pre-miRNA Information | |
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pre-miRNA | mmu-mir-374b |
Genomic Coordinates | chrX: 103573060 - 103573154 |
Description | Mus musculus miR-374b stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-374b-5p |
Sequence | 22| AUAUAAUACAACCUGCUAAGUG |43 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Gmeb1 | ||||||||||||||||||||
Synonyms | 1110050A04Rik, AI256615, AI481278 | ||||||||||||||||||||
Description | glucocorticoid modulatory element binding protein 1 | ||||||||||||||||||||
Transcript | NM_001122992 | ||||||||||||||||||||
Other Transcripts | NM_020273 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Gmeb1 | |||||||||||||||||||||
3'UTR of Gmeb1 (miRNA target sites are highlighted) |
>Gmeb1|NM_001122992|3'UTR 1 TTGGGGACAGGGCCAAGAGCTGTGTTTTGGTTTGGAATTTTAATTATGTTTATTTTTATCATTGTCCCGCTCATTTCCAC 81 ATAGAACTTTTTTTAAAAAAAAAACAAAAACAAACAAAAAAAAACCAAACTACAAAATCTCGTTGTAACTGCAAATGTTG 161 GGTTCCTCCTACTTCCTCATTGACAACTGGACAGAACAAGCTGCCTTTCCAGAAGTTAGAAACAGGGCACCCAGGGTCTG 241 AACCATCTTTCCCCAAGGAAGGTAATTGCTTTTAGGGGAAGTGTCAAAATATCCAGGAATCCTTTCCAGAATAGTCTGTC 321 TGTGTATACACGCATGGTCTCACTCTTGTAAAGACGCATTGACCAGACCCTGGAACACAGATCTGACTCCAGAAGATGAC 401 CAGCTCTGCTGTGGATACAGAAGCACGCTTGCCTCTGTGTCCTGGATATGATGGCCTCAGATGCTGGTGTGCAAAACTGA 481 AAGAACAGGAGGTTGGCTCTGCTTAGGGTGGAAAGTAGTGTGATCAGCAGCTCATAGGGGGAGCCCTTTGACAGGGAGGG 561 GCCGAGGAATGGTCTTCCAGAGGTGCATCTGATGCCCCTTGCGCTCTCTGAGGGTTGGGTACCATTTTCAATTTCAGAAG 641 AGGACAGAGATTATAGAAAGACACAAAGCAATCAAAAGATTGTCACAGCTGTGCTTTTGGGATAGCTCACCTTGCCCCCA 721 GCCTTGTCAAAGCCCTCACCCTCCTCGCCCAGGACTATCAGTCCATTCCTTTGCAGACTGTGATGTGGTATAAATTGTTC 801 TAATTCTTGGACTGTGGCTGTCATGGAGGTGGGGCTCCAAGGCCATCATTTTTCGTTTCTTGACTCCAGGAATGGCAGAG 881 TCCCTCGTGCAGACCAGCTGCTATTTTTGGTGGAGCCCTGCACGTAAGCATGCAAGTGTGTGTGTGTGTGTGTGTATGTG 961 TGTGTGTGTGTGTGTGTGTGTGTGTGTGTACATGTTTCGGGTTTGGAACCAAAAGCAGTCATTTCCCTGGTGCTTCCTTT 1041 TCTTTTCCTTCCGTCTGCTGGACCCCATGCTCAGTAGCTTTTTGGCAGACAGCAGTGACAGGTGCCTGCCTGCCTTCATT 1121 CTCTTTGCCATTCTCCTCTTCTGATACCACAGATGTTTCTGTGAGATACCGAACTCATAAAATGGCTTAGGCTTGGCAGG 1201 GACAACTGGTAACACCTTTCCTGAGGTGTGGACTAGATGGCTCCTGAGTGAGCTGCACTTTCTGGGAAAGGGACATTGTA 1281 TTTGACATTGTAAGAAGTATGACAGGAGTGTCAGTAACGTCCAGGCGTGGGGCTTCTTCCTAAATGCTGTTTGTACATTC 1361 GGTACTACTAGGTCACTCTTTCTGCTGTGATCCCATGTCGTTGATTCTCTTCAGCGTTTGGGGGAGAGTAAGCAGTTTCT 1441 GGTTTCTTTAATTATATTGTTTACTATGTTAGGGAAAATATAGAGACTCTCGAGGTGACTTTATAGGTCAAAAAAGCATA 1521 CAGCTTAGGAGCTGGAGGATTTATTATTATTATTAAAAGTAAAATTTTGGCTTTTGTTTAAAAAAAAAAAATAGAGAAGG 1601 