miRTarBase - #MIRT607885


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pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SATB1   
Synonyms -
Description SATB homeobox 1
Transcript NM_001131010   
Other Transcripts NM_002971   
Expression
Putative miRNA Targets on SATB1
3'UTR of SATB1
(miRNA target sites are highlighted)		 
>SATB1|NM_001131010|3'UTR
   1 GATAAAAGTATTTGTTTCGTTCAACAGTGCCACTGGTATTTACTAACAAAATGAAAAGTCCACCTTGTCTTCTCTCAGAA
  81 AACCTTTGTTGTTCATTGTTTGGCCAATGAATCTTCAAAAACTTGCACAAACAGAAAAGTTGGAAAAGGATAATACAGAC
 161 TGCACTAAATGTTTTCCTCTGTTTTACAAACTGCTTGGCAGCCCCAGGTGAAGCATCAAGGATTGTTTGGTATTAAAATT
 241 TGTGTTCACGGGATGCACCAAAGTGTGTACCCCGTAAGCATGAAACCAGTGTTTTTTGTTTTTTTTTTAGTTCTTATTCC
 321 GGAGCCTCAAACAAGCATTATACCTTCTGTGATTATGATTTCCTCTCCTATAATTATTTCTGTAGCACTCCACACTGATC
 401 TTTGGAAACTTGCCCCTTATTTAAAAAAAAAAAAGAAAAAAAAGAGTTTGTTACTCTATTGTATGTTACAAAAGAACTAT
 481 AGACTGTGGAATGCAGTTTAAAGATGACATATGCCAACAAATGCCTTGTATTATATGGCACTGCCGTAATTCAAATTTGT
 561 TTTTATTTTGGAAATAAAAGTTCACTGTACTTTTTTTTCATTCTCATTGTTACATGATTTTTTAAAAAAAGGAAAAGAAA
 641 ATGTGAAACACAATTTAGTCCTCATTATTTATTTGTAGATCCTGCAGCATCATGTTGTAATTAATTTTTTGGAAGTTTCC
 721 GTTAAATGTAATATTGCTTCTCTTGTTACCATACTGATTCTTTTCTATTTATAAATGTATTTTGATGGGCAGTAAAACAA
 801 AGTGTCTTAAAAGTTTTAAATAGAGAAAATGTGCTTTACACAGTTGCCTATAAAAAGTGCTCTATGTTATCCAAGCAATT
 881 CATACTATAAGCTTCACTCTTATTGTTGTATGCAATTTTTACTATCATGCAAATAAGCTTAGGTAAATAAAACTAATAGA
 961 TCACCTTAGAAAATTATGCAATTAATGTGAAAATAATTGATGTTTGCAATGTGTCTTCCTTTGGTTTACAATCAATTTTA
1041 AAGCTACATCTGTATAAAATTTCTGTATAAAGGTGTATTTCTTTTTTATGAGTTTATGGCTATGAAAACAGCTATTTTGT
1121 TACAGCTGGCTGTTTTTATAAGTGTATCACAATTTTCTTTATGCAGAAATGTTCTGACTAGGAGTGGTTATTGACTGTAA
1201 CTACACAATTAAAATTGTTTGTATCGTATGACATGGTAGGGTTTGTCTGCTTATGTGAAGTAACTAAAGGAGTCAAAGGA
1281 TGGCCCTCTCATTTAGGTGCATGTTAATAACTTGTTATTTCACTGATTTTAAAAAGAGCAATTGACAAGTTACTTGAAAC
1361 ACTGTAAATTTAAATCACAAACACATGCTCATTTTTAAATAGGTATGAAATTTCACAATGAAAATAACCTGTTTGGTTAA
1441 CATTTTGCTTAATAAGTAGAGATAGGATGGTCAAAAGACTCTCCGACAAAAACAAATCCAGTCTCTAGCAGTTATGTTGT
1521 TAGAATGGATTCATCTGTGCTTATTTCACAATACTTCATTTATAGCAATGCTTTTCCTTAAGCTAATGTATAAATATTTC
1601 TAAAGGCCATTAATAGTAACAAAATAAGTAGGGGAAAAAATGGACCTTCTGTATAAAAACCCCTTAGCTTTTTTTTTTCA
1681 CAAGTTATAAGTGGAATAAGTTAATAACTGAGCTCGTAAGTGTATCTCATAACTATAAGAGCTACATGAAGAAAATAGGA
1761 ATAACACACCTGGTATTTAAACACAATCTTCAAAATTCTTGCAACATTAAACATAGTAAAATGCCAGAATATAAAATGAG
1841 GTGTGCTAATGGTCACAGGATTGAGGCCAGCATTACAGTTTGGGGTGATTTTTCTTTTATTTGCTCCCTCACTTTGTTTC
1921 CTAGATGCTAGTAGGGGTATCTGGGTTGCTTGAGATACCATTTTGCAATTGCCCCTTCTCTTTCTGCCTACCATCTTCTC
2001 AGGCCCTGATGAGCTTATTGGTAGGCAACTGGGCTGCTTTAGTGTTGAACTTGTACTTTAGAAACTGAAGTGGAATCATT
2081 GAAAACTTTCAATAAAGCTTTAAAGTTCCATTTACTTTTGAAGCACAGCTAAGCTCCTCTGAAGGCAGCTGGTTTGTTGC
2161 AAACTTAAAATTGTACTGAAAAGTTGCCACTTTTTATTTAGTAAGAAAACAAACATTCTGGCTCACTAGAGTTCAGAAAA
2241 GTAATAATTTGAGCCAAAGGAATTTGAATTAAGAAAATAGAAACTAGGTTTCATGTATTTAAAAAATAGGAAATAAAATA
2321 GAAACTCAAATGCCATGAAGTTATCTTCCTCTTCCTTATATCCCCTAAGTTTGGGTTGCAAATAACTTTCCAATTCCTAA
2401 TAACCTAAATTATTTTGAAATAGTGTTTTCAGTGAAATGATGAATGTTTGAATGTTTGTTTGGTAATCAACATAACAATG
2481 CTAACAAAATTCCCACTTAGATTTTTTAACTTTTAAAAGTCAGCGTGGTTTTGATAATTTGATATTTTAAATGCCCACAC
2561 ATACACACACACACACACACACACACACACAAGCACATGTTAATAAACTGATAGGATGGAGTGAGCAAAATTGTTTTCAG
2641 GGAAGATGGCACATTTTAGAAAAGACTTGCCCAGATGATCTTCCATATTGCTCCCCCAATGTCATTTATCGCTCATGCCA
2721 ATCCTCCTCTTGTTACCTGTGGCTATGGTAAAATTCCTTTAACAAGCTTCATTGTGTCCAAGTATTTCAGAGACTTTTAA
2801 AAGCTGGGCATGACATAGCGTTTTGTGCTGTTAAGACCTTAGCAGAGTCAGGTAGTTTACGGGTAATATTCAACCTTGTG
2881 CATCTGAATCTGTCATGGATTCCCTTCACTCAGCACTTTGCCACTAATTTGTATTACACTCTGTGGCCATATAATACTTG
2961 CACATTATGCAAAAAAAAATGTTGATAGTATCTCCTTGCCACACAATATGCAGAGTTGACAACCTTTGAAAACCAAGGTA
3041 ACTAATATGTATGTCCTAGTTGTGTGGCGCTTGGTAACAAAGTCTGTACATATTATGTATAAAATGTGTATTGGTTAGCA
