pre-miRNA Information | |
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pre-miRNA | hsa-mir-4708 |
Genomic Coordinates | chr14: 65335117 - 65335183 |
Description | Homo sapiens miR-4708 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-4708-5p | ||||||||||||
Sequence | 9| AGAGAUGCCGCCUUGCUCCUU |29 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | Illumina | ||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | OAS3 | ||||||||||||||||||||
Synonyms | p100, p100OAS | ||||||||||||||||||||
Description | 2'-5'-oligoadenylate synthetase 3 | ||||||||||||||||||||
Transcript | NM_006187 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on OAS3 | |||||||||||||||||||||
3'UTR of OAS3 (miRNA target sites are highlighted) |
>OAS3|NM_006187|3'UTR 1 AGTTGAGAAAATCAGCGGTCCTACTGGATGAAGAGAAGATGGACACCAGCCCTCAGCATGAGGAAATTCAGGGTCCCCTA 81 CCAGATGAGAGAGATTGTGTACATGTGTGTGTGAGCACATGTGTGCATGTGTGTGCACACGTGTGCATGTGTGTGTTTTA 161 GTGAATCTGCTCTCCCAGCTCACACACTCCCCTGCCTCCCATGGCTTACACACTAGGATCCAGACTCCATGGTTTGACAC 241 CAGCCTGCGTTTGCAGCTTCTCTGTCACTTCCATGACTCTATCCTCATACCACCACTGCTGCTTCCCACCCAGCTGAGAA 321 TGCCCCCTCCTCCCTGACTCCTCTCTGCCCATGCAAATTAGCTCACATCTTTCCTCCTGCTGCAATCCATCCCTTCCTCC 401 CATTGGCCTCTCCTTGCCAAATCTAAATAGTTTATATAGGGATGGCAGAGAGTTCCCATCTCATCTGTCAGCCACAGTCA 481 TTTGGTACTGGCTACCTGGAGCCTTATCTTCTGAAGGGTTTTAAAGAATGGCCAATTAGCTGAGAAGAATTATCTAATCA 561 ATTAGTGATGTCTGCCATGGATGCAGTAGAGGAAAGTGGTGGTACAAGTGCCATGATTGATTAGCAATGTCTGCACTGGA 641 TACGGAAAAAAGAAGGTGCTTGCAGGTTTACAGTGTATATGTGGGCTATTGAAGAGCCCTCTGAGCTCGGTTGCTAGCAG 721 GAGAGCATGCCCATATTGGCTTACTTTGTCTGCCACAGACACAGACAGAGGGAGTTGGGACATGCATGCTATGGGGACCC 801 TCTTGTTGGACACCTAATTGGATGCCTCTTCATGAGAGGCCTCCTTTTCTTCACCTTTTATGCTGCACTCCTCCCCTAGT 881 TTACACATCTTGATGCTGTGGCTCAGTTTGCCTTCCTGAATTTTTATTGGGTCCCTGTTTTCTCTCCTAACATGCTGAGA 961 TTCTGCATCCCCACAGCCTAAACTGAGCCAGTGGCCAAACAACCGTGCTCAGCCTGTTTCTCTCTGCCCTCTAGAGCAAG 1041 GCCCACCAGGTCCATCCAGGAGGCTCTCCTGACCTCAAGTCCAACAACAGTGTCCACACTAGTCAAGGTTCAGCCCAGAA 1121 AACAGAAAGCACTCTAGGAATCTTAGGCAGAAAGGGATTTTATCTAAATCACTGGAAAGGCTGGAGGAGCAGAAGGCAGA 1201 GGCCACCACTGGACTATTGGTTTCAATATTAGACCACTGTAGCCGAATCAGAGGCCAGAGAGCAGCCACTGCTACTGCTA 1281 ATGCCACCACTACCCCTGCCATCACTGCCCCACATGGACAAAACTGGAGTCGAGACCTAGGTTAGATTCCTGCAACCACA 1361 AACATCCATCAGGGATGGCCAGCTGCCAGAGCTGCGGGAAGACGGATCCCACCTCCCTTTCTTAGCAGAATCTAAATTAC 1441 AGCCAGACCTCTGGCTGCAGAGGAGTCTGAGACATGTATGATTGAATGGGTGCCAAGTGCCAGGGGGCGGAGTCCCCAGC 1521 AGATGCATCCTGGCCATCTGTTGCGTGGATGAGGGAGTGGGTCTATCTCAGAGGAAGGAACAGGAAACAAAGAAAGGAAG 1601 CCACTGAACATCCCTTCTCTGCTCCACAGGAGTGCCTTAGACAGCCTGACTCTCCACAAACCACTGTTAAAACTTACCTG 1681 CTAGGAATGCTAGATTGAATGGGATGGGAAGAGCCTTCCCTCATTATTGTCATTCTTGGAGAGAGGTGAGCAACCAAGGG 1761 