ATGCCTGTCTAAATCTGTCTTCCTGCCTGCAGGTTTTGAAAACCCTGTAAGCAACCAAAAGTTGCACCTTCCATCTCTTA 1681 GACGGCCATGTGTCACCAGGGAAGCAAGCCCTCAGGGATCACTCTGAAGACCCTGAAGAGTGCGGCTTCTGAACTCTATT 1761 CAGATTTGTTTCAGCTTTAAAACTGGACTTTTCTTTTCAGACTCTTTAGTTAGGCTGGGGACAGAACTGAATTGGTAAAG 1841 TGGTCACCTAGCGTTCATGAAACCCTGGGCTCAGTCTCCAGCCAGAAGTAAACTGGGCATGGGGCCACATATCTGATCCT 1921 AACACTTGGGAAATAGAGACGGGAGACTTAGAAATTCAAGGTCATACATACCAAGTTCAAGACCAACCTGGGATATATGA 2001 AATAGTGTCTCAAAAAATTTTTGTTTAGGACAAGCTTTTGGTGAAAGAAGGAATTTATTCCTGCCTTCCTTACACTTTGT 2081 TAATACATAGGAATTTTTATTACATTTATTTATCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGATGGTG 2161 AGCTTGCTACGGTATGTATGTGAAGATCAGAGAACAACCTGCAGGAGTCTGTTCTCGCCTTCCACCATGTGGGTCCTGGG 2241 AATTGAACTCAGGTTGCCAGGCTTGGTGGTAAGCACCCTCATCCATTGAGCCATCTTGCCTGCTCTAAAAGTTTCGGTCT 2321 TCAGACCAAAACTGTTACTTGAACCTAGAAAGCCACATCGCATCCCTGTTGTGTCCTTTAGGTCATTTCTCTTTTCCAGA 2401 GATGGGCAGACCAATTCAGGACACGGGAGGCACCCTAGAGAATAGAGGCAGGCTCCTTCAGGTCCTGCCTTTTTGCTCTT 2481 CACAGCTGTTGTGTCATTAAAGGTTGTGTGAGCAGCATGCTTCCAAAGTCAGATTTCCTTCTTGAGACAGAGCCTGTTTA 2561 CTTAAAACAGATTACATGAGCTTTGCTGTTTTCCTGGTCTTCCAATTGCTGTCATTGCTAGCTGCAGTGGTACTTGGAGA 2641 GATGAGATCTCTCACAGACCTGGTCTAGATTATTTTAGGTGGGGTGATACACATGCAAGCTTCTGATGTGTGAATAGGCA 2721 GTTGCAATGAAATTACTCCTCAGGCTGACTTGATGGTAGCTATCTTTTCTCTAGCCATTCATTAAATAAACATTTGTAAG 2801 TACTGTCTATGTATAAGTACTAAACGCCAACTGATTGCGTCACCTAAGCCCCAGTAAGTACCATGAAGATGCAGGTTTTG 2881 TGCTAGACACTGATCTTGCAGACAAGACAATTCCTGTTCTTAAGAAGTTCATACCCAGACATCTTTGCAGTTAACCACAC 2961 TTTTTGTTTGTTTGGTTTGTTTTTTGAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGGAACTCTCACTATGTAGCC 3041 AGGCTGACTGGAACTCACAGAGATCTGTTTGCCTCTGTCTTCCAAGTGCTGGGATTAAAGGTGTGCACCACCACTGCCAT 3121 AGTGAATAGTCAACCGTATTTTAATGTCATTGGTTTCTTTTGTGATCCTGTTTTATCTTAAATATTGGGAAGGACTCTGA 3201 GTCTTTAGTTCCTAGGTTTCAACAGGCAAAGTCACAGAGGTGAAGCCACCCCTGGTGAGATTTTACCTTAGGTTGAGGTG 3281 ACTGTAGCTATGGTCTTTTTTTTTTTTTTTAAAGATTTATTTATTTATTATATGTAAGTACACTGTAGCTGTCTTCAGAC 3361 ACTCCAGAAGAGGGAGTCAGATCTTGTTACAGATGGCTGTGAGCCACCATGTGGTTGCTGGGATTTGAACTCTGGACCTT 3441 CGGAAGAACAGTCGGGTGCTCTTACCCACTGAGCCATCTCACCAGCCCCAGCTATGGTCTTTTGGCCTGGAGTTAAGCAC 3521 AAAAGATCAAGCACTTACTCAGCTTGGGGTCTGAATGGCTTCCGCTAATCTGAGGCAGTTCTCTGCATACCCTAGTTGCC 3601 CTTGAACTTGGCTATGTAGAGTAGCCTGGCTTTGAGCTCATAAAGGTCCATCTGCCTCTGCCTCCTAAGCATTGGGATTA 3681 AAGCTATCACACTTGGCTCTTGCTACTCCTCAGTTTCTAGGCTTCCAAAGAGTGGTGCTGCATGCGTGCCTGGGGCCCCG 3761 GCCCCAGAGGGCAGGGGCAAGAAGAGAGAAAGCTTCAAGATCCTGTCTCACAAACCAGAAATTTAGGCTTCCACATCCCA 3841 AACCCAAAGTTACTCTACTTTTGTTTGTGTCGCTCCCCCCTCCCCCATGGACAATAGACATTCAAGATTCAAACCCACTT 3921 