pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol OAS3   
Synonyms p100, p100OAS
Description 2'-5'-oligoadenylate synthetase 3
Transcript NM_006187   
Expression
Putative miRNA Targets on OAS3
3'UTR of OAS3
(miRNA target sites are highlighted)
>OAS3|NM_006187|3'UTR
   1 AGTTGAGAAAATCAGCGGTCCTACTGGATGAAGAGAAGATGGACACCAGCCCTCAGCATGAGGAAATTCAGGGTCCCCTA
  81 CCAGATGAGAGAGATTGTGTACATGTGTGTGTGAGCACATGTGTGCATGTGTGTGCACACGTGTGCATGTGTGTGTTTTA
 161 GTGAATCTGCTCTCCCAGCTCACACACTCCCCTGCCTCCCATGGCTTACACACTAGGATCCAGACTCCATGGTTTGACAC
 241 CAGCCTGCGTTTGCAGCTTCTCTGTCACTTCCATGACTCTATCCTCATACCACCACTGCTGCTTCCCACCCAGCTGAGAA
 321 TGCCCCCTCCTCCCTGACTCCTCTCTGCCCATGCAAATTAGCTCACATCTTTCCTCCTGCTGCAATCCATCCCTTCCTCC
 401 CATTGGCCTCTCCTTGCCAAATCTAAATAGTTTATATAGGGATGGCAGAGAGTTCCCATCTCATCTGTCAGCCACAGTCA
 481 TTTGGTACTGGCTACCTGGAGCCTTATCTTCTGAAGGGTTTTAAAGAATGGCCAATTAGCTGAGAAGAATTATCTAATCA
 561 ATTAGTGATGTCTGCCATGGATGCAGTAGAGGAAAGTGGTGGTACAAGTGCCATGATTGATTAGCAATGTCTGCACTGGA
 641 TACGGAAAAAAGAAGGTGCTTGCAGGTTTACAGTGTATATGTGGGCTATTGAAGAGCCCTCTGAGCTCGGTTGCTAGCAG
 721 GAGAGCATGCCCATATTGGCTTACTTTGTCTGCCACAGACACAGACAGAGGGAGTTGGGACATGCATGCTATGGGGACCC
 801 TCTTGTTGGACACCTAATTGGATGCCTCTTCATGAGAGGCCTCCTTTTCTTCACCTTTTATGCTGCACTCCTCCCCTAGT
 881 TTACACATCTTGATGCTGTGGCTCAGTTTGCCTTCCTGAATTTTTATTGGGTCCCTGTTTTCTCTCCTAACATGCTGAGA
 961 TTCTGCATCCCCACAGCCTAAACTGAGCCAGTGGCCAAACAACCGTGCTCAGCCTGTTTCTCTCTGCCCTCTAGAGCAAG
1041 GCCCACCAGGTCCATCCAGGAGGCTCTCCTGACCTCAAGTCCAACAACAGTGTCCACACTAGTCAAGGTTCAGCCCAGAA
1121 AACAGAAAGCACTCTAGGAATCTTAGGCAGAAAGGGATTTTATCTAAATCACTGGAAAGGCTGGAGGAGCAGAAGGCAGA
1201 GGCCACCACTGGACTATTGGTTTCAATATTAGACCACTGTAGCCGAATCAGAGGCCAGAGAGCAGCCACTGCTACTGCTA
1281 ATGCCACCACTACCCCTGCCATCACTGCCCCACATGGACAAAACTGGAGTCGAGACCTAGGTTAGATTCCTGCAACCACA
1361 AACATCCATCAGGGATGGCCAGCTGCCAGAGCTGCGGGAAGACGGATCCCACCTCCCTTTCTTAGCAGAATCTAAATTAC
1441 AGCCAGACCTCTGGCTGCAGAGGAGTCTGAGACATGTATGATTGAATGGGTGCCAAGTGCCAGGGGGCGGAGTCCCCAGC
1521 AGATGCATCCTGGCCATCTGTTGCGTGGATGAGGGAGTGGGTCTATCTCAGAGGAAGGAACAGGAAACAAAGAAAGGAAG
1601 CCACTGAACATCCCTTCTCTGCTCCACAGGAGTGCCTTAGACAGCCTGACTCTCCACAAACCACTGTTAAAACTTACCTG
1681 CTAGGAATGCTAGATTGAATGGGATGGGAAGAGCCTTCCCTCATTATTGTCATTCTTGGAGAGAGGTGAGCAACCAAGGG
1761 AAGCTCCTCTGATTCACCTAGAACCTGTTCTCTGCCGTCTTTGGCTCAGCCTACAGAGACTAGAGTAGGTGAAGGGACAG
1841 AGGACAGGGCTTCTAATACCTGTGCCATATTGACAGCCTCCATCCCTGTCCCCCATCTTGGTGCTGAACCAACGCTAAGG
1921 GCACCTTCTTAGACTCACCTCATCGATACTGCCTGGTAATCCAAAGCTAGAACTCTCAGGACCCCAAACTCCACCTCTTG
2001 GATTGGCCCTGGCTGCTGCCACACACATATCCAAGAGCTCAGGGCCAGTTCTGGTGGGCAGCAGAGACCTGCTCTGCCAA
2081 GTTGTCCAGCAGCAGAGTGGCCCTGGCCTGGGCATCACAAGCCAGTGATGCTCCTGGGAAGACCAGGTGGCAGGTCGCAG
2161 TTGGGTACCTTCCATTCCCACCACACAGACTCTGGGCCTCCCCGCAAAATGGCTCCAGAATTAGAGTAATTATGAGATGG
2241 TGGGAACCAGAGCAACTCAGGTGCATGATACAAGGAGAGGTTGTCATCTGGGTAGGGCAGAGAGGAGGGCTTGCTCATCT
2321 GAACAGGGGTGTATTTCATTCCAGGCCCTCAGTCTTTGGCAATGGCCACCCTGGTGTTGGCATATTGGCCCCACTGTAAC
2401 TTTTGGGGGCTTCCCGGTCTAGCCACACCCTCGGATGGAAAGACTTGACTGCATAAAGATGTCAGTTCTCCCTGAGTTGA
2481 TTGATAGGCTTAATGGTCACCCTAAAAACACCCACATATGCTTTTCGATGGAACCAGGTAAGTTGACGCTAAAGTTCTTA
2561 TGGAAAAATACACACGCAATAGCTAGGAAAACACAGGGAAAGAAGAGTTCTGAGCAGGGCCTAGTCTTAGCCAATATTAA
2641 AACATACTATGAAGCCTCTGATACTTAAACAGCATGGCGCTGGTACGTAAATAGACCAATGCAGTTAGGTGGCTCTTTCC
2721 AAGACTCTGGGGAAAAAAGTAGTAAAAAGCTAAATGCAATCAATCAGCAATTGAAAGCTAAGTGAGAGAGCCAGAGGGCC
2801 TCCTTGGTGGTAAAAGAGGGTTGCATTTCTTGCAGCCAGAAGGCAGAGAAAGTGAAGACCAAGTCCAGAACTGAATCCTA
2881 AGAAATGCAGGACTGCAAAGAAATTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAATTTTTAAAAAGTTTTT
2961 ATTGAGATACAAGTCAATACCATAAAGCTCTCACCCTTCTAAAGTGTACAATTCAGTGGTGTGAGTATATTCATAAGATT
3041 TATACTTGGTGTCTATTCATAAGACTTATATCCAGCATATTCATAACTAGAGCCATATCACAGATGCATTCATCATAATA
3121 ATTCCAGACATTTTCATCACCCTAAAAGGAAACCCTGAAACCCATTAGCAGTCATTCCCCATTCCTCCAACCCATTCTCT
3201 CCCTAATCCCTAGAAACCACCAATCTGCTGTGTATTTCATCTATTGCCAACATTTCATATAAATGGCATCATACAAAAAA
3281 AAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuccUCGUUCCGCCGUAGAGa 5'
              || |:||: ||||:|| 
Target 5' taaaAG-AGGGTTGCATTTCt 3'
2811 - 2830 140.00 -14.10
2
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             || ||:||  |:||:|| 
Target 5' tctGAACAGGGGTGTATTTCa 3'
2318 - 2338 130.00 -12.60
3
miRNA  3' uuCCUCGUUCCGCCGUAGAGa 5'
            | || :|| :  |||||| 
Target 5' tgGCAGAGAGTTCCCATCTCa 3'
443 - 463 123.00 -9.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8577453 1 COSMIC
COSN13369803 47 COSMIC
COSN1557765 47 COSMIC
COSN30544392 108 COSMIC
COSN31611892 205 COSMIC
COSN26495433 530 COSMIC
COSN15614056 1143 COSMIC
COSN1142436 1253 COSMIC
COSN21153716 1314 COSMIC
COSN27700403 1546 COSMIC
COSN1557767 1838 COSMIC
COSN15181783 1841 COSMIC
COSN6534836 1900 COSMIC
COSN29573876 2201 COSMIC
COSN8538285 2405 COSMIC
COSN26522569 2812 COSMIC
COSN24884335 2940 COSMIC
COSN27256537 2941 COSMIC
COSN27301388 2941 COSMIC
COSN29074170 2941 COSMIC
COSN8695212 3050 COSMIC
COSN29214254 3121 COSMIC
rs2072134 1399 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780673046 2 dbSNP
rs747623969 4 dbSNP
rs755596868 12 dbSNP
rs370046037 15 dbSNP
rs748927297 17 dbSNP
rs201675555 18 dbSNP
rs1468181153 21 dbSNP
rs373346131 22 dbSNP
rs769354849 28 dbSNP
rs1478211966 32 dbSNP
rs1176559785 47 dbSNP
rs1197722448 51 dbSNP
rs45560247 51 dbSNP
rs777009278 51 dbSNP
rs1456297135 58 dbSNP
rs537312871 60 dbSNP
rs377262638 61 dbSNP
rs369557868 68 dbSNP
rs7313970 72 dbSNP
rs988108257 75 dbSNP
rs1281987717 76 dbSNP
rs7314920 79 dbSNP
rs541060669 84 dbSNP
rs1330303772 88 dbSNP
rs7978382 94 dbSNP
rs1402925413 102 dbSNP
rs1265141405 103 dbSNP
rs1489925210 106 dbSNP
rs1184353982 108 dbSNP
rs200956146 115 dbSNP
rs574824759 115 dbSNP
rs956805778 115 dbSNP
rs1056094108 120 dbSNP
