miRNA Infomation | |
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miRNA name | mmu-miR-1194 |
Gene Information | |
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Gene Symbol | Mzt1 |
Synonyms | 2410129H14Rik, AI120158, Mozart1 |
Description | mitotic spindle organizing protein 1 |
Transcript | NM_175245 |
Expression | |
Putative miRNA Targets on Mzt1 | |
3'UTR of Mzt1 (miRNA target sites are highlighted) |
>Mzt1|NM_175245|3'UTR 1 CTTCCAGAGAATTCCTGATGAGATATGTCAAGCTTAGCAAGAAAATTTGAAGATTCCATCATAGTCAAGATATAAAATGA 81 CAATGCTGCATGCTGAGTAGAAAATGTTTTCTTTTACAAAGAATTATAAAACCATGGCTGAGCATGTCAGTGGGAAGTGG 161 CTTGAGCGAGAATCAGCACGTGTGTTTACATCACGTCTTGTTGTAATGGCCCCAACTCCAGAGTGTTGCCACACTTATTT 241 ATGTATATTTATAGCTCTGCTAGCTGTGAGTTTCTAAACAGCATCTACCCGACATGCACAGCTGCTGAGCCTGTTTGAAG 321 TTAGTGGGTTGTATCAGAGGTGATGTGTAGTAGTTATGACTTGTTGACATTACCAATATAAACCTTAATTTTGAATTGTT 401 TAAGCATAAAAACTGGCTGTGTGTTCCATTGAGCTGTAAGTTAATGGAATTTGAGCTGCTGTTTGTGAAGTTTTCTGTTT 481 CACATCTTGTTTTTAAAAATAGGATCCAAAACATCTCAAATCATCTCCTTAACAGAATATTTTGTTTTTTACCCAGTTTT 561 TGGCAGTTAAAGGTGTAAAGAAGATCATTTTTATATTGCCGAAAACTTAGAACTTTTAGAAACTTGGATTTTTAAAAAGG 641 AATGCCAGGGCTTGACTTAGCATTATTTGTAGTTTGAACCATTAAAATCTAATAAGAACAGCTGAAATGCATTTCTCTGT 721 AAATCTTATAACCACATAAAGGTCCACAAAATAATGTATGAAGTGAAAACAGCAAACATACAAAATTCCTTTTTAATGTT 801 ATTGCATAAAAACAATAAGCTTACTAGCGAATCTTGAGTGGCTATTAAGTCAGTACATAGGTGGTGTATTTCAACAGATT 881 AATTCATGTTTTCTAAAGAAGTAGGATTTCCAGTTGTTCAACAAAAACTAATGAAATATGTACCAGTATTATTTGCAGAA 961 AATGTTTGTAATTTTTACCATTAAAGCTTTTAACTCATTAAAATGATGGTCAAAGATAAATTTGAAAAGCTGGATGGAGT 1041 TGCTTCTGCCCCTGTTACAGAATCTCAGTGGGATATTTTCATGAGCTCAGTGTGTATTTAATCTGAATTTTTTGATTCTT 1121 AAATTGTTTTTGTTTTGTTTTGTTTTGTTTTTCAAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACTCATTCT 1201 GTAGACCAGGCTGGCCTTGAACTCAGAAATCCACCTGCCTCTGCCTCCCAAGTGCTGGGAGTAAAGGCATGCGCCACCAC 1281 CGCCTGTCTTGATTCTTAAATTTTAAGTTTGATTCCATGCCAACCCTTTTTTATTTCAGAGAAGCCAAGGTGGTTTTAAG 1361 CCACTTAGTAATGAAGTAGCTGTTTCCTCTGCTCTGAGACTCATCTCGTCTGCTGGTCAGTAGTCCCTGCTGTCAGAGGC 1441 TGAGGCCGAGGAACGGTGACTCGCAGGCCAGCGTACGCTGCTTAGGCAACAAAGTGAGACCTGATCTCTACAGACAAAAT 1521 CTTGATTGTGATTGTTTTGACTTTTTACATGTATGGCATCTTTACTAAGTAAATTGAAAGGTCTATTACAGGCATCTCTT 1601 CCAAGTTGGGAGACAGTAAGAACTTGTAAGAACCATTTGATTAGTGATATGCATATATTGTATATTATTTTTAAAATCAG 1681 AAAGTACTTTCTCAGATTTCACAGTTTGTATGTATTTCTAGACCACAGAGTTGGTTGGTAGTTTTATTTTTGATTTTGTA 1761 GATTAAGTTATGTGTGAAACAAACTAGGAAATTATATTTAGGAAAGATTATGTTTAGAGAGAACTTCCTAATTGTGTCAC 1841 ATTTTTAGATGTAAACATATTTTTAATGAGTACATAAGTAATATTTAAGAAACCAGCGATACATGTTTGTCACCAGTGAC 1921 AAAAATAAAATCATTTTGTGTTATTG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | mESCs |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM622573. RNA binding protein: AGO2. Condition:KO1
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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CLIP-seq Support 1 for dataset GSM622573 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | mESCs / KO1 |
Location of target site | NM_175245 | 3UTR | AGCCCUGGCUGUCCUGGAACUCAUUCUGUAGACCAGGCUGGCCUUGAACUCAGAAAUCCACCUGCCUCUGCCUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21258322 / GSE25310 |
CLIP-seq Viewer | Link |
39 mmu-miR-1194 Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577399 | Usp29 | ubiquitin specific peptidase 29 | ![]() |
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2 | 2 | ||||||
MIRT578645 | Gtf2h2 | general transcription factor II H, polypeptide 2 | ![]() |
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2 | 4 | ||||||
MIRT583791 | Elf1 | E74-like factor 1 | ![]() |
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2 | 2 | ||||||
MIRT585587 | Tox4 | TOX high mobility group box family member 4 | ![]() |
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2 | 4 | ||||||
MIRT585769 | Spg21 | SPG21, maspardin | ![]() |
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2 | 2 | ||||||
MIRT586369 | Pctp | phosphatidylcholine transfer protein | ![]() |
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2 | 6 | ||||||
MIRT586934 | H2-T24 | histocompatibility 2, T region locus 24 | ![]() |
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2 | 4 | ||||||
