pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF543   
Synonyms -
Description zinc finger protein 543
Transcript NM_213598   
Expression
Putative miRNA Targets on ZNF543
3'UTR of ZNF543
(miRNA target sites are highlighted)
>ZNF543|NM_213598|3'UTR
   1 AAGGGAACATCTTACCATCTGGCCATTCACACTGAAGAGAAACTTCATAAGCATCCTCTCTTTGAGAAAACGTGTAATAG
  81 ATGATCATTTGTCGTCTAAACAATCAAGTTAGAAATTGAACCAGCCTGGAGTCTTATTCTCCACCTGAGAATTCACCCAT
 161 GAGAGAGACCCAGTGGTTGCTATGCACTTAGGAAAACTTTCAGCCACATCTTTCTTCTTAGTTTACAGTGAAATATTATC
 241 TCAGGGATATTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCT
 321 CACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCA
 401 CTACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGGGATGGTCTCGATCTCCTGACC
 481 TCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCATCTCAGGGATATT
 561 TAAACAAAGGAAGAGGAAATATAGGGAAGAGAAAGAAACCACAGCTTCTTTTAGACTTGTCTGACAAGCCTATGGCAATT
 641 TTGTCGTCCCTTTGTTATTTTATGTGGGAGAGGGAAATGTTTCAGAAACGAAAGATCTCATCCCCTTTATTTTTCTGTGT
 721 ATGCATTCACTGCTGCCCAGTGTCAGAACAGTTATACAAACGAGGGCTTGAAAACATTTTGTGAAAACTTGCTTAGTCCT
 801 GCAACGTTCTCCACTCTCGAGGTGCAGAAGCATACATCTTTATAAAAAATATGGAGGCTTGAGTTATGAAACACTTTTAT
 881 AAGGAGATAAGGATGTACATATGTTTGGACACATTGTCCACTTCAGATGCTTGTTTAAAAAAATGTTTCACCATGTGTCT
 961 TTACCCAATACACATACTTTTTCTTGATGTGGATTTACTTTTTTTTTTTTTTTTTAAGTTTTCCTGGGATAGGGATGATA
1041 GTGTAATTGTTCATGCCCACAGTAATCCTGGGAATCTTAGTTTTTTCCTATGATTGTGGTTTCTCAGCTTCTTTACCTCT
1121 CCTTTGAGTTAGGTCCACCTCAGTTTTCTAAAGGTCAAATTAAGGCCCCCCCAAAAATACAGTATGTAGCTGAATTCCTT
1201 TGAAAGATCATGATAAACTCAGAAGAACAAACATAGAAGGAATGTCATTTTTAATCTTTTTAAAGAGTGTGTGAAAATTC
1281 ACTTTAACTGGAATTTTAACAGGCAAGCCGGCATGCATATATGTAGGGATGTGTGACTTTCACAGTTGTCACCATGGACT
1361 TAGGCTTGATTAAAATGCTACACATTTAGAGCGTTTTGTAATTCCTTTTTTATATTTTTAAGACTAGATTTTGAGCCATG
1441 TGATAGTTTTACCTCATATTAAATATATTGTACAGAAGTAAAAATAATCATGTATTCACTTTGAACTCCTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGGUCGG---AGCGGGUCg 5'
            |: ||:   |||||||| 
Target 5' gtCTCGCTCTGTCGCCCAGg 3'
274 - 293 147.00 -16.70
2
miRNA  3' acGGUCGGAGCGGGUCg 5'
            ||| || |||||:| 
Target 5' agCCA-CCGCGCCCGGc 3'
530 - 545 138.00 -25.50
3
miRNA  3' acGGUCGGAGCGGGUCg 5'
            :|| :  :|||||| 
Target 5' atTCACTGCTGCCCAGt 3'
725 - 741 127.00 -13.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30499224 10 COSMIC
COSN30175087 20 COSMIC
COSN31511246 38 COSMIC
COSN30468198 51 COSMIC
COSN31516975 56 COSMIC
COSN1772784 58 COSMIC
COSN30139154 62 COSMIC
COSN27006226 64 COSMIC
COSN30179641 65 COSMIC
COSN30179607 67 COSMIC
COSN30506803 72 COSMIC
COSN30180297 81 COSMIC
COSN30192051 106 COSMIC
COSN31599951 150 COSMIC
COSN16682378 162 COSMIC
COSN27054316 539 COSMIC
COSN6669933 620 COSMIC
COSN6148051 691 COSMIC
COSN21567480 700 COSMIC
COSN22770256 814 COSMIC
COSN4907489 879 COSMIC
