miRTarBase - #MIRT607555


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pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol GLI2   
Synonyms CJS, HPE9, PHS2, THP1, THP2
Description GLI family zinc finger 2
Transcript NM_005270   
Expression
Putative miRNA Targets on GLI2
3'UTR of GLI2
(miRNA target sites are highlighted)		 
>GLI2|NM_005270|3'UTR
   1 AGGCCCGAGCGCCTGGTGCTGAGTGCACCCGGAGGGGTCATCGCTGCCCAGAGCCTGGGGATTCCAGCTGTCTTGTCTTT
  81 TTCCAAAAAAGTGTTAAATAGGCTTGAGGGGTTGTTGCGCAATGGCCGCTTCAGATGACAGATGTTGTAAGAGAAGGTTT
 161 ATGGGCATCCTCTCTGGTCTTTTGGATTATTCCTCAGAACAATGAAAAAAGTCTCCATAGGACAGGAAGGAATGCAAAAC
 241 TCATTTACACAGTGCTTTCCAGCCTTTGGTGCTTACAGGACCGCGCTGTTCCGGCTTCTTCACGGCTGACATTCGGCTAA
 321 CGAGGGATTACTTTGGCCAAAACCTTTCAAAGGATATGCAGAAAGATGGTAGGGAGCATTTGGGTTTGAATCTGAATGCT
 401 ATACTGGATACTCTGCTCCGGAAAGATGAGCTTTTTATTCTACTACTTGGAAGGAAAAGGAATTCCTGGTCCACCTGAAT
 481 TCCTCTATGAAGCCTAACTCTTGAGGTCTCTAACATACCTTGTCATAGAGGAAAAGCACAGATTATACCTGGATGATTCA
 561 GGAGCACATTCTGATTCCAGGTTTGGTAGAGCTGGCTCTTCTACTCCGTAAAGCCGAGTCTGGGACTGGCAGCCCATCCA
 641 AGTGTATATGAATGAATAAAGCATCCAAGTATATATGAATGAATAAAGTATGTAAGTATCACCAGAAAAAGGAAAGAAAA
 721 AATGTACTCCTTGGGGCAAGCCCAGAAGCTGCCCTGGCCTCTCCAGACCGTGTTTACAGTGTTTGCATGTAGAATGTAGC
 801 CCTTCCTGAAAAGAAGACTTGTTTCTAAATACCTCGGGGCTGCTGGAGCCGCTGTGGGTTAGGGATGGACTGAGGCCTCG
 881 AGGAGTGAGGGTGCACCCGGGGCCCAGCCTCAGGCTGCCCTAGGGATCTCTCAGTAGGAAGAGGAAGTTGCGTGTTTACC
 961 CAATCCTGTTTCTCCAATGCAACGTCCACCCACTTTACCACCAAAAACTCCAGGGCCTGACGGCAGCCCGGTCCCCCAGC
1041 ACTCACCAGCAGCCCAGTGTTCTCCACCAAGCCACAGTGTGCATGCCTGGTATCCTCCGGATTCCCTTCCTTCTGCCCGC
1121 TGAGTCACTGGGCAGAGAATGATGACATGTGTAGGTGGTGTGGTTGGGGGTGGAAAGGGGAAGGGGTTGATCCTCAGGAC
1201 TCTGAGGGAGCATCGTTGAATTTTCCTGTTCAGTGTGACCAAGACCCACCTGGAAATGGAATTTGGAACTGGCTTCAGGA
1281 GACATCATTCCTGAACACACTGTAGGGTGAATTGGTGCATCTTCCCCACCATACACACACACACACACACACACACACAC
1361 ACACACACACACACACCCCAAACCTTTTCATGGGGAATGTGTGGCAACCTTGCCAAACAGCACCACTCAGAGTGTGACTC
1441 TGACTGTGACCTTGGCCTTAATGAGGAACTTCTTAGGAGAGTTTGAGGACAAGGCCAACATCGTCATCTGGGCTCGCTGC
1521 GTCCCAGCACATCAAACTCTGTCCAGAGACAAGGCCAACTGCAAATGAAAGCCAGGGAACATTGCTAAGGGTCTGTGGCT
1601 CTGTGGTGGTGTTCATCGCCTTCCTGAGATAGGATTTCCCTTGCCAGTCCCAACCTGTATATATTCTGTACAGAAGACAT
1681 CCCTGAATATACTGTAGGTGAGTCGTCCAGCCAAATTTATATCTCCAAAACATTTTTAGCTTTTTCTACATGCTATGAAT
1761 TGAGATGACATGCTCAACTTGTAAATAAGTCTTTTTGTACATTAAAAAAGTAATTTTTTCATAATTTATCTTGTCTATCT