3121 TTTAGTACTAAGAAATTCTGAGTTTAAAATAAGTGATTTTTTTCAAAGTAGCGATATCTATATCTGTGTTTATCTAAAAA
3201 TACTGGCTTGAATAGAAAACATTCTCAGATGATTCAAGATTGAGTAAAAATGAGAATCCCATACATTCCATTATTAAATT
3281 CTGCCCTATTCCCAATTGTTAGCATCTGGCTGATATTAAGGTCTTTGATTGTCACAATATTCTCAATAAATGAGACATTC
3361 TGAACTGCCTGGTGATATTTTCAAAAAGAGCAATTAAAATGTGTATTCCCTCTAATACAGCTGATAGAACTGTTGTGTTA
3441 AAGCAAGTTGGAAATTTGCATGATAGTGTGGAAACCAATGGAGGTCCAAAATATTAATCATATCTAAAATATCAGAAAAT
3521 ATCAATACTAGTCTTCTTTATGCATATTTTTGACTTTTTAAGAGGGCTTATGAATTCAATGTTTCTTCTGAGGCAATCCT
3601 TTTAATGTAAATACTAAATACTTGCATGTCTTTTGACAAAGGCTAAACTACAATCTATTAATATGCACATTTTTGATAAA
3681 ATATAAAGTACCCTAATTAAAGAAATTGTGGTAGAAGGTGTATGTCCTGAATACTATACCTGTTTAACAATACCAAATGT
3761 TAAATAAAAATAGTTTGAAATT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acgGAGGAGGUCCU-AGGUGUGu 5'
             :|:|| :|| | ||||||| 
Target 5' ttaTTTCTGTAGCACTCCACACt 3'
 374 - 396 159.00 -17.30
2 
miRNA  3' acggAGGAGGUCC--UAGGUGUGu 5'
              |: |||| |  ||:||:|| 
Target 5' tatgTTATCCAAGCAATTCATACt 3'
 863 - 886 128.00 -10.30
3 
miRNA  3' acggaGGAGGUCCUAGGUGUGu 5'
               :||||  |  |||||| 
Target 5' tagtaTCTCCTTG--CCACACa 3'
 2986 - 3005 124.00 -18.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15626200 1 COSMIC
COSN31587323 7 COSMIC
COSN30104798 17 COSMIC
COSN510548 18 COSMIC
COSN30486850 53 COSMIC
COSN19668956 62 COSMIC
COSN30514767 85 COSMIC
COSN30156071 158 COSMIC
COSN30529623 172 COSMIC
COSN30159099 182 COSMIC
COSN31589028 198 COSMIC
COSN1273128 265 COSMIC
COSN31532464 298 COSMIC
COSN31595275 298 COSMIC
COSN31577201 299 COSMIC
COSN5041618 334 COSMIC
COSN30166999 422 COSMIC
COSN31561713 422 COSMIC
COSN27502516 423 COSMIC
COSN31548578 423 COSMIC
COSN7628301 435 COSMIC
COSN31515198 520 COSMIC
COSN31480762 605 COSMIC
COSN31537115 620 COSMIC
COSN30165681 624 COSMIC
COSN31585626 834 COSMIC
COSN30543957 875 COSMIC
COSN31548587 887 COSMIC
COSN31528936 971 COSMIC
COSN26603647 979 COSMIC
COSN31522121 993 COSMIC
COSN6757491 1072 COSMIC
COSN26649432 1123 COSMIC
COSN1935930 1217 COSMIC
COSN31554878 1322 COSMIC
COSN24294864 1468 COSMIC
COSN24294863 1469 COSMIC
COSN16324960 1590 COSMIC
COSN27561853 1669 COSMIC
COSN28398732 1707 COSMIC
COSN32064762 2568 COSMIC
COSN22105308 2693 COSMIC
COSN7839901 2943 COSMIC
COSN1273118 2971 COSMIC
COSN21192853 3016 COSMIC
COSN7839900 3043 COSMIC
COSN19431613 3478 COSMIC
COSN28202075 3493 COSMIC
COSN1935924 3715 COSMIC
COSN28082576 3770 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1394181317 5 dbSNP
rs957711562 8 dbSNP
rs1286687001 13 dbSNP
rs1412129749 14 dbSNP
rs775184608 16 dbSNP
rs188148416 18 dbSNP
rs759455400 19 dbSNP
rs775494646 22 dbSNP
rs1469309350 23 dbSNP
rs774276276 24 dbSNP
rs770656584 25 dbSNP
rs1302570918 28 dbSNP
rs749073521 30 dbSNP
rs777517042 36 dbSNP
rs768919963 37 dbSNP
rs747219358 42 dbSNP
rs1379102883 45 dbSNP
rs1249226756 54 dbSNP
rs967061417 66 dbSNP
rs987431044 76 dbSNP
rs1030243478 77 dbSNP
rs1426921083 77 dbSNP
rs567693220 84 dbSNP
rs1172885101 91 dbSNP
rs551090941 91 dbSNP
rs955018997 92 dbSNP
rs1032327592 94 dbSNP
rs537643572 95 dbSNP
rs1335459461 104 dbSNP
rs1437451983 119 dbSNP
rs571828924 126 dbSNP
rs1018326393 127 dbSNP
rs1276979704 136 dbSNP
rs372243991 141 dbSNP
rs999058098 149 dbSNP
rs1219189577 151 dbSNP
rs1451443761 151 dbSNP
rs904666910 162 dbSNP
rs1248649833 180 dbSNP
rs1006904217 184 dbSNP
rs367640095 186 dbSNP
rs888520342 187 dbSNP
rs1487619698 191 dbSNP
rs1436863023 198 dbSNP
rs1267060665 199 dbSNP
rs183014127 201 dbSNP
rs1199057049 204 dbSNP
rs552117708 206 dbSNP
rs528753452 208 dbSNP
rs1238522714 216 dbSNP
rs1431539895 217 dbSNP
rs149964114 224 dbSNP
rs1272414176 229 dbSNP
rs1054834219 242 dbSNP
rs897403562 247 dbSNP
rs1046650934 249 dbSNP
