miRTarBase - #MIRT607302


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pre-miRNA Information
pre-miRNA hsa-mir-6818   
Genomic Coordinates chr22: 30007049 - 30007113
Description Homo sapiens miR-6818 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6818-3p
Sequence 44| UUGUCUCUUGUUCCUCACACAG |65
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1325627700 2 dbSNP
rs750902684 3 dbSNP
rs756542190 6 dbSNP
rs1365035732 17 dbSNP
Putative Targets

Gene Information
Gene Symbol RREB1   
Synonyms FINB, HNT, LZ321, RREB-1, Zep-1
Description ras responsive element binding protein 1
Transcript NM_001003698   
Other Transcripts NM_001003699 , NM_001003700 , NM_001168344   
Expression
Putative miRNA Targets on RREB1
3'UTR of RREB1
(miRNA target sites are highlighted)		 
>RREB1|NM_001003698|3'UTR
   1 CAGCCTCAGTCCCCCTCAGCACAGACAAAAGCCAGCAGAGCAAAGCGTCTATACTTCATGGGGTTTCCTCAGTGCCCTTT
  81 GGCTGTTGAGGAGTGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAAGCAGGAGCGTGGCTGCTCGCT
 161 CAGTGCCATAGCCTTACCGCAGCCTGCGCGGGAGGCCACAGCCCGTGCCGATTCCAGTGCCTTAACTACTTACCGGATCC
 241 CTCCATATTATCATGGGTGTTGTATTTTTCCAAAATGACTTCTTAAACAAAACAAATATTATAATGAATTGTCTGGAGAG
 321 GACCTCTTCATTTGAGCATTAGCGTTATTTTGTATTGGTGTGTGTGAGCTTGTTCTTGTGAATCTGTGATAGCACCGTTT
 401 GTTCTGTGAGCTGGAAACAGAAGGAAAAAACATACCCTTGGGTACCCATAGCCAATAACTGGAAGAAAATGATGTGAATT
 481 TCATGTAAATGACCAGAGGAAAGATGGATAAGATGATAATTTCTTAAATAGACATTTTCCTTTTTTCTTTGTGCTTCATG
 561 GTGGAGCTGTCATCTGGTCCTTGGTATTACAGGATGTGGTTGATGAAGGTTTCCAATATGGTTTCAGGCCAAAACCAGGG
 641 AAGATTCTAGCTTCAGCCTCATGTCCATTTCCAGTCTGTCAGCATTAGACATGGTCACTGTTCAAGTTTCAAGACATCCA
 721 TTCTTAACTATAGAGAAGAGTTACTCCCCTGGCGTCTTAACCTATGGAAAACATGCACGGATAGGATATATTTGATTGCC
 801 TCCTCTTCCCTTTCAGTATATGTATTATTAATATTATTATTATTATTATTATTATTAGTTCATCAGTTTGCTGTTCTCTG
 881 CAGTGAGCAGAATCAAATGGGCAATATTTGTCCTGGGAGACCTGTGCCGCACCCAGGTCCCCGTGTTAACGTGTGCCTGC
 961 GGTTGTGGTTGGCACCCTCGGGTGGTAGCTCTTCTACTGTAATGAGACAAGCCTTTCTTCTGTCACTGCAGAATTTAGAA
1041 GGGGCCGTGAGCAGTCTTCCCAAGCATGGTCCAGGAGCAGCTCAGAGAGGGTGGAGTGAGGATGCATGCATCCAGGGAAC
1121 AGGCATCAAGAAGCCAGGGCCGTGCCTGGAGCACTGCAGAGATGACTTTGGAGAAAGCAAAGCAGTGACCCAGTGACCAG
1201 GCACATTACTCGTGAGCGAGGTATTCCCAGTCTTCCTGCTAAGCCTAATCCAAGCCTTACCCAGCTGTGCTACTGTCATT
1281 TGCAAAGCAAGGAAATACTACTACTGGTAATAAAACTACACATGCAAGATGTCAGATAAGAAATAGGTTTATATTTACCT
1361 TCCTGCGATGTGGGGTTGGTGCTTGAAGATAAATGTGCTGTTTCTAGTTTCTTAAATAGCCCACACCCCTGGATGCAAAA
1441 AGGCAGGGTTATTTTTACCCATGAGCATCCTGTGCAGGCAATAGACTTCCCTCACTGTCTCCGCCTGCAGGGAGGAGAAT
1521 GTACCCCACTGCACCTGAGCTCCTGGTCCCTCAGCCAAGACCTCAGGGGTCCCCAGCCAGCCTGCTGCTGGGGACCCCTG
1601 TGCTTGCTGCAGTGTATGGAGCCTCTTGCCTTCCCCTGGGGAGGCACCCCTGTACCCCAGCTTCCTTCCCCTGGCCTTTT
1681 CTGGCCCCAGTGCTCCTCCTTTACATAGACTTGTTCACACAGAAACGTGCACGCCCCCTTTTCTCCGCCACTTCACCAGT
1761 TTCTGAAATCCAACCTCCCAGACTTCACAGGAAGATAGATATTCTTGAGATAATGAAAAGTGATATCTTCGCATACGAAA
1841 GGAAAAAAGGTTGAGGTATATATGATTTTTAACTGTATTAGGGGTGTATGAACCAGTTTAAAAACGAGGTTTTATTTACT
1921 GTAGAGATGAATGCAAATCAGAACCAATGATCCCTTGGCCTACTTAGTTAAAACCAGTTCATACATCCCTTAGGGTTTTT
2001 ATTATTATTATTATTATTATTACAGTTGTTATTGTTGTTTTTGTTGTTATTATTATTTGGGGTTTCTTGTGTTTTTTCTT
2081 TGCGACTCTCCACACTAAACTTGCAATATTGTGGGGAGAAGCTGTGACTAAACTCTACGCTGCGGTGAGATGTAGCAGTA
2161 ATCAGCTCCCAGCGACGTGTGTAGCTGGGGCTGCCGCTCGCAATAATCACTATTGATTTAAAGCTTTACTTAGCCTTGAT
2241 CTGTACCCTCGTAGTCAATAAGGTCTTGCCACATTTTATTAGTGAGGTGGAGAAACGTATTATTTGTTTGTTGTTTTTGC
2321 CCTTCCCCCACCCCCCAATATTAAACTGTGAAATTTGTGATTTGTTTAAACTCTGGGTGAATCATAGCTTAGTTTGCATG
2401 TCCAGCTAATTTGTTTCTATACATTTTGTTTGATTCTCTTTCTCCTTCTCTCAGGGCTTTTACAAAAAAATATATATATA
2481 TGGATCTTCTGAAAAGTTTTTTGAGGTGCAAGTTTTTTCTCTTTTTTTTTTTTTTTTTTTTTTCTCATTGATTAATGGAC
2561 ATGATGCTGAGATTCAATCACTACATGAAACACCTGGCTGTGAAAACAAAACAACCCAGAGGGCTGTGTTCCAAGCAGCG
2641 CTGGGGAAGCTACGTAACAGTCGGATGCCAGTTTTGGAAGATTCACCATGCGTTCTGACCCTCTGTTCGTCTCTTTCCTC
2721 TCCTCTTTCTTCAAGAAGGAAATTGATCCTAGTGATTTCAGCCCATGCATTAAACAGGAAACAATAATAAATTTGTAGAA
2801 TTCATATTTTTCTAAAGGGAACTTAAAAACTGCTGCTACATGTTATGTACAAAACTGGTTTATGCCACATGAACAGAGAA
2881 TCACAAGTTTGGTTTTGGTACTTTTTGTTCCTCTTTGTATTCAGTTGTATAGAACTTCCAAATTCAGAATGAGAAGAAAG
2961 CTGTTCTGTATCAAACCATTTAAGCAATAAATGTTATATTTTAAAAGCTGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCACACUC-CUUGUUCUCUGUu 5'
            | | ||| ||: :||||||| 
Target 5' gaGAGAGAGAGAGAGAGAGACAa 3'
 117 - 139 160.00 -16.90
2 
miRNA  3' gacAC-ACUCCUUGUUCUCUGUu 5'
             || ||||||:::||||| | 