1841 GCTTCCCCCTTGACAGTAGTTAATGAGAACCTGGGCAGTAAATTTGGTGCATTCGAGCAGAAATTAGGCTGTATTTTTTC
1921 TTAACAGTGTCAAAATTGACTATCCCGCCTTTGCCAAGAAATGTTTAATGCTGAGGCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaacguagauaGGUUUGGAa 5'
                      |||||||| 
Target 5' cacacacacaccCCAAACCTt 3'
 1366 - 1386 145.00 -11.30
2 
miRNA  3' auAACG--UAGAUAGGUUUGGAa 5'
            ||||  :|:|| |||| ||| 
Target 5' agTTGCGTGTTTACCCAATCCTg 3'
 946 - 968 137.00 -13.00
3 
miRNA  3' auAACGUAGAUAGGUUUGGAa 5'
            ||||  | :||| ||||| 
Target 5' ccTTGC--CAGTCCCAACCTg 3'
 1639 - 1657 131.00 -9.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
235079 1 ClinVar
330999 32 ClinVar
331000 43 ClinVar
331001 78 ClinVar
331002 119 ClinVar
894670 286 ClinVar
331003 379 ClinVar
892676 412 ClinVar
331004 420 ClinVar
331005 570 ClinVar
892677 713 ClinVar
892678 796 ClinVar
331006 817 ClinVar
331007 964 ClinVar
331008 1030 ClinVar
331009 1147 ClinVar
331010 1330 ClinVar
331011 1330 ClinVar
331012 1333 ClinVar
331013 1333 ClinVar
331014 1333 ClinVar
331015 1333 ClinVar
331016 1333 ClinVar
331017 1333 ClinVar
331018 1333 ClinVar
331019 1333 ClinVar
331020 1376 ClinVar
331021 1376 ClinVar
331022 1376 ClinVar
331023 1376 ClinVar
331024 1376 ClinVar
331025 1629 ClinVar
893479 1661 ClinVar
893480 1736 ClinVar
893481 1754 ClinVar
331026 1786 ClinVar
331027 1820 ClinVar
331028 1827 ClinVar
331029 1834 ClinVar
331030 1889 ClinVar
331031 1896 ClinVar
893780 1948 ClinVar
COSN31510493 11 COSMIC
COSN30106879 31 COSMIC
COSN13932001 32 COSMIC
COSN13932002 44 COSMIC
COSN30150461 76 COSMIC
COSN5478590 97 COSMIC
COSN30122033 98 COSMIC
COSN28186350 119 COSMIC
COSN31496116 120 COSMIC
COSN26435740 127 COSMIC
COSN1222805 295 COSMIC
COSN1782475 413 COSMIC
COSN5478591 621 COSMIC
COSN31484307 721 COSMIC
COSN31538003 727 COSMIC
COSN26563021 757 COSMIC
COSN28767504 817 COSMIC
COSN31488343 929 COSMIC
COSN31541060 1010 COSMIC
COSN8607142 1020 COSMIC
COSN8607143 1069 COSMIC
COSN7331458 1194 COSMIC
COSN17181690 1308 COSMIC
COSN1222806 1333 COSMIC
COSN32055773 1376 COSMIC
COSN20097107 1377 COSMIC
COSN32056916 1378 COSMIC
COSN23620503 1394 COSMIC
COSN26575399 1413 COSMIC
COSN25281176 1431 COSMIC
COSN28785217 1521 COSMIC
COSN31482267 1534 COSMIC
COSN1782476 1553 COSMIC
COSN28740664 1606 COSMIC
COSN28741688 1607 COSMIC
COSN9857099 1673 COSMIC
COSN1782477 1797 COSMIC
