pre-miRNA Information
pre-miRNA mmu-mir-741   
Genomic Coordinates chrX: 66796805 - 66796875
Description Mus musculus miR-741 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA mmu-miR-741-3p
Sequence 45| UGAGAGAUGCCAUUCUAUGUAGA |67
Evidence Experimental
Experiments Cloned
Putative Targets

Gene Information
Gene Symbol Dnajc1   
Synonyms 4733401K02Rik, AA960110, D230036H06Rik, Dnajl1, ERdj1, ERj1p, MTJ1
Description DnaJ heat shock protein family (Hsp40) member C1
Transcript NM_007869   
Expression
Putative miRNA Targets on Dnajc1
3'UTR of Dnajc1
(miRNA target sites are highlighted)
>Dnajc1|NM_007869|3'UTR
   1 ATCTTCTGGAAGGTGACGATCAATGACCATCATTTTCCAAACAAGTACTCGAGAAATCTCATGCAGAAACTTATATTTTG
  81 TACCTCAGTATTTCTAAACATCATGTGCCTTAGTAAAAAAAAGAAAGGAAGAAAGAAAGAAAGAAAAAGAGAGGGGGGGG
 161 AGAAAGAAAGAAAAAAAGAAAGAAAGAATGAATCAATTATAGATGCTGTAAGGTGCCATTTACAGGCCTTCCTTGTGTTT
 241 CCAGGGGAGAGTGTGGTGCCAAAAATATGAGGTCCTCTGTTGGCCAGCGAAGGAGGGAAAAACAGGTGCACCAGGTGGAA
 321 TTTGAGATAAAGCAAATAAGTTTGATTGTCAAATGAGAAATTTAAGCCTGGAAGGTGGTTCAGTGGATAAAACCGCTGAC
 401 TGCTAAGCCTGCCAGTCTGCACTCACTCTCCAGCAAGCACATGTTCACAGGAGCTGTCCTCTGACCTCTGCATTCATATT
 481 GTGGTACAGCACACACATCCGAGCCCACATAGACACATGCACATGAATACATGGATCTAAAATTTTTAAAGAATTTCTTG
 561 CTTTTGTTTGAAACTTGAAAACGCTTTGGGCTTGTTCTTCAGTTTTGTTGTGTTTTGGAGAGAATGCTTTGCTTTTGTGT
 641 ATGTCTGTGTACCAGAAGACGACATTGGATCCCATAGATCTGTTGTATGGATGGCTGTAAGTCACCATGTATGTAGGTGA
 721 TGGAAATTGAACTTCAGTCCAGCCCCTTGTTTGAAACTTTAGAAGGAAACTTCAAACTGCTGCCAAGCAAGAGATGTGCT
 801 CCACTGGCTACAGTGTGCTGTTTGTGGTCATGCCCAGTTCTACACAATGACACCTCAGTACCCAGTATGTTACTGTTAGC
 881 AGGTAAGGCCTCTCAGTGTGATGAGCTGTTGCCAAAACTCAATGTCTGCCCCTTCGCCTAAGGTCTCAAAGACAAACCAA
 961 CAACTCCAAAGTCCATGCAGGCTAACCTTATATAGTTTATATAGGGTTACTTACAGTGGATGAGGGCTTATGGGTTGGAG
1041 CAGAGGTGACCTTAAAGCAGCCACACTGGAAGGTCTGCAGCCGGAAGGGATGGTGTCTTCCCAAGGCTTCATTGAGGGAG
1121 CCAGCTTCCCTAATCCTTCCTACCTACAGAGTCTAACACCTTCCAGAGACCCTAAAGCACATGCAATTAGAACAGAATTG
1201 CATACAGCTGGATAGTGGGGGTTGCCTGGCTACTCACATAACTGTTCCATGACTCCCTCCCCAACCCCTCCTTTCCAAGA
1281 TGTGAGTCCAAGTCTGTCAAGCAGACCCAGCTGGCCTCCTGAAGGTGGTGGCAATTTGACCTATTATCATGGGCATAACC
1361 ACACACAAAGTCCCTAGGAAGCCAATGGTCTTCTTCCTCTCATTGAAGAACAGGCCTGGCAAAGATGCACTCTGGCTTCA
1441 GCCTCCAACTTCCAGCAGAGCTGCTTCTGCTTTTAGCCACTATGCATGTTGTTAAAGAGTGGTTTTCTAGAGAGGCCCTG
1521 TCCCGTAAGTACCTGTGGACTGTCGTTAAGGGTGTCAGACATGGCCTCCCACTTACTACTTACTTTTCAGCTCGTTATCC
1601 GTTTCCTGAACCTCTCCTCACATCCAACTTGCTCGCATCACTGTCCACCCAAGTACTGCACCCATAGCATTTTCTGATCC