rs542340990 121 dbSNP
rs988152202 121 dbSNP
rs1472523326 123 dbSNP
rs1239838700 125 dbSNP
rs7965473 128 dbSNP
rs910364537 130 dbSNP
rs551494853 137 dbSNP
rs1424833047 141 dbSNP
rs1211069763 142 dbSNP
rs1356444150 144 dbSNP
rs1308005365 149 dbSNP
rs943242163 164 dbSNP
rs1040293293 170 dbSNP
rs1310505414 171 dbSNP
rs865864160 182 dbSNP
rs1163623532 185 dbSNP
rs901775277 189 dbSNP
rs1436366492 190 dbSNP
rs1363250616 196 dbSNP
rs1326145595 209 dbSNP
rs1405954662 214 dbSNP
rs1359992373 215 dbSNP
rs11837367 216 dbSNP
rs776761221 224 dbSNP
rs1441848076 226 dbSNP
rs1308059742 236 dbSNP
rs1047424460 249 dbSNP
rs796828996 250 dbSNP
rs887474820 261 dbSNP
rs1244843966 271 dbSNP
rs1006367498 275 dbSNP
rs1451663605 277 dbSNP
rs770234120 279 dbSNP
rs996755156 285 dbSNP
rs45437793 288 dbSNP
rs1002389802 294 dbSNP
rs7300330 296 dbSNP
rs576228353 299 dbSNP
rs1031643515 313 dbSNP
rs1277057611 319 dbSNP
rs1379607303 326 dbSNP
rs564376193 331 dbSNP
rs1227471902 339 dbSNP
rs1296466316 346 dbSNP
rs528442449 347 dbSNP
rs1421727003 349 dbSNP
rs774125262 353 dbSNP
rs1175632846 362 dbSNP
rs988393096 363 dbSNP
rs1310319252 374 dbSNP
rs1413640796 380 dbSNP
rs546262514 384 dbSNP
rs1422872948 392 dbSNP
rs1174246346 393 dbSNP
rs1478341128 400 dbSNP
rs568075990 404 dbSNP
rs1207589466 411 dbSNP
rs1489001010 419 dbSNP
rs1263368079 426 dbSNP
rs1209000543 427 dbSNP
rs2010604 431 dbSNP
rs1220285999 434 dbSNP
rs1317885122 436 dbSNP
rs970205977 437 dbSNP
rs1401851771 438 dbSNP
rs1482794475 456 dbSNP
rs1341226887 489 dbSNP
rs1302470783 490 dbSNP
rs1203033857 493 dbSNP
rs1446178096 502 dbSNP
rs1178032011 517 dbSNP
rs369514472 524 dbSNP
rs1422787595 530 dbSNP
rs1168447000 532 dbSNP
rs1478482277 534 dbSNP
rs1419679294 536 dbSNP
rs1239782147 538 dbSNP
rs1483865259 549 dbSNP
rs1181595313 552 dbSNP
rs1180916001 557 dbSNP
rs1482093598 559 dbSNP
rs979907585 584 dbSNP
rs1211198750 587 dbSNP
rs960293520 588 dbSNP
rs1256655476 590 dbSNP
rs1318692287 606 dbSNP
rs1450917966 606 dbSNP
rs1168878131 612 dbSNP
rs910657822 614 dbSNP
rs1381555995 618 dbSNP
rs1303677753 634 dbSNP
rs992245147 639 dbSNP
rs55934941 644 dbSNP
rs1040241554 645 dbSNP
rs1335638401 651 dbSNP
rs1467178101 673 dbSNP
rs923145932 676 dbSNP
rs1359604902 678 dbSNP
rs1163519715 682 dbSNP
rs1421563802 689 dbSNP
rs929197919 696 dbSNP
rs1447240818 703 dbSNP
rs1038079191 705 dbSNP
rs146433980 709 dbSNP
rs887419970 710 dbSNP
rs878986361 711 dbSNP
rs1236805110 712 dbSNP
rs1201041704 719 dbSNP
rs1005902286 724 dbSNP
rs1044508936 726 dbSNP
rs139848842 729 dbSNP
rs1481276624 731 dbSNP
rs180794522 739 dbSNP
rs891051033 747 dbSNP
rs1298702229 750 dbSNP
rs1313634590 753 dbSNP
rs1002743919 756 dbSNP
rs760249351 763 dbSNP
rs1306855133 766 dbSNP
rs1053552747 776 dbSNP
rs891800021 782 dbSNP
rs896693763 783 dbSNP
rs1009761747 784 dbSNP
rs1021725651 785 dbSNP
rs149699147 787 dbSNP