COSN23420552 1895 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs876661327 1 dbSNP
rs1198928603 3 dbSNP
rs933724614 4 dbSNP
rs753119981 5 dbSNP
rs761025643 7 dbSNP
rs372740091 8 dbSNP
rs757737111 11 dbSNP
rs972504473 12 dbSNP
rs1347131114 14 dbSNP
rs1250893913 17 dbSNP
rs1405233302 20 dbSNP
rs547627886 21 dbSNP
rs1279226868 26 dbSNP
rs1343127403 26 dbSNP
rs1215744962 29 dbSNP
rs374028698 31 dbSNP
rs377195281 32 dbSNP
rs769137473 34 dbSNP
rs1294452547 35 dbSNP
rs993108620 35 dbSNP
rs780984452 37 dbSNP
rs1013093493 41 dbSNP
rs185228238 43 dbSNP
rs557657719 44 dbSNP
rs749213592 47 dbSNP
rs907294868 48 dbSNP
rs772893195 49 dbSNP
rs570645559 50 dbSNP
rs1166620612 51 dbSNP
rs774341082 52 dbSNP
rs1188683608 57 dbSNP
rs1436841678 60 dbSNP
rs1405810368 62 dbSNP
rs978896135 63 dbSNP
rs537926196 71 dbSNP
rs886054819 78 dbSNP
rs998978073 78 dbSNP
rs1032156012 84 dbSNP
rs1186992447 85 dbSNP
rs1183699449 89 dbSNP
rs1427713602 90 dbSNP
rs1415211839 91 dbSNP
rs1474128646 101 dbSNP
rs1256575074 114 dbSNP
rs957434713 115 dbSNP
rs190824141 119 dbSNP
rs778424802 120 dbSNP
rs1455393774 126 dbSNP
rs376001716 128 dbSNP
rs574458022 129 dbSNP
rs900851769 130 dbSNP
rs1049673112 143 dbSNP
rs933620866 143 dbSNP
rs975227486 148 dbSNP
rs922466304 149 dbSNP
rs1343726385 150 dbSNP
rs1005424345 152 dbSNP
rs1401412312 152 dbSNP
rs1385546554 162 dbSNP
rs933799335 169 dbSNP
rs982590232 170 dbSNP
rs1161230055 180 dbSNP
rs908280913 212 dbSNP
rs1474196238 220 dbSNP
rs1416820188 222 dbSNP
rs535784524 224 dbSNP
rs1038003123 227 dbSNP
rs894748023 230 dbSNP
rs899274069 240 dbSNP
rs745402062 243 dbSNP
rs948922091 253 dbSNP
rs1240058504 261 dbSNP
rs1191817387 263 dbSNP
rs771954064 264 dbSNP
rs993615377 270 dbSNP
rs1212303547 278 dbSNP
rs1046001598 283 dbSNP
rs907393114 284 dbSNP
rs554399356 285 dbSNP
rs536145925 286 dbSNP
rs572649440 292 dbSNP
rs1368066224 293 dbSNP
rs1218237261 294 dbSNP
rs993199285 295 dbSNP
rs1031790969 296 dbSNP
rs1406924607 298 dbSNP
rs893177974 304 dbSNP
rs747009136 305 dbSNP
rs1266946342 315 dbSNP
rs768497665 316 dbSNP
rs1191282559 322 dbSNP
rs546420216 323 dbSNP
rs1248783347 332 dbSNP
rs975322711 337 dbSNP
rs1306091557 338 dbSNP
rs1272763855 343 dbSNP
rs1029989575 344 dbSNP
rs1478545557 345 dbSNP
rs1440332813 350 dbSNP
rs1191031793 366 dbSNP
rs1370126196 378 dbSNP
rs886054820 379 dbSNP
rs1326542226 392 dbSNP
rs1438560937 397 dbSNP
