pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NCDN   
Synonyms -
Description neurochondrin
Transcript NM_001014839   
Other Transcripts NM_001014841 , NM_014284   
Expression
Putative miRNA Targets on NCDN
3'UTR of NCDN
(miRNA target sites are highlighted)
>NCDN|NM_001014839|3'UTR
   1 GGGGTGTCCACCGGGGACAGACCCAGGGGCGGGCAGAGAGGGAAGGAGGGAGGAGGCATCTTCCCTGAAGCCCCCAATCT
  81 GGCCCCCCCCTCCCCAGACTTCCTCCCCAAAACACCCCAGCTTTCTGGCTTTTCTGAGGGCAAGGGCATGGTGCCCACCC
 161 CTCAAGTGTAAGGAACTGCGTTCCGCCCCTCAGGCCCCCATGGGGGCAGGGATCGGCTTGGAAATCAACGTGGTTGTCCC
 241 CGCCAGGCCGGGGAAGGTTGGAGCAGCCCCCAGGGAGGGGGGCACTAGGTGTCATTGTGCCCGATGTCTGGCTCCCCTGC
 321 AGGAGGGAGGCTCCAGGGTAAGACAGGGCTGGCAGGAGCAGACTGCCTCAGCCCATGTGCCCTGCCGGCCAGGGCGTGGG
 401 CTCCCCTCGGCTGTGGTGCCTCCTCTGGCCCCCCAGGTCCACGTCCTTTAAATTGGCCCTTTGGCTCTTGCCCTTGGCTC
 481 CCTTGGGCAGACAGCAGGCTTAGGCCATTGATATCGCAGTTCTTCCTATCAGCTTCAGTGACCCAGGGTCTGAACTGCCT
 561 CCATCCTAGGGCAACCTGGGGCAGACAGGCCTGGTGGGGGGTGGGGAAACCTCCTTCCACCTGAGCTTGCTTGAAGGGAC
 641 CCAGAGTCTTTGGGCCCAGATCTTTAAACCTTTGTGTCGTGTTGCAGCAGAGTGACGATGGGGGTTGGGGGGTTATTTAT
 721 TTTGCCTGTCCTTATCCCTGCTTGGACACCTGAGCATCTGATTCCTGTCCCCCTGGTGCCATCTGGCCTGGCTGGAGCCA
 801 GGAACAGGAGGGACACTTCCCCAGAATCCGCATGTTTCCCCAGTGATTACACTCCACTGCCACCGTGGTGCCTGGCTTTA
 881 ACTCCCACCCCTGCTATGACTCCTCTCTGCAGAGACGCGACTGGCGGCTCCAGCAGGGACTACCTTTCTTATAAACCCAG
 961 GGGGACCACACACACACACACACACACACACACACACACACACACACACACACACACTCTTGATCCCTTGCTTCCCTCCC
1041 CCAGTGCGTTCTGTGATCGCCAAGTTCAAAGCTGTGCACATGTGGACACTCAATAAATGTTCATTGGTGACGAGAAAAAA
1121 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acgGAGGAGGUCCUAGGUGUGu 5'
             ||:| |||| ||||:||: 
Target 5' acaCTTCCCCAGAATCCGCATg 3'
813 - 834 143.00 -24.30
2
miRNA  3' acGGAGGAGGUC-------CUAGGUGUGu 5'
            |||||||::|       |:|||||:: 
Target 5' tgCCTCCTCTGGCCCCCCAGGTCCACGTc 3'
417 - 445 136.00 -28.71
3
miRNA  3' acGGAGGA-------GGU--CCUAGGUGUGu 5'
            |:|:||       |||  ||: |||||| 
Target 5' acCTTTCTTATAAACCCAGGGGGACCACACa 3'
942 - 972 126.00 -23.81
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24297432 32 COSMIC
COSN28866274 91 COSMIC
COSN30538432 94 COSMIC
COSN31544104 130 COSMIC
COSN30173523 174 COSMIC
COSN20237851 185 COSMIC
COSN21994754 545 COSMIC
COSN19322641 968 COSMIC
COSN31571814 1048 COSMIC
COSN31541954 1049 COSMIC
COSN1103527 1071 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753668634 2 dbSNP
rs1167165755 4 dbSNP
rs887228686 5 dbSNP
rs1378852436 11 dbSNP
rs1396850927 13 dbSNP
rs75817414 14 dbSNP
rs1305882763 15 dbSNP
rs751812100 16 dbSNP
