pre-miRNA Information | |
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pre-miRNA | mmu-mir-3110 |
Genomic Coordinates | chrX: 38210441 - 38210520 |
Description | Mus musculus miR-3110 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-3110-5p |
Sequence | 13| UUCUGCCUCCCCUGAAGGCUC |33 |
Evidence | Experimental |
Experiments | Illumina |
Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | Mysm1 | ||||||||||||||||||||
Synonyms | C130067A03Rik, C530050H10Rik | ||||||||||||||||||||
Description | myb-like, SWIRM and MPN domains 1 | ||||||||||||||||||||
Transcript | NM_177239 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on Mysm1 | |||||||||||||||||||||
3'UTR of Mysm1 (miRNA target sites are highlighted) |
>Mysm1|NM_177239|3'UTR 1 TTATTTTAAAGTAAGATGTTCTAATCTTGGCATGCTACTGTAAATAATTGAGATTTTAAAGCAATATAAATTATGTTTTT 81 TTTTTAATCCATAAAACTCTAAACTTTCTCACATAGATAATGTGAGAAGGAAGAGAGAGCCCTTGTTCTCATAGTGGTAA 161 TCAAGAGTGGTAGAGCCCTGCCTATGCTAAGCTGTGCAGTGGGCATGAAAGCTTGAGCTCTGCTCTGCCTCGTGGTGTGC 241 GGCTTAATAACTAGGAGATGACCGAGCTCCGCTTTTTCTCAGAGGGACTGTTTCTCACTTTGCCATCTCATTACACACAC 321 TTTCTTCCCATATGTTCTGGTGGTGAGATTGTGTGTGTGTGTGTGTGTGTTATTTGGATGTTGCAGCCTAGGTGTGGAAC 401 ATTAATGGGGTTGAGAACTACTGACTAATAAATCTAACAGCATGCCAACACAGCAAAAGGGAGCATCCTTAGTAATGTTC 481 AGACAGGAGTCCAAAGGGGAGAAGAACCAATTTTCAGTCTGCGGTGTGTGCTTCATCTTACTGTGTACACTATACCATAG 561 GACAGTCAGCCTCCTCTGCGATTTAAATGTTTAAATGAATTTCACAAGGGAAATAATTAGCTCCAACTCTGTCCAATTGC 641 AGTAGCATGTGACAAAATGTCATTGAACTAGACTTGGTAATGTAGCCCTCAACCTAGCTTTTTTCCCTACTGTCAGGAGA 721 AAGAGAAAAATGAGTCACATATTACAATAGAAAAAAAAATGCCATCTGGTATTTTACATAGCTTAACCCAGTTTCATGCA 801 CTTGCTGAATATTAAAAGTAAACTTTTTTCATGTTGTAAATTCAAATTGTTCATGTAAGTATTAGTGAATATTTCTGCTT 881 GCTGGAGAACTGGTGTTTGACCCTGTCCAGGCCTTCTTATTGGCAACAGTTTTGTTATATTGAAACTGAATGTGAGTTTA 961 GAGTTTTCTTTTTTCTTTTTTTTTTTTTTTTTTTTTGCTGTAGTTGTAGCCAAAGGGGGAGGCAGCACTGGATGGAGTGA 1041 CTGCAGTCATAGGTGACCTGAATCTGATTTGGGCACTGTGATTTAAAGAAAAGGCGTTTGCTTTCTCTAGGCCAAGTTTG 1121 TCTTATGTAGCTGAGGCTAATCCAGCCCTGAGTGTTGCTCCTACTCTGATTTATCTGCTGGCTTGTTAGGCTGCACTTTT 1201 GGAACTTTATAAGATCGTGTAATTGCAAAATTAATGTGTAGCTTTAAAAGAGAACTAGCAGTTTTTCCATTTCCCTCTGT 1281 ACATTTAATACGAACAATGAAACATACTTTGTAAAATCCTCTTGAAATCTGGAAGTGCAAGGACTCCAGAGCAAAAATCA 1361 GGAATCCTGAGCTCTCAACCTAATCTGCTTAAGCTTTGGTAAGGGGCCTCGCTCCACGCTCAGCTCTCTAAACTCATCAG 1441 TTGAGATTCAAAGAGCTGAATTCTATCACTTGTTGTCTCTTCAAGCACACAAGGCTACAAAAGTCAGTAGCAATTAATTC 1521 ATTCCTTTCTGTTTTCCTTCCTCTTCACCTGTCTCTTCATAGGCTGTTGGCACAGACCTGAAATGGATGATAATTTACTT 1601 