rs1352487089 399 dbSNP
rs1169491913 405 dbSNP
rs1410179850 406 dbSNP
rs781716066 408 dbSNP
rs1473731779 412 dbSNP
rs564656545 413 dbSNP
rs982986699 416 dbSNP
rs759023139 417 dbSNP
rs370777016 420 dbSNP
rs941065616 421 dbSNP
rs1350438968 422 dbSNP
rs1484150386 428 dbSNP
rs973746455 429 dbSNP
rs1233618161 443 dbSNP
rs915609482 451 dbSNP
rs760734268 469 dbSNP
rs948350346 474 dbSNP
rs1371180906 484 dbSNP
rs1297382462 488 dbSNP
rs1046054343 509 dbSNP
rs763178121 520 dbSNP
rs1272926208 524 dbSNP
rs911173085 526 dbSNP
rs934855389 527 dbSNP
rs1310659395 539 dbSNP
rs543505250 543 dbSNP
rs1374980655 546 dbSNP
rs1053660343 550 dbSNP
rs893241003 553 dbSNP
rs561674779 564 dbSNP
rs1417845531 565 dbSNP
rs75544832 570 dbSNP
rs897000124 575 dbSNP
rs1255884698 586 dbSNP
rs1210376679 590 dbSNP
rs1287107103 593 dbSNP
rs139395401 602 dbSNP
rs1215069048 608 dbSNP
rs770505059 609 dbSNP
rs1452755744 616 dbSNP
rs1352043444 617 dbSNP
rs895885332 656 dbSNP
rs1053735 661 dbSNP
rs748027944 669 dbSNP
rs1375758850 671 dbSNP
rs1484123408 672 dbSNP
rs1304068303 676 dbSNP
rs1451060439 676 dbSNP
rs1345085168 678 dbSNP
rs1160418935 679 dbSNP
rs1183184844 681 dbSNP
rs900549580 688 dbSNP
rs1258589026 692 dbSNP
rs1475650063 692 dbSNP
rs774534580 692 dbSNP
rs1184822325 702 dbSNP
rs1485560164 703 dbSNP
rs1261406695 704 dbSNP
rs1471633224 713 dbSNP
rs1331145718 717 dbSNP
rs1271036606 722 dbSNP
rs559639045 724 dbSNP
rs1340681445 727 dbSNP
rs955428021 728 dbSNP
rs1314481904 734 dbSNP
rs1380201527 735 dbSNP
rs1360604607 749 dbSNP
rs1288955371 752 dbSNP
rs1437895934 760 dbSNP
rs759658861 761 dbSNP
rs533060567 770 dbSNP
rs767752721 771 dbSNP
rs182068021 788 dbSNP
rs1168536757 793 dbSNP
rs1015813455 796 dbSNP
rs753241057 801 dbSNP
rs1190678689 808 dbSNP
rs1466191559 810 dbSNP
rs2278741 817 dbSNP
rs1410014503 830 dbSNP
rs1267018490 834 dbSNP
rs764448940 836 dbSNP
rs1306565268 837 dbSNP
rs989344069 838 dbSNP
rs1348299079 843 dbSNP
rs1230038186 847 dbSNP
rs1369386323 851 dbSNP
rs915661961 852 dbSNP
rs1393250906 855 dbSNP
rs955289014 857 dbSNP
rs985150120 880 dbSNP
rs969746107 881 dbSNP
rs910911053 884 dbSNP
rs940977357 887 dbSNP
rs1394590869 891 dbSNP
rs1192877177 893 dbSNP
rs1452123682 894 dbSNP
rs537965459 899 dbSNP
rs549823322 900 dbSNP
rs187223898 901 dbSNP
rs112733334 902 dbSNP
rs368566580 903 dbSNP
rs1288104210 904 dbSNP
rs1344794848 906 dbSNP