COSN20116150 1016 COSMIC
COSN27272259 1016 COSMIC
COSN16430033 1023 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs143736129 4 dbSNP
rs1227350917 6 dbSNP
rs1368819572 7 dbSNP
rs747020312 10 dbSNP
rs1337467643 12 dbSNP
rs1410470470 13 dbSNP
rs1401340350 15 dbSNP
rs371065636 15 dbSNP
rs745411872 15 dbSNP
rs757558196 17 dbSNP
rs781509396 18 dbSNP
rs746077353 26 dbSNP
rs1429695089 30 dbSNP
rs768641758 33 dbSNP
rs866885430 36 dbSNP
rs1472288306 41 dbSNP
rs113669012 45 dbSNP
rs1420282875 51 dbSNP
rs1406946270 52 dbSNP
rs906621938 56 dbSNP
rs1461600218 58 dbSNP
rs367565035 59 dbSNP
rs956174477 61 dbSNP
rs1011510232 71 dbSNP
rs1021927844 73 dbSNP
rs1281365047 75 dbSNP
rs1291650612 77 dbSNP
rs964543178 79 dbSNP
rs575602494 80 dbSNP
rs974571902 94 dbSNP
rs931322580 95 dbSNP
rs544807005 101 dbSNP
rs1158056872 102 dbSNP
rs763041436 102 dbSNP
rs1325685379 106 dbSNP
rs1413790357 113 dbSNP
rs1369149143 116 dbSNP
rs1048646218 138 dbSNP
rs1177418299 157 dbSNP
rs890026218 159 dbSNP
rs1472199029 164 dbSNP
rs954432718 164 dbSNP
rs1186082504 174 dbSNP
rs942954972 177 dbSNP
rs191218685 181 dbSNP
rs1041231699 183 dbSNP
rs901370343 184 dbSNP
rs1325484689 186 dbSNP
rs866362851 187 dbSNP
rs1286693703 188 dbSNP
rs1224665139 192 dbSNP
rs530296697 194 dbSNP
rs1340020716 196 dbSNP
rs1454515974 198 dbSNP
rs891439086 202 dbSNP
rs1319790006 207 dbSNP
rs1346709223 212 dbSNP
rs1037962635 214 dbSNP
rs1404347458 217 dbSNP
rs916777312 226 dbSNP
rs536609098 227 dbSNP
rs71354045 230 dbSNP
rs1271047266 231 dbSNP
rs1469693429 234 dbSNP
rs969931808 235 dbSNP
rs980029657 238 dbSNP
rs560760003 240 dbSNP
rs1244171863 244 dbSNP
rs1491215614 247 dbSNP
rs1491545423 248 dbSNP
rs138844194 249 dbSNP
rs11355141 250 dbSNP
rs1226049880 250 dbSNP
rs1287829585 250 dbSNP
rs796094957 250 dbSNP
rs960154914 250 dbSNP
rs972817900 252 dbSNP
rs999547622 261 dbSNP
rs1478437236 266 dbSNP
rs1164762314 267 dbSNP
rs1392904605 271 dbSNP
rs1463406200 272 dbSNP
rs984527721 274 dbSNP
rs1388981955 275 dbSNP
rs1168568185 277 dbSNP
rs535209849 279 dbSNP
rs1052924641 280 dbSNP
rs1380123886 283 dbSNP
rs1245267048 294 dbSNP
rs893816219 298 dbSNP
rs1011285303 301 dbSNP
rs1273942749 302 dbSNP
rs1226135366 303 dbSNP
rs1309120127 304 dbSNP
rs1319755430 305 dbSNP
rs1021583090 309 dbSNP
rs1218489512 309 dbSNP
rs1232621039 310 dbSNP
rs1284850581 311 dbSNP
rs1405155140 312 dbSNP
rs868729299 317 dbSNP
rs996041109 318 dbSNP
rs1460929530 323 dbSNP
rs1356848719 324 dbSNP
rs1030152978 327 dbSNP
rs1336811500 334 dbSNP
rs866443483 335 dbSNP
rs1259876210 336 dbSNP
rs1480861158 339 dbSNP
rs954507324 341 dbSNP
rs1485682608 342 dbSNP
rs112438872 349 dbSNP
rs918679289 350 dbSNP
rs1264718827 353 dbSNP
rs1488691649 354 dbSNP
rs963076819 363 dbSNP
rs551842784 365 dbSNP
rs1476461800 367 dbSNP
rs1165958985 374 dbSNP