TCTTGCAATTTTCCTAGAATGCTGTTGAATTTTAAAAAGTTCTTTCTCAAATCTGGACTTTACACATGCCAGTGGTTAAG 1681 AGTATTCACTACCCTGATCTATACATTGTAAGGACCCAACGGGTGCCAATAGTCAGAGTGTAGGGCCTTGAGAACAGAAG 1761 TTTTTAAGCAACTATTGAGAAAATACAACTATTTTCTGACTGTAGAATATATTTGTAATTTATCTTATGAAATATTTTTA 1841 AATACAGTGAAATATATACAAAGTGCAAGTATCTCAAACCTACTGTTGAGGAAATATTTTACATAGGAATCAGATTCTTA 1921 ACCAGTTTTTAACAGCATAAATTCAGGATATTCAGTTATTGTTTGTCTGCTTTTGTTTTCTGTCTGTTCTCTGTGCTGCC 2001 TTCTCTTCTCTTGTCCTAGTGTCTACTTGCTCTGGCAGCTGTAGGTGGCCAACCTAGGCCTCCTGAGACTGGTTAGAGCC 2081 AAGACCTTAAAGAAGCACAGATGAGTCTGGAACTTGAGGGGACATGTAACACAGAAGTTCATGGAGAGAGAGAGAGAGAG 2161 AGAGACAGAGACAGAGACAGAGAGAGACAGACAGAGACCGCCCTTCCCAACAGTGTTTGCAGAAGTGGAGGACCAGCAAT 2241 GCCTGAGTCTCTTTATCCTGGGTTCTATTTTTATTGGTGCATAAAAATAGAAATTGAGCTTAAATTTTGTCTCTTATTCT 2321 GACATGGTTAAGGACACTTAATAATAGTACTTCTCTTATATTAGACTTACTGTTCTTCAAAACTAATACTCAAGAAAGCA 2401 AAATCAGTGGAACAAGACCAGTAAGGTAAAACTCGCTGGCCATTGTTTAACCTTGGCCCTTCTTCTCCACTCCTTTTAAA 2481 TGGCTAGGAGCTCCCAGTCTTGGAGTTGGTATGGCCACCTGCTCAATGCTCATGAGGTTTTAGGCACCAAGCACTTTAGC 2561 TCACTTTGACCTCTTCCATATAGAATTTAAAATTACATTTTATAATTGTGTTTGTATAACATGACAGTATTCACATTTTG 2641 GATTAAAATATTCCTTTAATCTAAAACTTGGATTATTTTTCCTAATAAAATTAAGTAAAATGTTTGTTATACACCCTTCA 2721 AAATTCTGAGAATTTGAGACTGTACCTGATGAATGGTTTATGTTCTGAGAGGGTTGTTGGAAAAATGCAGACCGTGTTCT 2801 CCATCCCTTACCACCACTCAGGTGTTTGTTTCACTCCAGCCAGGAGCACTGCAGGTCCTCCTGTCACAAGCCTGGACATC 2881 TGAACTTCGTCCTTCCCATCCTAGCCAGAACTCAGTATGGCTTAGATCATCCATGGGAGGCGGAGGTGCAGTAGTTAGAA 2961 ATCAGTAGATAGGAATTTTATTTAGGTTCCTACTTTTACAGCTTGTGCGCCACCTCACAGGGTGAGGTGCCTTTTTTCCC 3041 TTTACTGTCAAACCCTCATATTCATCTATTCATCCATTCTCACAGCTCATAGGTACAAGAGCTTTATATCATTCATTGAA 3121 AGTAATTAAACAGACCCATTCAGAAAATGCCTGCAGTCATTTATTGTTTAGCATTGGTCCAGGCTTCTCCACAGAATGTT 3201 CCTCTCGGGCTAGGTGAGGTTGGTAGCATGCAGACTGGAAGCACCGTTAGCCTCTTCGTTTCTAAGGACAGAGAAAGTGG 3281 CAGCCCCGGCATTCCAGCCTAAGCTGTCCTACTGCTCTTTAGTTTACCTTTTCCCATGTACATTGCTGAGTCCTGACGGA 3361 AGGAAGGCGCTAGAGAAGCCAACAAAGCCTGTGCACGCCTCCACTCTGTCTCTGCTCTGTGCCAACTGAAGACACCCAAT 3441 TGGCCACCTGCTTGTGGACACACTTGAAGTTCACCGGCAGACATCCTATGTTGGTTTCTCAGCAGGAGAGGTGGCCACCC 3521 AAATTTCCCTTTTCTACTTACCAGCAAGGCACTTAATCTGGTGTCACGTGACACTCATAGAGAAAAGCACCTGCACAGAA 3601 GCACAAGAAGAGCACACACATTCTGTTGTGTTAGCATTAACAAACTTAACGAACAAACTTTATCTCTAGAGCTTCATCTC 3681 TAGTTTTGTATTTAGCTCTTAGAACAATATATCTTATAATGTATCCAGAAAAATCAGAATAATGTAATATCCTTCGATTA 3761 TTATTTCCTGACCTTTCTGAAAAAGTTTCATGCATGCTTTCATTTCCTGTAACTTTGTTTTCTGATATCTCTTCTACCTT 3841 ACTCCCTTATTGCCCCGACCAAATCAGGAGGAAATAAAAGCATCCAAGAGGAACTTAAAAGGTTCTAAATGAAACTAAAC 3921 