pre-miRNA Information | |
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pre-miRNA | mmu-mir-664 |
Genomic Coordinates | chr1: 185242975 - 185243043 |
Synonyms | mmu-mir-664, Mir664 |
Description | Mus musculus miR-664 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-664-3p |
Sequence | 38| UAUUCAUUUACUCCCCAGCCUA |59 |
Evidence | Experimental |
Experiments | Illumina |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Emx2 | ||||||||||||||||||||
Synonyms | Pdo | ||||||||||||||||||||
Description | empty spiracles homeobox 2 | ||||||||||||||||||||
Transcript | NM_010132 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Emx2 | |||||||||||||||||||||
3'UTR of Emx2 (miRNA target sites are highlighted) |
>Emx2|NM_010132|3'UTR 1 AAGTCCAAACCCAATCCTACAAAAATGGACAGCACAGAGCAAGAAAGACAGGGAGAGGAGGGGAAGAAAAACCCTACAAA 81 ACAAAAACAAACTGCACACACATCCACCGAGAAAGGGAGAGAGGGAATCAGAGCAGTGACGCTCGCAGCAGACTTTGGAC 161 AGCGAGGGCACTGGACCGGGAACCGGCGCCGGGCCGGGCACCGCTTACAGGACAGCAGAGGACGGAGGCCCGATCATCAA 241 CATGCAACCCTCGTCTAAAGAGGCAGCTGAGTGAGTGAGAGAGACAGAGACTGGGAGGGAGAGAGAGGAATGAGAGAGAG 321 AGAGAGAGAGAATGAATGATCCTTGTGAGGCAAAGGCACATTCTGACAAGGGGAGCTGTCAGTCAAATGCCAAACCAGGG 401 AAACAAGATGATTGGCGGGTATTCCGCTTATCGAAGTCCATTTAGAAATGATAATGATTTTTTTTTTTGGAAAAAAAAAG 481 GCACAGGACTTTTAATTTTGCACTTCACAGTGTTTCCCCCTCATCTTTAATTAGAAATAACATACAAAATTCCATGTCTA 561 GCCCCATCCTACACCTGTTTCAAAACTTGAATTGCATGTAGCAGTTGTCGGGCGAATGGTGTCTAAAAACTGAATTGTAA 641 TTTTATTCCTCTTTTAAAGACAGGTTCTGTGTATTTTTATTTTTTATTTTTTTTCTGAGAAATGTTCAGTCTGTAAAAAC 721 ACTTTTTTGATACCTTCTATTGTCAAAGTGATTGTGAAAGCTAAACGAAGTAGGCTCGGAGATAGTGGTCCTCTGACAGA 801 GAAATGAGGGAGCAGGACTGGGATGGAGGGCGGGGGAGGGTGCCCCTGAGAAGAATCAGGACTCATGCTAGGGGTAAAAA 881 CAACCCACGATAAAAGACCCAAATTAATTCTATTTCTTGGATATTTCCTTTCCTAACATTCTGATACTTTAAATCACCAA 961 GTCAACTTTTCCTTTTAGTGGTTGGAGAGATTGACTGCATCCAGCCACTCATCATAATGGCCATTCAGAACTTTTAAGTC 1041 TGTCTATTGCAAAAGTGGAAGGAAGGACTGTATTTAATGGGGTGATGGTGGCGTGGCCAAGGACATGGGAGTTTTCAAGC 1121 ACTGAGTTTCTCTTCCAAGACCATAGACTTACTAAAGAGGGTTACAAATGCTTCCTTAGTGTCTTCTATACCAGATTGTA 1201 AATATTTTTGTGTTTTGTGTTAATTTGTTAGAATTCTAACACACTATATACTTCCAAGAAGTATGTCAATGTCAATATTT 1281 TGTCAATAAAGATTTATCAATATGCCCTCA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | ||||||||||
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miRNA:Target | ---- | |||||||||
Validation Method |
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Conditions | mESCs | |||||||||
Location of target site | 3'UTR | |||||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | |||||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM622573. RNA binding protein: AGO2. Condition:KO1
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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34 mmu-miR-664-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT577936 | Prl5a1 | prolactin family 5, subfamily a, member 1 | ![]() |
