pre-miRNA Information | |
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pre-miRNA | hsa-mir-4446 |
Genomic Coordinates | chr3: 113594876 - 113594942 |
Description | Homo sapiens miR-4446 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||
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Mature miRNA | hsa-miR-4446-5p | ||||||
Sequence | 8| AUUUCCCUGCCAUUCCCUUGGC |29 | ||||||
Evidence | Experimental | ||||||
Experiments | Illumina | ||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | IL1RAPL1 | ||||||||||||||||||||
Synonyms | IL-1-RAPL-1, IL-1RAPL-1, IL1R8, IL1RAPL, IL1RAPL-1, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2 | ||||||||||||||||||||
Description | interleukin 1 receptor accessory protein like 1 | ||||||||||||||||||||
Transcript | NM_014271 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on IL1RAPL1 | |||||||||||||||||||||
3'UTR of IL1RAPL1 (miRNA target sites are highlighted) |
>IL1RAPL1|NM_014271|3'UTR
1 CAGAAAAGCAAGGGACATCCCGTCCCTGGGAGGTTGAGTGGAATCTGCAGTCCAGTGCCTGGAACTAAATCCTCGACTGC
Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HeLa | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B
... - Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Chi SW; Zang JB; Mele A; Darnell RB - Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | BCBL-1 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1015448. RNA binding protein: AGO2. Condition:BCBL-1 mRNA
... - Haecker I; Gay LA; Yang Y; Hu J; Morse AM; et al., 2012, PLoS pathogens. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Haecker I; Gay LA; Yang Y; Hu J; Morse AM; et al. - PLoS pathogens, 2012
KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential role in viral pathogenesis and tumorigenesis. MiRNA-mediated regulation of gene expression is a complex network with each miRNA having many potential targets, and to date only few KSHV miRNA targets have been experimentally determined. A detailed understanding of KSHV miRNA functions requires high-through putribonomics to globally analyze putative miRNA targets in a cell type-specific manner. We performed Ago HITS-CLIP to identify viral and cellular miRNAs and their cognate targets in two latently KSHV-infected PEL cell lines. Ago HITS-CLIP recovered 1170 and 950 cellular KSHV miRNA targets from BCBL-1 and BC-3, respectively. Importantly, enriched clusters contained KSHV miRNA seed matches in the 3'UTRs of numerous well characterized targets, among them THBS1, BACH1, and C/EBPbeta. KSHV miRNA targets were strongly enriched for genes involved in multiple pathways central for KSHV biology, such as apoptosis, cell cycle regulation, lymphocyte proliferation, and immune evasion, thus further supporting a role in KSHV pathogenesis and potentially tumorigenesis. A limited number of viral transcripts were also enriched by HITS-CLIP including vIL-6 expressed only in a subset of PEL cells during latency. Interestingly, Ago HITS-CLIP revealed extremely high levels of Ago-associated KSHV miRNAs especially in BC-3 cells where more than 70% of all miRNAs are of viral origin. This suggests that in addition to seed match-specific targeting of cellular genes, KSHV miRNAs may also function by hijacking RISCs, thereby contributing to a global de-repression of cellular gene expression due to the loss of regulation by human miRNAs. In summary, we provide an extensive list of cellular and viral miRNA targets representing an important resource to decipher KSHV miRNA function.
LinkOut: [PMID: 22927820]
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Experimental Support 3 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293S |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2
HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3
HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb
HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb
HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb
HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb
HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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Experimental Support 4 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | MCF7 , MDA-MB-231 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1395163. RNA binding protein: AGO. Condition:MCF7 AGO HITS-CLIP Replicate 1
HITS-CLIP data was present in GSM1395171. RNA binding protein: AGO. Condition:MDA-MB-231 AGO HITS-CLIP Replicate 3
... - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment. |
Article |
- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al. - Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
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Experimental Support 5 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Cardiac Tissues |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA
HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA
HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA
... - Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research. |
Article |
Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.