Target 5' ggcTGTTGAGGAGTGAGAGAGAg 3'
 81 - 103 143.00 -25.80
3 
miRNA  3' gaCACACUCCUUGU----UCUCUGUu 5'
            |||   |||:||    |||||:: 
Target 5' ccGTGCCTGGAGCACTGCAGAGATGa 3'
 1140 - 1165 126.00 -13.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24394256 19 COSMIC
COSN20066413 128 COSMIC
COSN6514473 136 COSMIC
COSN31577677 138 COSMIC
COSN26577410 166 COSMIC
COSN26481523 180 COSMIC
COSN32056939 211 COSMIC
COSN26576054 218 COSMIC
COSN2175646 295 COSMIC
COSN31483502 358 COSMIC
COSN19373883 379 COSMIC
COSN31593333 390 COSMIC
COSN19525645 426 COSMIC
COSN2175648 519 COSMIC
COSN31563174 858 COSMIC
COSN26645229 916 COSMIC
COSN30538359 981 COSMIC
COSN26639379 1029 COSMIC
COSN26556846 1097 COSMIC
COSN20091338 1511 COSMIC
COSN22645209 1694 COSMIC
COSN23733676 1823 COSMIC
COSN18779865 2524 COSMIC
COSN20370162 2525 COSMIC
rs78588343 260 GWAS
rs3778321 1070 GWAS
rs2714338 1760 GWAS
rs2842352 1837 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1269153748 3 dbSNP
rs1198142710 4 dbSNP
rs1489626033 5 dbSNP
rs962715943 9 dbSNP
rs1217289083 11 dbSNP
rs200233790 12 dbSNP
rs1281889561 13 dbSNP
rs974123364 14 dbSNP
rs757480250 28 dbSNP
rs763061687 32 dbSNP
rs1182627827 36 dbSNP
rs766354041 42 dbSNP
rs1471698162 46 dbSNP
rs918056537 47 dbSNP
rs1377869723 48 dbSNP
rs199624682 51 dbSNP
rs1288740218 52 dbSNP
rs970213882 55 dbSNP
rs1416509242 60 dbSNP
rs1429621552 76 dbSNP
rs868864911 88 dbSNP
rs1175225527 90 dbSNP
rs1201649200 91 dbSNP
rs1479229888 91 dbSNP
rs1264733920 92 dbSNP
rs1186536215 93 dbSNP
rs1183554874 95 dbSNP
rs1242312803 95 dbSNP
rs1242770788 95 dbSNP
rs1279742005 95 dbSNP
rs1336430890 95 dbSNP
rs1417344493 95 dbSNP
rs1425318601 95 dbSNP
rs1427384252 95 dbSNP
rs1461672338 95 dbSNP
rs1467918424 95 dbSNP
rs1485540386 95 dbSNP
rs397843286 95 dbSNP
rs4053178 95 dbSNP
rs56047304 95 dbSNP
rs576350185 95 dbSNP
rs61055209 95 dbSNP
rs66585613 95 dbSNP
rs67081602 95 dbSNP
rs70978946 95 dbSNP
rs749851598 95 dbSNP
rs756604177 95 dbSNP
rs763742071 95 dbSNP
rs1201467573 97 dbSNP
rs1257649034 100 dbSNP
rs1486259932 101 dbSNP
rs1253282817 102 dbSNP
rs1228312006 106 dbSNP
rs1306966293 107 dbSNP
rs1293474555 108 dbSNP
rs1182113751 109 dbSNP
rs982023347 110 dbSNP
rs1314804668 112 dbSNP
rs1450893699 114 dbSNP
rs1402080276 118 dbSNP
rs1298362895 120 dbSNP
rs1166211486 122 dbSNP
rs1461137589 122 dbSNP
rs1384526740 126 dbSNP
rs1445168292 126 dbSNP
rs1249993507 127 dbSNP
rs780960197 127 dbSNP
rs928872963 128 dbSNP
rs978716429 128 dbSNP
rs1162344456 130 dbSNP
rs1224729211 130 dbSNP
rs1308089743 132 dbSNP
rs1337934089 132 dbSNP
rs1390472981 132 dbSNP
rs1364941319 134 dbSNP
rs796503183 134 dbSNP
rs934916289 134 dbSNP
rs989084576 135 dbSNP
rs1421253644 136 dbSNP
rs1421402577 136 dbSNP
rs1424999240 138 dbSNP
rs1418728144 139 dbSNP
rs150028450 143 dbSNP
rs1490524958 145 dbSNP
rs565442789 149 dbSNP
rs1054161157 158 dbSNP
rs892899522 159 dbSNP
rs1238771186 161 dbSNP
rs1175565697 163 dbSNP
rs1314820528 166 dbSNP
rs1376176240 172 dbSNP
rs1405075509 172 dbSNP
rs1344360642 173 dbSNP
rs1300695592 175 dbSNP
rs1383866120 178 dbSNP
rs529714355 179 dbSNP
rs1306126471 180 dbSNP
rs900251606 182 dbSNP
rs559253694 188 dbSNP
rs901636935 189 dbSNP
rs1052052489 190 dbSNP
rs779212816 190 dbSNP
rs1197281498 192 dbSNP
rs1449297925 193 dbSNP
rs886297993 195 dbSNP
rs1263025948 201 dbSNP
rs548392719 205 dbSNP
rs758506657 206 dbSNP
rs544585353 210 dbSNP
rs1016245983 211 dbSNP
rs1280818674 212 dbSNP
rs1228973169 213 dbSNP
rs1327015595 220 dbSNP
rs145249665 225 dbSNP
rs1317513030 226 dbSNP
rs781061602 244 dbSNP
rs1273100764 245 dbSNP
rs1012708079 248 dbSNP
rs565634682 254 dbSNP
rs78588343 260 dbSNP
rs1178121581 271 dbSNP
rs769597416 279 dbSNP
rs1470428029 281 dbSNP
rs1267155142 285 dbSNP
rs981609036 288 dbSNP
rs555170557 296 dbSNP
rs1476418867 297 dbSNP
rs574431508 303 dbSNP
rs1193139474 304 dbSNP
rs1445728980 307 dbSNP
rs1245369202 309 dbSNP
rs1204639684 312 dbSNP
rs956221072 313 dbSNP
rs1460650898 314 dbSNP
rs971296094 320 dbSNP
rs1260854518 322 dbSNP
rs1197076739 324 dbSNP
rs1195757834 331 dbSNP
rs978390962 333 dbSNP
rs571081950 336 dbSNP
rs968333470 337 dbSNP
rs974827509 344 dbSNP
rs148733110 345 dbSNP
rs989791878 349 dbSNP
rs1405689832 351 dbSNP
rs1332401740 353 dbSNP
rs1411828785 357 dbSNP
rs1397332601 366 dbSNP
rs1167347843 367 dbSNP