rs1365317031 250 dbSNP
rs1298780870 258 dbSNP
rs1368048517 259 dbSNP
rs906478104 263 dbSNP
rs546313882 270 dbSNP
rs1048087741 271 dbSNP
rs929172781 273 dbSNP
rs780503188 274 dbSNP
rs1291633909 276 dbSNP
rs949546764 282 dbSNP
rs1248406005 298 dbSNP
rs1449496258 298 dbSNP
rs377448223 298 dbSNP
rs537449329 298 dbSNP
rs760030629 299 dbSNP
rs916729021 299 dbSNP
rs987462266 302 dbSNP
rs1369249942 304 dbSNP
rs1388915663 309 dbSNP
rs149083875 309 dbSNP
rs954856068 309 dbSNP
rs769341596 310 dbSNP
rs1321643760 320 dbSNP
rs1425712727 321 dbSNP
rs1433550806 327 dbSNP
rs978049644 333 dbSNP
rs1341565316 335 dbSNP
rs1244950767 339 dbSNP
rs990969737 341 dbSNP
rs1285439016 343 dbSNP
rs936436648 355 dbSNP
rs1232230561 367 dbSNP
rs1268543321 370 dbSNP
rs1021765071 371 dbSNP
rs1203352435 377 dbSNP
rs1370298893 378 dbSNP
rs529684197 387 dbSNP
rs370772187 395 dbSNP
rs1261011949 396 dbSNP
rs1442921285 401 dbSNP
rs1189787832 404 dbSNP
rs1366720173 413 dbSNP
rs1475008865 417 dbSNP
rs1160115742 419 dbSNP
rs1167268131 420 dbSNP
rs1432106100 421 dbSNP
rs1390927783 422 dbSNP
rs1456015587 423 dbSNP
rs1198241411 426 dbSNP
rs1013085896 427 dbSNP
rs925046941 429 dbSNP
rs1272683491 435 dbSNP
rs1335628241 435 dbSNP
rs1352956208 435 dbSNP
rs398062130 435 dbSNP
rs1288546972 436 dbSNP
rs1033418131 439 dbSNP
rs1003235393 442 dbSNP
rs1259924289 444 dbSNP
rs906169409 444 dbSNP
rs776363008 445 dbSNP
rs1228956152 446 dbSNP
rs1255515357 447 dbSNP
rs1485361535 447 dbSNP
rs1182947643 448 dbSNP
rs560699572 453 dbSNP
rs191655383 461 dbSNP
rs764753438 474 dbSNP
rs1249279426 483 dbSNP
rs1040892749 486 dbSNP
rs761619997 496 dbSNP
rs1378509429 500 dbSNP
rs1207285919 509 dbSNP
rs1171287533 510 dbSNP
rs899000876 511 dbSNP
rs1308095935 512 dbSNP
rs1254948399 513 dbSNP
rs1306036118 514 dbSNP
rs1389255326 514 dbSNP
rs1037531265 524 dbSNP
rs975942753 531 dbSNP
rs943192611 533 dbSNP
rs1278150811 536 dbSNP
rs1347034235 541 dbSNP
rs964532495 545 dbSNP
rs1276864181 546 dbSNP
rs770365685 564 dbSNP
rs1176774875 565 dbSNP
rs535756794 568 dbSNP
rs1301580816 570 dbSNP
rs1192111508 580 dbSNP
rs1277980762 587 dbSNP
rs35438413 589 dbSNP
rs28572257 590 dbSNP
rs1350269657 595 dbSNP
rs933348191 596 dbSNP
rs1412297075 599 dbSNP
rs1460167423 599 dbSNP
rs564706923 600 dbSNP
rs1390962829 603 dbSNP
rs1388347172 607 dbSNP
rs544781053 613 dbSNP
rs1464625274 616 dbSNP
rs977702282 617 dbSNP
rs866520205 624 dbSNP
rs994583468 626 dbSNP
rs1299934077 628 dbSNP
rs1379401266 631 dbSNP
rs914821167 631 dbSNP
rs991686926 632 dbSNP
rs1489577231 641 dbSNP
rs1212281049 644 dbSNP
rs1450649049 645 dbSNP
rs1191005622 652 dbSNP
rs897127643 653 dbSNP
rs1426260004 675 dbSNP
rs1177442448 676 dbSNP
rs1472381722 677 dbSNP
rs1046701498 679 dbSNP
rs1350171416 690 dbSNP
rs1013871630 704 dbSNP
rs1323653858 707 dbSNP
rs1393383320 707 dbSNP
rs573086026 712 dbSNP
rs1055333017 715 dbSNP
rs936850373 720 dbSNP
rs777309387 721 dbSNP
rs553220915 725 dbSNP
rs1214114042 728 dbSNP
rs1026360739 729 dbSNP
rs1323733609 730 dbSNP
rs763596408 731 dbSNP
rs1272965436 736 dbSNP
rs993175695 745 dbSNP
rs1210936340 746 dbSNP
rs1240915682 750 dbSNP
rs1042103655 753 dbSNP
rs1485818602 754 dbSNP
rs186700075 760 dbSNP
rs1185500485 761 dbSNP
rs1413804387 764 dbSNP
rs899116593 768 dbSNP
rs573929803 771 dbSNP
rs945049031 781 dbSNP
rs1256013368 791 dbSNP
rs557498094 815 dbSNP
rs1227464339 820 dbSNP
rs1457612012 821 dbSNP
rs1160995358 830 dbSNP
rs1037563054 832 dbSNP
rs922915635 862 dbSNP
rs1413197895 864 dbSNP
rs1007365261 866 dbSNP
rs1230595893 869 dbSNP
rs1336673732 876 dbSNP
rs771963935 886 dbSNP
rs1282594171 896 dbSNP
rs888918640 897 dbSNP
rs537507719 899 dbSNP
rs1394729084 903 dbSNP
rs1211371395 910 dbSNP
rs1051804027 913 dbSNP
rs1237573177 915 dbSNP