1 | 1 | |||||||
MIRT578554 | Hopx | HOP homeobox | ![]() |
1 | 1 | |||||||
MIRT579006 | Cyp19a1 | cytochrome P450, family 19, subfamily a, polypeptide 1 | ![]() |
1 | 1 | |||||||
MIRT579669 | 1200011I18Rik | GPALPP motifs containing 1 | ![]() |
1 | 1 | |||||||
MIRT580267 | Trim12c | tripartite motif-containing 12C | ![]() |
1 | 1 | |||||||
MIRT580632 | Sycp2 | synaptonemal complex protein 2 | ![]() |
1 | 1 | |||||||
MIRT580981 | Slc12a2 | solute carrier family 12, member 2 | ![]() |
1 | 1 | |||||||
MIRT581678 | Ppp1r3d | protein phosphatase 1, regulatory subunit 3D | ![]() |
1 | 1 | |||||||
MIRT582092 | Ogdh | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | ![]() |
1 | 1 | |||||||
MIRT582126 | Nr2c1 | nuclear receptor subfamily 2, group C, member 1 | ![]() |
1 | 1 | |||||||
MIRT583126 | Heca | hdc homolog, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT583594 | Fam78b | family with sequence similarity 78, member B | ![]() |
1 | 1 | |||||||
MIRT583662 | Fam160b2 | family with sequence similarity 160, member B2 | ![]() |
1 | 5 | |||||||
MIRT584399 | Cdc27 | cell division cycle 27 | ![]() |
1 | 1 | |||||||
MIRT584815 | Arid4b | AT rich interactive domain 4B (RBP1-like) | ![]() |
1 | 1 | |||||||
MIRT585915 | Slc16a9 | solute carrier family 16 (monocarboxylic acid transporters), member 9 | ![]() |
1 | 1 | |||||||
MIRT586057 | Rnmt | RNA (guanine-7-) methyltransferase | ![]() |
1 | 1 | |||||||
MIRT586080 | Rgs4 | regulator of G-protein signaling 4 | ![]() |
1 | 1 | |||||||
MIRT587942 | Atl2 | atlastin GTPase 2 | ![]() |
1 | 2 | |||||||
MIRT590595 | Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | ![]() |
1 | 1 | |||||||
MIRT590735 | Ado | 2-aminoethanethiol (cysteamine) dioxygenase | ![]() |
1 | 1 | |||||||
MIRT591492 | Aqp3 | aquaporin 3 | ![]() |
1 | 2 | |||||||
MIRT594084 | Scoc | short coiled-coil protein | ![]() |
1 | 1 | |||||||
MIRT594733 | Zfp62 | zinc finger protein 62 | ![]() |
1 | 1 | |||||||
MIRT595057 | Aldh1l2 | aldehyde dehydrogenase 1 family, member L2 | ![]() |
1 | 1 | |||||||
MIRT595113 | Rgs17 | regulator of G-protein signaling 17 | ![]() |
1 | 1 | |||||||
MIRT595239 | Rhbdl1 | rhomboid, veinlet-like 1 (Drosophila) | ![]() |
1 | 1 | |||||||
MIRT595762 | Otud6b | OTU domain containing 6B | ![]() |
1 | 1 | |||||||
MIRT595778 | Mc1r | melanocortin 1 receptor | ![]() |
1 | 1 | |||||||
MIRT596728 | Wdr59 | WD repeat domain 59 | ![]() |
1 | 1 | |||||||
MIRT598239 | Mlph | melanophilin | ![]() |
1 | 1 | |||||||
MIRT600005 | 4930563E22Rik | RIKEN cDNA 4930563E22 gene | ![]() |
1 | 1 | |||||||
MIRT602439 | Emx2 | empty spiracles homeobox 2 | ![]() |
1 | 1 | |||||||
MIRT736865 | Smad4 | SMAD family member 4 | ![]() |
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4 | 0 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||
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