rs914198377 370 dbSNP
rs933048484 376 dbSNP
rs1387629902 379 dbSNP
rs1184659937 385 dbSNP
rs1444376194 385 dbSNP
rs1241638999 390 dbSNP
rs943139014 391 dbSNP
rs553373195 397 dbSNP
rs923166191 398 dbSNP
rs907708355 415 dbSNP
rs771165140 418 dbSNP
rs1442573141 419 dbSNP
rs1380350188 422 dbSNP
rs371705689 424 dbSNP
rs1444656713 425 dbSNP
rs899098038 426 dbSNP
rs1328356072 428 dbSNP
rs186042270 431 dbSNP
rs995489351 436 dbSNP
rs1044806574 448 dbSNP
rs1364096191 472 dbSNP
rs905885637 479 dbSNP
rs1470346733 483 dbSNP
rs770431764 484 dbSNP
rs1231940892 493 dbSNP
rs1003354102 499 dbSNP
rs1035809435 500 dbSNP
rs1225524561 501 dbSNP
rs886371014 504 dbSNP
rs1297159095 507 dbSNP
rs1309750447 509 dbSNP
rs956188615 514 dbSNP
rs1010411964 517 dbSNP
rs1265178596 520 dbSNP
rs1279169141 520 dbSNP
rs1021851641 535 dbSNP
rs1347489925 537 dbSNP
rs969395732 540 dbSNP
rs1404880108 543 dbSNP
rs1348637265 545 dbSNP
rs1487717733 548 dbSNP
rs1215719836 552 dbSNP
rs1253866845 554 dbSNP
rs1449159242 555 dbSNP
rs1186733394 562 dbSNP
rs975045976 570 dbSNP
rs921584038 577 dbSNP
rs554831260 578 dbSNP
rs1406842848 589 dbSNP
rs1156542406 593 dbSNP
rs1268994540 608 dbSNP
rs1481186894 608 dbSNP
rs576153209 615 dbSNP
rs774151667 617 dbSNP
rs543739789 641 dbSNP
rs879121367 649 dbSNP
rs1164005884 652 dbSNP
rs1243765648 657 dbSNP
rs1216300645 659 dbSNP
rs907634787 661 dbSNP
rs1281837869 662 dbSNP
rs1347834826 673 dbSNP
rs1226808306 678 dbSNP
rs188454440 685 dbSNP
rs940496756 690 dbSNP
rs181413206 693 dbSNP
rs1025478625 694 dbSNP
rs1366176152 708 dbSNP
rs920486769 714 dbSNP
rs970949222 715 dbSNP
rs1432058657 716 dbSNP
rs540647920 717 dbSNP
rs1318887455 725 dbSNP
rs868531893 733 dbSNP
rs1470754997 735 dbSNP
rs1429549015 740 dbSNP
rs540287249 742 dbSNP
rs577623800 746 dbSNP
rs1432503772 749 dbSNP
rs1290076728 755 dbSNP
rs767451921 766 dbSNP
rs1031104823 774 dbSNP
rs1205321922 778 dbSNP
rs776110995 779 dbSNP
rs551670791 780 dbSNP
rs914270578 782 dbSNP
rs964726519 798 dbSNP
rs974544865 802 dbSNP
rs558889464 804 dbSNP
rs867495410 809 dbSNP
rs1002913917 817 dbSNP
rs529775579 821 dbSNP
rs1335642451 822 dbSNP
rs1178288706 823 dbSNP
rs1409371552 823 dbSNP
rs1464197723 823 dbSNP
rs1388230473 826 dbSNP
rs933057256 827 dbSNP
rs1047615473 829 dbSNP
rs891893890 829 dbSNP
rs1181519373 830 dbSNP
rs1207081989 831 dbSNP
rs1021783269 832 dbSNP
rs1375060889 832 dbSNP
rs1384034669 832 dbSNP
rs147889691 832 dbSNP
rs570695709 832 dbSNP
rs60940908 832 dbSNP
rs968944310 832 dbSNP
rs1298306027 833 dbSNP
rs116169691 834 dbSNP
rs941935238 835 dbSNP
rs1165428273 838 dbSNP
rs1037615094 841 dbSNP
rs895187769 848 dbSNP
rs996824667 855 dbSNP
rs1029288890 856 dbSNP
rs1422355982 856 dbSNP
rs948035904 859 dbSNP
rs954487994 860 dbSNP
rs760522111 862 dbSNP
rs1482754293 873 dbSNP
rs987108670 877 dbSNP
rs1225398028 881 dbSNP
rs1014600687 884 dbSNP
rs1181422755 891 dbSNP
rs865974280 900 dbSNP
rs1265291169 924 dbSNP
rs1411516164 929 dbSNP
rs563589167 930 dbSNP
rs1307223751 931 dbSNP
rs1408796291 934 dbSNP
rs906627521 935 dbSNP
rs999526353 936 dbSNP
rs764506308 943 dbSNP
rs973148780 944 dbSNP
rs531005884 951 dbSNP
rs571375500 952 dbSNP
rs981092786 955 dbSNP
rs371873371 961 dbSNP
rs776795715 962 dbSNP
rs1409870953 965 dbSNP
rs1201676558 973 dbSNP
rs1490672287 974 dbSNP
rs1319894602 980 dbSNP
rs964439690 981 dbSNP
rs537280487 988 dbSNP
rs762246093 991 dbSNP
rs1029975777 996 dbSNP
rs1227413906 997 dbSNP
rs1326559788 1002 dbSNP
rs1284726067 1004 dbSNP
rs1354092075 1007 dbSNP
rs111600143 1008 dbSNP
rs1417208900 1017 dbSNP
rs1223580236 1021 dbSNP
rs1294235392 1028 dbSNP
rs946101511 1032 dbSNP
rs954449010 1042 dbSNP
rs563597848 1043 dbSNP
rs753425493 1048 dbSNP
rs1456923254 1060 dbSNP
rs200051308 1061 dbSNP
rs1029626249 1066 dbSNP
rs1480785672 1067 dbSNP
rs3778321 1070 dbSNP
rs1197397041 1071 dbSNP
rs1008496037 1073 dbSNP
rs1262871192 1081 dbSNP
rs1255543271 1084 dbSNP
rs71559154 1088 dbSNP
rs1463313617 1095 dbSNP
rs1264595950 1099 dbSNP
rs1014523216 1103 dbSNP
rs916497488 1107 dbSNP
rs961713745 1113 dbSNP
rs113152260 1114 dbSNP
rs1272526723 1118 dbSNP
rs1229542678 1122 dbSNP
rs1326887628 1123 dbSNP
rs973117815 1125 dbSNP
rs1432603349 1128 dbSNP
rs576391394 1130 dbSNP
rs547048945 1136 dbSNP
rs1046832000 1142 dbSNP
rs906499540 1143 dbSNP
rs935449794 1144 dbSNP
rs1052467641 1146 dbSNP
rs1471490899 1149 dbSNP