TGGTGTGTCGTTCCCTCACCTGCCATAGCAGGAGAGAGAACTAATATAGATGAATAGCAGGTGATTCTTTTAATGTTGCT 4001 GGTTTGTCCCATTTCATGAGAGACACTATAGATAAGTATATATGGGGAGTACTGATTTTATTTACAAAAAAAAAAAATGT 4081 ACATTTAGTGTGCTTGTGTGTGTGTGGCATGCCGGAGTACATGGTGTCTTTATCAATGAACAGCTTTCAGGATTCAGTTC 4161 TCGCCTTCCACTGTGTGGGTCCCAGGGGTCAAATTCAGTTTGCCAGGCTTGGCAAGCAAGCACCTCTACTCACTGAGCTA 4241 TCTTGCTGGCCCAATGAGATTTTTTCTTTTTCATGTATTTATTTTAGTTTATAATTGTTCTTGCAAGTATGTATGTGCAC 4321 CTCACCTCTCACGCATGCCTGGTATCTGACGTGGTTGGTCGGAGAACATTTCTGATCCCCTGGAACTGGTGTTAGAGATG 4401 GTGTCTGCTACCATGTGGGCGCTGGAAATCCAACCCAGGTTCTCTGAATGAATACATGCTCTCAACTGAGCTGTCTCTTC 4481 GGGTGATATTATAAATAACAAAACTGTTGTGAAATATGGAGTCATTGAGTCAGAACTGACCCATAATGGAGGACTATCTA 4561 GGAGATGGAAAAGAATCCTTCCCTCAACCCTCCCCAAAAAAGGTTGAATTCTGAAATTAAGCACAAAGTGGTGGTGGCAC 4641 ACATCTTTGATCCCAGCACGTAGGAGCCAGTTGGATCTCTGAGTTCAAGGCCAGACTTGTCTCGAGGACAGCCAAGGCTA 4721 CACAGAGAAATCACATCTTG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | mESCs |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM622571. RNA binding protein: AGO2. Condition:WT1B
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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76 mmu-miR-374b-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT418787 | Map2 | microtubule-associated protein 2 | ![]() |
1 | 1 | |||||||
MIRT577252 | Zfp84 | zinc finger protein 84 | ![]() |
1 | 1 | |||||||
MIRT577346 | Zfp11 | zinc finger protein 11 | ![]() |
1 | 1 | |||||||
MIRT577582 | Tcf21 | transcription factor 21 | ![]() |
1 | 1 | |||||||
MIRT577695 | Slc35d2 | solute carrier family 35, member D2 | ![]() |
1 | 1 | |||||||
MIRT577869 | Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | ![]() |
1 | 1 | |||||||
MIRT577940 | Ppp6r1 | protein phosphatase 6, regulatory subunit 1 | ![]() |
1 | 1 | |||||||
MIRT577949 | Pou4f2 | POU domain, class 4, transcription factor 2 | ![]() |
1 | 1 | |||||||
MIRT578202 | Nadsyn1 | NAD synthetase 1 | ![]() |
1 | 1 | |||||||
MIRT578468 | Impg2 | interphotoreceptor matrix proteoglycan 2 | ![]() |
1 | 1 | |||||||
MIRT578587 | Hist1h1d | histone cluster 1, H1d | ![]() |
1 | 1 | |||||||
MIRT579056 | Cradd | CASP2 and RIPK1 domain containing adaptor with death domain | ![]() |
1 | 1 | |||||||
MIRT579823 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 2 | |||||||
MIRT579840 | Zer1 | zyg-11 related, cell cycle regulator | ![]() |
1 | 1 | |||||||
MIRT579950 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT579992 | Wnt3 | wingless-type MMTV integration site family, member 3 | ![]() |
1 | 1 | |||||||