rs916862697 375 dbSNP
rs984101218 380 dbSNP
rs911264697 383 dbSNP
rs982267319 384 dbSNP
rs1465933422 385 dbSNP
rs1404398611 387 dbSNP
rs942922568 389 dbSNP
rs1178951851 391 dbSNP
rs1041326345 392 dbSNP
rs928154766 393 dbSNP
rs935472596 394 dbSNP
rs1179926839 397 dbSNP
rs568958192 398 dbSNP
rs935517988 399 dbSNP
rs1413672889 400 dbSNP
rs1310516021 403 dbSNP
rs57227955 405 dbSNP
rs1204126421 406 dbSNP
rs893879925 409 dbSNP
rs537506191 425 dbSNP
rs1052844288 431 dbSNP
rs946773654 431 dbSNP
rs1040098383 433 dbSNP
rs1306027351 438 dbSNP
rs1424062515 439 dbSNP
rs1314851652 441 dbSNP
rs1395957756 444 dbSNP
rs891526436 445 dbSNP
rs1339256724 448 dbSNP
rs1453920603 449 dbSNP
rs8108680 450 dbSNP
rs1030227909 452 dbSNP
rs890304556 458 dbSNP
rs1005081741 459 dbSNP
rs1014713754 461 dbSNP
rs1442840412 462 dbSNP
rs963448858 463 dbSNP
rs1021245366 469 dbSNP
rs905572535 470 dbSNP
rs1206556682 472 dbSNP
rs969002862 479 dbSNP
rs567939735 484 dbSNP
rs928181083 487 dbSNP
rs1036033072 490 dbSNP
rs959869970 491 dbSNP
rs935553183 492 dbSNP
rs988708461 493 dbSNP
rs994391761 494 dbSNP
rs1025497966 495 dbSNP
rs952769672 499 dbSNP
rs10417105 500 dbSNP
rs911191196 502 dbSNP
rs1164154800 505 dbSNP
rs1448749507 506 dbSNP
rs553689905 507 dbSNP
rs964042063 516 dbSNP
rs933948478 519 dbSNP
rs1194986273 522 dbSNP
rs1447355808 523 dbSNP
rs1380575877 527 dbSNP
rs1219764024 528 dbSNP
rs1490712322 533 dbSNP
rs1433658596 534 dbSNP
rs977007917 535 dbSNP
rs369876565 537 dbSNP
rs1339226055 538 dbSNP
rs867947981 539 dbSNP
rs922857987 540 dbSNP
rs1376671410 543 dbSNP
rs1300904847 544 dbSNP
rs1466499991 545 dbSNP
rs935626770 548 dbSNP
rs1297597425 550 dbSNP
rs1053015552 554 dbSNP
rs774492030 566 dbSNP
rs1394324587 570 dbSNP
rs915451264 571 dbSNP
rs576685276 583 dbSNP
rs1376835401 586 dbSNP
rs1042798307 588 dbSNP
rs1377957153 591 dbSNP
rs1004751607 602 dbSNP
rs1180756547 608 dbSNP
rs112863913 620 dbSNP
rs1481458999 624 dbSNP
rs1271551303 625 dbSNP
rs539026154 626 dbSNP
rs905499158 630 dbSNP
rs1262862388 633 dbSNP
rs1036589458 639 dbSNP
rs1350075288 643 dbSNP
rs1001167072 646 dbSNP
rs73633730 647 dbSNP
rs1330879627 655 dbSNP
rs1410419538 674 dbSNP
rs184081445 687 dbSNP
rs895702703 690 dbSNP
rs1470760881 691 dbSNP
rs1239126180 710 dbSNP
rs1157914631 726 dbSNP
rs994135278 744 dbSNP
rs117304550 751 dbSNP
rs1234064795 756 dbSNP
rs952530132 757 dbSNP
rs1005600795 762 dbSNP
rs1438828405 771 dbSNP
rs1414220167 773 dbSNP
rs1396493331 782 dbSNP
rs1242930417 797 dbSNP
rs1035269450 802 dbSNP
rs1326103038 805 dbSNP
rs1018388541 806 dbSNP
rs188619983 807 dbSNP
rs1348664012 808 dbSNP
rs1281315070 809 dbSNP
rs1442844935 810 dbSNP
rs10417949 813 dbSNP
rs8108930 819 dbSNP
rs915415943 820 dbSNP
rs957177000 825 dbSNP
rs1440466518 826 dbSNP
rs1301601286 828 dbSNP
rs2361121 829 dbSNP
