pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NKTR   
Synonyms p104
Description natural killer cell triggering receptor
Transcript NM_005385   
Expression
Putative miRNA Targets on NKTR
3'UTR of NKTR
(miRNA target sites are highlighted)
>NKTR|NM_005385|3'UTR
   1 AAACGTCCGGATACAAATTATATCTTATTTGTAAATATCTGGCAACTTAGCTTAAGAAATGTAATGACAGTCTGTTGTTC
  81 TATTTCAATATCAGAGGTGAATTTCAAAAATAGACACTTCTTAATTGTTACTGGTTCATTTACATGTGGGGAGAAGAATT
 161 TAAAATACAGATATGTCTCCTAAAAATATTTTTATGCCACATTTTACAGTAGCCAACTATGGAAATGAATTTCATTTTCT
 241 TGAATCAAGAAATCGTGAAATTTATCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTATCTTACGTATCC
 321 CTTAGAATACAGATTCTTTTTGCCTGTTTTTCCAGTTTTAGCATATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTG
 401 TTAAAGGCGGCCAAATATTTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAACAAACCACCCAGAATTG
 481 ATACTGTTGGTAACCAGGAGTATAAGGCAGTGGCTCTGGGGTTCTTAATTCATTCCTAACTTCTTTGATACTTCACAGGA
 561 TTAGGAAAGTGGTCATCATACATCCCACACAGTCTGTATTACTTCAGGCTTGTGGGCAAGGTTAGGAAGAATCAATCAGC
 641 CTTAACTATAAATACCTGCACTGTCTCTGAGGACTTACTATTTTATGTTCTTTTTAATCAATACCGATCAGAAGTTTAGG
 721 TTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTTTGGTGCGTCTTTAAGCATTACTCTTATATATCATAT
 801 ATTAAAATACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTTTATTCTGAGCTGTCTTCACTTTGAC
 881 TATTTGGGGGGCTTCTCTCAAGTACAGATGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCAGTAAGAGATATTGGC
 961 CACTCAAGTCTACTGTGTGTGTGTGCCTCTGGAAGAGTGAAGAATGGACTTCAAAAGTAACATCAAAAATCTAACTGCCA
1041 CCATCCTGGAGACATTTTGCAGGGCTTTCCTTTCAAGTCTTTCAAGTACAGGATATTACCACAACAGCAGCTGAACTGTT
1121 GTAACCAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGCTGACTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAG
1201 ACAGGGGAAGAGGGATAGAGGGTATAGCATAAATTACATATTTTCATGGCTTTGGGTGGTTCCTCCAAAAATAATTGGAC
1281 CTGTAAAAACTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAATCTTTACTTTGAATTTGTT
1361 CCCCAAGTGTACTTAATCACCTTAGTGCCAGTTTAATCCAGTTATGCAGAAGAAATTCATATTGGTTGCCTGATGTAGAG
1441 CTCAGCACCACCCTACCACAGGCCTTGTCTGGTGTATTTGGGAAGTGGAAAAGAGCCCTCAGTTGGAGGGAGCTGACAAC
1521 CCTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCACCCAAAGAAGGTATGAAAACAGGGTAAGGTGGTCAGT
1601 TGTTTGCCAGGTCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATACTGGATACTGAATACAA
1681 AACAGTATGATTTATATTAAAGGTTTCCAAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAAAATGC
1761 ATTCAGAACCCAAGCAGAAACTGCCAAATGTAATTAGGTTAAGAAAAGTTACCCTTGGGCAGTGTATTAGTTTTCTATTG
1841 CTGTGTGACAAATTACCCCAAATTTAGCAGTTTAAAAAACAATACCCATAGCAGTTCTGTAGCTCATGAGTCTGGCACAG
1921 TGTGGCTGGATTCTCTGCTCAGGGTCTTAAAGGCTGAAATAAGGGTTGGCAGGACAACATTCCTTCATGGAGGCTCTGGG
2001 GAAGAATCTGCTTCTAAGTTCATTCAGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTCAGCTGGAGGCCCCTCTCTC
2081 ACCTCAAGGCTGCCTGCATTCCTTCTTATGTGGTCCCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTCATGCTTCAT
2161 ATCTCTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAAGCCCACAGATATATTTTAAGGTTGATTGTGCGATA
2241 GAACATAATTGCAGGAGTACTGTCTCATCTCATCATATTCACGGGTTCTGGAGATTAGCTCATTGAAAGTGGGAGGGGCA
2321 TTTTCAAATTCTGCCTACCACAGGCAATAACTGCCCATCTCAGCTGTAGGTGGAATTTTTACCCAGAAAAGATAGGCCCT
2401 AGAAGCCTCATTTCTTTTCTCCATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTGTTTACTGACAGAGTGA
2481 ACTACAGAAATAGCTTTTCTTCCTAAAGGGGATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGT
2561 GTATTGTGCTTCTTAATAGGAAATGCATTATTGGACTGTTTTTGTAACATCCTGTTTATTGCAAATAGCTAGTATCGTTC
2641 AAAAACTGTATAAAATACTTTTGTACATATTAGCAATGTCTAATTTGTATACACTTCAGTTAAATTTCCCTAAAACTTGA
2721 AAGGGGACCTTGTAGAAATTAAAATATATACTTAGTCTAAGTCTGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agauugugguguCACACCAAAc 5'
                      ||||||||| 
Target 5' gtgtgtgtgtgtGTGTGGTTTt 3'
1311 - 1332 150.00 -10.30
2
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            |::||||| |   |||||| 
Target 5' acTGGCACCA-AAAATGGTTTa 3'
837 - 857 131.00 -17.30
3
miRNA  3' agAUUGUGGUGUCACACCAAac 5'
            | |:: | : | ||||||  
Target 5' ttTCATGGCTTTGGGTGGTTcc 3'
1242 - 1263 128.00 -9.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30132970 6 COSMIC
COSN29994173 7 COSMIC
COSN1277122 18 COSMIC
COSN6768291 80 COSMIC
COSN31516730 237 COSMIC
COSN31542637 297 COSMIC
COSN31531639 371 COSMIC
COSN24299861 454 COSMIC
COSN30174070 481 COSMIC
COSN25089033 546 COSMIC
COSN26579139 656 COSMIC
COSN15091481 703 COSMIC
COSN30158144 736 COSMIC
COSN31601126 738 COSMIC
COSN20090804 772 COSMIC
COSN31515557 789 COSMIC
COSN30158038 812 COSMIC
COSN26380977 868 COSMIC
COSN27234250 1328 COSMIC
COSN29372886 1562 COSMIC
COSN9551379 1844 COSMIC
COSN20132999 1994 COSMIC
COSN23793586 2230 COSMIC
COSN27931036 2250 COSMIC
COSN5044577 2534 COSMIC
COSN25517345 2736 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1298486400 2 dbSNP
rs769989803 4 dbSNP
rs200060605 5 dbSNP
rs749870247 6 dbSNP
rs771562843 9 dbSNP
rs774045632 10 dbSNP
rs1259109555 20 dbSNP
rs1322852723 21 dbSNP
rs1291251915 23 dbSNP
rs759095680 24 dbSNP
rs896767856 29 dbSNP
rs1287304516 32 dbSNP
rs993754352 39 dbSNP
rs771779087 43 dbSNP
rs1269644386 57 dbSNP
rs1235490591 61 dbSNP
rs1274251360 67 dbSNP
rs112994830 69 dbSNP
rs762049177 72 dbSNP
rs559634051 73 dbSNP
rs753615526 82 dbSNP
rs528264713 83 dbSNP
rs765125399 84 dbSNP
rs767672954 89 dbSNP
rs1026904341 112 dbSNP
rs1322884394 114 dbSNP
rs1197156131 118 dbSNP
rs1393521708 118 dbSNP
rs376299235 121 dbSNP
rs1433544275 128 dbSNP
rs1200566933 132 dbSNP
rs952205382 135 dbSNP
rs1370919865 138 dbSNP
rs1249497857 146 dbSNP
rs895677016 147 dbSNP
rs1267149993 152 dbSNP
rs1210843998 153 dbSNP
rs547904837 157 dbSNP
rs1168729607 159 dbSNP
rs773330625 162 dbSNP
rs760636484 166 dbSNP
rs1250141860 173 dbSNP
rs1016669404 174 dbSNP
rs963748181 175 dbSNP
rs1439036419 187 dbSNP
rs1370576673 195 dbSNP