rs1230197332 910 dbSNP
rs1056692325 912 dbSNP
rs764528096 923 dbSNP
rs756883324 926 dbSNP
rs535892173 927 dbSNP
rs1305297992 931 dbSNP
rs553873307 952 dbSNP
rs914764088 953 dbSNP
rs1189631544 960 dbSNP
rs191669588 964 dbSNP
rs764897618 969 dbSNP
rs905883271 970 dbSNP
rs1000116291 978 dbSNP
rs1039127461 984 dbSNP
rs900559507 985 dbSNP
rs930217579 986 dbSNP
rs1379349279 988 dbSNP
rs750127299 992 dbSNP
rs1418246981 993 dbSNP
rs1052174640 995 dbSNP
rs1010434609 1008 dbSNP
rs1206783348 1011 dbSNP
rs1484486643 1013 dbSNP
rs879053833 1020 dbSNP
rs796373688 1022 dbSNP
rs1004566429 1023 dbSNP
rs1167796384 1028 dbSNP
rs182760827 1030 dbSNP
rs1397418792 1032 dbSNP
rs1351435778 1034 dbSNP
rs1290613403 1036 dbSNP
rs143185959 1037 dbSNP
rs962575860 1045 dbSNP
rs1355136574 1049 dbSNP
rs1339384703 1051 dbSNP
rs1447888951 1060 dbSNP
rs1334893449 1061 dbSNP
rs1313516707 1069 dbSNP
rs995332996 1073 dbSNP
rs1022729616 1079 dbSNP
rs1382919825 1080 dbSNP
rs1156691813 1087 dbSNP
rs1229579678 1090 dbSNP
rs969757492 1099 dbSNP
rs369271015 1100 dbSNP
rs543543933 1102 dbSNP
rs1474011742 1105 dbSNP
rs1256432691 1117 dbSNP
rs147096573 1119 dbSNP
rs1202422674 1120 dbSNP
rs918543872 1133 dbSNP
rs1205001619 1144 dbSNP
rs1330435657 1147 dbSNP
rs199943079 1147 dbSNP
rs1231909732 1150 dbSNP
rs1185577980 1158 dbSNP
rs757892838 1162 dbSNP
rs1450489589 1164 dbSNP
rs989504370 1168 dbSNP
rs1324700068 1169 dbSNP
rs992028643 1171 dbSNP
rs1434272158 1178 dbSNP
rs1389356418 1184 dbSNP
rs917760595 1185 dbSNP
rs947859289 1188 dbSNP
rs914816508 1190 dbSNP
rs947563178 1204 dbSNP
rs1459718287 1205 dbSNP
rs1383977829 1206 dbSNP
rs974842394 1209 dbSNP
rs1044465498 1215 dbSNP
rs1473583413 1229 dbSNP
rs1450083929 1232 dbSNP
rs779609443 1234 dbSNP
rs1187461296 1236 dbSNP
rs1187626176 1239 dbSNP
rs905915804 1245 dbSNP
rs1388102236 1249 dbSNP
rs1468278546 1250 dbSNP
rs1291052476 1266 dbSNP
rs1230170538 1270 dbSNP
rs1337769584 1286 dbSNP
rs1467214049 1288 dbSNP
rs933372284 1300 dbSNP
rs936041795 1313 dbSNP
rs1172827817 1315 dbSNP
rs1051843679 1320 dbSNP
rs886463029 1328 dbSNP
rs1438654670 1329 dbSNP
rs1167391339 1330 dbSNP
rs1349034466 1330 dbSNP
rs1417021981 1330 dbSNP
rs886054822 1330 dbSNP
rs886054821 1332 dbSNP
rs1171271663 1333 dbSNP
rs1193250328 1333 dbSNP
rs1251579492 1333 dbSNP
rs1306972359 1333 dbSNP
rs1352574496 1333 dbSNP
rs1371795565 1333 dbSNP