1681 TGAAAATCAGTATGAGTCCTCTTTTGATCACATTCTTTCATGGGAATAGAAGTAAATGCCCCACATTCTGGGACGGAACT
1761 CTCTCAACTAGTAGAGTACTTCCCAGCATTCATGAAGCCCTGAGAGTCTATCCCCAGCACCCTATAAACCTGGGTGTGGT
1841 GCTGCATGGCTGTCCTCCCAGAACTCAAACCGTGGGAGAATCAGGTCACCTTTAGATACAGAGTGAGTTCCAGGCCAGCC
1921 ATGCTGTGGTGGTCTTCATGAGATGTCTCCCGTAAGTTGCTAGCATTTGAATACCTGGCTTTGTTCCAAAAGCCATTTCA
2001 AAGTCAGCTTTGCTGCTTGTGGCTCCTGTAGGCCACTCATCCCATGAACTGCTACTGCCACCTCCATCTAGCCACCAGGG
2081 ACTCATACTCTGGAACCATAGGCCCCAGATAAACCCTTTTATAAGTTGCTTTGGTCATGGTGTTTTGTAACAGCAACAGA
2161 CAAGCAACTAATACAAGGGGGAGGGGGAGCAGGAGAAGAGGGGGAGAGAGAACAAGCGGTGTATTCAAAGTTGCCACTGA
2241 TTGGTACTGAGCAGAGCCACTGGGGGTCAGTATCCCTAAGGGACCCGAACTTGCTTTTCTATGCCAGAACATGTCCACGT
2321 GTTCCCCTGAATTCTTCACATCAGCCCCAATCCCCAGTCCTAACATGGGTCCTATCTTTGCTACCTCTTGTCCCTCTGTA
2401 CTATGACATCTTACTTCTGTTCTGTGATCATGCTATGTGATACTGGTGCAGTGAGCCAAGCAACACATAGGGCTTCCACC
2481 TCCTAGTCTTCCCCAAACAGCCAAGACTGTTTAAAGGCCAAGTATTTAAATGCTAGAGACTTATGGGAGACAGCTCACTG
2561 AGGCCACAGCATGGCTGGTCTGGAGCTCACTCTGTAGCTAAAGATGACCAGATCCTCCTATGGTTTGAGTTCTGGGATGA
2641 CAGCTATTCAGCACCACACCCAGGTTTTCACCTATCCTGGGGCCTGGGAAGGGCATGGGCAGGTGAGGGGCCCTGAAGAA
2721 CAGGGTAGCTGGTTTGCTGTAGTGGAAAGGGTCTCAACCCCAACAAATCTCAAGTTCCACACTGGCTCTATCCAGGAAAC
2801 TATCCCAGACAGCACTACAAAAAAAAGTCAACAGGTATTACCTGCCTCAGATAATTACTGTGCAATGCTTACATGGCCTT
2881 GTGTGACTAAACCATTGCCTCACTAATCTGTGAAACAGGGAAAACAGAGTCTGGCTATGTCAAGTCTAGAGGAAGCTTGC
2961 TCTTGTGGCAGCAACCAAGGAAAGAAAAGCAATACATGCTTGCCAGGAGTCACCATGTCTTACAGAGCAGTTTTGAGGAA
3041 ATCAGATGAGTCAGGTTGTGTGGCCCAGCCCAGAAAACCCCCTTCAGGCCACTTCATGCTATTCCAAGTTTGCAGCACGA
3121 AGAAGGCTGGTGAGAAGTAACTGGATAACAAATCTCCTGGGGCCCTCGATCTAGAAAACAGCATGTCTGGCTCTGCCTCT
3201 CTTTCCCTCACTGCTGTCCCCATCAGCCAGCCCTGGGGCCCATGCTTTGCCTCTTGCCCTGTGCAGCTGCTGACAGCAGC
3281 TTAGCTGCACACATGTTCAAAGCTCTTTTCTGCTCTCCTATCAGACTCCAGTGTTGTACAGGTCCCACCCTCCGGCTCCC
3361 CAACAACCCCTTGCTTTGCCAGACAGGTCGACATGGTGGAAGCTGCAAAGGTTCACCAGGAACTTAAGGAACTATATAAA
3441 GTTCAGCTCCTAAAATCTAAACTCTTTCATATGTGCCACTTTAATAAAGTAACAAAAGTAGGTCAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agaUGU---AUCUUACCGU-AGAGAGu 5'
             |||   |:|:| || | |||||| 
Target 5' cccACATTCTGGGACGGAACTCTCTCa 3'
1740 - 1766 132.00 -14.40
2
miRNA  3' agaUGUAUCUUACCGUAGAGAgu 5'
             |||| |::|  :||||:|  
Target 5' ctaACAT-GGGTCCTATCTTTgc 3'
2360 - 2381 123.00 -11.80
3
miRNA  3' agAUGUAUC------UUA------CCGUAGAGAGu 5'