rs754956677 19 dbSNP
rs781317782 25 dbSNP
rs752785686 31 dbSNP
rs1255221308 32 dbSNP
rs768539494 41 dbSNP
rs1183283894 42 dbSNP
rs1259190412 43 dbSNP
rs1341651963 47 dbSNP
rs1477246536 49 dbSNP
rs756581218 56 dbSNP
rs529573626 59 dbSNP
rs1276708323 67 dbSNP
rs1467673244 72 dbSNP
rs1174516485 78 dbSNP
rs58718331 79 dbSNP
rs1009488987 83 dbSNP
rs776248027 83 dbSNP
rs757649362 85 dbSNP
rs1304883965 86 dbSNP
rs778468809 87 dbSNP
rs745545529 88 dbSNP
rs1399575355 89 dbSNP
rs904195693 89 dbSNP
rs541917030 90 dbSNP
rs747996133 90 dbSNP
rs769563259 91 dbSNP
rs867441673 91 dbSNP
rs563328250 92 dbSNP
rs1342402151 97 dbSNP
rs1254225258 101 dbSNP
rs1346994049 102 dbSNP
rs1031297174 103 dbSNP
rs1258232185 105 dbSNP
rs1486784067 108 dbSNP
rs1464598872 110 dbSNP
rs1277798671 111 dbSNP
rs1312596978 114 dbSNP
rs1403452832 115 dbSNP
rs766019488 116 dbSNP
rs1258649806 118 dbSNP
rs1487765325 119 dbSNP
rs1296688571 120 dbSNP
rs1008590796 135 dbSNP
rs1219673368 139 dbSNP
rs530779480 154 dbSNP
rs72659625 157 dbSNP
rs972159618 159 dbSNP
rs964139284 180 dbSNP
rs976076172 181 dbSNP
rs952043046 185 dbSNP
rs920222502 186 dbSNP
rs759244376 187 dbSNP
rs1194192429 188 dbSNP
rs982826928 189 dbSNP
rs1266871002 204 dbSNP
rs1162957805 206 dbSNP
rs908530973 212 dbSNP
rs552165192 215 dbSNP
rs368706575 216 dbSNP
rs1021511697 221 dbSNP
rs1157346429 222 dbSNP
rs570447840 225 dbSNP
rs538307425 230 dbSNP
rs547360504 231 dbSNP
rs1302933608 237 dbSNP
rs1366383854 239 dbSNP
rs1427567583 242 dbSNP
rs915750403 243 dbSNP
rs948548401 250 dbSNP
rs565739553 251 dbSNP
rs1355786460 257 dbSNP
rs575147294 261 dbSNP
rs1216986424 267 dbSNP
rs904259701 268 dbSNP
rs1487602605 270 dbSNP
rs1193115886 275 dbSNP
rs1384949494 283 dbSNP
rs904480015 284 dbSNP
rs999162226 286 dbSNP
rs889401856 288 dbSNP
rs1164467664 289 dbSNP
rs1052750297 299 dbSNP
rs1459812577 301 dbSNP
rs536310795 303 dbSNP
rs898005114 304 dbSNP
rs1008602197 306 dbSNP
rs1017272606 307 dbSNP
rs1445328752 317 dbSNP
rs964807265 339 dbSNP
rs1306460927 340 dbSNP
rs1378973916 343 dbSNP
rs997062489 345 dbSNP
rs1311986252 359 dbSNP
rs555088804 367 dbSNP
rs1027547992 369 dbSNP
rs994049047 371 dbSNP
rs953019633 373 dbSNP
rs1027741647 375 dbSNP
rs952072483 379 dbSNP
rs1028089629 382 dbSNP
rs1196748774 382 dbSNP
rs558923918 387 dbSNP
rs1278859253 392 dbSNP
rs528036413 396 dbSNP
rs537681976 397 dbSNP
rs1225422442 407 dbSNP
rs1425911947 409 dbSNP
rs1033675348 414 dbSNP
rs1464808992 429 dbSNP
rs1328631548 431 dbSNP
rs752565362 434 dbSNP
rs908562204 435 dbSNP
rs1270682159 443 dbSNP