- Spengler RM; Zhang X; Cheng C; McLendon JM; et al.- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
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CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | HeLa / HeLa cell Control B |
Location of target site | ENST00000378993.1 | 3UTR | CGGGGGAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 19536157 / Chi_HITSCLIP |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1015448 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | BCBL-1 / BCBL-1 mRNA |
Location of target site | ENST00000378993.1 | 3UTR | CGGGGGAAAAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22927820 / GSE41357 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM1084043 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_arsenite_rep2 |
Location of target site | ENST00000378993.1 | 3UTR | CGGGGGAAAAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM1084044 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noarsenite_rep3 |
Location of target site | ENST00000378993.1 | 3UTR | UCGGGGGAAAAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM1084066 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_SantaCruzAb |
Location of target site | ENST00000378993.1 | 3UTR | GGGGGAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM1084069 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_SigmaAb |
Location of target site | ENST00000378993.1 | 3UTR | GGGGGAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM1084081 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb |
Location of target site | ENST00000378993.1 | 3UTR | CGGGGGAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 8 for dataset GSM1084082 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep2_SigmaAb |
Location of target site | ENST00000378993.1 | 3UTR | GGGGGAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 9 for dataset GSM1395163 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | MCF7 / MCF7 AGO HITS-CLIP Replicate 1 |
Location of target site | ENST00000378993.1 | 3UTR | CGGGGGAAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 24906430 / GSE57855 |
CLIP-seq Viewer | Link |
CLIP-seq Support 10 for dataset GSM1395171 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | MDA-MB-231 / MDA-MB-231 AGO HITS-CLIP Replicate 3 |
Location of target site | ENST00000378993.1 | 3UTR | CGGGGGAAAAAAAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 24906430 / GSE57855 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT078060 | PCTP | phosphatidylcholine transfer protein | ![]() |
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2 | 2 | ||||||
MIRT099072 | FOXC1 | forkhead box C1 | ![]() |
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2 | 2 | ||||||
MIRT130186 | TXNIP | thioredoxin interacting protein | ![]() |
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2 | 2 | ||||||
MIRT148786 | NARS | asparaginyl-tRNA synthetase | ![]() |
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2 | 2 | ||||||
MIRT261965 | SEPHS1 | selenophosphate synthetase 1 | ![]() |
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2 | 2 | ||||||
MIRT345867 | SRSF2 | serine and arginine rich splicing factor 2 | ![]() |
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2 | 2 | ||||||
MIRT409087 | HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | ![]() |
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2 | 2 | ||||||
MIRT451883 | SOD2 | superoxide dismutase 2 | ![]() |
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2 | 4 | ||||||
MIRT469236 | RHOB | ras homolog family member B | ![]() |
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2 | 2 | ||||||
MIRT469435 | REL | REL proto-oncogene, NF-kB subunit | ![]() |
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2 | 2 | ||||||
MIRT483055 | FOXB1 | forkhead box B1 | ![]() |
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2 | 8 | ||||||
MIRT484640 | TBC1D5 | TBC1 domain family member 5 | ![]() |
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2 | 6 | ||||||
MIRT493106 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | ![]() |
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2 | 6 | ||||||
MIRT497307 | TMEFF2 | transmembrane protein with EGF like and two follistatin like domains 2 | ![]() |
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2 | 2 | ||||||
MIRT497798 | GABRB1 | gamma-aminobutyric acid type A receptor beta1 subunit | ![]() |
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2 | 2 | ||||||
MIRT501273 | SCARB2 | scavenger receptor class B member 2 | ![]() |
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2 | 4 | ||||||
MIRT506756 | KMT2D | lysine methyltransferase 2D | ![]() |
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2 | 2 | ||||||
MIRT511986 | EEF2 | eukaryotic translation elongation factor 2 | ![]() |
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2 | 4 | ||||||
MIRT513126 | ZNF431 | zinc finger protein 431 | ![]() |
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2 | 2 | ||||||
MIRT519733 | ZNF394 | zinc finger protein 394 | ![]() |
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2 | 4 | ||||||