rs375942292 924 dbSNP
rs1486346352 929 dbSNP
rs1185124271 936 dbSNP
rs1337470352 939 dbSNP
rs73038350 940 dbSNP
rs1456954116 957 dbSNP
rs933359328 957 dbSNP
rs1160087791 962 dbSNP
rs73038349 963 dbSNP
rs1410009197 977 dbSNP
rs1400060179 978 dbSNP
rs964626707 980 dbSNP
rs1161583741 981 dbSNP
rs1470409301 984 dbSNP
rs910467849 986 dbSNP
rs748145554 988 dbSNP
rs1312335451 993 dbSNP
rs1351404594 996 dbSNP
rs1444554162 1020 dbSNP
rs1042147573 1022 dbSNP
rs1372993810 1025 dbSNP
rs951880486 1035 dbSNP
rs1185349207 1037 dbSNP
rs1425470770 1038 dbSNP
rs558418634 1042 dbSNP
rs1027498654 1044 dbSNP
rs1256329372 1050 dbSNP
rs1483185324 1051 dbSNP
rs994242522 1054 dbSNP
rs991718090 1065 dbSNP
rs372622951 1069 dbSNP
rs961743059 1071 dbSNP
rs1191533372 1073 dbSNP
rs1396873780 1074 dbSNP
rs1452494229 1075 dbSNP
rs1173097357 1085 dbSNP
rs1371182217 1086 dbSNP
rs958875243 1090 dbSNP
rs1327053849 1096 dbSNP
rs1269647144 1099 dbSNP
rs1437695565 1109 dbSNP
rs183191214 1110 dbSNP
rs1013586725 1113 dbSNP
rs1234124898 1123 dbSNP
rs981887308 1126 dbSNP
rs566286148 1127 dbSNP
rs1342196553 1128 dbSNP
rs895437891 1133 dbSNP
rs970923716 1136 dbSNP
rs1026050930 1139 dbSNP
rs1436849149 1143 dbSNP
rs776394334 1146 dbSNP
rs1254573601 1147 dbSNP
rs754813678 1150 dbSNP
rs753940701 1156 dbSNP
rs549650253 1160 dbSNP
rs1452519428 1169 dbSNP
rs780419978 1195 dbSNP
rs1192878581 1199 dbSNP
rs532952199 1200 dbSNP
rs1476455672 1204 dbSNP
rs1166211036 1209 dbSNP
rs1419153512 1220 dbSNP
rs1016146831 1223 dbSNP
rs529662699 1225 dbSNP
rs923010522 1226 dbSNP
rs1440859451 1235 dbSNP
rs1040050251 1248 dbSNP
rs888949721 1250 dbSNP
rs1030616333 1255 dbSNP
rs1322814282 1270 dbSNP
rs942999459 1286 dbSNP
rs1389816407 1291 dbSNP
rs1274840508 1297 dbSNP
rs1161236461 1302 dbSNP
rs566883895 1307 dbSNP
rs1473759377 1317 dbSNP
rs1212808203 1318 dbSNP
rs910477998 1322 dbSNP
rs550280326 1325 dbSNP
rs1448652396 1339 dbSNP
rs1191209334 1340 dbSNP
rs1241526801 1342 dbSNP
rs997348963 1343 dbSNP
rs1439414096 1345 dbSNP
rs1415911463 1346 dbSNP
rs1461291976 1350 dbSNP
rs1187794091 1352 dbSNP
rs903298508 1359 dbSNP
rs1041788220 1365 dbSNP
rs113158626 1366 dbSNP
rs1325303044 1366 dbSNP
rs868058648 1376 dbSNP
rs1294788524 1377 dbSNP
rs1249271019 1378 dbSNP
rs564620551 1385 dbSNP
rs1332190661 1386 dbSNP
rs767746559 1390 dbSNP
rs1261093483 1397 dbSNP
rs1352757950 1405 dbSNP
rs1203254518 1410 dbSNP
rs1283686713 1416 dbSNP
rs919122107 1417 dbSNP
rs1190122989 1418 dbSNP
rs1255740556 1421 dbSNP
rs972297739 1433 dbSNP
rs1289670131 1441 dbSNP
rs1475000472 1447 dbSNP
rs961520900 1450 dbSNP
rs746683305 1451 dbSNP
rs3935618 1452 dbSNP
rs992160063 1456 dbSNP
rs1228226122 1458 dbSNP
rs982051336 1462 dbSNP
rs528283991 1463 dbSNP
rs1299903746 1466 dbSNP
rs930141727 1473 dbSNP
rs1431834171 1474 dbSNP
rs1033943387 1478 dbSNP
rs1001100289 1483 dbSNP
rs771772536 1484 dbSNP
rs963021314 1484 dbSNP
rs904084562 1485 dbSNP
rs1365916719 1489 dbSNP
rs1167885255 1493 dbSNP
rs985754803 1493 dbSNP
rs1348483707 1497 dbSNP
rs953327777 1498 dbSNP
rs1021151643 1499 dbSNP
rs1030237168 1499 dbSNP
rs1010141421 1506 dbSNP
rs997784686 1509 dbSNP
rs902993714 1510 dbSNP
rs1253143951 1511 dbSNP
rs1417748032 1515 dbSNP
rs1391557359 1525 dbSNP
rs1020802591 1527 dbSNP
rs530474959 1537 dbSNP
rs1405425339 1541 dbSNP
rs1455965948 1548 dbSNP
rs1167961458 1553 dbSNP
rs386658970 1554 dbSNP
rs901604484 1556 dbSNP
rs1040066546 1559 dbSNP
rs1011635291 1563 dbSNP
rs893145601 1568 dbSNP
rs1055843527 1597 dbSNP
rs1398156367 1598 dbSNP
rs1389514694 1611 dbSNP
rs1200502052 1613 dbSNP
rs1306014242 1615 dbSNP
rs937317506 1623 dbSNP
rs1269980601 1625 dbSNP
rs1205149118 1628 dbSNP
rs1340651180 1635 dbSNP
rs907472052 1637 dbSNP
rs1228209583 1638 dbSNP
rs1195658162 1641 dbSNP
