pre-miRNA Information | |
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pre-miRNA | mmu-mir-203 |
Genomic Coordinates | chr12: 112130880 - 112130955 |
Synonyms | Mirn203, mmu-mir-203, Mir203 |
Description | Mus musculus miR-203 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations. |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-203-3p |
Sequence | 48| GUGAAAUGUUUAGGACCACUAG |69 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Rs1 | ||||||||||||||||||||
Synonyms | Rs1h, Xlrs1, tmgc1 | ||||||||||||||||||||
Description | retinoschisis (X-linked, juvenile) 1 (human) | ||||||||||||||||||||
Transcript | NM_011302 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Rs1 | |||||||||||||||||||||
3'UTR of Rs1 (miRNA target sites are highlighted) |
>Rs1|NM_011302|3'UTR 1 TGTCTATTTCAGCTCAGTTCTGTCACTTGCAGGGAGAGCTTTGGGGGGAGGGCACCCTGAAATACCACTGGGATGAATGG 81 GGCTATATCTTATAAGCACTTTACAATGTAGATCTGGGTAGAGAATATTTCACTTTTTAAAAGATAGTTTCAAATTTCAA 161 AGGGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAGCTTTTAAGCTTTTCTTCAACTCAGGGCCAAAGA 241 AAATAAGAACAAAGAAAGTATCTCTCAAACCAATTTTCTTACACAAACCCAAATAGCAGGGGTAATTTGCTGCTCTGGCT 321 CCCCATCTTTTTCTCTTTGTCTCAGTGACACCGTCAAAGGTGCAGGCCCAGGGGAACACAAAGCAGCTCTGATAATTTGA 401 AAATTCTTTTTGGCTCTTAGCACATTCAGAAGAGGAGCGTACTCTTTGGCAAAGCCTCACATGAACACTTGCATGAAATC 481 CTCACTATAGAGGCCTGGTGACAAGTACATAGGTGTGAAGAAAGCAGAAGGAAGCCTGGCGTATGGCCCACGAGTCTGGA 561 GCCAGTAACCAACCAACCAACTAACCAACTAACCAACCAGTCAAGGCTTCCCCCTCCCTGGAATTGCTTTTGCCTGGAAG 641 GGGTGGAGCTCCTTGTGCAGAAACTCCATTCTACAGCCCTTTTGGCAATGTGTCCTTCTGTGATTGCCTGGAGATGAATG 721 CAAGGGGCAGGCTATATGTGTGTGTGGATAGTGAGGTTTCCCTTAAACTGAGGAAGCCCAAATAACTAGAATACATCACA 801 CCTTCTTTATCCATGGCTACAGTTTCCCAGAAATTGAACAGGCTTAGAAAACAGCTGAGATAAACCATATCTCTATCTAC 881 TGGGAAGAGATCATGCTTTGGGGGAAGGGGTTAGGACTCCTATCATAGAGGACTGTACACAGATGATCTGTCAGTAAAGG 961 GCTTGCTGTACAGCATAGGAACTTGAGATTATATTTCTAGAATGCATGTAAAAAGCTAGGTATGGACAGGTATGGTGGAA 1041 CATGCCATTAGTCTTAGTATTTGGAAGACAGAGGCAAGCAGATCTGAGTTCAGGGCCAGCCTGGTCTACATAGCAGTTCC 1121 AAGCTAGCCAAGGCTACACAGTAAGGCCCTGTTTCAAGAAAAAAAGACCAGGCATGGAGGGGCACACCTGCAAATCCAGG 1201 ACTAGGAGGCAGGCAGAGACAGGATGATGCCTAGAGCTTGTCTGCCAATCAGTACACTCCAGGTTCATGGTCAGACCCTG 1281 TCTCAAAACTAAAGTGAAGAGCTATTGAGGAAGATACCAGATGTCAACCTCTGTCCAACATGCACACATACACATACACT 1361 GGTAGGTTTCAAACCTGGGGCAAATGGCAGAGGTGCCTAGTTAAGGTTCTCCCAGCATCTCTCAGCCCCTACCAGGTCCT 1441 CCTAGTTGGCATACCCCGCCCCCTACCCCGAAACTCTTCAGCCCAGGGGGTTGGGCTTCTTCCCTATATAATCCAACTAT 1521 TTTGGTCACCCTTTCTCTTTGTACCTTTGGGCCTCCTGGTTGCTGCATCTGGTTCCTCTGTTCTCCCTTATCTCTTTTCC 