MIRT520351 | UBE2K | ubiquitin conjugating enzyme E2 K | ![]() |
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2 | 4 | ||||||
MIRT520542 | TPPP | tubulin polymerization promoting protein | ![]() |
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2 | 8 | ||||||
MIRT530782 | HDHD2 | haloacid dehalogenase like hydrolase domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT531112 | ZYG11B | zyg-11 family member B, cell cycle regulator | ![]() |
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2 | 2 | ||||||
MIRT532144 | GALNT8 | polypeptide N-acetylgalactosaminyltransferase 8 | ![]() |
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2 | 2 | ||||||
MIRT533208 | WAPAL | WAPL cohesin release factor | ![]() |
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2 | 2 | ||||||
MIRT533419 | TWF1 | twinfilin actin binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT534063 | SRSF10 | serine and arginine rich splicing factor 10 | ![]() |
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2 | 2 | ||||||
MIRT534288 | SLAIN2 | SLAIN motif family member 2 | ![]() |
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2 | 2 | ||||||
MIRT537796 | EFNB2 | ephrin B2 | ![]() |
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2 | 2 | ||||||
MIRT538017 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | ![]() |
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2 | 2 | ||||||
MIRT538058 | DMD | dystrophin | ![]() |
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2 | 2 | ||||||
MIRT538132 | DDI2 | DNA damage inducible 1 homolog 2 | ![]() |
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2 | 2 | ||||||
MIRT538680 | CCDC80 | coiled-coil domain containing 80 | ![]() |
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2 | 2 | ||||||
MIRT538788 | C3orf52 | chromosome 3 open reading frame 52 | ![]() |
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2 | 2 | ||||||
MIRT542762 | PPAP2B | phospholipid phosphatase 3 | ![]() |
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2 | 2 | ||||||
MIRT546861 | RAB10 | RAB10, member RAS oncogene family | ![]() |
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2 | 4 | ||||||
MIRT547418 | MED4 | mediator complex subunit 4 | ![]() |
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2 | 4 | ||||||
MIRT551633 | TRUB1 | TruB pseudouridine synthase family member 1 | ![]() |
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2 | 4 | ||||||
MIRT552329 | ZNF704 | zinc finger protein 704 | ![]() |
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2 | 2 | ||||||
MIRT556124 | MFSD9 | major facilitator superfamily domain containing 9 | ![]() |
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2 | 4 | ||||||
MIRT559290 | ATXN1 | ataxin 1 | ![]() |
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2 | 2 | ||||||
MIRT562125 | IGFBP5 | insulin like growth factor binding protein 5 | ![]() |
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2 | 2 | ||||||
MIRT563777 | HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | ![]() |
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2 | 2 | ||||||
MIRT564430 | EIF2S3 | eukaryotic translation initiation factor 2 subunit gamma | ![]() |
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2 | 2 | ||||||
MIRT566102 | RBPJ | recombination signal binding protein for immunoglobulin kappa J region | ![]() |
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2 | 2 | ||||||
MIRT567126 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT571213 | RRS1 | ribosome biogenesis regulator homolog | ![]() |
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2 | 2 | ||||||
MIRT571939 | LCLAT1 | lysocardiolipin acyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT571967 | KIF21A | kinesin family member 21A | ![]() |
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2 | 2 | ||||||
MIRT606792 | IL1RAPL1 | interleukin 1 receptor accessory protein like 1 | ![]() |
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2 | 8 | ||||||
MIRT607351 | TNS1 | tensin 1 | ![]() |
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2 | 4 | ||||||
MIRT609416 | GJB7 | gap junction protein beta 7 | ![]() |
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2 | 4 | ||||||
MIRT609522 | AZI2 | 5-azacytidine induced 2 | ![]() |
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2 | 4 | ||||||
MIRT611218 | FAM174B | family with sequence similarity 174 member B | ![]() |
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2 | 2 | ||||||
MIRT611385 | TRIP10 | thyroid hormone receptor interactor 10 | ![]() |
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2 | 2 | ||||||
MIRT612053 | KLB | klotho beta | ![]() |
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2 | 4 | ||||||
MIRT612102 | CHRM3 | cholinergic receptor muscarinic 3 | ![]() |
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2 | 2 | ||||||
MIRT612146 | SIX1 | SIX homeobox 1 | ![]() |
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2 | 4 | ||||||
MIRT612488 | SIX3 | SIX homeobox 3 | ![]() |
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2 | 4 | ||||||
MIRT613685 | QPRT | quinolinate phosphoribosyltransferase | ![]() |