            |||||:|      |||       | ||:|||: 
Target 5' aaTACATGGATCTAAAATTTTTAAAGAATTTCTTg 3'
526 - 560 117.00 -9.30
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions mESCs
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM622573. RNA binding protein: AGO2. Condition:KO1 ...

- Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauguaucuuaccgUAGAGAGu 5'
                         ||||||| 
Target 5' --------------gAUCUCUCu 3'
1 - 9
2
miRNA  3' agauguaucuuaccguAGAGAGu 5'
                          |||||| 
Target 5' ucucucucucucucucUCUCUCu 3'
11 - 33
Article - Leung AK; Young AG; Bhutkar A; Zheng GX; et al.
- Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
70 mmu-miR-741-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT577358 Zcchc9 zinc finger, CCHC domain containing 9 1 1
MIRT577968 Pla2g4f phospholipase A2, group IVF 1 1
MIRT578333 Lyrm7 LYR motif containing 7 1 1
MIRT580150 Ubap2 ubiquitin-associated protein 2 1 1
MIRT580536 Tcte1 t-complex-associated testis expressed 1 1 1
MIRT581216 S1pr3 sphingosine-1-phosphate receptor 3 1 1
MIRT581676 Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma 1 1
MIRT583764 Epas1 endothelial PAS domain protein 1 1 1
MIRT583808 Eif4e2 eukaryotic translation initiation factor 4E member 2 1 5
MIRT584890 Ank1 ankyrin 1, erythroid 1 1
MIRT587270 Fam161b family with sequence similarity 161, member B 1 1
MIRT587313 Epb4.1l5 erythrocyte membrane protein band 4.1 like 5 1 1
MIRT587704 Cd38 CD38 antigen 1 2
MIRT588808 Srgap3 SLIT-ROBO Rho GTPase activating protein 3 1 2
MIRT589434 Nhsl2 NHS-like 2 1 3
MIRT589731 Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 1 1
MIRT592014 Tyw3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 1 1
MIRT592469 Rpusd2 RNA pseudouridylate synthase domain containing 2 1 1
MIRT592881 Srd5a3 steroid 5 alpha-reductase 3 1 2
MIRT592882 Six2 sine oculis-related homeobox 2 1 2
MIRT592937 Bhlha15 basic helix-loop-helix family, member a15 1 3
MIRT593014 St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 1 2
MIRT593066 Ddr2 discoidin domain receptor family, member 2 1 1
MIRT593164 Fmo5 flavin containing monooxygenase 5 1 2
MIRT593184 Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 1 2
MIRT593252 Wfdc13 WAP four-disulfide core domain 13 1 2
MIRT593276 Prrx1 paired related homeobox 1 1 2
MIRT593280 Kynu kynureninase (L-kynurenine hydrolase) 1 3