rs1323918346 201 dbSNP
rs1388314721 206 dbSNP
rs1301822608 210 dbSNP
rs1167328732 211 dbSNP
rs1429809418 214 dbSNP
rs1390476946 217 dbSNP
rs766114918 221 dbSNP
rs999831940 223 dbSNP
rs564405103 228 dbSNP
rs1453379936 235 dbSNP
rs975089341 249 dbSNP
rs146285641 255 dbSNP
rs549780488 256 dbSNP
rs1226943092 261 dbSNP
rs1205139341 263 dbSNP
rs1276815194 267 dbSNP
rs1483405250 267 dbSNP
rs1298477536 269 dbSNP
rs569675256 280 dbSNP
rs913744712 283 dbSNP
rs946503567 285 dbSNP
rs1021113857 292 dbSNP
rs1484959918 297 dbSNP
rs139368112 299 dbSNP
rs1333820210 302 dbSNP
rs549254787 305 dbSNP
rs566295570 309 dbSNP
rs1043564851 310 dbSNP
rs1410395221 316 dbSNP
rs1372360783 320 dbSNP
rs1310490366 335 dbSNP
rs926717969 344 dbSNP
rs543450260 347 dbSNP
rs564753701 358 dbSNP
rs1488688010 361 dbSNP
rs752345347 364 dbSNP
rs938074923 373 dbSNP
rs1479197554 377 dbSNP
rs757947801 381 dbSNP
rs1181948857 389 dbSNP
rs1211372383 391 dbSNP
rs534881096 394 dbSNP
rs1254617444 398 dbSNP
rs1208737763 399 dbSNP
rs563336123 401 dbSNP
rs1441986692 403 dbSNP
rs1279581127 408 dbSNP
rs994157160 409 dbSNP
rs1348232019 410 dbSNP
rs866539222 412 dbSNP
rs1259261901 416 dbSNP
rs1047951356 421 dbSNP
rs1427595299 423 dbSNP
rs943322781 424 dbSNP
rs1188798699 428 dbSNP
rs1446646428 428 dbSNP
rs1391542125 431 dbSNP
rs1359287509 434 dbSNP
rs1398553519 435 dbSNP
rs1383819828 437 dbSNP
rs141960647 441 dbSNP
rs1158818950 442 dbSNP
rs1458103268 445 dbSNP
rs1442178265 448 dbSNP
rs888015262 449 dbSNP
rs558302681 452 dbSNP
rs1472494901 455 dbSNP
rs879053648 458 dbSNP
rs571269805 461 dbSNP
rs973408380 464 dbSNP
rs920470791 467 dbSNP
rs929235149 472 dbSNP
rs1209048921 475 dbSNP
rs1331031772 479 dbSNP
rs1271178520 485 dbSNP
rs1162222526 496 dbSNP
rs1379848113 504 dbSNP
rs1285399804 507 dbSNP
rs1428059380 508 dbSNP
rs1363931084 522 dbSNP
rs1368356142 531 dbSNP
rs935533824 532 dbSNP
rs777247712 549 dbSNP
rs1295702705 560 dbSNP
rs537101715 563 dbSNP
rs949942592 568 dbSNP
rs1163361466 579 dbSNP
rs1405243247 593 dbSNP
rs1415181976 606 dbSNP
rs191528227 607 dbSNP
rs1474469988 608 dbSNP
rs963799556 613 dbSNP
rs573676864 617 dbSNP
rs1434734549 636 dbSNP
rs1189517318 641 dbSNP
rs905630996 647 dbSNP
rs996518410 649 dbSNP
rs1250866178 667 dbSNP
rs1220585100 668 dbSNP
rs139315070 674 dbSNP
rs866592682 675 dbSNP
rs891490576 679 dbSNP
rs553289612 681 dbSNP
rs955044889 700 dbSNP
rs756604675 707 dbSNP
rs913846844 708 dbSNP
rs1436219740 710 dbSNP
rs1246858790 718 dbSNP
rs967938306 719 dbSNP
rs1427886931 720 dbSNP
rs954875169 726 dbSNP
rs1169340793 730 dbSNP
rs1485413722 733 dbSNP
rs979298535 738 dbSNP
rs987648476 741 dbSNP
rs926432635 743 dbSNP
rs1208979542 758 dbSNP
rs1248375710 760 dbSNP
rs1202417673 761 dbSNP
rs150018513 771 dbSNP
rs544899306 772 dbSNP
rs1230002269 774 dbSNP
rs964792585 781 dbSNP
rs1056511543 784 dbSNP
rs1219001229 790 dbSNP