1601 TCCCTCCTCTCCTCACAAGGCCCAGCTTAGAGTGTTCATGTCTATTCTGGACTCTCTCCCGGATGCCCCTGCCTCTGGCT 1681 ATGCTCTCCCACATATCTACCATAAACTCTCTCCTCTACCATACCTAGGACAAGTCATGTTCCTTTCCTTTTCCTTTTTG 1761 TTTCCCATTCAAACATGTAAATAGGAAAAACAAAATACAACAACAACAAACAAAAATAAAACCACAAAAGCCTTCTCTCC 1841 GAGCGGCTTCCTCCCGTCCTGCCCACCCAAACATGCTTACTCAGACATGACATTTGAAACTTCTTTCGGTAGTCATTCTC 1921 TGGCAGGAATAGCTCATTTAATCAGGAGCTTTGGAGCCTGAGAGAATGACTACTGGTCTCTAGCTCATTTCCATCTGTAG 2001 CTCAAGCTGGGTTTGAGGCTCTTCTCTGGGAGAGGCTGTTAACTGGAGTGAGGGTCAAAAAGGCATGCGGGGAGAAGCTG 2081 AGAATGAGAACTGCCCAGAGACAAGGTCTTGGCCTCACACACACACAATACAGCCTTGGTTAGTACTTTTCTCTGAGCTA 2161 TTTTCTATTTCCAGGTATTAAAGGAGATTACATGGATTCACACCAAAATAACTTTGGATGGCCAGACATGGTATCTTCCA 2241 TCTTTAATCCTAGCACTGGGAAAACACAGACAGGTGGATCTCTGTGAGTTCAAGGCCAGGTTTGCATAGCAAGCTCCAGA 2321 CCAGCCAAGGCTATGTAGTGAGACTGTCTCAAAAATCAATCCATCAATCAAATGATCTTGGATGTCACATTCTTCTCAGT 2401 GAATAGAACAACATTTTAATAGCATCAAATTTCCTACCTAGTATTTTGGAGTTCCACAGGTGTGTGTGTATGTGTGGCAA 2481 TGTACAACAATATTCCTGGTATGACTACATATGTACAAATTCATTTTGGATAATATTCCTGACAGCAGACCTTTATTTGG 2561 AAAATTGAGTTACCTTTCTCACCACACTGAGTAATTGTTAGAGAAAAATGGCAATAACTTAAGAATACTGATCAGGGAGA 2641 AAAAAACCCAAATGGTACAAGGCATGGGTAAATAGTCATCAAATTAAAAAATCATGCCATAAATTTGTTTTCTAATAGTT 2721 TCATTAACTTCACATAAACAGTCCTAATTCATTTAAGGTGTGTAATTCAATATAGTATATTCAAACTTGAACAATCATCA 2801 CTACAAGTAACTTTAGACTATTCTTATCACCCCCAAGAGAATCCTCTAACAATGGGCCATCAGCCACCACAGCTCTAGAT 2881 TACTCGTCATCCATTTTCTATTTGTGTGTGGATTTTTTTTCCATTCTGGGCATTTCTCCACACAAATGGAATCTTAGAAT 2961 ATATAGTAGTTTATGACTTGTTTCTTGTACTTATCATAGTGTTTTTAAAGTCCATGTGTTGGAGAAGTACATCCTCCTTT 3041 TTTGTTATTAACATTCTGTGTAGGGTATTGTATTATTATTTATCCATGCATTTGGGTGGGGCTAGTATGAATAATGCTGC 3121 TTCATGAAAATTTATATGTAAGTTATTGCGTGGACATGTTTTATCTTGGGCATACTCACACTGAGAATAGAGAATTGTTG 3201 GGTCTCTTGGGAACTATTTCTCCAGGTGGCTGTACCATCTTCTGTTCCCACCAGCAATGTCTAATGCTTCCAGCCTCTCA 3281 TCTTTAGCAATGCTTCTTGTATTTCATTAGATCTGTCCTAGTATGTATGAAGTAGCATTCGATGATGAATTTGATTTGCA 3361 TTTCTCTAATAACCAATGTTTTTTGAGCATCTTTTCAAGTCACCAGTGACATATTTTTGGAGAAAGTTCTATTCAGACCC 3441 TTGCCCATATAAAGATTTCATTTCACGGATTCATTAAGAGTTCTTTGGGTGTTCTACATACAATTCTCTTATGCAAACAT 3521 TTCTTCCATCCTGTTTTTCTTCTTGTCATTGTCTTGGTTTAGTTTTGCACCAGGATTTCACTATGTAGCTCAGGCTGGCC 3601 TGGAACTTGCAAAGATCCTTCTGTCTCTGCCTCCCAGGTTCTGAGATTCTGGGTATTTGCCACCACACCTGGCCTTTCTC 3681 TGAAGCACAACAAATACCAAATTTTAATGAAGTCCAACCTTCCGGTTTCCTTTTTTGGTGTATTATCTGAGAAACTACTG 3761 TCAAACCATGGTCAAGAAGATTCACTCTTGTGTTTTCTTCTAAATGTTTTGAAAAAAAATTTTTAAAAAGTTTTAAAGTT 3841 