCAG 2641 TAGTTAAGAGCACTGACTGCTCTTCCAGAGGTCATGAGTTCAATTCCCAGGAACCACATTGTGGCTCACAGCCATCTGTA 2721 ATGGGATCTGATGCTCTATTCTGGTGTGTCTGATGATATCTACTCACATAAATAAATAAATAAATAAAAAACAAATAAAT 2801 AAATAAATCTTAATTAAAAAGAGTTGGAGGCAAGCCTAGCTATATAATGACTTTAAGTCCAGTTAAGGCATTATAGAGAC 2881 CCCTATATTTAAAAAAAAAAAAAAGACA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | mESCs |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM622572. RNA binding protein: AGO2. Condition:WT2
HITS-CLIP data was present in GSM622573. RNA binding protein: AGO2. Condition:KO1
HITS-CLIP data was present in GSM622574. RNA binding protein: AGO2. Condition:KO2
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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70 mmu-miR-741-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577358 | Zcchc9 | zinc finger, CCHC domain containing 9 | ![]() |
1 | 1 | |||||||
MIRT577968 | Pla2g4f | phospholipase A2, group IVF | ![]() |
1 | 1 | |||||||
MIRT578333 | Lyrm7 | LYR motif containing 7 | ![]() |
1 | 1 | |||||||
MIRT580150 | Ubap2 | ubiquitin-associated protein 2 | ![]() |
1 | 1 | |||||||
MIRT580536 | Tcte1 | t-complex-associated testis expressed 1 | ![]() |
1 | 1 | |||||||
MIRT581216 | S1pr3 | sphingosine-1-phosphate receptor 3 | ![]() |
1 | 1 | |||||||
MIRT581676 | Ppp2r2c | protein phosphatase 2, regulatory subunit B, gamma | ![]() |
1 | 1 | |||||||
MIRT583764 | Epas1 | endothelial PAS domain protein 1 | ![]() |
1 | 1 | |||||||
MIRT583808 | Eif4e2 | eukaryotic translation initiation factor 4E member 2 | ![]() |
1 | 5 | |||||||
MIRT584890 | Ank1 | ankyrin 1, erythroid | ![]() |
1 | 1 | |||||||
MIRT587270 | Fam161b | family with sequence similarity 161, member B | ![]() |
1 | 1 | |||||||
MIRT587313 | Epb4.1l5 | erythrocyte membrane protein band 4.1 like 5 | ![]() |
1 | 1 | |||||||
MIRT587704 | Cd38 | CD38 antigen | ![]() |
1 | 2 | |||||||
MIRT588808 | Srgap3 | SLIT-ROBO Rho GTPase activating protein 3 | ![]() |
1 | 2 | |||||||
MIRT589434 | Nhsl2 | NHS-like 2 | ![]() |
1 | 3 | |||||||
MIRT589731 | Kcnj2 | potassium inwardly-rectifying channel, subfamily J, member 2 | ![]() |
1 | 1 | |||||||
MIRT592014 | Tyw3 | tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) | ![]() |
1 | 1 | |||||||
MIRT592469 | Rpusd2 | RNA pseudouridylate synthase domain containing 2 | ![]() |
1 | 1 | |||||||
MIRT592881 | Srd5a3 | steroid 5 alpha-reductase 3 | ![]() |
1 | 2 | |||||||
MIRT592882 | Six2 | sine oculis-related homeobox 2 | ![]() |
1 | 2 | |||||||
MIRT592937 | Bhlha15 | basic helix-loop-helix family, member a15 | ![]() |
1 | 3 | |||||||
MIRT593014 | St8sia1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | ![]() |
1 | 2 | |||||||
MIRT593066 | Ddr2 | discoidin domain receptor family, member 2 | ![]() |
1 | 1 | |||||||
MIRT593164 | Fmo5 | flavin containing monooxygenase 5 | ![]() |
1 | 2 | |||||||
MIRT593184 | Asap2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | ![]() |
1 | 2 | |||||||
MIRT593252 | Wfdc13 | WAP four-disulfide core domain 13 | ![]() |
1 | 2 | |||||||
MIRT593276 | Prrx1 | paired related homeobox 1 | ![]() |
1 | 2 | |||||||
MIRT593280 | Kynu | kynureninase (L-kynurenine hydrolase) | ![]() |
1 | 3 | |||||||
MIRT593375 | Nab2 | Ngfi-A binding protein 2 | ![]() |
1 | 2 | |||||||