TTTAAAGCCGAAATTAATTCGCAGCATCTGTGTAGCTTTTATTTTTGTCCTTTGCTGTTTCTGTCATATATTCATGTGAG 4001 TTCCAGGGAAAATAACCTGCTTTGTTGTGTCTGAGGGTTCCTAGTAGCTTATCAGGAATTCAATAAATTCATATTTCCGG 4081 TGTTATATGTTATCAAAAAATTGAGGCCTGTGTGGTGGTGCACACCTTTAATCCCAGAACTCAGAAGCAGAGTCAGGGAG 4161 CTCTCCAGTGCTCAAGGTTAGCCTGGAACAGGAGGACTACATAGTAAGACCCTGTCATTTAAAAATAAAACAAAACAAAC 4241 AAACAAACAAAAAAAACAAGACAAAACAAAGCTGGGCATGGTGGCGCACGCCTTTAATCCCAGCACTCGGGAGGCCGAGG 4321 CAGAGGCAGAGGCAGGCGAATTTCTGAGTTCGAGGCCAGCCTGGTCTACAAAGTGAGTTCCAGGACATCCAGGGCTACAC 4401 AGAGAAACCCTGTCTTGAAAAGAAAAAAAAAAAAAAAAGATCATCTGCTTCAGCATATGAGTACTAAAGTTGTAATTAGA 4481 TTTTAGCATGATTTATGTAGAGGAGTCTTTTATAAACGCCTTTAAATGTGTAGATTGGAGTTGATTTATACAGTTGTGTT 4561 GTATATAAGATATTGCATGACAGTTTATGAACTTGTTGCTGTTTTCTCACAATATTAACAGTTTTGTAAATTTTTTCACT 4641 ATGCATTTACAGTGTTCTATAACAATATATGACTTAAAACTATTTTATACATTTAAATGTTATGTTGTATATATCTACAT 4721 TAAAGAATATTGTAAATATCAATGTTTGTAAAATTATAAGTTTTCCAAAAATATAAACTCATTTTTCCATATCTACTTGT 4801 GGCATATTAAAAATACCAGTTTTTAAGCTTTGACGTATTATCTTGTAGTGAAAGAGGAGGATCATGCTGTCAATTCAATG 4881 TAAGCAAATGTTAAAAATAAAACAGGTAGTTTTTGATGTCTTTG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | mESCs | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
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HITS-CLIP data was present in GSM622570. RNA binding protein: AGO2. Condition:WT1A
... - Leung AK; Young AG; Bhutkar A; Zheng GX; et al., 2011, Nature structural & molecular biology. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Leung AK; Young AG; Bhutkar A; Zheng GX; et al. - Nature structural & molecular biology, 2011
MicroRNAs (miRNAs) are 19-22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq). We also performed CLIP-seq in Dicer(-)/(-) mESCs that lack mature miRNAs, allowing us to define whether the association of Ago2 with the identified sites was miRNA dependent. A significantly enriched motif, GCACUU, was identified only in wild-type mESCs in 3' untranslated and coding regions. This motif matches the seed of a miRNA family that constitutes ~68% of the mESC miRNA population. Unexpectedly, a G-rich motif was enriched in sequences cross-linked to Ago2 in both the presence and absence of miRNAs. Expression analysis and reporter assays confirmed that the seed-related motif confers miRNA-directed regulation on host mRNAs and that the G-rich motif can modulate this regulation.
LinkOut: [PMID: 21258322]
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185 mmu-miR-3110-5p Target Genes:
Functional analysis: