miRTarBase - #MIRT609041


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pre-miRNA Information
pre-miRNA hsa-mir-4481   
Genomic Coordinates chr10: 12653138 - 12653197
Description Homo sapiens miR-4481 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4481
Sequence 1| GGAGUGGGCUGGUGGUU |17
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1299710636 5 dbSNP
rs1433739601 12 dbSNP
rs1266754238 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol EP300   
Synonyms KAT3B, RSTS2, p300
Description E1A binding protein p300
Transcript NM_001429   
Expression
Putative miRNA Targets on EP300
3'UTR of EP300
(miRNA target sites are highlighted)		 
>EP300|NM_001429|3'UTR
   1 AGACACCTTGTAGTATTTTGGGAGCAAAAAAATTATTTTCTCTTAACAAGACTTTTTGTACTGAAAACAATTTTTTTGAA
  81 TCTTTCGTAGCCTAAAAGACAATTTTCCTTGGAACACATAAGAACTGTGCAGTAGCCGTTTGTGGTTTAAAGCAAACATG
 161 CAAGATGAACCTGAGGGATGATAGAATACAAAGAATATATTTTTGTTATGGCTGGTTACCACCAGCCTTTCTTCCCCTTT
 241 GTGTGTGTGGTTCAAGTGTGCACTGGGAGGAGGCTGAGGCCTGTGAAGCCAAACAATATGCTCCTGCCTTGCACCTCCAA
 321 TAGGTTTTATTATTTTTTTTAAATTAATGAACATATGTAATATTAATAGTTATTATTTACTGGTGCAGATGGTTGACATT
 401 TTTCCCTATTTTCCTCACTTTATGGAAGAGTTAAAACATTTCTAAACCAGAGGACAAAAGGGGTTAATGTTACTTTAAAA
 481 TTACATTCTATATATATATAAATATATATAAATATATATTAAAATACCAGTTTTTTTTCTCTGGGTGCAAAGATGTTCAT
 561 TCTTTTAAAAAATGTTTAAAAAAAAAAAAAAACTGCCTTTCTTCCCCTCAAGTCAACTTTTGTGCTCCAGAAAATTTTCT
 641 ATTCTGTAAGTCTGAGCGTAAAACTTCAAGTATTAAAATAATTTGTACATGTAGAGAGAAAAATGACTTTTTCAAAAATA
 721 TACAGGGGCAGCTGCCAAATTGATGTATTATATATTGTGGTTTCTGTTTCTTGAAAGAATTTTTTTCGTTATTTTTACAT
 801 CTAACAAAGTAAAAAAATTAAAAAGAGGGTAAGAAACGATTCCGGTGGGATGATTTTAACATGCAAAATGTCCCTGGGGG
 881 TTTCTTCTTTGCTTGCTTTCTTCCTCCTTACCCTACCCCCCACTCACACACACACACACACACACACACACACACACACA
 961 CACACACTTTCTATAAAACTTGAAAATAGCAAAAACCCTCAACTGTTGTAAATCATGCAATTAAAGTTGATTACTTATAA
1041 ATATGAACTTTGGATCACTGTATAGACTGTTAAATTTGATTTCTTATTACCTATTGTTAAATAAACTGTGTGAGACAGAC
1121 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            |:|||  ||||||| 
Target 5' ccCTACC-CCCCACTCa 3'
 911 - 926 150.00 -18.60
2 
miRNA  3' uugguggucGGGUGAGg 5'
                   |:||||: 
Target 5' cctattttcCTCACTTt 3'
 405 - 421 108.00 -9.20
3 
miRNA  3' uugGUG-GUCGGGUGAGg 5'
             ||| || | ||||: 
Target 5' acaCACACA-CACACTTt 3'
 954 - 970 101.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
158570 1 ClinVar
158555 10 ClinVar
341833 38 ClinVar
341838 333 ClinVar
341843 578 ClinVar
341844 578 ClinVar
341845 578 ClinVar
341846 745 ClinVar
341848 780 ClinVar
341851 916 ClinVar
341852 923 ClinVar
341853 923 ClinVar
341854 923 ClinVar
341855 923 ClinVar
341856 923 ClinVar
341857 923 ClinVar
341858 923 ClinVar
341862 925 ClinVar
341863 925 ClinVar
341864 925 ClinVar
341865 925 ClinVar
341873 1081 ClinVar
COSM6992091 1 COSMIC
COSN30468132 8 COSMIC
COSN20117492 14 COSMIC
COSN26975084 33 COSMIC
COSN30178194 34 COSMIC
COSN30148415 36 COSMIC
COSN30462723 43 COSMIC
COSN30466273 43 COSMIC
COSN31546598 83 COSMIC
COSN27500208 94 COSMIC
COSN31555085 250 COSMIC
COSN26642852 472 COSMIC
COSN28760408 499 COSMIC