TTAACTCTTACTTTGTGAACAGTTATAAAGTAAGGGTGTAATTTCATTCTTTGGATATCAATATGCAGCTGTCTTGGTAG 3921 CTTGTGTTGTCTTCACCACAGTCAATGGTCTTTATTCTTCCAAAAACAACTGACCAAGAATATTAGAGTATATGCTAGGC 4001 CTCATAATTCTATTACCACATAGTCTTCATTACTGTAGCATTGTAGTGAGTTGTGGAATTAGGACATATAAATCTTCCAA 4081 TTCTGGTTATGTTTCAAGACTGAACTAACTATTCTGGGTTCCTTAAACTTCTAAGTAAGTATATCTGTAAATAAGCCAGC 4161 CAGGGGTCTCACAATGGAAAATGTTTTCAATTTCAAAATTAAATAAACAATGAGATATTAAGATCTGCAAGATATTTATC 4241 TGTAGTTAATTTTCTTTCAATAGTTAATGAAAATGTTAGCATTTTCTTCCTTTTGTGTTAGGATATATATATAAAAGAAA 4321 CCCTATTATTAAAGTAAACCTGAAAAAGAATCTTCCTATTAAACAAAAAATATGTTTGCAATATTATTTCTTTTAGGGGG 4401 CAACTAATTCAATAAAGATTATATAATGGAGGAAAGTCATTCCTATCTTAACACATTTTGTTTATTTTTACCACTAGACT 4481 TTGGGTTATTAAGGATTTTATTTTTTATGGTTTTGAGGACATAACCCAGGTTTTTCATACATGGTAGGCAAATACTCTTC 4561 AATTGAGTTCTCTCTGCAGCCTGCAGATCAAAACAAAACAAAACATTATGGTAAAGCATAACAATTTACATACTTTTAGT 4641 TAACTGTGAAGCATTAAATAATGATATTAAGAAAAAAATGGAAGTAATCCTGGTAGTTGATGTGGGAGGTTATATAGTGT 4721 GGTGGTTTGGATATGCTTGGCCTATTAGGAGGTGTGGCTTTGTTGGAGTAGGTGTGGCCTTGTTGGAAGAAGTACATCAT 4801 TGTGGGAGTGGGCTTTGACACCCTCCTCCTCGCTGCCCGAAAGACAGTATTCTGGCTACCTTTGGATCAAGATATAGAAC 4881 TCTTGGCTCCTTCTCCAGCACCATGTCTGCCTGCATGCTGTTGGCTAGGATGATAATTGACTAAACATCTGAAACTGTAA 4961 GCCAGCCCCAATTAAATGTTGTCTTTCTAAGAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Brain (Mouse neocortex) |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_BrainC_130_50. RNA binding protein: AGO. Condition:Brain C 2A8 P13 130 KD
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | mESCs |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM622570. RNA binding protein: AGO2. Condition:WT1A
HITS-CLIP data was present in GSM622572. RNA binding protein: AGO2. Condition:WT2
HITS-CLIP data was present in GSM622573. RNA binding protein: AGO2. Condition:KO1
HITS-CLIP data was present in GSM622574. RNA binding protein: AGO2. Condition:KO2
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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34 mmu-miR-203-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT004247 | Trp63 | transformation related protein 63 | ![]() |
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4 | 3 | ||||
MIRT004268 | Zfp281 | zinc finger protein 281 | ![]() |
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2 | 1 | ||||||
MIRT053248 | Snora62 | small nucleolar RNA, H/ACA box 62 | ![]() |
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2 | 1 | ||||||
MIRT053309 | Cav1 | caveolin 1, caveolae protein | ![]() |
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2 | 1 | ||||||