rs1490939542 444 dbSNP
rs756063234 456 dbSNP
rs559208662 458 dbSNP
rs1317474135 465 dbSNP
rs1217056345 468 dbSNP
rs1260288454 473 dbSNP
rs1200663303 477 dbSNP
rs1458245263 478 dbSNP
rs992747401 481 dbSNP
rs959989881 484 dbSNP
rs992920862 489 dbSNP
rs916033180 496 dbSNP
rs577581923 499 dbSNP
rs1182766013 500 dbSNP
rs1469021373 516 dbSNP
rs1477076279 518 dbSNP
rs917127759 527 dbSNP
rs948814294 529 dbSNP
rs945921453 534 dbSNP
rs978643382 544 dbSNP
rs1332941773 560 dbSNP
rs1408741753 568 dbSNP
rs1357289239 570 dbSNP
rs925713103 572 dbSNP
rs535338767 573 dbSNP
rs1339570257 575 dbSNP
rs935745940 587 dbSNP
rs754334677 596 dbSNP
rs12046738 597 dbSNP
rs944342116 598 dbSNP
rs1367739414 599 dbSNP
rs1211416764 611 dbSNP
rs1040647552 624 dbSNP
rs1487512389 628 dbSNP
rs898032303 629 dbSNP
rs993671399 631 dbSNP
rs1475537608 635 dbSNP
rs1171438551 644 dbSNP
rs1405294005 647 dbSNP
rs1415729329 647 dbSNP
rs1174150096 649 dbSNP
rs934611258 653 dbSNP
rs750495760 655 dbSNP
rs1052925660 660 dbSNP
rs1327892246 668 dbSNP
rs1049248268 671 dbSNP
rs1299812259 671 dbSNP
rs890125737 674 dbSNP
rs79080032 679 dbSNP
rs1038671861 680 dbSNP
rs1235205700 691 dbSNP
rs900272399 697 dbSNP
rs550951605 698 dbSNP
rs1219160482 703 dbSNP
rs1287225269 704 dbSNP
rs149256824 707 dbSNP
rs201597802 707 dbSNP
rs1293464982 710 dbSNP
rs1193781770 713 dbSNP
rs200433534 714 dbSNP
rs1359765909 732 dbSNP
rs780306954 737 dbSNP
rs11545627 738 dbSNP
rs1160186737 748 dbSNP
rs1385375243 753 dbSNP
rs867620004 754 dbSNP
rs1321827050 755 dbSNP
rs1024230909 770 dbSNP
rs1441658431 789 dbSNP
rs1308627949 797 dbSNP
rs1375271219 798 dbSNP
rs967666430 806 dbSNP
rs1280692109 811 dbSNP
rs1356050901 818 dbSNP
rs541556602 830 dbSNP
rs1239376883 831 dbSNP
rs1452987375 832 dbSNP
rs1444060675 856 dbSNP
rs1161792212 857 dbSNP
rs1437334301 865 dbSNP
rs747142608 866 dbSNP
rs1364382519 867 dbSNP
rs563424892 871 dbSNP
rs1161261794 872 dbSNP
rs1416150175 875 dbSNP
rs1462189693 884 dbSNP
rs1330701650 886 dbSNP
rs1425481974 894 dbSNP
rs957142791 912 dbSNP
rs1167569197 916 dbSNP
rs985855669 917 dbSNP
rs768926702 919 dbSNP
rs1242995040 920 dbSNP
rs992869885 927 dbSNP
rs1329442368 930 dbSNP
rs1023371141 936 dbSNP
rs910268547 939 dbSNP
rs1197099481 942 dbSNP
rs1251086078 947 dbSNP
rs970199041 957 dbSNP
rs1449796898 966 dbSNP
rs1192742069 967 dbSNP
rs1198636498 967 dbSNP
rs1228892659 967 dbSNP
rs1251421146 967 dbSNP
rs1259577224 967 dbSNP
rs1261227558 967 dbSNP
rs1314830122 967 dbSNP
rs1344150995 967 dbSNP
rs1369997656 967 dbSNP
rs1430525677 967 dbSNP