MIRT579997 | Wnt11 | wingless-type MMTV integration site family, member 11 | ![]() |
1 | 1 | |||||||
MIRT580191 | Ttll7 | tubulin tyrosine ligase-like family, member 7 | ![]() |
1 | 1 | |||||||
MIRT580256 | Trim2 | tripartite motif-containing 2 | ![]() |
1 | 1 | |||||||
MIRT580383 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT580415 | Tmem161b | transmembrane protein 161B | ![]() |
1 | 1 | |||||||
MIRT580534 | Tead3 | TEA domain family member 3 | ![]() |
1 | 1 | |||||||
MIRT580565 | Tbx4 | T-box 4 | ![]() |
1 | 1 | |||||||
MIRT580611 | Syp | synaptophysin | ![]() |
1 | 1 | |||||||
MIRT581171 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT581538 | Pten | phosphatase and tensin homolog | ![]() |
1 | 1 | |||||||
MIRT581571 | Prrx1 | paired related homeobox 1 | ![]() |
1 | 1 | |||||||
MIRT581741 | Plxnc1 | plexin C1 | ![]() |
1 | 1 | |||||||
MIRT581794 | Plaur | plasminogen activator, urokinase receptor | ![]() |
1 | 1 | |||||||
MIRT581822 | Pkib | protein kinase inhibitor beta, cAMP dependent, testis specific | ![]() |
1 | 1 | |||||||
MIRT581971 | Pdcd10 | programmed cell death 10 | ![]() |
1 | 1 | |||||||
MIRT582055 | Osbp | oxysterol binding protein | ![]() |
1 | 1 | |||||||
MIRT582142 | Npr3 | natriuretic peptide receptor 3 | ![]() |
1 | 1 | |||||||
MIRT582168 | Nkx2-2 | NK2 homeobox 2 | ![]() |
1 | 1 | |||||||
MIRT582469 | Mex3a | mex3 RNA binding family member A | ![]() |
1 | 1 | |||||||
MIRT582518 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT582589 | Lrrtm2 | leucine rich repeat transmembrane neuronal 2 | ![]() |
1 | 1 | |||||||
MIRT582667 | Lmtk2 | lemur tyrosine kinase 2 | ![]() |
1 | 1 | |||||||
MIRT583063 | Hoxa11 | homeobox A11 | ![]() |
1 | 1 | |||||||
MIRT583111 | Hexim1 | hexamethylene bis-acetamide inducible 1 | ![]() |
1 | 1 | |||||||
MIRT583233 | Gpc6 | glypican 6 | ![]() |
1 | 1 | |||||||
MIRT583395 | Fzd5 | frizzled class receptor 5 | ![]() |
1 | 1 | |||||||
MIRT583429 | Frmpd4 | FERM and PDZ domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT583613 | Fam46a | family with sequence similarity 46, member A | ![]() |
1 | 1 | |||||||
MIRT583848 | Eea1 | early endosome antigen 1 | ![]() |
1 | 1 | |||||||
MIRT584669 | B3gat1 | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | ![]() |
1 | 1 | |||||||
MIRT584731 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | ![]() |
1 | 1 | |||||||
MIRT584872 | Ap3m1 | adaptor-related protein complex 3, mu 1 subunit | ![]() |
1 | 1 | |||||||
MIRT585039 | Lrrc71 | leucine rich repeat containing 71 | ![]() |