rs1215215021 1641 dbSNP
rs1479773203 1641 dbSNP
rs1253954588 1642 dbSNP
rs1470233216 1648 dbSNP
rs143355156 1651 dbSNP
rs371766146 1651 dbSNP
rs943053300 1660 dbSNP
rs1273327112 1661 dbSNP
rs757657675 1668 dbSNP
rs918728814 1673 dbSNP
rs1374501243 1674 dbSNP
rs1370128786 1679 dbSNP
rs1383500332 1679 dbSNP
rs1460092371 1679 dbSNP
rs373501498 1679 dbSNP
rs971789280 1680 dbSNP
rs1297813145 1681 dbSNP
rs1305992136 1685 dbSNP
rs1307161606 1685 dbSNP
rs1274227243 1687 dbSNP
rs1407966415 1688 dbSNP
rs1049189144 1694 dbSNP
rs1252983608 1700 dbSNP
rs563116252 1704 dbSNP
rs1186592832 1707 dbSNP
rs1263148492 1708 dbSNP
rs908955935 1715 dbSNP
rs111304924 1716 dbSNP
rs953033482 1718 dbSNP
rs919163280 1722 dbSNP
rs1030684824 1726 dbSNP
rs1413446707 1729 dbSNP
rs1422366535 1735 dbSNP
rs975998104 1736 dbSNP
rs1173983228 1744 dbSNP
rs1480553183 1750 dbSNP
rs764310588 1758 dbSNP
rs1359901680 1763 dbSNP
rs1181870615 1780 dbSNP
rs1294184296 1783 dbSNP
rs1357588275 1786 dbSNP
rs1231914674 1794 dbSNP
rs542840721 1800 dbSNP
rs1272866138 1805 dbSNP
rs1482387658 1816 dbSNP
rs1218497933 1817 dbSNP
rs1235123866 1820 dbSNP
rs1192275500 1822 dbSNP
rs1257859507 1822 dbSNP
rs1484629672 1822 dbSNP
rs752056998 1825 dbSNP
rs1412733362 1837 dbSNP
rs1401242763 1843 dbSNP
rs1441918145 1848 dbSNP
rs949824046 1852 dbSNP
rs1343335473 1853 dbSNP
rs1419234156 1854 dbSNP
rs1276517513 1877 dbSNP
rs1357608609 1879 dbSNP
rs1020078335 1881 dbSNP
rs1293085302 1884 dbSNP
rs918011312 1886 dbSNP
rs992214324 1887 dbSNP
rs77519357 1888 dbSNP
rs754385030 1889 dbSNP
rs1226373601 1895 dbSNP
rs114099651 1897 dbSNP
rs968363791 1898 dbSNP
rs141418566 1900 dbSNP
rs1215344319 1903 dbSNP
rs1021621644 1904 dbSNP
rs1009746424 1905 dbSNP
rs1447126414 1907 dbSNP
rs1486458072 1911 dbSNP
rs1208221901 1915 dbSNP
rs1236716940 1918 dbSNP
rs560412577 1925 dbSNP
rs1335617748 1931 dbSNP
rs1178709452 1936 dbSNP
rs1018669067 1938 dbSNP
rs1007288663 1940 dbSNP
rs1438933863 1944 dbSNP
rs888853292 1955 dbSNP
rs1174351159 1957 dbSNP
rs543817508 1959 dbSNP
rs765989232 1961 dbSNP
rs760423726 1968 dbSNP
rs897395529 1974 dbSNP
rs1038535765 1978 dbSNP
rs1296805727 1989 dbSNP
rs1376820648 1991 dbSNP
rs760357273 1993 dbSNP
rs186493387 1994 dbSNP
rs1349372187 2000 dbSNP
rs1410529282 2002 dbSNP
rs1277542097 2005 dbSNP
rs908992091 2006 dbSNP
rs1050113972 2011 dbSNP
rs931654782 2014 dbSNP
rs1457277159 2015 dbSNP
rs1194140316 2018 dbSNP
rs922930574 2021 dbSNP
rs772666270 2029 dbSNP
rs1452712941 2036 dbSNP
rs68076437 2042 dbSNP
rs967361198 2047 dbSNP
rs913133025 2054 dbSNP
rs1399965408 2056 dbSNP
rs71634842 2059 dbSNP
rs78900929 2059 dbSNP
rs1206990820 2061 dbSNP
rs1369405363 2069 dbSNP
rs1433756700 2070 dbSNP
rs1318519570 2071 dbSNP
rs1036653288 2072 dbSNP
rs534954932 2079 dbSNP
rs1215911113 2083 dbSNP
rs917061589 2086 dbSNP
rs577626527 2087 dbSNP
rs1270659678 2090 dbSNP
rs1317110925 2090 dbSNP
rs1214068965 2093 dbSNP
rs1254877189 2104 dbSNP
rs1198254685 2105 dbSNP
rs1467081293 2105 dbSNP
rs1242718529 2106 dbSNP
rs1476527533 2115 dbSNP
rs1055616559 2116 dbSNP
rs1227739818 2132 dbSNP
rs1423149542 2134 dbSNP
rs1376849057 2139 dbSNP
rs1316595762 2142 dbSNP
rs566219697 2144 dbSNP
rs1387224335 2147 dbSNP
rs926692553 2154 dbSNP
rs1318131043 2158 dbSNP
rs1322328661 2165 dbSNP
rs148313415 2167 dbSNP
rs1001584566 2174 dbSNP
rs180771302 2185 dbSNP
rs1347371935 2187 dbSNP
rs1233743879 2195 dbSNP
rs1274744095 2196 dbSNP
rs1209116335 2201 dbSNP
rs1354182535 2201 dbSNP
rs1160280245 2203 dbSNP
rs566947796 2209 dbSNP
rs1412296649 2213 dbSNP
rs1185927165 2214 dbSNP
rs1445324045 2216 dbSNP
rs914172155 2218 dbSNP
rs1024347056 2223 dbSNP
rs988330514 2227 dbSNP
rs1190525422 2228 dbSNP
rs768534727 2231 dbSNP
rs1416077214 2233 dbSNP