rs1160155080 1161 dbSNP
rs1188383051 1163 dbSNP
rs1408253948 1174 dbSNP
rs969587006 1177 dbSNP
rs531202783 1183 dbSNP
rs893998154 1185 dbSNP
rs1275905282 1187 dbSNP
rs927841230 1191 dbSNP
rs1340042106 1200 dbSNP
rs1273782418 1203 dbSNP
rs1011019339 1212 dbSNP
rs1018417876 1213 dbSNP
rs76530228 1218 dbSNP
rs1315405271 1219 dbSNP
rs998410494 1236 dbSNP
rs1437059712 1244 dbSNP
rs535531117 1248 dbSNP
rs1449034675 1256 dbSNP
rs1314022115 1264 dbSNP
rs1030419940 1266 dbSNP
rs74853988 1273 dbSNP
rs55792466 1274 dbSNP
rs946070597 1275 dbSNP
rs146234214 1278 dbSNP
rs904615609 1280 dbSNP
rs1472301928 1288 dbSNP
rs1374287713 1291 dbSNP
rs1218893992 1293 dbSNP
rs1278225779 1297 dbSNP
rs932116101 1304 dbSNP
rs1183401450 1305 dbSNP
rs1050636688 1308 dbSNP
rs963095454 1308 dbSNP
rs536857064 1323 dbSNP
rs973662912 1339 dbSNP
rs1202952115 1344 dbSNP
rs186617559 1350 dbSNP
rs1211425838 1353 dbSNP
rs541343900 1360 dbSNP
rs531528875 1361 dbSNP
rs982041114 1365 dbSNP
rs756059029 1367 dbSNP
rs1477470196 1368 dbSNP
rs1307440255 1369 dbSNP
rs935313860 1370 dbSNP
rs1408545019 1382 dbSNP
rs1191373646 1383 dbSNP
rs577080316 1392 dbSNP
rs1015162901 1395 dbSNP
rs1405103818 1396 dbSNP
rs777775889 1398 dbSNP
rs915341673 1401 dbSNP
rs147841979 1425 dbSNP
rs1040279845 1427 dbSNP
rs41302869 1439 dbSNP
rs1472679544 1442 dbSNP
rs1027781914 1447 dbSNP
rs1179380615 1448 dbSNP
rs969178342 1456 dbSNP
rs1002421994 1457 dbSNP
rs1167474934 1458 dbSNP
rs1370459697 1461 dbSNP
rs1408753193 1462 dbSNP
rs574094275 1463 dbSNP
rs1051350546 1464 dbSNP
rs1330015494 1465 dbSNP
rs1355505001 1471 dbSNP
rs1435957939 1481 dbSNP
rs1301531431 1483 dbSNP
rs1034848064 1485 dbSNP
rs960564353 1492 dbSNP
rs890150347 1495 dbSNP
rs541568355 1497 dbSNP
rs781651131 1503 dbSNP
rs140297053 1504 dbSNP
rs913824163 1521 dbSNP
rs1320614640 1525 dbSNP
rs1297029178 1526 dbSNP
rs530598090 1527 dbSNP
rs1387437698 1536 dbSNP
rs978800392 1543 dbSNP
rs1481114831 1544 dbSNP
rs527516592 1548 dbSNP
rs75204207 1554 dbSNP
rs1273372738 1565 dbSNP
rs1476968529 1574 dbSNP
rs1243640393 1575 dbSNP
rs1209119306 1578 dbSNP
rs1450823527 1580 dbSNP
rs111748467 1582 dbSNP
rs1023922616 1596 dbSNP
rs969245251 1601 dbSNP
rs1254473575 1605 dbSNP
rs564684259 1607 dbSNP
rs982460077 1613 dbSNP
rs1454480100 1614 dbSNP
rs1219160198 1617 dbSNP
rs373350538 1635 dbSNP
rs528820797 1641 dbSNP
rs1272345678 1648 dbSNP
rs1436247751 1649 dbSNP
rs771706031 1650 dbSNP
rs956595917 1657 dbSNP
rs1050970759 1658 dbSNP
rs988122740 1672 dbSNP
rs1359252022 1677 dbSNP
rs1474684450 1678 dbSNP
rs1421560610 1680 dbSNP
rs1170164671 1690 dbSNP
rs1189037181 1691 dbSNP
rs1448672474 1693 dbSNP
rs915205269 1696 dbSNP
rs912051586 1697 dbSNP
rs1420587358 1699 dbSNP
rs1405137341 1700 dbSNP
rs1238189596 1703 dbSNP
rs547308954 1706 dbSNP
rs1311005723 1710 dbSNP
rs78958832 1714 dbSNP
rs58719817 1718 dbSNP
rs150341716 1727 dbSNP
rs777230832 1728 dbSNP
rs1051812970 1731 dbSNP
rs879041784 1733 dbSNP
rs887374005 1734 dbSNP
rs190670045 1747 dbSNP
rs904886286 1748 dbSNP
rs1229429983 1753 dbSNP
rs138027622 1759 dbSNP
rs2714338 1760 dbSNP
rs1355622004 1773 dbSNP
rs1036036004 1774 dbSNP
rs1425837496 1775 dbSNP
rs1257095607 1778 dbSNP
rs1274856917 1781 dbSNP
rs960490978 1783 dbSNP
rs1254011283 1793 dbSNP
rs898823346 1794 dbSNP
rs1009412926 1798 dbSNP
rs558506261 1799 dbSNP
rs1247428657 1802 dbSNP
rs773389234 1810 dbSNP
rs763224783 1815 dbSNP
rs979783846 1817 dbSNP
rs766429038 1821 dbSNP
rs1034795301 1826 dbSNP
rs956628078 1827 dbSNP
rs867359718 1831 dbSNP
rs751576509 1832 dbSNP
rs2842352 1837 dbSNP
rs763897202 1838 dbSNP
rs1420520750 1839 dbSNP
rs1462122139 1842 dbSNP
rs532288317 1843 dbSNP
rs529156605 1845 dbSNP
rs1158212699 1851 dbSNP
rs1367635218 1856 dbSNP
rs934041050 1858 dbSNP
rs1383156695 1863 dbSNP
rs944840884 1871 dbSNP
rs373991216 1874 dbSNP
rs1182985118 1876 dbSNP
rs1383981433 1879 dbSNP
rs1319118186 1880 dbSNP
rs1036500722 1881 dbSNP
rs1489031802 1884 dbSNP
rs1265164803 1885 dbSNP
rs1218928647 1900 dbSNP
rs1330766258 1905 dbSNP
rs1339771319 1906 dbSNP
rs149491820 1907 dbSNP
rs1227219789 1922 dbSNP
rs1294845947 1924 dbSNP
rs41302871 1930 dbSNP
rs745911604 1932 dbSNP
rs940287960 1940 dbSNP
rs1291508393 1951 dbSNP
rs1456645739 1952 dbSNP
rs1352471300 1959 dbSNP
rs1205183198 1961 dbSNP
rs144673261 1963 dbSNP
rs1485609692 1965 dbSNP
rs898848385 1968 dbSNP