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2 | 2 | ||||||
MIRT613763 | TTC38 | tetratricopeptide repeat domain 38 | ![]() |
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2 | 2 | ||||||
MIRT613876 | FGD1 | FYVE, RhoGEF and PH domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT613965 | PPP1R3D | protein phosphatase 1 regulatory subunit 3D | ![]() |
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2 | 4 | ||||||
MIRT614894 | PAPOLG | poly(A) polymerase gamma | ![]() |
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2 | 2 | ||||||
MIRT614912 | NFIA | nuclear factor I A | ![]() |
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2 | 2 | ||||||
MIRT615013 | ERGIC2 | ERGIC and golgi 2 | ![]() |
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2 | 2 | ||||||
MIRT615106 | BCL7A | BCL tumor suppressor 7A | ![]() |
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2 | 2 | ||||||
MIRT615242 | FAM227A | family with sequence similarity 227 member A | ![]() |
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2 | 4 | ||||||
MIRT615695 | NEGR1 | neuronal growth regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT615956 | ERBB3 | erb-b2 receptor tyrosine kinase 3 | ![]() |
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2 | 4 | ||||||
MIRT615979 | FSTL4 | follistatin like 4 | ![]() |
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2 | 2 | ||||||
MIRT616053 | PTPRE | protein tyrosine phosphatase, receptor type E | ![]() |
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2 | 4 | ||||||
MIRT616073 | TBX2 | T-box 2 | ![]() |
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2 | 4 | ||||||
MIRT616234 | NPAS3 | neuronal PAS domain protein 3 | ![]() |
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2 | 2 | ||||||
MIRT616306 | CELF2 | CUGBP Elav-like family member 2 | ![]() |
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2 | 2 | ||||||
MIRT616474 | MACC1 | MACC1, MET transcriptional regulator | ![]() |
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2 | 2 | ||||||
MIRT616662 | ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT616887 | ATP5E | ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit | ![]() |
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2 | 2 | ||||||
MIRT616902 | LINC00598 | long intergenic non-protein coding RNA 598 | ![]() |
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2 | 2 | ||||||
MIRT617025 | SYT6 | synaptotagmin 6 | ![]() |
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2 | 2 | ||||||
MIRT617162 | SLC16A5 | solute carrier family 16 member 5 | ![]() |
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2 | 2 | ||||||
MIRT617318 | DPF3 | double PHD fingers 3 | ![]() |
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2 | 2 | ||||||
MIRT617792 | CHRM2 | cholinergic receptor muscarinic 2 | ![]() |
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2 | 2 | ||||||
MIRT618418 | DNAJC30 | DnaJ heat shock protein family (Hsp40) member C30 | ![]() |
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2 | 2 | ||||||
MIRT618663 | RPP40 | ribonuclease P/MRP subunit p40 | ![]() |
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2 | 2 | ||||||
MIRT620212 | VN1R1 | vomeronasal 1 receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT620413 | TFDP3 | transcription factor Dp family member 3 | ![]() |
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2 | 2 | ||||||
MIRT620667 | BBS5 | Bardet-Biedl syndrome 5 | ![]() |
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2 | 2 | ||||||
MIRT620709 | ASB16 | ankyrin repeat and SOCS box containing 16 | ![]() |
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2 | 2 | ||||||
MIRT620956 | SFT2D2 | SFT2 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT621225 | LMAN1 | lectin, mannose binding 1 | ![]() |
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2 | 2 | ||||||
MIRT621333 | SLC11A1 | solute carrier family 11 member 1 | ![]() |
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2 | 2 | ||||||
MIRT621696 | TSKU | tsukushi, small leucine rich proteoglycan | ![]() |
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2 | 2 | ||||||
MIRT623484 | KCTD11 | potassium channel tetramerization domain containing 11 | ![]() |
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2 | 2 | ||||||
MIRT623777 | GOSR1 | golgi SNAP receptor complex member 1 | ![]() |
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2 | 2 | ||||||
MIRT624215 | DCAF5 | DDB1 and CUL4 associated factor 5 | ![]() |
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2 | 2 | ||||||
MIRT624675 | ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | ![]() |
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2 | 2 | ||||||
MIRT627369 | PRICKLE4 | prickle planar cell polarity protein 4 | ![]() |
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2 | 2 | ||||||
MIRT628252 | EFCAB14 | EF-hand calcium binding domain 14 | ![]() |
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2 | 2 | ||||||
MIRT630790 | TGIF2 | TGFB induced factor homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT635631 | PRR15L | proline rich 15 like | ![]() |
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2 | 2 | ||||||