rs1186973200 2236 dbSNP
rs1486970465 2244 dbSNP
rs1401996448 2249 dbSNP
rs1295807397 2252 dbSNP
rs994565520 2266 dbSNP
rs966249451 2270 dbSNP
rs1261135907 2272 dbSNP
rs1414959337 2273 dbSNP
rs550192676 2278 dbSNP
rs147278761 2279 dbSNP
rs1243759605 2282 dbSNP
rs1038568194 2284 dbSNP
rs1352738727 2287 dbSNP
rs1319647886 2289 dbSNP
rs1214636148 2292 dbSNP
rs529821498 2293 dbSNP
rs1486132457 2302 dbSNP
rs571054394 2302 dbSNP
rs1363842064 2305 dbSNP
rs1423643969 2307 dbSNP
rs1182964100 2309 dbSNP
rs1366125768 2309 dbSNP
rs953198182 2316 dbSNP
rs1027780225 2318 dbSNP
rs1468994322 2318 dbSNP
rs1379102687 2321 dbSNP
rs931713058 2321 dbSNP
rs923012685 2325 dbSNP
rs1040075081 2327 dbSNP
rs994518797 2333 dbSNP
rs1436248358 2335 dbSNP
rs1337474674 2336 dbSNP
rs913176752 2343 dbSNP
rs1308657702 2345 dbSNP
rs1348436390 2345 dbSNP
rs990037683 2346 dbSNP
rs1166036839 2350 dbSNP
rs897452883 2352 dbSNP
rs1036298873 2353 dbSNP
rs188308824 2355 dbSNP
rs539950135 2361 dbSNP
rs1456842000 2363 dbSNP
rs1178525736 2366 dbSNP
rs143960375 2369 dbSNP
rs1282195111 2370 dbSNP
rs1190787066 2371 dbSNP
rs1487384942 2372 dbSNP
rs1174964404 2373 dbSNP
rs1375649350 2378 dbSNP
rs1465177851 2381 dbSNP
rs1055669163 2382 dbSNP
rs1024795422 2385 dbSNP
rs1444266345 2390 dbSNP
rs1270704158 2391 dbSNP
rs780035163 2392 dbSNP
rs1223204524 2404 dbSNP
rs1341360949 2409 dbSNP
rs972780498 2410 dbSNP
rs1299199566 2411 dbSNP
rs961654738 2420 dbSNP
rs1228366777 2423 dbSNP
rs1253481914 2425 dbSNP
rs1316488467 2428 dbSNP
rs1017156155 2432 dbSNP
rs1254245849 2437 dbSNP
rs528283016 2443 dbSNP
rs1192437108 2444 dbSNP
rs1300176060 2446 dbSNP
rs1384663184 2447 dbSNP
rs1344086713 2455 dbSNP
rs889956330 2458 dbSNP
rs1463882105 2463 dbSNP
rs150225073 2463 dbSNP
rs1044171849 2467 dbSNP
rs80116025 2468 dbSNP
rs1370462484 2471 dbSNP
rs186341678 2472 dbSNP
rs549029122 2474 dbSNP
rs1373650161 2476 dbSNP
rs1395214813 2478 dbSNP
rs988090134 2478 dbSNP
rs529231598 2479 dbSNP
rs1291909890 2490 dbSNP
rs1366959554 2495 dbSNP
rs998754637 2499 dbSNP
rs1431637406 2500 dbSNP
rs1431244959 2503 dbSNP
rs1218411448 2508 dbSNP
rs901623201 2508 dbSNP
rs912145441 2512 dbSNP
rs1040510215 2513 dbSNP
rs1219971905 2513 dbSNP
rs1487887808 2514 dbSNP
rs986267899 2518 dbSNP
rs1197418815 2524 dbSNP
rs953634464 2525 dbSNP
rs1192746003 2529 dbSNP
rs73038344 2538 dbSNP
rs994970255 2543 dbSNP
rs1325207594 2545 dbSNP
rs935942810 2546 dbSNP
rs1285640287 2547 dbSNP
rs927184763 2554 dbSNP
rs1358938019 2555 dbSNP
rs1224536435 2560 dbSNP
rs961801242 2562 dbSNP
rs1014627019 2564 dbSNP
rs1226919644 2564 dbSNP
rs1317979699 2566 dbSNP
rs137902985 2566 dbSNP
rs1397374743 2568 dbSNP
rs199887504 2568 dbSNP
rs1302326127 2569 dbSNP
rs1215402244 2572 dbSNP
rs1055680646 2574 dbSNP
rs1001382293 2584 dbSNP
rs200218314 2587 dbSNP
rs1468468045 2589 dbSNP
rs1179841678 2592 dbSNP
rs1257730431 2592 dbSNP
rs1378523244 2592 dbSNP
rs138708883 2592 dbSNP
rs1419594199 2592 dbSNP
rs1484124586 2592 dbSNP
rs201285371 2592 dbSNP
rs201837067 2592 dbSNP
rs71634841 2592 dbSNP
rs771582777 2592 dbSNP
rs879033479 2592 dbSNP
rs961369765 2592 dbSNP
rs1408541379 2593 dbSNP
rs759882770 2593 dbSNP
rs778898999 2593 dbSNP
rs904331488 2594 dbSNP
rs1310867681 2597 dbSNP
rs984085562 2598 dbSNP
rs1350905046 2599 dbSNP
rs543877875 2603 dbSNP
rs1361793637 2606 dbSNP
rs1280614916 2607 dbSNP
rs766837644 2614 dbSNP
rs1313514515 2619 dbSNP
rs1028519818 2636 dbSNP
rs1236664325 2646 dbSNP
rs757360156 2664 dbSNP
rs1180395601 2672 dbSNP
rs946820057 2673 dbSNP
rs1439182555 2676 dbSNP
rs1018704103 2677 dbSNP
rs1427611135 2677 dbSNP
rs1198209238 2680 dbSNP
rs892545231 2681 dbSNP
rs1462230704 2684 dbSNP
rs1329935438 2685 dbSNP
rs1376735181 2698 dbSNP
rs1010362044 2699 dbSNP
rs1274919313 2703 dbSNP