MIRT594244 | St8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | ![]() |
1 | 1 | |||||||
MIRT594280 | Prkca | protein kinase C, alpha | ![]() |
1 | 1 | |||||||
MIRT594582 | Zfhx3 | zinc finger homeobox 3 | ![]() |
1 | 1 | |||||||
MIRT596747 | Vav1 | vav 1 oncogene | ![]() |
1 | 1 | |||||||
MIRT597032 | Thada | thyroid adenoma associated | ![]() |
1 | 1 | |||||||
MIRT597262 | Slc25a42 | solute carrier family 25, member 42 | ![]() |
1 | 1 | |||||||
MIRT597402 | Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | ![]() |
1 | 1 | |||||||
MIRT597467 | Rgs20 | regulator of G-protein signaling 20 | ![]() |
1 | 1 | |||||||
MIRT598650 | Iars | isoleucine-tRNA synthetase | ![]() |
1 | 1 | |||||||
MIRT598979 | Gadl1 | glutamate decarboxylase-like 1 | ![]() |
1 | 1 | |||||||
MIRT599097 | Edem1 | ER degradation enhancer, mannosidase alpha-like 1 | ![]() |
1 | 1 | |||||||
MIRT599155 | Dkk1 | dickkopf WNT signaling pathway inhibitor 1 | ![]() |
1 | 1 | |||||||
MIRT599398 | Chst3 | carbohydrate (chondroitin 6/keratan) sulfotransferase 3 | ![]() |
1 | 1 | |||||||
MIRT599633 | BC052040 | cDNA sequence BC052040 | ![]() |
1 | 1 | |||||||
MIRT599637 | BC048403 | cDNA sequence BC048403 | ![]() |
1 | 1 | |||||||
MIRT599952 | 9330159F19Rik | RIKEN cDNA 9330159F19 gene | ![]() |
1 | 1 | |||||||
MIRT600131 | Zfp780b | zinc finger protein 780B | ![]() |
1 | 1 | |||||||
MIRT600221 | Trim67 | tripartite motif-containing 67 | ![]() |
1 | 1 | |||||||
MIRT600517 | Prkce | protein kinase C, epsilon | ![]() |
1 | 1 | |||||||
MIRT600603 | Myo5a | myosin VA | ![]() |
1 | 1 | |||||||
MIRT600626 | Mrc2 | mannose receptor, C type 2 | ![]() |
1 | 1 | |||||||
MIRT600914 | Faim2 | Fas apoptotic inhibitory molecule 2 | ![]() |
1 | 1 | |||||||
MIRT600973 | Dlc1 | deleted in liver cancer 1 | ![]() |
1 | 1 | |||||||
MIRT601388 | Vamp5 | vesicle-associated membrane protein 5 | ![]() |
1 | 1 | |||||||
MIRT601755 | Rasgrp1 | RAS guanyl releasing protein 1 | ![]() |
1 | 1 | |||||||
MIRT601906 | Padi2 | peptidyl arginine deiminase, type II | ![]() |
1 | 1 | |||||||
MIRT601957 | Nf2 | neurofibromin 2 | ![]() |
1 | 1 | |||||||
MIRT601985 | Mylk4 | myosin light chain kinase family, member 4 | ![]() |
1 | 1 | |||||||
MIRT602477 | Dnajc1 | DnaJ heat shock protein family (Hsp40) member C1 | ![]() |
1 | 1 | |||||||
MIRT602478 | Dmbx1 | diencephalon/mesencephalon homeobox 1 | ![]() |
1 | 1 | |||||||
MIRT602774 | Armc2 | armadillo repeat containing 2 | ![]() |
1 | 1 | |||||||
MIRT602881 | 4931428F04Rik | RIKEN cDNA 4931428F04 gene | ![]() |
1 | 1 | |||||||
MIRT602949 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT602996 | Qk | quaking | ![]() |
1 | 1 | |||||||
MIRT603591 | Bloc1s6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin | ![]() |
1 | 1 | |||||||
MIRT603895 | Ifi203 | interferon activated gene 203 | ![]() |
1 | 1 | |||||||
MIRT603911 | Homez | homeodomain leucine zipper-encoding gene | ![]() |
1 | 1 | |||||||
MIRT604573 | Ube2v2 | ubiquitin-conjugating enzyme E2 variant 2 | ![]() |
1 | 1 | |||||||
MIRT605235 | Agpat5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) | ![]() |
1 | 1 | |||||||
MIRT605416 | T2 | brachyury 2 | ![]() |
1 | 1 | |||||||
MIRT606761 | Ncam1 | neural cell adhesion molecule 1 | ![]() |
1 | 1 |