MIRT636425 | MARCH1 | membrane associated ring-CH-type finger 1 | ![]() |
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2 | 2 | ||||||
MIRT637295 | ACTN2 | actinin alpha 2 | ![]() |
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2 | 2 | ||||||
MIRT637345 | PIGP | phosphatidylinositol glycan anchor biosynthesis class P | ![]() |
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2 | 2 | ||||||
MIRT637842 | SLC2A9 | solute carrier family 2 member 9 | ![]() |
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2 | 2 | ||||||
MIRT638327 | RCAN1 | regulator of calcineurin 1 | ![]() |
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2 | 2 | ||||||
MIRT638375 | RABL3 | RAB, member of RAS oncogene family like 3 | ![]() |
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2 | 2 | ||||||
MIRT638751 | EPHA4 | EPH receptor A4 | ![]() |
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2 | 2 | ||||||
MIRT638965 | ARHGAP6 | Rho GTPase activating protein 6 | ![]() |
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2 | 2 | ||||||
MIRT639094 | GLIPR1L2 | GLI pathogenesis related 1 like 2 | ![]() |
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2 | 2 | ||||||
MIRT639172 | CEP70 | centrosomal protein 70 | ![]() |
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2 | 2 | ||||||
MIRT639254 | SLC38A1 | solute carrier family 38 member 1 | ![]() |
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2 | 4 | ||||||
MIRT639368 | ZCCHC24 | zinc finger CCHC-type containing 24 | ![]() |
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2 | 4 | ||||||
MIRT639504 | CACNA1G | calcium voltage-gated channel subunit alpha1 G | ![]() |
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2 | 2 | ||||||
MIRT639644 | WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | ![]() |
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2 | 2 | ||||||
MIRT640486 | EXOC5 | exocyst complex component 5 | ![]() |
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2 | 2 | ||||||
MIRT641424 | SCUBE3 | signal peptide, CUB domain and EGF like domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT641550 | LIPG | lipase G, endothelial type | ![]() |
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2 | 2 | ||||||
MIRT642180 | TOR1AIP1 | torsin 1A interacting protein 1 | ![]() |
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2 | 2 | ||||||
MIRT642656 | RGS6 | regulator of G protein signaling 6 | ![]() |
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2 | 2 | ||||||
MIRT642873 | SAMD1 | sterile alpha motif domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT643355 | TRIM10 | tripartite motif containing 10 | ![]() |
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2 | 2 | ||||||
MIRT643531 | DNTTIP2 | deoxynucleotidyltransferase terminal interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT643998 | PPP1R3G | protein phosphatase 1 regulatory subunit 3G | ![]() |
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2 | 2 | ||||||
MIRT644105 | PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT644421 | VDR | vitamin D receptor | ![]() |
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2 | 2 | ||||||
MIRT644481 | SLFN12 | schlafen family member 12 | ![]() |
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2 | 2 | ||||||
MIRT644573 | SPOP | speckle type BTB/POZ protein | ![]() |
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2 | 2 | ||||||
MIRT645354 | SPNS1 | sphingolipid transporter 1 (putative) | ![]() |
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2 | 2 | ||||||
MIRT645383 | FBLIM1 | filamin binding LIM protein 1 | ![]() |
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2 | 2 | ||||||
MIRT645758 | SURF6 | surfeit 6 | ![]() |
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2 | 2 | ||||||
MIRT646060 | VANGL2 | VANGL planar cell polarity protein 2 | ![]() |
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2 | 2 | ||||||
MIRT646194 | DUSP10 | dual specificity phosphatase 10 | ![]() |
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2 | 2 | ||||||
MIRT647915 | RGS5 | regulator of G protein signaling 5 | ![]() |
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2 | 2 | ||||||
MIRT649216 | AMMECR1L | AMMECR1 like | ![]() |
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2 | 2 | ||||||
MIRT649265 | C17orf64 | chromosome 17 open reading frame 64 | ![]() |
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2 | 2 | ||||||
MIRT649522 | GTF3C3 | general transcription factor IIIC subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT649605 | ITPKC | inositol-trisphosphate 3-kinase C | ![]() |
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2 | 2 | ||||||
MIRT650392 | ORMDL2 | ORMDL sphingolipid biosynthesis regulator 2 | ![]() |
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2 | 2 | ||||||
MIRT650835 | SEMA4G | semaphorin 4G | ![]() |
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2 | 2 | ||||||
MIRT651273 | ZDHHC5 | zinc finger DHHC-type containing 5 | ![]() |
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2 | 2 | ||||||
MIRT651674 | VPS37A | VPS37A, ESCRT-I subunit | ![]() |