rs1426540378 1333 dbSNP
rs1430014577 1333 dbSNP
rs1433098131 1333 dbSNP
rs1438406400 1333 dbSNP
rs1468890331 1333 dbSNP
rs150397467 1333 dbSNP
rs878912620 1333 dbSNP
rs878975646 1333 dbSNP
rs879176517 1333 dbSNP
rs886054823 1333 dbSNP
rs886054824 1333 dbSNP
rs886054825 1333 dbSNP
rs1183097525 1335 dbSNP
rs1322037885 1339 dbSNP
rs1367968448 1342 dbSNP
rs1436484499 1343 dbSNP
rs1297262980 1345 dbSNP
rs1325081318 1348 dbSNP
rs1235942193 1350 dbSNP
rs1275641830 1352 dbSNP
rs1344654657 1353 dbSNP
rs1278280384 1355 dbSNP
rs1198799877 1357 dbSNP
rs1270099469 1359 dbSNP
rs940700023 1363 dbSNP
rs1465244436 1365 dbSNP
rs1208051745 1366 dbSNP
rs1209581132 1367 dbSNP
rs1245915825 1367 dbSNP
rs1434652718 1369 dbSNP
rs1037391250 1370 dbSNP
rs1472638763 1371 dbSNP
rs1161979191 1373 dbSNP
rs1220894607 1373 dbSNP
rs1279294660 1373 dbSNP
rs1370834779 1373 dbSNP
rs1287493364 1374 dbSNP
rs1359266268 1374 dbSNP
rs898383479 1374 dbSNP
rs1199367921 1375 dbSNP
rs200730065 1376 dbSNP
rs375108550 1376 dbSNP
rs886054826 1376 dbSNP
rs59277032 1377 dbSNP
rs1376702919 1378 dbSNP
rs373519869 1378 dbSNP
rs1224363125 1379 dbSNP
rs1286469391 1382 dbSNP
rs1209308728 1392 dbSNP
rs866934761 1395 dbSNP
rs1466047525 1399 dbSNP
rs905625999 1402 dbSNP
rs1263473440 1405 dbSNP
rs892073236 1429 dbSNP
rs1388762326 1433 dbSNP
rs1003067872 1435 dbSNP
rs1010925117 1438 dbSNP
rs775337877 1445 dbSNP
rs541054154 1449 dbSNP
rs1035440651 1458 dbSNP
rs1321764786 1468 dbSNP
rs1437918611 1469 dbSNP
rs1392650501 1470 dbSNP
rs1293377004 1482 dbSNP
rs955930284 1494 dbSNP
rs1370466666 1495 dbSNP
rs1383499513 1503 dbSNP
rs1168375454 1504 dbSNP
rs891307718 1507 dbSNP
rs1388880272 1509 dbSNP
rs988459731 1513 dbSNP
rs749119960 1515 dbSNP
rs1189074375 1516 dbSNP
rs377404002 1517 dbSNP
rs974894371 1521 dbSNP
rs760627112 1522 dbSNP
rs1018077352 1531 dbSNP
rs933485620 1534 dbSNP
rs1340785210 1555 dbSNP
rs1297699763 1570 dbSNP
rs1231249733 1580 dbSNP
rs973762671 1581 dbSNP
rs770742108 1582 dbSNP
rs1025712795 1598 dbSNP
rs1227902953 1599 dbSNP
rs1393363360 1599 dbSNP
rs559064382 1600 dbSNP
rs907945924 1601 dbSNP
rs940695624 1605 dbSNP
rs1037667109 1613 dbSNP
rs1266412738 1616 dbSNP
rs138493936 1618 dbSNP
rs992498899 1619 dbSNP
rs1465470535 1624 dbSNP
rs898434558 1625 dbSNP
rs886054827 1629 dbSNP
rs1197864978 1643 dbSNP
rs1433516639 1645 dbSNP
rs1269229065 1650 dbSNP
rs1179483825 1660 dbSNP