rs1485872965 967 dbSNP
rs1491298970 967 dbSNP
rs371112044 967 dbSNP
rs56974171 967 dbSNP
rs570824683 967 dbSNP
rs71831349 967 dbSNP
rs759215590 967 dbSNP
rs1491127280 968 dbSNP
rs764651842 969 dbSNP
rs1464645113 970 dbSNP
rs1040409428 971 dbSNP
rs1226171373 974 dbSNP
rs1249271383 975 dbSNP
rs1419424010 986 dbSNP
rs1337835645 990 dbSNP
rs1197973885 993 dbSNP
rs919549936 1003 dbSNP
rs1461227320 1009 dbSNP
rs1182312015 1011 dbSNP
rs1244981245 1012 dbSNP
rs1364121455 1013 dbSNP
rs1424477915 1014 dbSNP
rs1329967665 1016 dbSNP
rs1215539500 1017 dbSNP
rs1230518912 1017 dbSNP
rs188515142 1017 dbSNP
rs1283661084 1018 dbSNP
rs934452970 1019 dbSNP
rs575330822 1026 dbSNP
rs988594704 1030 dbSNP
rs1267023645 1032 dbSNP
rs1431501005 1037 dbSNP
rs1195596034 1040 dbSNP
rs201506039 1041 dbSNP
rs944606748 1046 dbSNP
rs1439658745 1047 dbSNP
rs1002345511 1049 dbSNP
rs143571041 1059 dbSNP
rs900137264 1060 dbSNP
rs930428161 1068 dbSNP
rs1049249014 1100 dbSNP
rs1382806205 1104 dbSNP
rs1381214091 1105 dbSNP
rs781363836 1112 dbSNP
rs768666059 1113 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048188. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_ptb_knockdown ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggaggagguccuaGGUGUGu 5'
                         |||||| 
Target 5' ------------ggaCCACACa 3'
1 - 10
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acggaggagguccuaGGUGUGu 5'
                         |||||| 
Target 5' ------------ggaCCACACa 3'
1 - 10
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395164. RNA binding protein: AGO. Condition:MCF7 AGO HITS-CLIP Replicate 2 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1048188
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_ptb_knockdown
Location of target site ENST00000356090.4 | 3UTR | GGACCACACACACACACACACACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000356090.4 | 3UTR | GGACCACACACACACACACACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1395164
Method / RBP HITS-CLIP / AGO
Cell line / Condition MCF7 / MCF7 AGO HITS-CLIP Replicate 2
Location of target site ENST00000356090.4 | 3UTR | GGACCACACACACACACACACACACACACACACACACACACACACACACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.736 0.03 -0.714 0.04 7 Click to see details
BRCA 0.245 0.35 0.100 0.44 5 Click to see details
LUSC -0.098 0.45 0.400 0.3 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
THCA -0.01 0.5 -0.200 0.4 4 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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