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2 | 2 | ||||||
MIRT651763 | VASP | vasodilator stimulated phosphoprotein | ![]() |
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2 | 2 | ||||||
MIRT652250 | TPD52L3 | tumor protein D52 like 3 | ![]() |
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2 | 2 | ||||||
MIRT652277 | TOM1L2 | target of myb1 like 2 membrane trafficking protein | ![]() |
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2 | 2 | ||||||
MIRT652316 | TNFSF15 | TNF superfamily member 15 | ![]() |
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2 | 2 | ||||||
MIRT652342 | TMOD3 | tropomodulin 3 | ![]() |
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2 | 2 | ||||||
MIRT652373 | TMEM57 | transmembrane protein 57 | ![]() |
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2 | 2 | ||||||
MIRT652438 | TMEM236 | transmembrane protein 236 | ![]() |
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2 | 2 | ||||||
MIRT652723 | TGFB2 | transforming growth factor beta 2 | ![]() |
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2 | 2 | ||||||
MIRT652752 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT653310 | SMOC1 | SPARC related modular calcium binding 1 | ![]() |
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2 | 2 | ||||||
MIRT653327 | SMIM18 | small integral membrane protein 18 | ![]() |
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2 | 2 | ||||||
MIRT653406 | SLC7A2 | solute carrier family 7 member 2 | ![]() |
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2 | 2 | ||||||
MIRT653512 | SLC41A1 | solute carrier family 41 member 1 | ![]() |
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2 | 2 | ||||||
MIRT653912 | SERPINC1 | serpin family C member 1 | ![]() |
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2 | 2 | ||||||
MIRT654111 | RPS6KA5 | ribosomal protein S6 kinase A5 | ![]() |
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2 | 2 | ||||||
MIRT654153 | RORB | RAR related orphan receptor B | ![]() |
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2 | 2 | ||||||
MIRT654548 | RAB14 | RAB14, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT654920 | POLR3D | RNA polymerase III subunit D | ![]() |
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2 | 2 | ||||||
MIRT655169 | PHF19 | PHD finger protein 19 | ![]() |
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2 | 2 | ||||||
MIRT655412 | PAN2 | PAN2 poly(A) specific ribonuclease subunit | ![]() |
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2 | 2 | ||||||
MIRT655784 | NOVA2 | NOVA alternative splicing regulator 2 | ![]() |
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2 | 2 | ||||||
MIRT655836 | NGDN | neuroguidin | ![]() |
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2 | 2 | ||||||
MIRT656079 | MTA3 | metastasis associated 1 family member 3 | ![]() |
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2 | 2 | ||||||
MIRT656404 | MCTP1 | multiple C2 and transmembrane domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT656720 | LMLN | leishmanolysin like peptidase | ![]() |
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2 | 2 | ||||||
MIRT656774 | LARP1 | La ribonucleoprotein domain family member 1 | ![]() |
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2 | 2 | ||||||
MIRT656922 | KIAA1462 | junctional cadherin 5 associated | ![]() |
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2 | 2 | ||||||
MIRT657004 | KCNMB4 | potassium calcium-activated channel subfamily M regulatory beta subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT657477 | HCAR2 | hydroxycarboxylic acid receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT657539 | GSTO2 | glutathione S-transferase omega 2 | ![]() |
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2 | 2 | ||||||
MIRT657911 | GCC1 | GRIP and coiled-coil domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT658478 | EXOC8 | exocyst complex component 8 | ![]() |
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2 | 2 | ||||||
MIRT658612 | ENPP5 | ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | ![]() |
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2 | 2 | ||||||
MIRT658823 | SRCAP | Snf2 related CREBBP activator protein | ![]() |
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2 | 2 | ||||||
MIRT658965 | DNAJB5 | DnaJ heat shock protein family (Hsp40) member B5 | ![]() |
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2 | 4 | ||||||
MIRT659706 | CCDC93 | coiled-coil domain containing 93 | ![]() |
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2 | 2 | ||||||
MIRT660034 | C15orf61 | chromosome 15 open reading frame 61 | ![]() |
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2 | 2 | ||||||
MIRT660108 | BTBD3 | BTB domain containing 3 | ![]() |
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2 | 2 | ||||||
MIRT660697 | AMOTL2 | angiomotin like 2 | ![]() |
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2 | 2 | ||||||
MIRT660763 | ALDH6A1 | aldehyde dehydrogenase 6 family member A1 | ![]() |
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2 | 2 | ||||||