rs931192232 1661 dbSNP
rs1274713524 1665 dbSNP
rs1044326374 1673 dbSNP
rs947891338 1678 dbSNP
rs905728255 1683 dbSNP
rs1234629553 1692 dbSNP
rs1156398013 1693 dbSNP
rs1286856159 1694 dbSNP
rs1409437941 1695 dbSNP
rs1002699302 1703 dbSNP
rs1351402106 1705 dbSNP
rs1035854222 1706 dbSNP
rs891503230 1708 dbSNP
rs1394405279 1712 dbSNP
rs1459906631 1715 dbSNP
rs1294431291 1720 dbSNP
rs1401623812 1721 dbSNP
rs867252415 1722 dbSNP
rs1021215929 1724 dbSNP
rs968341903 1732 dbSNP
rs376387656 1736 dbSNP
rs1472047755 1744 dbSNP
rs1029198512 1745 dbSNP
rs1252140257 1747 dbSNP
rs763977107 1749 dbSNP
rs1183933486 1751 dbSNP
rs1208353842 1753 dbSNP
rs1254884833 1756 dbSNP
rs1201457370 1760 dbSNP
rs1347834253 1760 dbSNP
rs1266614836 1771 dbSNP
rs1228222003 1776 dbSNP
rs1330055069 1779 dbSNP
rs927415536 1782 dbSNP
rs150539352 1786 dbSNP
rs987624109 1792 dbSNP
rs1054523566 1811 dbSNP
rs1339889377 1811 dbSNP
rs1396521877 1812 dbSNP
rs1408272099 1814 dbSNP
rs754885960 1820 dbSNP
rs1456468221 1826 dbSNP
rs139459477 1827 dbSNP
rs1159877740 1830 dbSNP
rs1471607291 1832 dbSNP
rs558203417 1834 dbSNP
rs886054828 1834 dbSNP
rs1051786506 1838 dbSNP
rs891382639 1840 dbSNP
rs973416461 1841 dbSNP
rs1323361650 1845 dbSNP
rs185605889 1846 dbSNP
rs568257834 1854 dbSNP
rs1018439778 1862 dbSNP
rs1465591223 1868 dbSNP
rs1270436285 1872 dbSNP
rs898270917 1874 dbSNP
rs568727149 1881 dbSNP
rs1284830614 1888 dbSNP
rs747928542 1889 dbSNP
rs535564669 1895 dbSNP
rs76865566 1896 dbSNP
rs1044365347 1906 dbSNP
rs543298780 1907 dbSNP
rs565898553 1911 dbSNP
rs951125020 1914 dbSNP
rs540132601 1921 dbSNP
rs1403234656 1928 dbSNP
rs1207096489 1934 dbSNP
rs1389632143 1936 dbSNP
rs1163304924 1944 dbSNP
rs991797008 1945 dbSNP
rs558445244 1947 dbSNP
rs938514119 1948 dbSNP
rs570358416 1961 dbSNP
rs1179306576 1973 dbSNP
rs1450645491 1977 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BT474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395167. RNA binding protein: AGO. Condition:BT474 AGO HITS-CLIP Replicate 2 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1395167
Method / RBP HITS-CLIP / AGO
Cell line / Condition BT474 / BT474 AGO HITS-CLIP Replicate 2
Location of target site ENST00000452319.1 | 3UTR | CACACACACACACACACACACACACACACACACACACCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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