MIRT587278 | Fam154b | stabilizer of axonemal microtubules 2 | ![]() |
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2 | 2 | ||||||
MIRT589358 | Osbpl8 | oxysterol binding protein-like 8 | ![]() |
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2 | 4 | ||||||
MIRT591418 | Cd300a | CD300A molecule | ![]() |
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2 | 4 | ||||||
MIRT594881 | Lpar6 | lysophosphatidic acid receptor 6 | ![]() |
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2 | 2 | ||||||
MIRT594899 | Hs6st2 | heparan sulfate 6-O-sulfotransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT595087 | Unc5d | unc-5 netrin receptor D | ![]() |
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2 | 2 | ||||||
MIRT595608 | Jazf1 | JAZF zinc finger 1 | ![]() |
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2 | 2 | ||||||
MIRT595914 | Syne2 | spectrin repeat containing, nuclear envelope 2 | ![]() |
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2 | 2 | ||||||
MIRT596713 | Ybey | ybeY metallopeptidase | ![]() |
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2 | 2 | ||||||
MIRT597013 | Thoc6 | THO complex 6 | ![]() |
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2 | 2 | ||||||
MIRT597522 | Rbak | RB-associated KRAB zinc finger | ![]() |
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2 | 2 | ||||||
MIRT598050 | Nip7 | NIP7, nucleolar pre-rRNA processing protein | ![]() |
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2 | 2 | ||||||
MIRT598082 | Neu3 | neuraminidase 3 | ![]() |
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2 | 2 | ||||||
MIRT598528 | Itsn1 | intersectin 1 (SH3 domain protein 1A) | ![]() |
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2 | 2 | ||||||
MIRT598953 | Ggps1 | geranylgeranyl diphosphate synthase 1 | ![]() |
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2 | 2 | ||||||
MIRT598967 | Gata5 | GATA binding protein 5 | ![]() |
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2 | 2 | ||||||
MIRT599086 | Efcab4a | calcium release activated channel regulator 2B | ![]() |
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2 | 2 | ||||||
MIRT599348 | Commd7 | COMM domain containing 7 | ![]() |
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2 | 2 | ||||||
MIRT599554 | C3ar1 | complement component 3a receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT600166 | Xpo7 | exportin 7 | ![]() |
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2 | 2 | ||||||
MIRT600668 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
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2 | 2 | ||||||
MIRT600971 | Dlc1 | deleted in liver cancer 1 | ![]() |
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2 | 2 | ||||||
MIRT601455 | Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | ![]() |
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2 | 2 | ||||||
MIRT601502 | Tmem88b | transmembrane protein 88B | ![]() |
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2 | 2 | ||||||
MIRT601514 | Tmem151a | transmembrane protein 151A | ![]() |
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2 | 2 | ||||||
MIRT601558 | T2 | brachyury 2 | ![]() |
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2 | 2 | ||||||
MIRT601925 | Onecut3 | one cut domain, family member 3 | ![]() |
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2 | 2 | ||||||
MIRT601984 | Mzt1 | mitotic spindle organizing protein 1 | ![]() |
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2 | 2 | ||||||
MIRT602669 | Car5b | carbonic anhydrase 5b, mitochondrial | ![]() |
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2 | 2 | ||||||
MIRT603331 | Slc35d2 | solute carrier family 35, member D2 | ![]() |
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2 | 2 | ||||||
MIRT605546 | Ppp1r16b | protein phosphatase 1, regulatory (inhibitor) subunit 16B | ![]() |
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2 | 2 | ||||||
MIRT606291 | Nrcam | neuronal cell adhesion molecule | ![]() |
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2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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