rs921312889 830 dbSNP
rs1182255352 835 dbSNP
rs1462976236 852 dbSNP
rs1244080299 867 dbSNP
rs915379086 868 dbSNP
rs1445429180 869 dbSNP
rs879321369 875 dbSNP
rs1294881672 879 dbSNP
rs934017375 880 dbSNP
rs1051084328 888 dbSNP
rs946891028 892 dbSNP
rs1312895326 911 dbSNP
rs911839952 912 dbSNP
rs1306297111 920 dbSNP
rs1383297777 921 dbSNP
rs192841561 925 dbSNP
rs545796114 926 dbSNP
rs1288001333 927 dbSNP
rs1259123935 934 dbSNP
rs1428227115 944 dbSNP
rs57553940 949 dbSNP
rs1036257851 951 dbSNP
rs1423492879 953 dbSNP
rs185200644 954 dbSNP
rs1254537992 959 dbSNP
rs937128802 964 dbSNP
rs1478139224 971 dbSNP
rs1057196508 972 dbSNP
rs1186235967 976 dbSNP
rs547926508 977 dbSNP
rs1185454751 978 dbSNP
rs1416725087 984 dbSNP
rs1244122013 990 dbSNP
rs567805159 993 dbSNP
rs1044832641 994 dbSNP
rs895516217 995 dbSNP
rs1491538875 998 dbSNP
rs981835532 998 dbSNP
rs11297071 999 dbSNP
rs1230163651 999 dbSNP
rs1363207901 999 dbSNP
rs1380032510 999 dbSNP
rs1403903086 999 dbSNP
rs1491305624 999 dbSNP
rs58246444 999 dbSNP
rs869199642 999 dbSNP
rs869285926 999 dbSNP
rs1304366364 1016 dbSNP
rs1427127136 1016 dbSNP
rs1171232100 1017 dbSNP
rs527492363 1019 dbSNP
rs1417068181 1023 dbSNP
rs1459745052 1024 dbSNP
rs1170357456 1025 dbSNP
rs1408614044 1032 dbSNP
rs1422032138 1033 dbSNP
rs1327639946 1041 dbSNP
rs1480194332 1044 dbSNP
rs994455793 1046 dbSNP
rs1351854911 1057 dbSNP
rs1437402182 1060 dbSNP
rs1047016230 1061 dbSNP
rs1034631373 1065 dbSNP
rs1250727874 1070 dbSNP
rs770114760 1072 dbSNP
rs1005402954 1075 dbSNP
rs1018149881 1079 dbSNP
rs1222533301 1081 dbSNP
rs899900707 1089 dbSNP
rs998320491 1091 dbSNP
rs1284790658 1093 dbSNP
rs1359881315 1097 dbSNP
rs3761061 1100 dbSNP
rs956740693 1107 dbSNP
rs988761934 1109 dbSNP
rs1279458648 1111 dbSNP
rs1356645107 1118 dbSNP
rs1171763420 1132 dbSNP
rs1334732415 1138 dbSNP
rs763238655 1139 dbSNP
rs921381282 1152 dbSNP
rs776326783 1157 dbSNP
rs955427056 1160 dbSNP
rs767784454 1164 dbSNP
rs1175446188 1166 dbSNP
rs1264663386 1166 dbSNP
rs368538869 1166 dbSNP
rs986821369 1166 dbSNP
rs968297815 1168 dbSNP
rs908554313 1169 dbSNP
rs1214550937 1172 dbSNP
rs141791543 1174 dbSNP
rs926831953 1181 dbSNP
rs937077431 1185 dbSNP
rs539386458 1187 dbSNP
rs992597661 1207 dbSNP
rs1376237046 1210 dbSNP
rs1332621210 1215 dbSNP
rs750781960 1215 dbSNP
rs577832558 1233 dbSNP
rs1256775562 1236 dbSNP
rs1404330960 1247 dbSNP
rs1338967460 1253 dbSNP
rs1466711620 1262 dbSNP
rs556402636 1263 dbSNP
rs929676570 1265 dbSNP
rs1156945060 1266 dbSNP
rs1420944371 1267 dbSNP
rs150137393 1267 dbSNP
rs1166864473 1268 dbSNP
rs1182880828 1272 dbSNP
rs538230960 1276 dbSNP
rs1459853151 1283 dbSNP
rs1244702143 1292 dbSNP
rs930512308 1305 dbSNP
rs1414164285 1307 dbSNP
rs1485307370 1309 dbSNP
rs1046986361 1310 dbSNP
rs888352815 1311 dbSNP