rs1021186352 790 dbSNP
rs1210089230 792 dbSNP
rs968431848 808 dbSNP
rs1241648417 833 dbSNP
rs979472463 840 dbSNP
rs970091408 853 dbSNP
rs1018073672 863 dbSNP
rs1420089554 865 dbSNP
rs1002127461 868 dbSNP
rs1189992760 880 dbSNP
rs1466579607 883 dbSNP
rs1035832441 895 dbSNP
rs960594752 913 dbSNP
rs1216121286 927 dbSNP
rs573979561 928 dbSNP
rs1288451473 935 dbSNP
rs1336131796 938 dbSNP
rs75671682 938 dbSNP
rs79754354 939 dbSNP
rs76831339 940 dbSNP
rs76290572 941 dbSNP
rs1300487908 946 dbSNP
rs763893114 947 dbSNP
rs1385075177 948 dbSNP
rs1369063923 953 dbSNP
rs923085304 954 dbSNP
rs961038367 961 dbSNP
rs960266907 966 dbSNP
rs867973469 971 dbSNP
rs1474224667 974 dbSNP
rs780404295 977 dbSNP
rs1160095042 982 dbSNP
rs929145277 984 dbSNP
rs535365024 992 dbSNP
rs1425290343 1003 dbSNP
rs553072842 1005 dbSNP
rs909143398 1006 dbSNP
rs1256139938 1017 dbSNP
rs941657242 1023 dbSNP
rs753850168 1025 dbSNP
rs1192979285 1026 dbSNP
rs1390559258 1030 dbSNP
rs932392503 1032 dbSNP
rs1205957762 1041 dbSNP
rs1435620877 1045 dbSNP
rs1319663117 1056 dbSNP
rs574800301 1057 dbSNP
rs1255234855 1061 dbSNP
rs1230949977 1067 dbSNP
rs541926256 1071 dbSNP
rs1276663972 1075 dbSNP
rs1283887831 1077 dbSNP
rs3940271 1081 dbSNP
rs1398781422 1091 dbSNP
rs985726391 1095 dbSNP
rs938426821 1096 dbSNP
rs739903 1097 dbSNP
rs1261875964 1105 dbSNP
rs1301505322 1107 dbSNP
rs896641422 1109 dbSNP
rs1009710821 1126 dbSNP
rs1430558609 1130 dbSNP
rs1170599146 1142 dbSNP
rs575465528 1150 dbSNP
rs1425958142 1165 dbSNP
rs750637565 1181 dbSNP
rs1053033297 1192 dbSNP
rs1254362908 1195 dbSNP
rs1198477710 1197 dbSNP
rs760434590 1201 dbSNP
rs1267928779 1204 dbSNP
rs1218004188 1207 dbSNP
rs1021597142 1212 dbSNP
rs904114515 1213 dbSNP
rs1271465975 1218 dbSNP
rs2010549 1220 dbSNP
rs780266604 1221 dbSNP
rs1398082688 1224 dbSNP
rs947371429 1227 dbSNP
rs1331244254 1235 dbSNP
rs183970620 1242 dbSNP
rs145300478 1245 dbSNP
rs45536237 1246 dbSNP
rs1001611374 1247 dbSNP
rs1197177245 1265 dbSNP
rs1036290392 1286 dbSNP
rs1414024819 1287 dbSNP
rs976144743 1289 dbSNP
rs895982274 1291 dbSNP
rs1005428513 1293 dbSNP
rs1015135019 1300 dbSNP
rs1030437444 1302 dbSNP
rs572046570 1303 dbSNP
rs1399141597 1308 dbSNP
rs973725836 1309 dbSNP
rs1355043097 1312 dbSNP
rs1026595140 1314 dbSNP
rs45540838 1318 dbSNP
rs1325852276 1331 dbSNP
rs1331740039 1332 dbSNP
rs149194104 1333 dbSNP
rs1309052632 1341 dbSNP
rs1445059678 1342 dbSNP
rs909084181 1346 dbSNP
rs1281459653 1347 dbSNP
rs1352826114 1350 dbSNP
rs1229573765 1364 dbSNP
rs143363621 1373 dbSNP
rs1404783121 1388 dbSNP
rs980461670 1392 dbSNP
rs1349037080 1394 dbSNP
rs926965583 1395 dbSNP
rs938374669 1396 dbSNP
rs781521151 1397 dbSNP
rs2072134 1399 dbSNP
rs891561648 1404 dbSNP
rs945515378 1405 dbSNP
rs188648431 1407 dbSNP
rs147956284 1411 dbSNP
rs1043105616 1412 dbSNP
rs905842372 1413 dbSNP