rs778919876 1977 dbSNP
rs1409803391 1984 dbSNP
rs1490569463 1988 dbSNP
rs1201658441 1989 dbSNP
rs930311860 1990 dbSNP
rs1020784152 1999 dbSNP
rs1045095181 1999 dbSNP
rs1326485957 1999 dbSNP
rs529940820 1999 dbSNP
rs761336584 1999 dbSNP
rs778999231 1999 dbSNP
rs1257176311 2002 dbSNP
rs904957221 2002 dbSNP
rs1233896644 2003 dbSNP
rs903719560 2005 dbSNP
rs1299006954 2023 dbSNP
rs1000780006 2025 dbSNP
rs1028695644 2029 dbSNP
rs1386567420 2032 dbSNP
rs796285483 2032 dbSNP
rs1174381579 2033 dbSNP
rs953364981 2037 dbSNP
rs772184247 2041 dbSNP
rs1181609406 2044 dbSNP
rs1018955535 2047 dbSNP
rs1174460418 2047 dbSNP
rs1187545033 2047 dbSNP
rs1034825030 2050 dbSNP
rs1257729215 2051 dbSNP
rs1455573861 2057 dbSNP
rs1200527779 2061 dbSNP
rs182889407 2062 dbSNP
rs1254147987 2070 dbSNP
rs892294384 2078 dbSNP
rs1374948779 2079 dbSNP
rs1009478908 2084 dbSNP
rs1434722950 2086 dbSNP
rs1324908578 2088 dbSNP
rs1314654069 2092 dbSNP
rs1022150682 2098 dbSNP
rs1401527500 2098 dbSNP
rs1172352047 2101 dbSNP
rs1432096309 2105 dbSNP
rs1391182285 2107 dbSNP
rs1168338391 2110 dbSNP
rs985022388 2111 dbSNP
rs1356085364 2113 dbSNP
rs968483100 2124 dbSNP
rs575276279 2126 dbSNP
rs1187696886 2127 dbSNP
rs1304665250 2131 dbSNP
rs1253408168 2133 dbSNP
rs1337132988 2134 dbSNP
rs926877477 2136 dbSNP
rs1483336777 2137 dbSNP
rs545859409 2139 dbSNP
rs1028702242 2140 dbSNP
rs186412675 2144 dbSNP
rs986875156 2145 dbSNP
rs1339951123 2160 dbSNP
rs908749680 2163 dbSNP
rs940150449 2168 dbSNP
rs896179540 2174 dbSNP
rs1212478392 2175 dbSNP
rs1393261667 2177 dbSNP
rs775552958 2178 dbSNP
rs1472219470 2183 dbSNP
rs920201462 2187 dbSNP
rs760582691 2188 dbSNP
rs1183714619 2189 dbSNP
rs1472901969 2190 dbSNP
rs1225543720 2191 dbSNP
rs948960493 2192 dbSNP
rs1044740314 2197 dbSNP
rs191219979 2200 dbSNP
rs939140515 2201 dbSNP
rs1061635 2207 dbSNP
rs1056141785 2210 dbSNP
rs1210675328 2217 dbSNP
rs1355893405 2220 dbSNP
rs1291586617 2229 dbSNP
rs1230266839 2230 dbSNP
rs1351698224 2242 dbSNP
rs889713020 2244 dbSNP
rs1007490330 2245 dbSNP
rs1351986913 2248 dbSNP
rs1061637 2251 dbSNP
rs138548651 2252 dbSNP
rs966045127 2259 dbSNP
rs972120012 2263 dbSNP
rs1026360865 2272 dbSNP
rs1410533371 2272 dbSNP
rs1175417672 2273 dbSNP
rs182962276 2282 dbSNP
rs952213531 2285 dbSNP
rs1009342944 2297 dbSNP
rs746466076 2298 dbSNP
rs1210769304 2303 dbSNP
rs529583189 2303 dbSNP
rs1022057385 2309 dbSNP
rs550715870 2324 dbSNP
rs776356555 2326 dbSNP
rs1222573611 2328 dbSNP
rs77130024 2329 dbSNP
rs537013359 2331 dbSNP
rs1398397248 2332 dbSNP
rs1436183428 2336 dbSNP
rs1369176777 2337 dbSNP
rs992441902 2339 dbSNP
rs1435283442 2347 dbSNP
rs1387295469 2350 dbSNP
rs1156298459 2351 dbSNP
rs955554338 2356 dbSNP
rs1416168889 2362 dbSNP
rs1302247077 2364 dbSNP
rs1171831703 2372 dbSNP
rs1452363869 2373 dbSNP
rs1249618858 2378 dbSNP
rs1190758224 2383 dbSNP
rs1465464285 2389 dbSNP
rs986906249 2392 dbSNP
rs1241653818 2393 dbSNP
rs1213697599 2395 dbSNP
rs1314520442 2399 dbSNP
rs1015671457 2406 dbSNP
rs533295791 2413 dbSNP
rs1346176356 2417 dbSNP
rs1303553699 2420 dbSNP
rs748732232 2438 dbSNP
rs917583543 2439 dbSNP
rs945060877 2442 dbSNP
rs974255858 2443 dbSNP
rs756342633 2445 dbSNP
rs920047935 2446 dbSNP
rs1196810534 2451 dbSNP
rs770136727 2457 dbSNP
rs925030751 2459 dbSNP
rs936487681 2461 dbSNP
rs749338886 2463 dbSNP
rs1050042989 2464 dbSNP
rs1419052788 2464 dbSNP
rs187637475 2470 dbSNP
rs889649885 2470 dbSNP
rs371211306 2472 dbSNP
rs926350396 2473 dbSNP
rs939003018 2474 dbSNP
rs1195550228 2479 dbSNP
rs1229635110 2490 dbSNP
rs1395806672 2492 dbSNP
rs1056171716 2493 dbSNP
rs1412915488 2499 dbSNP
rs1372320895 2509 dbSNP
rs1427801466 2518 dbSNP
rs1428901114 2520 dbSNP
rs1223328001 2522 dbSNP
rs1230903963 2522 dbSNP
rs1272059390 2522 dbSNP
rs1288948267 2522 dbSNP
rs1321933110 2522 dbSNP
rs1365871621 2522 dbSNP
rs1370927626 2522 dbSNP
rs1409072986 2522 dbSNP
rs1491321531 2522 dbSNP
rs34678863 2522 dbSNP
rs397888334 2522 dbSNP
rs747198771 2522 dbSNP
rs980510791 2522 dbSNP
rs534519974 2523 dbSNP
rs778890728 2523 dbSNP
rs1164362497 2524 dbSNP
rs61092730 2524 dbSNP
rs2714339 2525 dbSNP
rs993468673 2525 dbSNP
rs397834173 2526 dbSNP
rs879166611 2527 dbSNP
rs1462289824 2528 dbSNP
rs1325026377 2530 dbSNP
rs1391790922 2532 dbSNP
rs1330613305 2533 dbSNP
rs1026371197 2534 dbSNP
rs1238316133 2537 dbSNP
rs200191326 2541 dbSNP