rs1346752924 2709 dbSNP
rs774101900 2710 dbSNP
rs1052426768 2711 dbSNP
rs1307886271 2718 dbSNP
rs891547960 2723 dbSNP
rs944672308 2728 dbSNP
rs1054155532 2729 dbSNP
rs1457261608 2734 dbSNP
rs578069252 2736 dbSNP
rs905799349 2752 dbSNP
rs1259319831 2755 dbSNP
rs865983750 2756 dbSNP
rs758872992 2760 dbSNP
rs1477186274 2771 dbSNP
rs932185259 2774 dbSNP
rs949930331 2799 dbSNP
rs917037944 2801 dbSNP
rs1168895713 2806 dbSNP
rs753042194 2813 dbSNP
rs564427243 2815 dbSNP
rs1323698009 2816 dbSNP
rs1332283696 2819 dbSNP
rs368665497 2820 dbSNP
rs962134624 2830 dbSNP
rs1014679003 2832 dbSNP
rs1220311469 2833 dbSNP
rs1276054695 2835 dbSNP
rs1317274810 2844 dbSNP
rs560916080 2847 dbSNP
rs1214213067 2850 dbSNP
rs992496913 2860 dbSNP
rs762902996 2861 dbSNP
rs959661084 2863 dbSNP
rs555903231 2869 dbSNP
rs1478921851 2874 dbSNP
rs1456905494 2876 dbSNP
rs1034285845 2879 dbSNP
rs575614895 2884 dbSNP
rs909963148 2885 dbSNP
rs1475841084 2899 dbSNP
rs1165538497 2905 dbSNP
rs765616309 2905 dbSNP
rs775662509 2919 dbSNP
rs1403105389 2920 dbSNP
rs1322304958 2921 dbSNP
rs1360838216 2923 dbSNP
rs1401440703 2926 dbSNP
rs954028099 2928 dbSNP
rs138502446 2931 dbSNP
rs576366235 2937 dbSNP
rs772858302 2939 dbSNP
rs1285897469 2945 dbSNP
rs1010070514 2964 dbSNP
rs1227878765 2966 dbSNP
rs1243154972 2969 dbSNP
rs1286807436 2972 dbSNP
rs892555676 2976 dbSNP
rs556433798 2978 dbSNP
rs1009729625 2980 dbSNP
rs1052438209 2980 dbSNP
rs377737670 2980 dbSNP
rs965576853 2980 dbSNP
rs955801818 2981 dbSNP
rs1282645805 2982 dbSNP
rs1032742296 2986 dbSNP
rs1380346594 2998 dbSNP
rs1207238585 3008 dbSNP
rs1351125511 3016 dbSNP
rs1295988285 3021 dbSNP
rs1359434610 3023 dbSNP
rs766880924 3027 dbSNP
rs1265376824 3032 dbSNP
rs373983863 3038 dbSNP
rs536650140 3042 dbSNP
rs905496609 3042 dbSNP
rs1447166955 3046 dbSNP
rs1355980901 3048 dbSNP
rs890430262 3048 dbSNP
rs1050366497 3049 dbSNP
rs7427289 3051 dbSNP
rs1345977500 3052 dbSNP
rs1202613762 3055 dbSNP
rs1434703407 3055 dbSNP
rs551202246 3059 dbSNP
rs920847480 3061 dbSNP
rs773800971 3068 dbSNP
rs534686408 3069 dbSNP
rs768607672 3076 dbSNP
rs1441018018 3079 dbSNP
rs1156231895 3080 dbSNP
rs1389660651 3083 dbSNP
rs1466218073 3086 dbSNP
rs992554322 3088 dbSNP
rs1174153732 3089 dbSNP
rs781459450 3093 dbSNP
rs1331977947 3106 dbSNP
rs1378942002 3108 dbSNP
rs1426455643 3113 dbSNP
rs1034045428 3122 dbSNP
rs1385385930 3128 dbSNP
rs979785013 3136 dbSNP
rs1308614787 3138 dbSNP
rs1331952194 3143 dbSNP
rs1167381230 3144 dbSNP
rs1235655504 3150 dbSNP
rs932668476 3153 dbSNP
rs1344777347 3156 dbSNP
rs1243510705 3157 dbSNP
rs1199601511 3160 dbSNP
rs1193400296 3163 dbSNP
rs554566239 3164 dbSNP
rs1249182131 3168 dbSNP
rs1268611058 3168 dbSNP
rs976777129 3169 dbSNP
rs966047762 3173 dbSNP
rs1375517901 3176 dbSNP
rs535271011 3179 dbSNP
rs147108690 3180 dbSNP
rs77967114 3182 dbSNP
rs1032773382 3183 dbSNP
rs1491288730 3185 dbSNP
rs1491457788 3186 dbSNP
rs1388544977 3206 dbSNP
rs1299481343 3207 dbSNP
rs918127341 3210 dbSNP
rs1330676546 3212 dbSNP
rs999915031 3214 dbSNP
rs992412901 3220 dbSNP
rs181245836 3224 dbSNP
rs1330357760 3228 dbSNP
rs1316646659 3241 dbSNP
rs1301057328 3247 dbSNP
rs1031061228 3250 dbSNP
rs190035331 3257 dbSNP
rs1488531923 3259 dbSNP
rs746018197 3261 dbSNP
rs149019192 3263 dbSNP
rs1036890896 3264 dbSNP
rs1420941949 3265 dbSNP
rs1425473909 3266 dbSNP
rs996188008 3270 dbSNP
rs1004022107 3278 dbSNP
rs747383040 3285 dbSNP
rs1368927434 3294 dbSNP
rs888252022 3295 dbSNP
rs1459515057 3301 dbSNP
rs1291852978 3302 dbSNP
rs1048465694 3304 dbSNP
rs539701376 3306 dbSNP
rs1338940643 3315 dbSNP
rs564473564 3316 dbSNP
rs899415426 3321 dbSNP
rs1218347592 3327 dbSNP
rs7426741 3329 dbSNP
rs1041471854 3330 dbSNP
rs1246426603 3330 dbSNP
rs944032599 3332 dbSNP