rs1300169314 790 dbSNP
rs565058776 791 dbSNP
rs1277097643 792 dbSNP
rs973522646 792 dbSNP
rs1408498593 793 dbSNP
rs1370510940 795 dbSNP
rs533277920 810 dbSNP
rs1431711841 813 dbSNP
rs917927515 814 dbSNP
rs1175695430 821 dbSNP
rs929352949 822 dbSNP
rs1256212469 829 dbSNP
rs1048175894 830 dbSNP
rs543505774 838 dbSNP
rs563381449 839 dbSNP
rs1252465209 842 dbSNP
rs1206591218 853 dbSNP
rs145235635 856 dbSNP
rs949881602 868 dbSNP
rs3202350 869 dbSNP
rs1039185666 875 dbSNP
rs1313116703 880 dbSNP
rs1160188085 883 dbSNP
rs1281108645 885 dbSNP
rs1391057186 886 dbSNP
rs1450572925 887 dbSNP
rs1302385687 888 dbSNP
rs1411729909 891 dbSNP
rs900639867 900 dbSNP
rs1302455625 909 dbSNP
rs1466704937 911 dbSNP
rs1361134298 921 dbSNP
rs1156609917 923 dbSNP
rs1456510095 927 dbSNP
rs1412614427 928 dbSNP
rs532455650 935 dbSNP
rs997019036 947 dbSNP
rs780287888 951 dbSNP
rs1421519990 955 dbSNP
rs1254920109 957 dbSNP
rs550690712 963 dbSNP
rs562899568 968 dbSNP
rs1304708950 973 dbSNP
rs148579945 974 dbSNP
rs1207214482 976 dbSNP
rs1054159639 980 dbSNP
rs1269299269 985 dbSNP
rs890856310 985 dbSNP
rs1230820627 986 dbSNP
rs745656143 994 dbSNP
rs1228732738 1006 dbSNP
rs1381528720 1015 dbSNP
rs1269647310 1025 dbSNP
rs1321028975 1034 dbSNP
rs547979921 1036 dbSNP
rs1237619654 1043 dbSNP
rs1021036676 1051 dbSNP
rs967991041 1052 dbSNP
rs1367834097 1055 dbSNP
rs1164787788 1077 dbSNP
rs979306906 1078 dbSNP
rs1425109677 1079 dbSNP
rs779727598 1084 dbSNP
rs959167315 1086 dbSNP
rs1187597250 1097 dbSNP
rs1464707714 1098 dbSNP
rs992664185 1102 dbSNP
rs1487755832 1106 dbSNP
rs73829270 1112 dbSNP
rs1245603091 1114 dbSNP
rs1323640850 1120 dbSNP
rs528748522 1123 dbSNP
rs1366237909 1127 dbSNP
rs1322234957 1130 dbSNP
rs548565575 1131 dbSNP
rs183760980 1142 dbSNP
rs909186049 1145 dbSNP
rs1458977882 1146 dbSNP
rs994905323 1147 dbSNP
rs942289562 1149 dbSNP
rs371174850 1156 dbSNP
rs1167455248 1157 dbSNP
rs1202525790 1164 dbSNP
rs1414623491 1168 dbSNP
rs772300797 1172 dbSNP
rs567024907 1174 dbSNP
rs1450310417 1177 dbSNP
rs900693765 1178 dbSNP
rs933531549 1179 dbSNP
rs746464816 1184 dbSNP
rs1343056956 1188 dbSNP
rs1272215829 1193 dbSNP
rs983866636 1194 dbSNP
rs917136617 1201 dbSNP
rs774458351 1203 dbSNP
rs971287311 1206 dbSNP
rs1368659872 1211 dbSNP
rs1306806700 1216 dbSNP
rs1429829386 1223 dbSNP
rs1052345484 1226 dbSNP
rs1372014751 1227 dbSNP
rs1170504406 1230 dbSNP
rs890917742 1238 dbSNP
rs1009723314 1239 dbSNP
rs1020637224 1246 dbSNP
rs374785791 1247 dbSNP
rs903479128 1256 dbSNP
rs1410331803 1257 dbSNP
rs1377461312 1258 dbSNP
rs1276172851 1260 dbSNP
rs1250254072 1261 dbSNP
rs980024079 1266 dbSNP
rs9841926 1267 dbSNP
rs935858975 1276 dbSNP
rs1198991890 1291 dbSNP
rs1278820497 1291 dbSNP
rs1033566976 1292 dbSNP
rs1225135016 1292 dbSNP
rs1205322151 1293 dbSNP
rs1267399636 1293 dbSNP
rs1281872986 1293 dbSNP
rs1326880192 1293 dbSNP
rs1338363380 1293 dbSNP
rs1340695196 1293 dbSNP
rs1352787452 1293 dbSNP
rs1446669393 1293 dbSNP
rs1454897400 1293 dbSNP
rs1483058592 1293 dbSNP
rs376762349 1293 dbSNP
rs959259925 1293 dbSNP
rs1386961367 1295 dbSNP
rs1158936462 1299 dbSNP
rs1458185864 1308 dbSNP
rs1161471836 1312 dbSNP
rs1201780177 1314 dbSNP
rs1369252995 1314 dbSNP
rs1472545917 1314 dbSNP
rs1273138158 1315 dbSNP
rs1185709580 1316 dbSNP
rs1463351464 1316 dbSNP
rs1483045395 1316 dbSNP
rs1206460643 1317 dbSNP
rs1247138421 1318 dbSNP
rs1254486302 1318 dbSNP
rs1479626247 1319 dbSNP
rs1209144226 1320 dbSNP
rs1190830657 1321 dbSNP
rs1426080290 1322 dbSNP
rs1448603144 1322 dbSNP
rs1435003331 1323 dbSNP
rs1168485177 1324 dbSNP
rs1287650336 1324 dbSNP
rs1369991144 1325 dbSNP
rs1227232342 1326 dbSNP
rs1316682789 1326 dbSNP
rs1356498292 1326 dbSNP
rs1054107655 1327 dbSNP
rs1188890616 1327 dbSNP
rs1491515424 1327 dbSNP
rs754263585 1327 dbSNP
rs11442896 1328 dbSNP
rs1215505702 1328 dbSNP
rs1297968741 1328 dbSNP
rs1491353652 1328 dbSNP
rs912984375 1328 dbSNP
rs1304972568 1329 dbSNP
rs1370180904 1329 dbSNP
rs1427910392 1329 dbSNP
rs200637299 1329 dbSNP
rs796657249 1329 dbSNP
rs368136009 1330 dbSNP
rs1181905098 1331 dbSNP
rs1363502137 1332 dbSNP
rs10676488 1340 dbSNP
rs1435408748 1340 dbSNP
rs945696297 1340 dbSNP
rs1275108930 1341 dbSNP
rs1270963544 1343 dbSNP
rs1369229559 1344 dbSNP
rs1212420500 1348 dbSNP
rs1296287598 1349 dbSNP
rs1482473338 1350 dbSNP
rs1274888393 1362 dbSNP
rs1206233503 1365 dbSNP
rs557085265 1383 dbSNP
rs1391015627 1389 dbSNP
rs1276890628 1395 dbSNP
rs1219022114 1398 dbSNP
rs1346624452 1400 dbSNP
rs1229801764 1401 dbSNP
rs1277304539 1402 dbSNP
rs1349992921 1410 dbSNP
rs369041780 1416 dbSNP
rs1298850065 1426 dbSNP
rs1463675629 1434 dbSNP
rs188836513 1436 dbSNP
rs536232263 1444 dbSNP
rs1470183614 1449 dbSNP
rs1431328974 1452 dbSNP
rs1156922252 1454 dbSNP
rs1471962768 1458 dbSNP
rs909236751 1460 dbSNP
rs1009144474 1468 dbSNP
rs760530546 1478 dbSNP
rs1489611484 1488 dbSNP
rs1482038778 1494 dbSNP
rs766279165 1499 dbSNP
rs552908136 1514 dbSNP
rs1184992989 1516 dbSNP
rs1236539993 1520 dbSNP
rs942007944 1520 dbSNP
rs1209852014 1521 dbSNP
rs573073447 1522 dbSNP
rs974703385 1526 dbSNP
rs1039331848 1531 dbSNP
rs181120458 1534 dbSNP
rs1329101068 1536 dbSNP
rs1170419694 1538 dbSNP
rs558477469 1542 dbSNP
rs1383259597 1544 dbSNP
rs1393216740 1548 dbSNP
rs575085273 1549 dbSNP
rs1302542273 1561 dbSNP
rs543542511 1563 dbSNP
rs933565272 1564 dbSNP
rs900649821 1571 dbSNP
rs1051971747 1574 dbSNP
rs1318333466 1575 dbSNP
rs372806442 1577 dbSNP
rs552785110 1578 dbSNP
rs1027706101 1593 dbSNP
rs1160569718 1596 dbSNP
rs950865687 1598 dbSNP
rs1183863850 1600 dbSNP
rs1005008923 1601 dbSNP
rs376283315 1603 dbSNP
rs1245297631 1609 dbSNP
rs186764730 1610 dbSNP
rs1464786810 1611 dbSNP
rs1261890960 1612 dbSNP
rs190125461 1616 dbSNP
rs571081003 1619 dbSNP
rs1312246301 1621 dbSNP
rs1246941318 1623 dbSNP
rs1385295841 1626 dbSNP
rs1295059170 1628 dbSNP
rs1000561597 1630 dbSNP
rs1434102970 1631 dbSNP
rs1319398533 1640 dbSNP
rs67533173 1643 dbSNP
rs979969006 1651 dbSNP
rs895099462 1663 dbSNP
rs1013889245 1671 dbSNP
rs1446021017 1674 dbSNP
rs1229918000 1679 dbSNP
rs957170236 1684 dbSNP
rs371407282 1690 dbSNP
rs912940577 1709 dbSNP
rs542627378 1717 dbSNP
rs140966748 1719 dbSNP
rs528784114 1722 dbSNP
rs552047023 1725 dbSNP
rs1223344462 1727 dbSNP
rs1361779521 1739 dbSNP
rs1323863140 1745 dbSNP
rs556818560 1747 dbSNP
rs531111976 1750 dbSNP
rs912200447 1754 dbSNP
rs116191409 1759 dbSNP
rs115143792 1762 dbSNP
rs1366834019 1770 dbSNP
rs900762994 1772 dbSNP
rs1190537235 1794 dbSNP
rs144811548 1796 dbSNP
rs763625677 1799 dbSNP
rs1368299671 1802 dbSNP
rs1167624544 1813 dbSNP
rs147958835 1815 dbSNP
rs1373960745 1820 dbSNP
rs141805837 1825 dbSNP
rs913416542 1835 dbSNP
rs1005366043 1838 dbSNP
rs1400028983 1843 dbSNP
rs1490878241 1844 dbSNP
rs1024418975 1856 dbSNP
rs1195485725 1862 dbSNP
rs946176123 1871 dbSNP
rs1157999315 1874 dbSNP
rs751004642 1875 dbSNP
rs1230796326 1898 dbSNP
rs143455421 1902 dbSNP
rs150921658 1907 dbSNP
rs1034193411 1914 dbSNP
rs1348125925 1919 dbSNP
rs1306902821 1920 dbSNP
rs957286111 1927 dbSNP
rs936399189 1942 dbSNP
rs1398205965 1944 dbSNP
rs140686142 1945 dbSNP
rs756594613 1947 dbSNP
rs894766527 1948 dbSNP
rs1177852208 1957 dbSNP
rs868077283 1976 dbSNP
rs990122050 1977 dbSNP
rs537668580 1981 dbSNP
rs554308765 1988 dbSNP
rs1438539374 1993 dbSNP
rs1046715501 1998 dbSNP
rs886345919 2001 dbSNP
rs1198496804 2005 dbSNP
rs1226900759 2006 dbSNP
rs1004697285 2008 dbSNP
rs1016048316 2010 dbSNP
rs1263643114 2011 dbSNP
rs773487518 2011 dbSNP
rs150127319 2021 dbSNP
rs1330141512 2022 dbSNP
rs754266690 2023 dbSNP
rs996182582 2027 dbSNP
rs1028997662 2037 dbSNP
rs1337162160 2038 dbSNP
rs954847323 2039 dbSNP
rs35384559 2043 dbSNP
rs913501303 2046 dbSNP
rs182189975 2048 dbSNP
rs1181242185 2059 dbSNP
rs1158062067 2067 dbSNP
rs1470585999 2068 dbSNP
rs536219765 2070 dbSNP
rs1365731068 2079 dbSNP
rs1412396814 2084 dbSNP
rs573182881 2086 dbSNP
rs1461059364 2088 dbSNP
rs978961404 2089 dbSNP
rs1205350466 2099 dbSNP
rs1463440917 2102 dbSNP
rs779371577 2109 dbSNP
rs138446097 2110 dbSNP
rs1049350559 2120 dbSNP
rs1282032902 2125 dbSNP
rs1400886768 2126 dbSNP
rs886590480 2130 dbSNP
rs990547762 2134 dbSNP
rs1335487535 2140 dbSNP
rs940889763 2141 dbSNP
rs1342735055 2144 dbSNP
rs1343934058 2151 dbSNP
rs1408515382 2153 dbSNP
rs1318298600 2160 dbSNP
rs1046202294 2162 dbSNP
rs747915610 2162 dbSNP
rs1161554407 2166 dbSNP
rs907302646 2169 dbSNP
rs916261933 2172 dbSNP
rs565551351 2173 dbSNP
rs1447497413 2175 dbSNP
rs893172547 2176 dbSNP
rs1011893597 2180 dbSNP
rs1020223847 2185 dbSNP
rs748408581 2192 dbSNP
rs949101792 2201 dbSNP
rs1273230448 2207 dbSNP
rs967587781 2209 dbSNP
rs1046048916 2217 dbSNP
rs986660849 2218 dbSNP
rs886392813 2233 dbSNP
rs1201056273 2236 dbSNP
rs1359703333 2237 dbSNP
rs187617853 2238 dbSNP
rs1482055532 2239 dbSNP
rs963787120 2240 dbSNP
rs1037504985 2242 dbSNP
rs1270009325 2258 dbSNP
rs114251807 2262 dbSNP
rs1252342226 2263 dbSNP
rs919581987 2275 dbSNP
rs1473416400 2278 dbSNP
rs931019735 2283 dbSNP
rs985425397 2286 dbSNP
rs776894834 2292 dbSNP
rs1366416870 2297 dbSNP
rs1165762909 2304 dbSNP
rs8351 2311 dbSNP
rs529819612 2315 dbSNP
rs1186912300 2317 dbSNP
rs373062296 2318 dbSNP
rs116877584 2328 dbSNP
rs566378314 2348 dbSNP
rs1198048017 2351 dbSNP
rs1173871681 2356 dbSNP
rs1009335650 2360 dbSNP
rs559385876 2373 dbSNP
rs1202537548 2390 dbSNP
rs1306581064 2391 dbSNP
rs1272666354 2394 dbSNP
rs1215531401 2401 dbSNP
rs114235065 2406 dbSNP
rs1307948798 2407 dbSNP
rs551856552 2410 dbSNP
rs1055834334 2413 dbSNP
rs1305065255 2415 dbSNP
rs1440233731 2419 dbSNP
rs1354178981 2422 dbSNP
rs11553663 2432 dbSNP
rs1411509032 2434 dbSNP
rs1011595219 2439 dbSNP
rs141757321 2440 dbSNP
rs1480738716 2441 dbSNP
rs1270348172 2446 dbSNP
rs1321852129 2450 dbSNP
rs1480067083 2451 dbSNP
rs1033196750 2452 dbSNP
rs1205649196 2455 dbSNP
rs1439973751 2473 dbSNP
rs1261785418 2484 dbSNP
rs115821070 2486 dbSNP
rs1234193694 2503 dbSNP
rs1324910288 2509 dbSNP
rs1285208903 2519 dbSNP
rs1222201878 2520 dbSNP
rs1372856934 2521 dbSNP
rs190807251 2527 dbSNP
rs1444068268 2560 dbSNP
rs991661442 2562 dbSNP
rs963904244 2567 dbSNP
rs996581344 2580 dbSNP
rs1026755760 2611 dbSNP
rs1156312799 2611 dbSNP
rs1418063498 2613 dbSNP
rs181017725 2615 dbSNP
rs949162003 2620 dbSNP
rs185054037 2623 dbSNP
rs908079104 2624 dbSNP
rs1451863776 2626 dbSNP
rs770914051 2631 dbSNP
rs1200548159 2637 dbSNP
rs1387849773 2638 dbSNP
rs1462107066 2641 dbSNP
rs940612867 2658 dbSNP
rs1213700954 2668 dbSNP
rs377376760 2668 dbSNP
rs1316453396 2670 dbSNP
rs1168541426 2675 dbSNP
rs545407265 2676 dbSNP
rs1380867470 2684 dbSNP
rs1314020285 2692 dbSNP
rs1453185787 2696 dbSNP
rs1408197036 2705 dbSNP
rs1287097030 2732 dbSNP
rs776673943 2734 dbSNP
rs981693130 2735 dbSNP
rs190150875 2738 dbSNP
rs928792565 2748 dbSNP
rs1422301797 2749 dbSNP
rs1463955560 2754 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agauugugguguCACACCAaac 5'
                      |||||||   
Target 5' guguguguguguGUGUGGU--- 3'
24 - 42
2
miRNA  3' agauugUGGUGUCACAC-CAAAc 5'
                ||:|  ||||| || | 
Target 5' -----aACUAGUGUGUGUGUGUg 3'
1 - 18
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BT474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395166. RNA binding protein: AGO. Condition:BT474 AGO HITS-CLIP Replicate 1 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202481. RNA binding protein: AGO2. Condition:S6_LV_61yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000232978.8 | 3UTR | AACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000232978.8 | 3UTR | AAACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000232978.8 | 3UTR | AACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000232978.8 | 3UTR | AAACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000232978.8 | 3UTR | AAACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000232978.8 | 3UTR | ACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000232978.8 | 3UTR | AAACUAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1395166
Method / RBP HITS-CLIP / AGO
Cell line / Condition BT474 / BT474 AGO HITS-CLIP Replicate 1
Location of target site ENST00000232978.8 | 3UTR | GUGUGUGUGUGUGUGUGUGUGUGUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.879 3.8e-5 0.820 3.0e-4 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.513 6.2e-3 -0.464 1.3e-2 23 Click to see details
GSE28544 Breast cancer 0.479 8.9e-3 0.552 2.6e-3 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.394 2.8e-2 0.363 4.1e-2 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.347 6.7e-2 -0.119 3.1e-1 20 Click to see details
GSE21687 Ependynoma primary tumors 0.147 1.2e-1 0.062 3.1e-1 64 Click to see details
GSE17498 Multiple myeloma -0.181 1.3e-1 -0.249 6.1e-2 40 Click to see details
GSE32688 Pancreatic cancer -0.146 2.1e-1 -0.146 2.1e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.148 2.4e-1 -0.211 1.6e-1 25 Click to see details
GSE19350 CNS germ cell tumors -0.132 3.4e-1 -0.021 4.7e-1 12 Click to see details
GSE38226 Liver fibrosis -0.082 3.6e-1 0.028 4.5e-1 21 Click to see details
GSE38226 Liver fibrosis -0.082 3.6e-1 0.028 4.5e-1 21 Click to see details
GSE38226 Liver fibrosis -0.082 3.6e-1 0.028 4.5e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.24 0.06 0.252 0.05 42 Click to see details
UCEC 0.361 0.08 0.421 0.05 16 Click to see details
LUSC 0.238 0.1 0.263 0.08 30 Click to see details
LIHC -0.204 0.14 -0.062 0.37 30 Click to see details
CHOL 0.527 0.14 0.429 0.2 6 Click to see details
KIRC 0.157 0.16 0.115 0.23 43 Click to see details
THCA -0.151 0.16 -0.237 0.06 45 Click to see details
PAAD 0.636 0.18 0.400 0.3 4 Click to see details
ESCA -0.29 0.21 -0.309 0.19 10 Click to see details
STAD 0.156 0.25 0.090 0.35 21 Click to see details
BLCA -0.483 0.26 -0.400 0.3 4 Click to see details
PRAD -0.053 0.36 -0.216 0.07 46 Click to see details
LUAD 0.217 0.39 0.200 0.4 4 Click to see details
KICH 0.057 0.42 -0.129 0.32 15 Click to see details
HNSC -0.038 0.44 0.011 0.48 18 Click to see details
KIRP 0.007 0.49 0.018 0.47 21 Click to see details
KIRP 0.007 0.49 0.018 0.47 21 Click to see details
KIRP 0.007 0.49 0.018 0.47 21 Click to see details
KIRP 0.007 0.49 0.018 0.47 21 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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