1 | 1 | |||||||
MIRT585303 | Zfp248 | zinc finger protein 248 | ![]() |
1 | 3 | |||||||
MIRT585725 | T2 | brachyury 2 | ![]() |
1 | 1 | |||||||
MIRT585759 | St8sia3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | ![]() |
1 | 1 | |||||||
MIRT585986 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 | |||||||
MIRT586181 | Ptprr | protein tyrosine phosphatase, receptor type, R | ![]() |
1 | 1 | |||||||
MIRT586738 | Lcn5 | lipocalin 5 | ![]() |
1 | 1 | |||||||
MIRT586778 | Jmjd4 | jumonji domain containing 4 | ![]() |
1 | 1 | |||||||
MIRT587048 | Gm5531 | transmembrane epididymal protein 1B | ![]() |
1 | 1 | |||||||
MIRT587444 | Dimt1 | DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) | ![]() |
1 | 1 | |||||||
MIRT588190 | A130010J15Rik | RIKEN cDNA A130010J15 gene | ![]() |
1 | 1 | |||||||
MIRT588690 | Tet2 | tet methylcytosine dioxygenase 2 | ![]() |
1 | 1 | |||||||
MIRT589450 | Nck2 | non-catalytic region of tyrosine kinase adaptor protein 2 | ![]() |
1 | 1 | |||||||
MIRT590325 | Csgalnact2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | ![]() |
1 | 1 | |||||||
MIRT590458 | Car5b | carbonic anhydrase 5b, mitochondrial | ![]() |
1 | 1 | |||||||
MIRT590752 | Actr10 | ARP10 actin-related protein 10 | ![]() |
1 | 1 | |||||||
MIRT594398 | Ints6 | integrator complex subunit 6 | ![]() |
1 | 1 | |||||||
MIRT594639 | Mex3c | mex3 RNA binding family member C | ![]() |
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2 | 1 | ||||||
MIRT594870 | Man1a2 | mannosidase, alpha, class 1A, member 2 | ![]() |
1 | 1 | |||||||
MIRT595871 | Csmd1 | CUB and Sushi multiple domains 1 | ![]() |
1 | 1 | |||||||
MIRT596012 | Ceacam1 | carcinoembryonic antigen-related cell adhesion molecule 1 | ![]() |
1 | 1 | |||||||
MIRT596332 | Rpp14 | ribonuclease P 14 subunit | ![]() |
1 | 1 | |||||||
MIRT600146 | Zfp1 | zinc finger protein 1 | ![]() |
1 | 1 | |||||||
MIRT601141 | Bcl11b | B cell leukemia/lymphoma 11B | ![]() |
1 | 1 | |||||||
MIRT601571 | Sumf2 | sulfatase modifying factor 2 | ![]() |
1 | 1 | |||||||
MIRT605724 | Gmeb1 | glucocorticoid modulatory element binding protein 1 | ![]() |
1 | 1 | |||||||
MIRT731705 | Myf6 | myogenic factor 6 | ![]() |
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3 | 1 | |||||
MIRT735635 | Socs1 | suppressor of cytokine signaling 1 | ![]() |
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3 | 0 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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