rs532901781 1415 dbSNP
rs1181410362 1416 dbSNP
rs552335167 1441 dbSNP
rs1057208836 1450 dbSNP
rs570742395 1455 dbSNP
rs114033220 1458 dbSNP
rs1238346849 1460 dbSNP
rs753184007 1462 dbSNP
rs1301319094 1470 dbSNP
rs2072133 1483 dbSNP
rs995032669 1487 dbSNP
rs377721718 1488 dbSNP
rs953730844 1491 dbSNP
rs771796010 1498 dbSNP
rs1157084830 1500 dbSNP
rs45575939 1501 dbSNP
rs1005416817 1508 dbSNP
rs45627039 1509 dbSNP
rs141889907 1510 dbSNP
rs1477685316 1511 dbSNP
rs963573210 1517 dbSNP
rs1200912202 1520 dbSNP
rs1243373436 1521 dbSNP
rs980025285 1522 dbSNP
rs1214076836 1527 dbSNP
rs1449096370 1537 dbSNP
rs147031785 1545 dbSNP
rs913054251 1546 dbSNP
rs968644474 1550 dbSNP
rs1204330318 1552 dbSNP
rs528533891 1562 dbSNP
rs1444068725 1566 dbSNP
rs1339955838 1568 dbSNP
rs978671413 1571 dbSNP
rs1367701261 1573 dbSNP
rs776416297 1582 dbSNP
rs1444211303 1584 dbSNP
rs747371172 1585 dbSNP
rs1161955695 1590 dbSNP
rs927319432 1592 dbSNP
rs1413731331 1596 dbSNP
rs937362172 1598 dbSNP
rs1392085294 1604 dbSNP
rs1178517631 1607 dbSNP
rs1480472396 1615 dbSNP
rs1422379214 1618 dbSNP
rs1191024673 1620 dbSNP
rs1057436192 1632 dbSNP
rs539967320 1635 dbSNP
rs4767045 1636 dbSNP
rs1297682477 1639 dbSNP
rs940768030 1640 dbSNP
rs796851849 1646 dbSNP
rs1036512091 1651 dbSNP
rs1441052172 1655 dbSNP
rs899337589 1658 dbSNP
rs1204922631 1662 dbSNP
rs573009785 1663 dbSNP
rs1317369786 1667 dbSNP
rs995085158 1679 dbSNP
rs765162016 1694 dbSNP
rs540114948 1702 dbSNP
rs562017433 1707 dbSNP
rs1006575917 1715 dbSNP
rs1342440301 1718 dbSNP
rs1225988747 1722 dbSNP
rs1249137966 1728 dbSNP
rs573896401 1733 dbSNP
rs16942391 1737 dbSNP
rs1242278328 1739 dbSNP
rs1398898204 1743 dbSNP
rs1459858116 1752 dbSNP
rs1167639117 1768 dbSNP
rs563617658 1770 dbSNP
rs1419702320 1772 dbSNP
rs936850947 1783 dbSNP
rs762758343 1791 dbSNP
rs1245426415 1792 dbSNP
rs1039257863 1794 dbSNP
rs1457748589 1797 dbSNP
rs900761302 1798 dbSNP
rs997477898 1814 dbSNP
rs1206631858 1819 dbSNP
rs7308382 1820 dbSNP
rs886472554 1824 dbSNP
rs1289416077 1835 dbSNP
rs1009969766 1842 dbSNP
rs1380271233 1845 dbSNP
rs1450336791 1860 dbSNP
rs45537233 1863 dbSNP
rs532844589 1866 dbSNP
rs746106574 1867 dbSNP
rs1296385236 1878 dbSNP
rs1354667384 1879 dbSNP
rs1371434200 1889 dbSNP
rs1422404849 1890 dbSNP
rs1468013269 1891 dbSNP
rs1387447381 1893 dbSNP
rs1173737115 1895 dbSNP
rs1405808177 1896 dbSNP
rs1439478060 1901 dbSNP
rs1016784713 1904 dbSNP
rs769799413 1906 dbSNP
rs45583340 1914 dbSNP
rs138310733 1915 dbSNP
rs958845425 1917 dbSNP
rs528697224 1920 dbSNP
rs1365412446 1921 dbSNP
rs917220209 1923 dbSNP
rs45562445 1924 dbSNP
rs1332367674 1925 dbSNP
rs866821734 1935 dbSNP
rs45480796 1939 dbSNP
rs912893373 1942 dbSNP
rs1304770006 1943 dbSNP
rs967038047 1945 dbSNP
rs150219978 1946 dbSNP
rs925705946 1957 dbSNP
rs550978797 1962 dbSNP
rs936817908 1965 dbSNP
rs569294845 1985 dbSNP