COSN31567550 637 COSMIC
COSN30169382 683 COSMIC
COSN31550479 708 COSMIC
COSN31548993 709 COSMIC
COSN26548677 714 COSMIC
COSN17037451 751 COSMIC
COSN31546589 788 COSMIC
COSN31543938 907 COSMIC
COSN14673543 925 COSMIC
COSN31611337 943 COSMIC
COSN31543601 1084 COSMIC
COSN30165070 1105 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs587783622 1 dbSNP
rs771143704 5 dbSNP
rs200186236 6 dbSNP
rs544616799 7 dbSNP
rs765742153 8 dbSNP
rs936561690 8 dbSNP
rs35508493 10 dbSNP
rs397867944 12 dbSNP
rs759870815 13 dbSNP
rs201517499 14 dbSNP
rs948745540 16 dbSNP
rs199815769 17 dbSNP
rs775974454 19 dbSNP
rs1264263152 20 dbSNP
rs575190212 25 dbSNP
rs1183406155 26 dbSNP
rs1484382101 26 dbSNP
rs1192019816 30 dbSNP
rs1279188414 31 dbSNP
rs777871528 32 dbSNP
rs938259978 32 dbSNP
rs764668171 33 dbSNP
rs772729310 34 dbSNP
rs1164445443 35 dbSNP
rs751376755 38 dbSNP
rs886057572 38 dbSNP
rs1404633902 39 dbSNP
rs767351090 43 dbSNP
rs1342354776 44 dbSNP
rs1444484064 45 dbSNP
rs745928756 45 dbSNP
rs777517355 45 dbSNP
rs762549341 47 dbSNP
rs1277373696 48 dbSNP
rs766102030 51 dbSNP
rs1218504258 53 dbSNP
rs542406106 53 dbSNP
rs768518444 53 dbSNP
rs1435641920 55 dbSNP
rs1377488452 63 dbSNP
rs1156726737 64 dbSNP
rs1266235040 66 dbSNP
rs1247474986 69 dbSNP
rs1408670312 70 dbSNP
rs1047902807 71 dbSNP
rs1160178750 71 dbSNP
rs887959738 73 dbSNP
rs1188043782 75 dbSNP
rs1486483455 79 dbSNP
rs1184118133 83 dbSNP
rs1006422857 87 dbSNP
rs899324208 88 dbSNP
rs929507559 92 dbSNP
rs80147140 93 dbSNP
rs1225905552 94 dbSNP
rs1160342203 95 dbSNP
rs1292809430 98 dbSNP
rs565373820 99 dbSNP
rs1357646040 101 dbSNP
rs560974570 103 dbSNP
rs1429798137 106 dbSNP
rs1345507137 111 dbSNP
rs1320213156 112 dbSNP
rs1048248944 113 dbSNP
rs1417066791 117 dbSNP
rs376292667 118 dbSNP
rs750007292 118 dbSNP
rs528294138 119 dbSNP
rs1185512658 120 dbSNP
rs1416993374 120 dbSNP
rs1485746491 124 dbSNP
rs1017839584 126 dbSNP
rs549969725 134 dbSNP
rs900792978 137 dbSNP
rs997186440 137 dbSNP
rs113567138 138 dbSNP
rs75494658 139 dbSNP
rs977822118 139 dbSNP
rs1293720236 142 dbSNP
rs1032078418 146 dbSNP
rs538717731 149 dbSNP
rs1290475455 156 dbSNP
rs1289975012 159 dbSNP
rs756852477 160 dbSNP
rs1393698837 162 dbSNP
rs996763101 163 dbSNP
rs558734679 166 dbSNP
rs1462585691 168 dbSNP
rs188733753 169 dbSNP
rs1207075674 170 dbSNP
rs1283746845 171 dbSNP
rs916493311 172 dbSNP
rs949335144 175 dbSNP
rs1452917866 178 dbSNP
rs1032284101 183 dbSNP
rs1212271528 187 dbSNP
rs551826975 188 dbSNP
rs1489509327 190 dbSNP
rs1203898049 194 dbSNP
rs957845126 194 dbSNP
rs145182984 195 dbSNP
rs1483193261 198 dbSNP
rs1231851570 200 dbSNP
rs1369916597 203 dbSNP
rs1472248194 210 dbSNP
rs988004219 213 dbSNP
rs537781018 215 dbSNP
rs962286976 217 dbSNP
rs929348113 228 dbSNP
rs1021085704 232 dbSNP
rs1462021060 238 dbSNP
rs1047830313 240 dbSNP
rs1414636331 240 dbSNP
rs1171308271 241 dbSNP
rs566086251 242 dbSNP
rs1433261338 251 dbSNP
rs549594724 254 dbSNP
rs1471775423 256 dbSNP
rs887886124 257 dbSNP
rs1435484232 262 dbSNP
rs1249007891 272 dbSNP
rs567705659 276 dbSNP
rs942175438 278 dbSNP
rs535227210 279 dbSNP
rs982303617 280 dbSNP
rs778583274 282 dbSNP
rs926307576 290 dbSNP
rs900720787 297 dbSNP
rs552755933 299 dbSNP
rs1347417700 302 dbSNP
rs1280849458 304 dbSNP
rs937704901 313 dbSNP
rs998193570 321 dbSNP
rs1029967566 325 dbSNP
rs779681402 327 dbSNP
rs973614760 330 dbSNP
rs902172354 332 dbSNP
rs1310701808 333 dbSNP
rs1351735620 333 dbSNP
rs561569141 333 dbSNP
rs886057573 333 dbSNP
rs1358571899 335 dbSNP
rs920860918 341 dbSNP
rs781011524 342 dbSNP
rs1467875207 346 dbSNP
rs1348403704 349 dbSNP
rs990634116 350 dbSNP
rs577686550 353 dbSNP
rs970648884 353 dbSNP
rs982451873 354 dbSNP
rs538234665 357 dbSNP
rs929274439 358 dbSNP
rs983493638 358 dbSNP
rs1221058309 362 dbSNP
rs1239598643 363 dbSNP
rs1331127312 367 dbSNP
rs1276588045 370 dbSNP
rs1290969848 370 dbSNP
rs1355743806 372 dbSNP
rs1335739949 373 dbSNP
rs1485665847 374 dbSNP
rs1383188183 377 dbSNP
rs944799429 381 dbSNP
rs1288805837 388 dbSNP
rs1458277963 397 dbSNP
rs1414802714 398 dbSNP
rs757905892 402 dbSNP
rs1162924291 404 dbSNP
rs909289817 405 dbSNP
rs1418873298 406 dbSNP
rs1206522749 409 dbSNP
rs1260861728 410 dbSNP
rs942118923 414 dbSNP
rs1466238778 424 dbSNP
rs1482290045 424 dbSNP
rs1271164418 425 dbSNP
rs1039165430 427 dbSNP
rs900680104 437 dbSNP
rs1246963450 438 dbSNP
rs1039566025 439 dbSNP
rs900484865 441 dbSNP
rs902809952 442 dbSNP
rs1436232741 449 dbSNP
rs999139483 454 dbSNP
rs1429755976 458 dbSNP
rs1000225824 464 dbSNP
rs1053391604 465 dbSNP
rs1460998374 467 dbSNP
rs893517262 470 dbSNP
rs1165071275 475 dbSNP
rs1368578184 480 dbSNP
rs1032230734 481 dbSNP
rs374949987 482 dbSNP
rs893744867 486 dbSNP
rs1003402268 489 dbSNP
rs1023440362 489 dbSNP
rs970955088 489 dbSNP
rs1025564752 492 dbSNP
rs745323176 492 dbSNP
rs983419908 493 dbSNP
rs1009782150 496 dbSNP
rs1438861870 498 dbSNP
rs1273245893 500 dbSNP
rs909217536 502 dbSNP
rs963472896 502 dbSNP
rs1301899959 506 dbSNP
rs1229169144 508 dbSNP
rs975217904 508 dbSNP
rs1277450971 509 dbSNP
rs1396067017 510 dbSNP
rs1169421230 511 dbSNP
rs769190814 511 dbSNP
rs1020780007 513 dbSNP
rs1195653743 515 dbSNP
rs971007317 516 dbSNP
rs1192756121 517 dbSNP
rs981865960 521 dbSNP
rs1478341137 526 dbSNP
rs933480220 527 dbSNP
rs1179082480 531 dbSNP
rs1196309540 531 dbSNP
rs1273279026 531 dbSNP
rs1345278845 533 dbSNP
rs1278721851 536 dbSNP
rs1051916008 537 dbSNP
rs924161180 539 dbSNP
rs1251946988 540 dbSNP
rs1440149070 541 dbSNP
rs1449568837 542 dbSNP
rs1189913751 544 dbSNP
rs1388292884 545 dbSNP
rs1429026722 546 dbSNP
rs1163687462 548 dbSNP
rs935587158 551 dbSNP
rs886057574 553 dbSNP
rs1392635219 558 dbSNP
rs1414779458 560 dbSNP
rs886057575 560 dbSNP
rs1403324806 563 dbSNP
rs1321851186 564 dbSNP
rs533563820 569 dbSNP
rs1053359267 573 dbSNP
rs1251981985 574 dbSNP
rs1469195894 574 dbSNP
rs1370495308 575 dbSNP
rs1256339751 577 dbSNP
rs1484508636 577 dbSNP
rs1209883648 578 dbSNP
rs1230282852 578 dbSNP
rs1289134056 578 dbSNP
rs1391744700 578 dbSNP
rs1443312286 578 dbSNP
rs398037214 578 dbSNP
rs60283061 578 dbSNP
rs893477300 578 dbSNP
rs1011943912 579 dbSNP
rs1448489873 580 dbSNP
rs1360626778 583 dbSNP
rs1299909814 585 dbSNP
rs1363718638 586 dbSNP
rs1227359853 589 dbSNP
rs1315947151 589 dbSNP
rs1400114865 590 dbSNP
rs1045197042 591 dbSNP
rs1266478991 594 dbSNP
rs906322621 595 dbSNP
rs1208385072 596 dbSNP
rs1239637079 597 dbSNP
rs1473336778 597 dbSNP
rs972260255 602 dbSNP
rs1269269414 606 dbSNP
rs34217877 606 dbSNP
rs1025492733 608 dbSNP
rs775206725 621 dbSNP
rs1005492877 628 dbSNP
rs369359781 631 dbSNP
rs1245656028 632 dbSNP
rs1427351585 637 dbSNP
rs1268242094 640 dbSNP
rs920805459 642 dbSNP
rs1016888205 646 dbSNP
rs1322413825 646 dbSNP
rs1370065351 647 dbSNP
rs1459416671 649 dbSNP
rs551821297 650 dbSNP
rs1471714672 651 dbSNP
rs575180655 655 dbSNP
rs963688747 658 dbSNP
rs984141483 659 dbSNP
rs912058716 660 dbSNP
rs1457953154 661 dbSNP
rs922000696 664 dbSNP
rs954825119 668 dbSNP
rs1381676038 671 dbSNP
rs944893429 672 dbSNP
rs1314096851 673 dbSNP
rs1190999698 674 dbSNP
rs1467518503 674 dbSNP
rs1265008594 675 dbSNP
rs1039104274 678 dbSNP
rs1323782920 682 dbSNP
rs1271087384 690 dbSNP
rs1365570215 692 dbSNP
rs542469146 692 dbSNP
rs1299747862 693 dbSNP
rs1433770798 693 dbSNP
rs1438693028 701 dbSNP
rs1370148134 708 dbSNP
rs1293643213 712 dbSNP
rs1458971413 716 dbSNP
rs1352436634 720 dbSNP
rs561247456 722 dbSNP
rs1429528620 730 dbSNP
rs1391232837 732 dbSNP
rs1053952398 734 dbSNP
rs1170876022 736 dbSNP
rs915520303 740 dbSNP
rs1267246834 741 dbSNP
rs532524940 745 dbSNP
rs1329505388 746 dbSNP
rs1229872914 749 dbSNP
rs1231399411 749 dbSNP
rs762680482 750 dbSNP
rs886057576 754 dbSNP
rs1343119602 760 dbSNP
rs1485279330 762 dbSNP
rs1044771530 773 dbSNP
rs1231759017 776 dbSNP
rs891836937 778 dbSNP
rs1301851861 780 dbSNP
rs886057577 780 dbSNP
rs1388018757 781 dbSNP
rs939087859 782 dbSNP
rs1009484526 788 dbSNP
rs1170929149 789 dbSNP
rs779630643 789 dbSNP
rs1433194376 790 dbSNP
rs1187027814 791 dbSNP
rs1377588260 792 dbSNP
rs1412452721 792 dbSNP
rs1177343582 793 dbSNP
rs1434991715 797 dbSNP
rs1405955556 802 dbSNP
rs1473412298 803 dbSNP
rs886956098 806 dbSNP
rs1161685584 808 dbSNP
rs1256535817 811 dbSNP
rs1362225648 811 dbSNP
rs1453211107 815 dbSNP
rs1287206634 816 dbSNP
rs572918594 816 dbSNP
rs1005411098 820 dbSNP
rs1351974205 820 dbSNP
rs192560169 821 dbSNP
rs1017259846 824 dbSNP
rs906355559 828 dbSNP
rs1003801953 830 dbSNP
rs1033367362 831 dbSNP
rs1351495745 832 dbSNP
rs1343913144 835 dbSNP
rs1158580930 838 dbSNP
rs959119386 839 dbSNP
rs1230582824 840 dbSNP
rs1414477090 842 dbSNP
rs568903436 844 dbSNP
rs532999218 845 dbSNP
rs1201933715 854 dbSNP
rs1233423052 858 dbSNP
rs559571461 862 dbSNP
rs950471999 868 dbSNP
rs954933653 875 dbSNP
rs1267373803 878 dbSNP
rs1208843995 881 dbSNP
rs1330520663 881 dbSNP
rs1291071917 882 dbSNP
rs533499767 885 dbSNP
rs912159262 886 dbSNP
rs966208880 889 dbSNP
rs1210079561 891 dbSNP
rs987529154 895 dbSNP
rs551590068 896 dbSNP
rs921971462 900 dbSNP
rs1179724379 903 dbSNP
rs1248734402 905 dbSNP
rs989646867 907 dbSNP
rs1418717550 910 dbSNP
rs1176953997 911 dbSNP
rs1387112984 911 dbSNP
rs1309821198 915 dbSNP
rs1320419911 915 dbSNP
rs779301339 915 dbSNP
rs1161532977 916 dbSNP
rs1457851328 916 dbSNP
rs936064016 916 dbSNP
rs1457633275 918 dbSNP
rs1189070010 919 dbSNP
rs1189390488 919 dbSNP
rs1270797930 919 dbSNP
rs1369249391 919 dbSNP
rs1426476243 919 dbSNP
rs1466189343 919 dbSNP
rs915471744 919 dbSNP
rs1208692477 920 dbSNP
rs1379461724 920 dbSNP
rs1168982921 921 dbSNP
rs1193779887 921 dbSNP
rs1266790744 921 dbSNP
rs1269022601 921 dbSNP
rs1274427271 921 dbSNP
rs1320373706 921 dbSNP
rs1341014946 921 dbSNP
rs1427593641 921 dbSNP
rs1451298328 921 dbSNP
rs1451634649 921 dbSNP
rs201838162 921 dbSNP
rs772706624 921 dbSNP
rs775405084 921 dbSNP
rs778195651 921 dbSNP
rs868459601 921 dbSNP
rs1308460431 922 dbSNP
rs1325593238 922 dbSNP
rs1331696126 922 dbSNP
rs1431346951 922 dbSNP
rs1435856842 922 dbSNP
rs747125987 922 dbSNP
rs768698964 922 dbSNP
rs771445899 922 dbSNP
rs886057578 922 dbSNP
rs886057579 922 dbSNP
rs886057580 922 dbSNP
rs886057581 922 dbSNP
rs886057582 922 dbSNP
rs913213813 922 dbSNP
rs1171861309 923 dbSNP
rs1378929336 923 dbSNP
rs146984033 923 dbSNP
rs747975866 924 dbSNP
rs761630243 924 dbSNP
rs1183825066 925 dbSNP
rs1206934227 925 dbSNP
rs1209814917 925 dbSNP
rs1236152422 925 dbSNP
rs1252026371 925 dbSNP
rs1265490324 925 dbSNP
rs1328851906 925 dbSNP
rs1404668403 925 dbSNP
rs1412261656 925 dbSNP
rs1415013050 925 dbSNP
rs143475032 925 dbSNP
rs1443548498 925 dbSNP
rs1471599236 925 dbSNP
rs149250603 925 dbSNP
rs200776305 925 dbSNP
rs59721178 925 dbSNP
rs77174899 925 dbSNP
rs878933775 925 dbSNP
rs879010908 925 dbSNP
rs886057584 925 dbSNP
rs1432872813 926 dbSNP
rs140429533 927 dbSNP
rs948341214 927 dbSNP
rs1283436307 928 dbSNP
rs1377213255 928 dbSNP
rs142198417 929 dbSNP
rs1318382577 931 dbSNP
rs879634387 931 dbSNP
rs886057585 933 dbSNP
rs1372226506 935 dbSNP
rs1387002753 937 dbSNP
rs886057586 939 dbSNP
rs766627654 941 dbSNP
rs1289382586 943 dbSNP
rs754018515 943 dbSNP
rs1054890788 945 dbSNP
rs71200668 947 dbSNP
rs750044106 947 dbSNP
rs754823806 947 dbSNP
rs1344188121 949 dbSNP
rs1434370692 949 dbSNP
rs764956448 949 dbSNP
rs765953129 949 dbSNP
rs994541873 950 dbSNP
rs1202846485 951 dbSNP
rs1322027238 951 dbSNP
rs551789958 953 dbSNP
rs1250539770 955 dbSNP
rs927671749 956 dbSNP
rs1164950896 957 dbSNP
rs879467699 957 dbSNP
rs939056521 958 dbSNP
rs1167068857 959 dbSNP
rs1449445782 960 dbSNP
rs1188394721 961 dbSNP
rs1192001020 961 dbSNP
rs1487508713 964 dbSNP
rs1246360069 965 dbSNP
rs868440596 965 dbSNP
rs1027382904 966 dbSNP
rs1269694494 966 dbSNP
rs886057583 966 dbSNP
rs950400251 967 dbSNP
rs3210590 969 dbSNP
rs1391392790 970 dbSNP
rs1019168493 974 dbSNP
rs886895550 976 dbSNP
rs941162822 977 dbSNP
rs867076760 983 dbSNP
rs966697034 988 dbSNP
rs12158004 990 dbSNP
rs1244546165 993 dbSNP
rs975026739 1002 dbSNP
rs1029163861 1003 dbSNP
rs899706930 1004 dbSNP
rs957550000 1009 dbSNP
rs996793305 1010 dbSNP
rs1429472751 1014 dbSNP
rs1391335181 1016 dbSNP
rs1173093937 1021 dbSNP
rs1424632913 1024 dbSNP
rs1368306276 1027 dbSNP
rs752225547 1027 dbSNP
rs34842722 1028 dbSNP
rs1002712401 1032 dbSNP
rs1249828569 1036 dbSNP
rs990220467 1036 dbSNP
rs1439574651 1037 dbSNP
rs1204215586 1039 dbSNP
rs1483222162 1039 dbSNP
rs1297690710 1043 dbSNP
rs1208001973 1049 dbSNP
rs913322838 1054 dbSNP
rs1224765417 1059 dbSNP
rs1348280439 1061 dbSNP
rs796812751 1064 dbSNP
rs946047323 1064 dbSNP
rs1300261792 1068 dbSNP
rs751407190 1068 dbSNP
rs764318513 1068 dbSNP
rs1294690135 1078 dbSNP
rs561433394 1081 dbSNP
rs886057587 1081 dbSNP
rs981854664 1084 dbSNP
rs1359071341 1086 dbSNP
rs1176910140 1087 dbSNP
rs776521471 1094 dbSNP
rs751920048 1107 dbSNP
rs1181652478 1109 dbSNP
rs989574634 1110 dbSNP
rs1213204406 1112 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395164. RNA binding protein: AGO. Condition:MCF7 AGO HITS-CLIP Replicate 2 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uugguggucGGGUGAGg 5'
                   |:||| | 
Target 5' --------aCUCACACa 3'
 		1 - 9
2 
miRNA  3' uugGUG-GUCGGGUGAGg 5'
             ||| || | ||| | 
Target 5' acaCACACA-CACACACa 3'
 		11 - 27
Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1395164
Method / RBP HITS-CLIP / AGO
Cell line / Condition MCF7 / MCF7 AGO HITS-CLIP Replicate 2
Location of target site ENST00000263253.7 | 3UTR | ACUCACACACACACACACACACACACACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4481 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100715 TJAP1 tight junction associated protein 1 2 2
MIRT183589 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338033 DAZAP2 DAZ associated protein 2 2 4
MIRT395796 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443947 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450580 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451617 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452331 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453279 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455212 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455470 LYPLA2 lysophospholipase II 2 2
MIRT456503 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456687 LDB1 LIM domain binding 1 2 2
MIRT456915 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457603 IDS iduronate 2-sulfatase 2 2
MIRT457848 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458455 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460179 UNK unkempt family zinc finger 2 6
MIRT461465 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464739 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465279 TRIM28 tripartite motif containing 28 2 2
MIRT468450 SETD1B SET domain containing 1B 2 2
MIRT468620 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469152 RNF121 ring finger protein 121 2 2
MIRT470073 PTGES2 prostaglandin E synthase 2 2 2
MIRT470172 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473156 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474308 LAMC1 laminin subunit gamma 1 2 2
MIRT474782 KIAA0895L KIAA0895 like 2 2
MIRT476484 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477613 EFNA3 ephrin A3 2 2
MIRT479525 CDCA4 cell division cycle associated 4 2 2
MIRT479973 CARD10 caspase recruitment domain family member 10 2 2
MIRT480410 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480426 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483573 SYT2 synaptotagmin 2 2 2
MIRT483664 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484532 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484616 SIX3 SIX homeobox 3 2 6
MIRT485897 ZFP36 ZFP36 ring finger protein 2 2
MIRT486505 MYH11 myosin heavy chain 11 2 2
MIRT487505 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488852 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489464 MSC musculin 2 2
MIRT491170 LRP3 LDL receptor related protein 3 2 2
MIRT496627 TMEM67 transmembrane protein 67 2 2
MIRT497616 ANG angiogenin 2 2
MIRT497766 KIAA0895 KIAA0895 2 2
MIRT499680 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499774 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501745 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504995 ZNF652 zinc finger protein 652 2 2
MIRT511664 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511690 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511703 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511734 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512858 TBC1D13 TBC1 domain family member 13 2 2
MIRT513444 EMP1 epithelial membrane protein 1 2 6
MIRT515681 TFPI tissue factor pathway inhibitor 2 2
MIRT523529 GLUL glutamate-ammonia ligase 2 2
MIRT525546 PHB2 prohibitin 2 2 4
MIRT526209 SNX24 sorting nexin 24 2 2
MIRT531554 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533764 TMEM135 transmembrane protein 135 2 2
MIRT545582 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552434 ZNF460 zinc finger protein 460 2 2
MIRT561159 BCL2L12 BCL2 like 12 2 2
MIRT562345 EXOSC2 exosome component 2 2 2
MIRT570659 KDM6B lysine demethylase 6B 2 2
MIRT571076 TCHHL1 trichohyalin like 1 2 2
MIRT571330 TPCN2 two pore segment channel 2 2 2
MIRT571603 TOB2 transducer of ERBB2, 2 2 2
MIRT573013 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609041 EP300 E1A binding protein p300 2 2
MIRT613398 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635589 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT661118 FPR1 formyl peptide receptor 1 2 2
MIRT690103 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694972 PLAC8 placenta specific 8 2 2
MIRT695515 ALPI alkaline phosphatase, intestinal 2 2
MIRT695578 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699570 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701991 MIER3 MIER family member 3 2 2
MIRT725464 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4481 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-4481 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-4481 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4481 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4481 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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