AAGCTCCTCTGATTCACCTAGAACCTGTTCTCTGCCGTCTTTGGCTCAGCCTACAGAGACTAGAGTAGGTGAAGGGACAG 1841 AGGACAGGGCTTCTAATACCTGTGCCATATTGACAGCCTCCATCCCTGTCCCCCATCTTGGTGCTGAACCAACGCTAAGG 1921 GCACCTTCTTAGACTCACCTCATCGATACTGCCTGGTAATCCAAAGCTAGAACTCTCAGGACCCCAAACTCCACCTCTTG 2001 GATTGGCCCTGGCTGCTGCCACACACATATCCAAGAGCTCAGGGCCAGTTCTGGTGGGCAGCAGAGACCTGCTCTGCCAA 2081 GTTGTCCAGCAGCAGAGTGGCCCTGGCCTGGGCATCACAAGCCAGTGATGCTCCTGGGAAGACCAGGTGGCAGGTCGCAG 2161 TTGGGTACCTTCCATTCCCACCACACAGACTCTGGGCCTCCCCGCAAAATGGCTCCAGAATTAGAGTAATTATGAGATGG 2241 TGGGAACCAGAGCAACTCAGGTGCATGATACAAGGAGAGGTTGTCATCTGGGTAGGGCAGAGAGGAGGGCTTGCTCATCT 2321 GAACAGGGGTGTATTTCATTCCAGGCCCTCAGTCTTTGGCAATGGCCACCCTGGTGTTGGCATATTGGCCCCACTGTAAC 2401 TTTTGGGGGCTTCCCGGTCTAGCCACACCCTCGGATGGAAAGACTTGACTGCATAAAGATGTCAGTTCTCCCTGAGTTGA 2481 TTGATAGGCTTAATGGTCACCCTAAAAACACCCACATATGCTTTTCGATGGAACCAGGTAAGTTGACGCTAAAGTTCTTA 2561 TGGAAAAATACACACGCAATAGCTAGGAAAACACAGGGAAAGAAGAGTTCTGAGCAGGGCCTAGTCTTAGCCAATATTAA 2641 AACATACTATGAAGCCTCTGATACTTAAACAGCATGGCGCTGGTACGTAAATAGACCAATGCAGTTAGGTGGCTCTTTCC 2721 AAGACTCTGGGGAAAAAAGTAGTAAAAAGCTAAATGCAATCAATCAGCAATTGAAAGCTAAGTGAGAGAGCCAGAGGGCC 2801 TCCTTGGTGGTAAAAGAGGGTTGCATTTCTTGCAGCCAGAAGGCAGAGAAAGTGAAGACCAAGTCCAGAACTGAATCCTA 2881 AGAAATGCAGGACTGCAAAGAAATTGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTAATTTTTAAAAAGTTTTT 2961 ATTGAGATACAAGTCAATACCATAAAGCTCTCACCCTTCTAAAGTGTACAATTCAGTGGTGTGAGTATATTCATAAGATT 3041 TATACTTGGTGTCTATTCATAAGACTTATATCCAGCATATTCATAACTAGAGCCATATCACAGATGCATTCATCATAATA 3121 ATTCCAGACATTTTCATCACCCTAAAAGGAAACCCTGAAACCCATTAGCAGTCATTCCCCATTCCTCCAACCCATTCTCT 3201 CCCTAATCCCTAGAAACCACCAATCTGCTGTGTATTTCATCTATTGCCAACATTTCATATAAATGGCATCATACAAAAAA 3281 AAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293S |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb
HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb
HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb
HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb
HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb
HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb
HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb
HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb
HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb
HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb
HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Cardiac Tissues |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA
HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA
HITS-CLIP data was present in GSM2202481. RNA binding protein: AGO2. Condition:S6_LV_61yo_Male_AGO2_bound_RNA
... - Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research. |
Article |
Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.