rs1210296425 1987 dbSNP
rs1163843362 1991 dbSNP
rs1268548805 1996 dbSNP
rs1419466566 2010 dbSNP
rs930814827 2011 dbSNP
rs10744790 2017 dbSNP
rs1420253096 2020 dbSNP
rs889386454 2022 dbSNP
rs1197308929 2028 dbSNP
rs756579865 2033 dbSNP
rs1490863409 2045 dbSNP
rs1186183038 2052 dbSNP
rs778439772 2054 dbSNP
rs1009547891 2055 dbSNP
rs1259732556 2057 dbSNP
rs1435053961 2062 dbSNP
rs1199684272 2084 dbSNP
rs1216240493 2085 dbSNP
rs1485420364 2087 dbSNP
rs1429134147 2088 dbSNP
rs1258786240 2090 dbSNP
rs1241073162 2102 dbSNP
rs1317394329 2103 dbSNP
rs1040739462 2112 dbSNP
rs1468723916 2113 dbSNP
rs1221092308 2119 dbSNP
rs922133743 2120 dbSNP
rs900836322 2125 dbSNP
rs1303373707 2134 dbSNP
rs933551876 2145 dbSNP
rs904250828 2146 dbSNP
rs1454658299 2147 dbSNP
rs1377499409 2153 dbSNP
rs749624651 2157 dbSNP
rs1389893811 2158 dbSNP
rs886421814 2164 dbSNP
rs940705481 2167 dbSNP
rs1255804193 2178 dbSNP
rs1037763861 2183 dbSNP
rs75755877 2188 dbSNP
rs7138261 2193 dbSNP
rs1264151988 2195 dbSNP
rs1206633969 2196 dbSNP
rs1392254985 2199 dbSNP
rs747609914 2200 dbSNP
rs7138267 2204 dbSNP
rs895689256 2205 dbSNP
rs573862594 2219 dbSNP
rs1024345501 2221 dbSNP
rs1343506982 2225 dbSNP
rs1226082150 2226 dbSNP
rs962028543 2239 dbSNP
rs551823671 2240 dbSNP
rs1014115440 2244 dbSNP
rs185719368 2249 dbSNP
rs1383076003 2257 dbSNP
rs1020175127 2263 dbSNP
rs768044237 2270 dbSNP
rs1471267068 2272 dbSNP
rs1406893711 2273 dbSNP
rs1169999560 2275 dbSNP
rs967038991 2276 dbSNP
rs1288709097 2277 dbSNP
rs1460556506 2292 dbSNP
rs978840989 2314 dbSNP
rs1374943554 2316 dbSNP
rs920696547 2327 dbSNP
rs1428890485 2330 dbSNP
rs1316186117 2332 dbSNP
rs1215330609 2345 dbSNP
rs1259118801 2348 dbSNP
rs1032722090 2351 dbSNP
rs1462556621 2358 dbSNP
rs1263708225 2359 dbSNP
rs544125588 2363 dbSNP
rs535277037 2365 dbSNP
rs930698630 2372 dbSNP
rs964130926 2375 dbSNP
rs1252691438 2381 dbSNP
rs878883743 2390 dbSNP
rs975193706 2392 dbSNP
rs910689849 2400 dbSNP
rs1313440023 2401 dbSNP
rs71445587 2401 dbSNP
rs1454939008 2407 dbSNP
rs1384132966 2410 dbSNP
rs1331266518 2411 dbSNP
rs562118757 2413 dbSNP
rs747623297 2416 dbSNP
rs987699020 2417 dbSNP
rs1185037011 2433 dbSNP
rs769669198 2434 dbSNP
rs908139078 2438 dbSNP
rs1041019136 2443 dbSNP
rs1446228244 2455 dbSNP
rs1243614004 2465 dbSNP
rs892686876 2467 dbSNP
rs940668924 2469 dbSNP
rs773163976 2473 dbSNP
rs1252101592 2476 dbSNP
rs1195998644 2480 dbSNP
rs945695619 2489 dbSNP
rs1038110913 2491 dbSNP
rs1248538557 2493 dbSNP
rs1041377365 2494 dbSNP
rs1279483810 2497 dbSNP
rs1440700262 2498 dbSNP
rs1351199344 2500 dbSNP
rs11822 2512 dbSNP
rs1458113410 2513 dbSNP
rs899205684 2517 dbSNP
rs55734623 2519 dbSNP
rs572904908 2521 dbSNP
rs191474805 2522 dbSNP
rs182042384 2527 dbSNP
rs1411556384 2528 dbSNP
rs1308637812 2529 dbSNP
rs1468585075 2533 dbSNP
rs10744791 2539 dbSNP