MIRT437354 | ZNF148 | zinc finger protein 148 | ![]() |
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4 | 1 | ||||
MIRT437361 | Rbm44 | RNA binding motif protein 44 | ![]() |
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3 | 1 | |||||
MIRT577405 | Ung | uracil DNA glycosylase | ![]() |
1 | 3 | |||||||
MIRT579086 | Commd10 | COMM domain containing 10 | ![]() |
1 | 1 | |||||||
MIRT579797 | Zfp300 | zinc finger protein 300 | ![]() |
1 | 1 | |||||||
MIRT580486 | Thsd7b | thrombospondin, type I, domain containing 7B | ![]() |
1 | 1 | |||||||
MIRT580726 | Srsf12 | serine/arginine-rich splicing factor 12 | ![]() |
1 | 1 | |||||||
MIRT580745 | Srek1 | splicing regulatory glutamine/lysine-rich protein 1 | ![]() |
1 | 1 | |||||||
MIRT582530 | Mapk8 | mitogen-activated protein kinase 8 | ![]() |
1 | 1 | |||||||
MIRT582806 | Katnal1 | katanin p60 subunit A-like 1 | ![]() |
1 | 1 | |||||||
MIRT582851 | Itga4 | integrin alpha 4 | ![]() |
1 | 1 | |||||||
MIRT583438 | Frmd3 | FERM domain containing 3 | ![]() |
1 | 4 | |||||||
MIRT583523 | Fgf16 | fibroblast growth factor 16 | ![]() |
1 | 1 | |||||||
MIRT584165 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT584578 | Bnc2 | basonuclin 2 | ![]() |
1 | 1 | |||||||
MIRT584898 | Alkbh5 | alkB homolog 5, RNA demethylase | ![]() |
1 | 1 | |||||||
MIRT585047 | Ptchd4 | patched domain containing 4 | ![]() |
1 | 2 | |||||||
MIRT585735 | Stxbp4 | syntaxin binding protein 4 | ![]() |
1 | 1 | |||||||
MIRT586903 | Hist2h2be | histone cluster 2, H2be | ![]() |
1 | 1 | |||||||
MIRT587655 | Ces2g | carboxylesterase 2G | ![]() |
1 | 1 | |||||||
MIRT590502 | Uri1 | URI1, prefoldin-like chaperone | ![]() |
1 | 1 | |||||||
MIRT592154 | Pcdhb19 | protocadherin beta 19 | ![]() |
1 | 1 | |||||||
MIRT593932 | Cyld | CYLD lysine 63 deubiquitinase | ![]() |
1 | 1 | |||||||
MIRT595081 | Zmiz1 | zinc finger, MIZ-type containing 1 | ![]() |
1 | 1 | |||||||
MIRT595094 | Tlr4 | toll-like receptor 4 | ![]() |
1 | 1 | |||||||
MIRT595712 | Ccdc110 | coiled-coil domain containing 110 | ![]() |
1 | 1 | |||||||
MIRT595800 | Cp | ceruloplasmin | ![]() |
1 | 1 | |||||||
MIRT600445 | Rs1 | retinoschisis (X-linked, juvenile) 1 (human) | ![]() |
1 | 2 | |||||||
MIRT604774 | Prkcb | protein kinase C, beta | ![]() |
1 | 1 | |||||||
MIRT606394 | Gtpbp3 | GTP binding protein 3 | ![]() |
1 | 1 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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