MIRT660884 | ADCYAP1R1 | ADCYAP receptor type I | ![]() |
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2 | 2 | ||||||
MIRT660956 | ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT661217 | SCIMP | SLP adaptor and CSK interacting membrane protein | ![]() |
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2 | 2 | ||||||
MIRT661596 | C2orf15 | chromosome 2 open reading frame 15 | ![]() |
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2 | 2 | ||||||
MIRT661624 | UGT2B28 | UDP glucuronosyltransferase family 2 member B28 | ![]() |
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2 | 2 | ||||||
MIRT662430 | EID2 | EP300 interacting inhibitor of differentiation 2 | ![]() |
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2 | 2 | ||||||
MIRT664816 | NOX5 | NADPH oxidase 5 | ![]() |
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2 | 2 | ||||||
MIRT665548 | UCHL5 | ubiquitin C-terminal hydrolase L5 | ![]() |
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2 | 2 | ||||||
MIRT665815 | TMEM161B | transmembrane protein 161B | ![]() |
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2 | 2 | ||||||
MIRT666668 | RBM23 | RNA binding motif protein 23 | ![]() |
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2 | 2 | ||||||
MIRT667995 | HCFC2 | host cell factor C2 | ![]() |
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2 | 2 | ||||||
MIRT668064 | GPR180 | G protein-coupled receptor 180 | ![]() |
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2 | 2 | ||||||
MIRT669056 | CELSR3 | cadherin EGF LAG seven-pass G-type receptor 3 | ![]() |
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2 | 2 | ||||||
MIRT669637 | ACSBG1 | acyl-CoA synthetase bubblegum family member 1 | ![]() |
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2 | 2 | ||||||
MIRT699368 | SLC30A6 | solute carrier family 30 member 6 | ![]() |
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2 | 2 | ||||||
MIRT699882 | RUNX1 | runt related transcription factor 1 | ![]() |
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2 | 2 | ||||||
MIRT703834 | ETV3 | ETS variant 3 | ![]() |
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2 | 2 | ||||||
MIRT708528 | ZNF177 | zinc finger protein 177 | ![]() |
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2 | 2 | ||||||
MIRT709696 | DMWD | DM1 locus, WD repeat containing | ![]() |
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2 | 2 | ||||||
MIRT710381 | PARD6G | par-6 family cell polarity regulator gamma | ![]() |
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2 | 2 | ||||||
MIRT710639 | GLUL | glutamate-ammonia ligase | ![]() |
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2 | 2 | ||||||
MIRT711584 | SETD1A | SET domain containing 1A | ![]() |
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2 | 2 | ||||||
MIRT713208 | FAM13A | family with sequence similarity 13 member A | ![]() |
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2 | 2 | ||||||
MIRT714129 | IL20RB | interleukin 20 receptor subunit beta | ![]() |
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2 | 2 | ||||||
MIRT714204 | MRE11A | MRE11 homolog, double strand break repair nuclease | ![]() |
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2 | 2 | ||||||
MIRT714733 | CCNO | cyclin O | ![]() |
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2 | 2 | ||||||
MIRT714761 | ZNF462 | zinc finger protein 462 | ![]() |
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2 | 2 | ||||||
MIRT715624 | ZBTB8B | zinc finger and BTB domain containing 8B | ![]() |
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2 | 2 | ||||||
MIRT715755 | SKA2 | spindle and kinetochore associated complex subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT716075 | RNF150 | ring finger protein 150 | ![]() |
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2 | 2 | ||||||
MIRT716179 | MTRNR2L1 | MT-RNR2-like 1 | ![]() |
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2 | 2 | ||||||
MIRT717450 | RWDD2A | RWD domain containing 2A | ![]() |
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2 | 2 | ||||||
MIRT717866 | CACNA2D1 | calcium voltage-gated channel auxiliary subunit alpha2delta 1 | ![]() |
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2 | 2 | ||||||
MIRT720964 | ZBTB43 | zinc finger and BTB domain containing 43 | ![]() |
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2 | 2 | ||||||
MIRT721564 | SLC5A12 | solute carrier family 5 member 12 | ![]() |
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2 | 2 | ||||||
MIRT722348 | BAG2 | BCL2 associated athanogene 2 | ![]() |
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2 | 2 | ||||||
MIRT723235 | BTLA | B and T lymphocyte associated | ![]() |
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2 | 2 | ||||||
MIRT724018 | LMBRD2 | LMBR1 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT724507 | KLHL5 | kelch like family member 5 | ![]() |
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2 | 2 | ||||||
MIRT725478 | GPR26 | G protein-coupled receptor 26 | ![]() |
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2 | 2 |
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