rs1181855235 2543 dbSNP
rs752239542 2548 dbSNP
rs1224338607 2549 dbSNP
rs374673283 2552 dbSNP
rs1014053391 2559 dbSNP
rs1222445138 2560 dbSNP
rs766210515 2562 dbSNP
rs187134014 2571 dbSNP
rs1222914738 2572 dbSNP
rs562179811 2574 dbSNP
rs1343778751 2575 dbSNP
rs952151426 2576 dbSNP
rs1405827804 2577 dbSNP
rs138561558 2580 dbSNP
rs1317315862 2585 dbSNP
rs910754415 2592 dbSNP
rs1386965983 2597 dbSNP
rs1159832555 2598 dbSNP
rs1479821153 2603 dbSNP
rs1426643990 2604 dbSNP
rs1489896753 2606 dbSNP
rs774424478 2613 dbSNP
rs1033082878 2619 dbSNP
rs976237092 2630 dbSNP
rs551310236 2637 dbSNP
rs73422042 2644 dbSNP
rs945598023 2648 dbSNP
rs1041427863 2650 dbSNP
rs975141165 2661 dbSNP
rs1480598589 2663 dbSNP
rs1175795736 2669 dbSNP
rs1416447141 2679 dbSNP
rs796289868 2680 dbSNP
rs45493598 2687 dbSNP
rs551529320 2688 dbSNP
rs1431036432 2693 dbSNP
rs987646727 2696 dbSNP
rs566944651 2699 dbSNP
rs894186720 2710 dbSNP
rs1469271786 2714 dbSNP
rs1170552338 2716 dbSNP
rs908081096 2726 dbSNP
rs1177915168 2730 dbSNP
rs767639226 2736 dbSNP
rs1414544825 2738 dbSNP
rs1439975442 2739 dbSNP
rs1045509770 2743 dbSNP
rs1476589257 2752 dbSNP
rs1243099963 2756 dbSNP
rs1304339392 2758 dbSNP
rs1460335596 2762 dbSNP
rs1265579517 2772 dbSNP
rs1204312218 2776 dbSNP
rs1379685185 2791 dbSNP
rs1307006901 2799 dbSNP
rs940939166 2803 dbSNP
rs973716484 2808 dbSNP
rs897773535 2817 dbSNP
rs367741576 2819 dbSNP
rs1453639022 2822 dbSNP
rs192413025 2825 dbSNP
rs1357559154 2826 dbSNP
rs1451688137 2828 dbSNP
rs1380400293 2839 dbSNP
rs1338634934 2845 dbSNP
rs1027649166 2849 dbSNP
rs1353481522 2853 dbSNP
rs952134036 2859 dbSNP
rs1230626098 2861 dbSNP
rs1007524241 2863 dbSNP
rs371905393 2864 dbSNP
rs1273828452 2874 dbSNP
rs1390430725 2875 dbSNP
rs1163295785 2878 dbSNP
rs1443172394 2880 dbSNP
rs1018108038 2885 dbSNP
rs1183011641 2892 dbSNP
rs1480347122 2896 dbSNP
rs1206742825 2905 dbSNP
rs1231300524 2905 dbSNP
rs1308258012 2905 dbSNP
rs1307383744 2906 dbSNP
rs1220620564 2907 dbSNP
rs1293739940 2907 dbSNP
rs1406462809 2907 dbSNP
rs1483428963 2907 dbSNP
rs1489782194 2907 dbSNP
rs201609850 2907 dbSNP
rs35035664 2907 dbSNP
rs371197275 2907 dbSNP
rs71086128 2907 dbSNP
rs71787421 2907 dbSNP
rs757856479 2907 dbSNP
rs1491194155 2908 dbSNP
rs1209458558 2909 dbSNP
rs1304793872 2914 dbSNP
rs1224911148 2917 dbSNP
rs1350635024 2936 dbSNP
rs769962475 2938 dbSNP
rs369272821 2940 dbSNP
rs762630854 2941 dbSNP
rs372955267 2942 dbSNP
rs759484864 2942 dbSNP
rs1402763230 2950 dbSNP
rs1367075358 2951 dbSNP
rs1294445427 2954 dbSNP
rs917337304 2956 dbSNP
rs182194564 2963 dbSNP
rs1041527924 2968 dbSNP
rs185224877 2970 dbSNP
rs1240825218 2975 dbSNP
rs189746298 2996 dbSNP
rs979673226 3011 dbSNP
rs1268360674 3022 dbSNP
rs1054401752 3025 dbSNP
rs536498368 3031 dbSNP
rs925494194 3034 dbSNP
rs935670200 3038 dbSNP
rs555095969 3052 dbSNP
rs1329204072 3059 dbSNP