MIRT593375 Nab2 Ngfi-A binding protein 2 1 2
MIRT594244 St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 1 1
MIRT594280 Prkca protein kinase C, alpha 1 1
MIRT594582 Zfhx3 zinc finger homeobox 3 1 1
MIRT596747 Vav1 vav 1 oncogene 1 1
MIRT597032 Thada thyroid adenoma associated 1 1
MIRT597262 Slc25a42 solute carrier family 25, member 42 1 1
MIRT597402 Rrm2b ribonucleotide reductase M2 B (TP53 inducible) 1 1
MIRT597467 Rgs20 regulator of G-protein signaling 20 1 1
MIRT598650 Iars isoleucine-tRNA synthetase 1 1
MIRT598979 Gadl1 glutamate decarboxylase-like 1 1 1
MIRT599097 Edem1 ER degradation enhancer, mannosidase alpha-like 1 1 1
MIRT599155 Dkk1 dickkopf WNT signaling pathway inhibitor 1 1 1
MIRT599398 Chst3 carbohydrate (chondroitin 6/keratan) sulfotransferase 3 1 1
MIRT599633 BC052040 cDNA sequence BC052040 1 1
MIRT599637 BC048403 cDNA sequence BC048403 1 1
MIRT599952 9330159F19Rik RIKEN cDNA 9330159F19 gene 1 1
MIRT600131 Zfp780b zinc finger protein 780B 1 1
MIRT600221 Trim67 tripartite motif-containing 67 1 1
MIRT600517 Prkce protein kinase C, epsilon 1 1
MIRT600603 Myo5a myosin VA 1 1
MIRT600626 Mrc2 mannose receptor, C type 2 1 1
MIRT600914 Faim2 Fas apoptotic inhibitory molecule 2 1 1
MIRT600973 Dlc1 deleted in liver cancer 1 1 1
MIRT601388 Vamp5 vesicle-associated membrane protein 5 1 1
MIRT601755 Rasgrp1 RAS guanyl releasing protein 1 1 1
MIRT601906 Padi2 peptidyl arginine deiminase, type II 1 1
MIRT601957 Nf2 neurofibromin 2 1 1
MIRT601985 Mylk4 myosin light chain kinase family, member 4 1 1
MIRT602477 Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 1 1
MIRT602478 Dmbx1 diencephalon/mesencephalon homeobox 1 1 1
MIRT602774 Armc2 armadillo repeat containing 2 1 1
MIRT602881 4931428F04Rik RIKEN cDNA 4931428F04 gene 1 1
MIRT602949 Xpo7 exportin 7 1 1
MIRT602996 Qk quaking 1 1
MIRT603591 Bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 1 1
MIRT603895 Ifi203 interferon activated gene 203 1 1
MIRT603911 Homez homeodomain leucine zipper-encoding gene 1 1
MIRT604573 Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 1 1
MIRT605235 Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) 1 1
MIRT605416 T2 brachyury 2 1 1
MIRT606761 Ncam1 neural cell adhesion molecule 1 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-741 (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 up-regulated

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