rs555112045 1312 dbSNP
rs1316950674 1313 dbSNP
rs138614078 1320 dbSNP
rs1381087425 1321 dbSNP
rs1317531811 1323 dbSNP
rs1039555091 1324 dbSNP
rs1384602038 1327 dbSNP
rs904975571 1330 dbSNP
rs1343648247 1334 dbSNP
rs1455449000 1352 dbSNP
rs1361222110 1355 dbSNP
rs1401967713 1356 dbSNP
rs1442626789 1364 dbSNP
rs1386874178 1367 dbSNP
rs1188067183 1372 dbSNP
rs1427698854 1380 dbSNP
rs1298862486 1382 dbSNP
rs1259277550 1390 dbSNP
rs1206500157 1393 dbSNP
rs899700953 1394 dbSNP
rs540853179 1403 dbSNP
rs1029751683 1405 dbSNP
rs1246073463 1411 dbSNP
rs892440169 1413 dbSNP
rs1009554983 1420 dbSNP
rs1022273561 1423 dbSNP
rs1326181617 1425 dbSNP
rs771461238 1428 dbSNP
rs1384089923 1434 dbSNP
rs1341213897 1436 dbSNP
rs1302563268 1437 dbSNP
rs1422807113 1451 dbSNP
rs1223566764 1456 dbSNP
rs1163736496 1460 dbSNP
rs1281793476 1460 dbSNP
rs1355371332 1463 dbSNP
rs981021739 1466 dbSNP
rs377421617 1473 dbSNP
rs567758312 1475 dbSNP
rs960906920 1476 dbSNP
rs1216727790 1479 dbSNP
rs1194914740 1481 dbSNP
rs1477906921 1485 dbSNP
rs992963777 1487 dbSNP
rs1256140490 1489 dbSNP
rs904094922 1490 dbSNP
rs1490697123 1492 dbSNP
rs1292692208 1493 dbSNP
rs997043936 1500 dbSNP
rs369168236 1506 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BT474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395168. RNA binding protein: AGO. Condition:BT474 AGO HITS-CLIP Replicate 3 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggucggAGCGGGUCg 5'
                  |||||||| 
Target 5' --------UCGCCCAGg 3'
1 - 9
Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_213598 | 3UTR | AUUUUUUUUUUUUUUUUGAGACGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGGGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_213598 | 3UTR | UUUUUGAGACGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGGGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_213598 | 3UTR | UUUUUUUUGAGACGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGGGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAGGCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_213598 | 3UTR | UAUUUUUUUUUUUUUUUUGAGACGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGGGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_213598 | 3UTR | UUUUUUUUUUUUUUGAGACGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGGGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_213598 | 3UTR | UUUUUUGAGACGGAGUCUCGCUCUGUCGCCCAGGCUGGAGUGCAGUGGCGGGAUCUCGGCUCACUGCAAGCUCCGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1395168
Method / RBP HITS-CLIP / AGO
Cell line / Condition BT474 / BT474 AGO HITS-CLIP Replicate 3
Location of target site ENST00000321545.4 | 3UTR | UCGCCCAGGCUGGAGUGCAGUGGCGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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