rs1490097223 3338 dbSNP
rs1216930455 3342 dbSNP
rs572534356 3351 dbSNP
rs1197690802 3355 dbSNP
rs1487193925 3362 dbSNP
rs1185651434 3363 dbSNP
rs1414531761 3384 dbSNP
rs1490930007 3387 dbSNP
rs940851968 3391 dbSNP
rs908065870 3400 dbSNP
rs1204361668 3403 dbSNP
rs1384653046 3427 dbSNP
rs562028640 3432 dbSNP
rs1275185392 3436 dbSNP
rs988361368 3437 dbSNP
rs1358790427 3438 dbSNP
rs776232268 3443 dbSNP
rs1344538638 3446 dbSNP
rs938446243 3448 dbSNP
rs376112132 3454 dbSNP
rs1382030283 3457 dbSNP
rs925404259 3460 dbSNP
rs542063444 3463 dbSNP
rs760341801 3465 dbSNP
rs970248865 3466 dbSNP
rs1439920396 3471 dbSNP
rs1022702393 3473 dbSNP
rs1214879419 3474 dbSNP
rs1237813786 3478 dbSNP
rs1484217858 3501 dbSNP
rs1180076910 3503 dbSNP
rs992927711 3511 dbSNP
rs1378768144 3512 dbSNP
rs980180376 3514 dbSNP
rs968380519 3521 dbSNP
rs1177304195 3523 dbSNP
rs1452314644 3527 dbSNP
rs1464818335 3530 dbSNP
rs1328912639 3532 dbSNP
rs959709581 3536 dbSNP
rs753236946 3539 dbSNP
rs570462988 3540 dbSNP
rs1481627656 3544 dbSNP
rs1310797934 3545 dbSNP
rs778876511 3547 dbSNP
rs1222817518 3548 dbSNP
rs1177191703 3560 dbSNP
rs914490358 3562 dbSNP
rs988718775 3563 dbSNP
rs955936471 3564 dbSNP
rs550564128 3572 dbSNP
rs1008006619 3577 dbSNP
rs1234711150 3578 dbSNP
rs954830240 3579 dbSNP
rs1029038578 3581 dbSNP
rs1026808191 3605 dbSNP
rs1460889182 3621 dbSNP
rs996587570 3625 dbSNP
rs1261532857 3630 dbSNP
rs748694420 3641 dbSNP
rs996678710 3645 dbSNP
rs1192021815 3648 dbSNP
rs1205733470 3650 dbSNP
rs899136610 3655 dbSNP
rs1324013369 3656 dbSNP
rs1283291324 3658 dbSNP
rs1427462398 3663 dbSNP
rs1038089389 3664 dbSNP
rs865904054 3665 dbSNP
rs1222045232 3673 dbSNP
rs1375413256 3675 dbSNP
rs1401736294 3683 dbSNP
rs757474459 3685 dbSNP
rs1332837496 3688 dbSNP
rs535907272 3689 dbSNP
rs556446477 3689 dbSNP
rs1352292269 3690 dbSNP
rs1440768258 3691 dbSNP
rs1275083058 3698 dbSNP
rs1369195452 3707 dbSNP
rs886683558 3709 dbSNP
rs1041109577 3718 dbSNP
rs944046668 3723 dbSNP
rs747103532 3726 dbSNP
rs777769009 3728 dbSNP
rs1256029390 3736 dbSNP
rs938795134 3739 dbSNP
rs1379860218 3753 dbSNP
rs1052692364 3757 dbSNP
rs1487621448 3759 dbSNP
rs1199209300 3760 dbSNP
rs1338313140 3761 dbSNP
rs1478983297 3769 dbSNP
rs927044784 3771 dbSNP
rs1408863158 3773 dbSNP
rs1419354581 3773 dbSNP
rs936947802 3777 dbSNP
rs185089439 3781 dbSNP
rs1351314566 3782 dbSNP
rs1402692889 3782 dbSNP
rs1407381807 3786 dbSNP
rs1158793236 3787 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MCF7 , BT474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395164. RNA binding protein: AGO. Condition:MCF7 AGO HITS-CLIP Replicate 2 HITS-CLIP data was present in GSM1395167. RNA binding protein: AGO. Condition:BT474 AGO HITS-CLIP Replicate 2 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggaggagguccUAGGUGUGu 5'
                       || ||||| 
Target 5' ------------cAUACACACa 3'
 		1 - 10
Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1395164
Method / RBP HITS-CLIP / AGO
Cell line / Condition MCF7 / MCF7 AGO HITS-CLIP Replicate 2
Location of target site ENST00000338745.6 | 3UTR | CACAUACACACACACACACACACACACACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1395167
Method / RBP HITS-CLIP / AGO
Cell line / Condition BT474 / BT474 AGO HITS-CLIP Replicate 2
Location of target site ENST00000338745.6 | 3UTR | CAUACACACACACACACACACACACACACACAAGCACAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.869 0.03 -0.800 0.05 5 Click to see details
LUSC 0.752 0.12 1.000 0.5 4 Click to see details
HNSC 0.284 0.27 0.071 0.44 7 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
THCA 0.249 0.38 0.400 0.3 4 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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