rs1261914069 3060 dbSNP
rs1221185806 3061 dbSNP
rs1408119681 3074 dbSNP
rs1346930171 3091 dbSNP
rs1055443284 3093 dbSNP
rs202100377 3102 dbSNP
rs1381992920 3103 dbSNP
rs1360393558 3106 dbSNP
rs915659946 3109 dbSNP
rs1458271238 3115 dbSNP
rs1406536679 3116 dbSNP
rs1469039273 3125 dbSNP
rs1174320555 3137 dbSNP
rs899472843 3143 dbSNP
rs773228932 3151 dbSNP
rs1334458913 3153 dbSNP
rs1427699051 3156 dbSNP
rs996527505 3164 dbSNP
rs1380792749 3165 dbSNP
rs1190411036 3166 dbSNP
rs1465258992 3168 dbSNP
rs149294540 3185 dbSNP
rs949814780 3194 dbSNP
rs1201170034 3197 dbSNP
rs7023 3198 dbSNP
rs1256217897 3203 dbSNP
rs1226285382 3206 dbSNP
rs1270811406 3209 dbSNP
rs1361415536 3211 dbSNP
rs897658733 3213 dbSNP
rs955112343 3228 dbSNP
rs1004005252 3229 dbSNP
rs1015500892 3231 dbSNP
rs553528767 3233 dbSNP
rs962267835 3239 dbSNP
rs1281266328 3244 dbSNP
rs993409824 3245 dbSNP
rs567017497 3250 dbSNP
rs1454638322 3252 dbSNP
rs1403089011 3258 dbSNP
rs1203384009 3260 dbSNP
rs1261698767 3266 dbSNP
rs920867176 3267 dbSNP
rs958662184 3271 dbSNP
rs1007990569 3274 dbSNP
rs1193518538 3278 dbSNP
rs1017592737 3279 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202481. RNA binding protein: AGO2. Condition:S6_LV_61yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Liver Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2550618. RNA binding protein: AGO2. Condition:Patient 1 Tumor 1 HITS-CLIP data was present in GSM2550612. RNA binding protein: AGO2. Condition:Patient 5 Normal 1 ...

- Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al., 2017, Molecular cell.

Article - Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al.
- Molecular cell, 2017
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. We observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites. Motif analysis of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs. A large number of miR-122 targets were found to be species specific. Upregulation of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients. These results broadly define the molecular consequences of miR-122 downregulation in hepatocellular carcinoma.
LinkOut: [PMID: 28735896]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_006187 | 3UTR | CUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_006187 | 3UTR | UCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_006187 | 3UTR | UCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_006187 | 3UTR | UCCUCCCUGACUCCUCUCUGCCCAUGCAAAUUAGCUCACAUCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_006187 | 3UTR | UCACAUCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_006187 | 3UTR | ACAUCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000548514.1 | 3UTR | UCAAGGAAAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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