rs1442685667 2542 dbSNP
rs1303188078 2544 dbSNP
rs913667744 2544 dbSNP
rs1136035 2545 dbSNP
rs1360674310 2546 dbSNP
rs9379086 2546 dbSNP
rs552718681 2547 dbSNP
rs952247360 2548 dbSNP
rs1294052307 2550 dbSNP
rs1309844158 2551 dbSNP
rs1159980440 2552 dbSNP
rs1442141759 2552 dbSNP
rs1219610410 2555 dbSNP
rs1453757113 2556 dbSNP
rs1280611158 2557 dbSNP
rs1362531527 2560 dbSNP
rs1178812435 2562 dbSNP
rs945106069 2564 dbSNP
rs1058484 2574 dbSNP
rs1252693218 2576 dbSNP
rs1058485 2586 dbSNP
rs1465967543 2608 dbSNP
rs1215816976 2610 dbSNP
rs1248181407 2610 dbSNP
rs1253644112 2624 dbSNP
rs1204006538 2635 dbSNP
rs1484881664 2638 dbSNP
rs1257710213 2640 dbSNP
rs568027459 2641 dbSNP
rs1043574096 2654 dbSNP
rs903676019 2655 dbSNP
rs535345690 2659 dbSNP
rs3199110 2660 dbSNP
rs996814459 2661 dbSNP
rs9502567 2663 dbSNP
rs530706892 2664 dbSNP
rs1381693351 2667 dbSNP
rs1382834874 2669 dbSNP
rs1305119937 2672 dbSNP
rs925032041 2685 dbSNP
rs1394920170 2692 dbSNP
rs1008243029 2693 dbSNP
rs1450986850 2699 dbSNP
rs1390381218 2700 dbSNP
rs1049523499 2709 dbSNP
rs1444809971 2720 dbSNP
rs1462639918 2724 dbSNP
rs1165199220 2726 dbSNP
rs1015578192 2734 dbSNP
rs961454804 2743 dbSNP
rs1278001777 2748 dbSNP
rs1428024000 2749 dbSNP
rs1344638545 2757 dbSNP
rs1271012233 2764 dbSNP
rs1226890332 2777 dbSNP
rs1290168624 2779 dbSNP
rs943876750 2782 dbSNP
rs1401181473 2783 dbSNP
rs768249127 2786 dbSNP
rs897092395 2788 dbSNP
rs575173272 2794 dbSNP
rs1048175801 2798 dbSNP
rs887815039 2802 dbSNP
rs1187630142 2806 dbSNP
rs1006711906 2825 dbSNP
rs1255289504 2831 dbSNP
rs1184190577 2836 dbSNP
rs1483264862 2840 dbSNP
rs1271955402 2841 dbSNP
rs995558882 2849 dbSNP
rs1267346528 2851 dbSNP
rs1486124550 2851 dbSNP
rs1354851516 2853 dbSNP
rs1187151278 2856 dbSNP
rs191950501 2859 dbSNP
rs970630392 2866 dbSNP
rs1013771840 2870 dbSNP
rs1025204394 2878 dbSNP
rs1476062076 2883 dbSNP
rs1188463755 2884 dbSNP
rs980405780 2887 dbSNP
rs868732415 2901 dbSNP
rs960252939 2902 dbSNP
rs557843804 2908 dbSNP
rs766517581 2911 dbSNP
rs913531830 2917 dbSNP
rs945161872 2925 dbSNP
rs1414965764 2927 dbSNP
rs1184280840 2930 dbSNP
rs1160605959 2962 dbSNP
rs1232161332 2963 dbSNP
rs1179358270 2964 dbSNP
rs1436339009 2981 dbSNP
rs1269767276 2984 dbSNP
rs538571421 2985 dbSNP
rs761283181 2989 dbSNP
rs1334260385 2994 dbSNP
rs774664300 3002 dbSNP
rs1230833270 3005 dbSNP
rs1352024286 3012 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 6239.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714643. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaCACACUC-CUUGUUCUCUGUu 5'
            | | ||| ||: :||||| | 
Target 5' --GAGAGAGAGAGAGAGAGAGAg 3'
 		1 - 21
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MDA-MB-231
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395169. RNA binding protein: AGO. Condition:MDA-MB-231 AGO HITS-CLIP Replicate 1 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202481. RNA binding protein: AGO2. Condition:S6_LV_61yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM714643
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000379938.2 | 3UTR | GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000379938.2 | 3UTR | GAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000379938.2 | 3UTR | GAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000379938.2 | 3UTR | AGGAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000379938.2 | 3UTR | UUGAGGAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000379938.2 | 3UTR | GUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000379938.2 | 3UTR | UGAGGAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000379938.2 | 3UTR | GUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000379938.2 | 3UTR | GUGCCCUUUGGCUGUUGAGGAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000379938.2 | 3UTR | GAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000379938.2 | 3UTR | GAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000379938.2 | 3UTR | GAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000379938.2 | 3UTR | GUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000379938.2 | 3UTR | UGUUGAGGAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000379938.2 | 3UTR | UGAGGAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000379938.2 | 3UTR | GUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 17 for dataset GSM1395169
Method / RBP HITS-CLIP / AGO
Cell line / Condition MDA-MB-231 / MDA-MB-231 AGO HITS-CLIP Replicate 1
Location of target site ENST00000379938.2 | 3UTR | GAGUGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
150 hsa-miR-6818-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112122 TIMM17A translocase of inner mitochondrial membrane 17A 2 6
MIRT262243 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT446689 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT449923 TPST2 tyrosylprotein sulfotransferase 2 2 2
MIRT464356 USP12P1 ubiquitin specific peptidase 12 pseudogene 1 2 2
MIRT485703 CBX7 chromobox 7 2 2
MIRT497478 XPR1 xenotropic and polytropic retrovirus receptor 1 2 4
MIRT499435 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT514246 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT515032 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515065 PLA2G2C phospholipase A2 group IIC 2 2
MIRT520235 USP9X ubiquitin specific peptidase 9, X-linked 2 4
MIRT523685 FHL2 four and a half LIM domains 2 2 4
MIRT525524 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT525838 FAR2 fatty acyl-CoA reductase 2 2 2
MIRT528583 PTGER3 prostaglandin E receptor 3 2 2
MIRT530404 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530703 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT535118 PLSCR4 phospholipid scramblase 4 2 2
MIRT539880 IRGQ immunity related GTPase Q 2 2
MIRT540195 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540938 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541501 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT542544 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542559 ZNF280B zinc finger protein 280B 2 2
MIRT542689 RPS15A ribosomal protein S15a 2 2
MIRT548759 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT549735 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT553060 ULK1 unc-51 like autophagy activating kinase 1 2 2
MIRT556303 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT560816 DIP2A disco interacting protein 2 homolog A 2 2
MIRT567455 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT575143 Cd93 CD93 antigen 2 2
MIRT607217 ACSM2A acyl-CoA synthetase medium chain family member 2A 2 4
MIRT607286 CD300E CD300e molecule 2 6
MIRT607302 RREB1 ras responsive element binding protein 1 2 6
MIRT608645 ABCF3 ATP binding cassette subfamily F member 3 2 4
MIRT611095 MYO1F myosin IF 2 4
MIRT611576 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT614271 WSCD2 WSC domain containing 2 2 2
MIRT614855 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT617114 KANK2 KN motif and ankyrin repeat domains 2 2 2
MIRT618002 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618028 CTU1 cytosolic thiouridylase subunit 1 2 2
MIRT619062 BSND barttin CLCNK type accessory beta subunit 2 4
MIRT619289 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619356 CFHR5 complement factor H related 5 2 2
MIRT620725 CCL16 C-C motif chemokine ligand 16 2 2
MIRT620913 LRRTM2 leucine rich repeat transmembrane neuronal 2 2 2
MIRT621902 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT622025 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT622556 PTPN3 protein tyrosine phosphatase, non-receptor type 3 2 2
MIRT623137 NCKAP1 NCK associated protein 1 2 2
MIRT623140 NAV2 neuron navigator 2 2 2
MIRT623701 HHAT hedgehog acyltransferase 2 2
MIRT624602 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT625944 OLIG3 oligodendrocyte transcription factor 3 2 2
MIRT625988 SPATA17 spermatogenesis associated 17 2 2
MIRT628028 LSAMP limbic system-associated membrane protein 2 2
MIRT635521 MC2R melanocortin 2 receptor 2 2
MIRT638916 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT639796 EPX eosinophil peroxidase 2 2
MIRT640344 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT644806 VLDLR very low density lipoprotein receptor 2 2
MIRT645303 AGTRAP angiotensin II receptor associated protein 2 2
MIRT645629 SYTL4 synaptotagmin like 4 2 2
MIRT645683 TBC1D13 TBC1 domain family member 13 2 2
MIRT646216 DUSP10 dual specificity phosphatase 10 2 2
MIRT648505 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT649748 UTP20 UTP20, small subunit processome component 2 2
MIRT649797 CLEC2D C-type lectin domain family 2 member D 2 2
MIRT650482 UFM1 ubiquitin fold modifier 1 2 2
MIRT653199 SP9 Sp9 transcription factor 2 2
MIRT655741 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT659978 C2CD2L C2CD2 like 2 2
MIRT660350 BAG4 BCL2 associated athanogene 4 2 2
MIRT662185 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663290 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT666817 PRCP prolylcarboxypeptidase 2 2
MIRT671665 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT671838 PDE3A phosphodiesterase 3A 2 2
MIRT672193 F2 coagulation factor II, thrombin 2 2
MIRT673870 KLF2 Kruppel like factor 2 2 2
MIRT683563 CARD8 caspase recruitment domain family member 8 2 2
MIRT684545 ZNF708 zinc finger protein 708 2 2
MIRT685140 TACR3 tachykinin receptor 3 2 2
MIRT685413 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT686039 SLC5A5 solute carrier family 5 member 5 2 2
MIRT686126 B4GALT7 beta-1,4-galactosyltransferase 7 2 2
MIRT687473 NHLRC2 NHL repeat containing 2 2 2
MIRT687946 HHIP hedgehog interacting protein 2 2
MIRT688171 FRRS1 ferric chelate reductase 1 2 2
MIRT688295 FAM208A family with sequence similarity 208 member A 2 2
MIRT689044 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT689194 ZNF574 zinc finger protein 574 2 2
MIRT691253 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT695358 PHAX phosphorylated adaptor for RNA export 2 2
MIRT696674 APOC3 apolipoprotein C3 2 2
MIRT697358 ZNF394 zinc finger protein 394 2 2
MIRT697604 XIAP X-linked inhibitor of apoptosis 2 2
MIRT697726 USP6NL USP6 N-terminal like 2 2
MIRT697776 UBXN7 UBX domain protein 7 2 2
MIRT698478 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT698984 SPAG9 sperm associated antigen 9 2 2
MIRT699851 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT700172 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT704339 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT704589 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT705836 AHCY adenosylhomocysteinase 2 2
MIRT707085 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT707132 TRA2B transformer 2 beta homolog 2 2
MIRT707145 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT707234 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT707347 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT707445 PPFIBP1 PPFIA binding protein 1 2 2
MIRT707494 AXL AXL receptor tyrosine kinase 2 2
MIRT707638 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT707690 FAM118A family with sequence similarity 118 member A 2 2
MIRT707706 CDC6 cell division cycle 6 2 2
MIRT707817 TMEM170A transmembrane protein 170A 2 2
MIRT707957 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT707996 NUDT4 nudix hydrolase 4 2 2
MIRT708026 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT708058 LIX1L limb and CNS expressed 1 like 2 2
MIRT708089 KIAA1671 KIAA1671 2 2
MIRT708125 GK5 glycerol kinase 5 (putative) 2 2
MIRT708194 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT708201 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT710503 BSDC1 BSD domain containing 1 2 2
MIRT711308 IFNGR2 interferon gamma receptor 2 2 2
MIRT711740 DTX1 deltex E3 ubiquitin ligase 1 2 2
MIRT713202 SOCS6 suppressor of cytokine signaling 6 2 2
MIRT714380 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT715210 NPVF neuropeptide VF precursor 2 2
MIRT715559 EPHB4 EPH receptor B4 2 2
MIRT715835 SZT2 SZT2, KICSTOR complex subunit 2 2
MIRT716680 HLA-B major histocompatibility complex, class I, B 2 2
MIRT717660 THBS2 thrombospondin 2 2 2
MIRT718132 PALM paralemmin 2 2
MIRT718322 METTL7A methyltransferase like 7A 2 2
MIRT720693 RNF217 ring finger protein 217 2 2
MIRT720727 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT721376 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721983 FAM214B family with sequence similarity 214 member B 2 2
MIRT722163 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT722881 MOB3A MOB kinase activator 3A 2 2
MIRT723218 FMNL3 formin like 3 2 2
MIRT723788 MUC17 mucin 17, cell surface associated 2 2
MIRT724093 TMEM199 transmembrane protein 199 2 2
MIRT725265 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6818-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6818-3p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)

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