- Spengler RM; Zhang X; Cheng C; McLendon JM; et al.- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
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Experimental Support 3 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Liver Tissue |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM2550618. RNA binding protein: AGO2. Condition:Patient 1 Tumor 1
HITS-CLIP data was present in GSM2550612. RNA binding protein: AGO2. Condition:Patient 5 Normal 1
... - Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al., 2017, Molecular cell. |
Article |
- Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al. - Molecular cell, 2017
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. We observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites. Motif analysis of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs. A large number of miR-122 targets were found to be species specific. Upregulation of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients. These results broadly define the molecular consequences of miR-122 downregulation in hepatocellular carcinoma.
LinkOut: [PMID: 28735896]
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CLIP-seq Support 1 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_006187 | 3UTR | CUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903834 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_b |
Location of target site | NM_006187 | 3UTR | UCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903835 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_c |
Location of target site | NM_006187 | 3UTR | UCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM4903836 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_a |
Location of target site | NM_006187 | 3UTR | UCCUCCCUGACUCCUCUCUGCCCAUGCAAAUUAGCUCACAUCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM4903837 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_006187 | 3UTR | UCACAUCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM4903838 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_006187 | 3UTR | ACAUCUUUCCUCCUGCUGCAAUCCAUCCCUUCCUCCCAUUGGCCUCUCCUUGCCAAAUCUAAAUAGUUUAUAUAGGGAUGGCAGAGAGUUCCCAUCUCAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM1084064 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_AbnovaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 8 for dataset GSM1084065 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_AbnovaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 9 for dataset GSM1084067 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_SantaCruzAb |
Location of target site | ENST00000548514.1 | 3UTR | UCAAGGAAAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 10 for dataset GSM1084068 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noemetine_SigmaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 11 for dataset GSM1084069 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_SigmaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 12 for dataset GSM1084078 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 13 for dataset GSM1084079 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_AbnovaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 14 for dataset GSM1084081 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 15 for dataset GSM1084082 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_nohippuristanol_rep2_SigmaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 16 for dataset GSM1084083 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep2_SigmaAb |
Location of target site | ENST00000548514.1 | 3UTR | CAAGGAAAAAAAAAAAAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT095681 | RBM27 | RNA binding motif protein 27 | ![]() |
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2 | 4 | ||||||
MIRT104033 | USP42 | ubiquitin specific peptidase 42 | ![]() |
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2 | 6 | ||||||
MIRT114773 | CMPK1 | cytidine/uridine monophosphate kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT246923 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT392569 | ORAI2 | ORAI calcium release-activated calcium modulator 2 | ![]() |
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2 | 2 | ||||||
MIRT443949 | LRIT3 | leucine rich repeat, Ig-like and transmembrane domains 3 | ![]() |
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2 | 2 | ||||||
MIRT446695 | PAPPA | pappalysin 1 | ![]() |
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2 | 2 | ||||||
MIRT447383 | VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | ![]() |
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2 | 2 | ||||||
MIRT449321 | FAM120AOS | family with sequence similarity 120A opposite strand | ![]() |
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2 | 2 | ||||||
MIRT449717 | C1orf61 | chromosome 1 open reading frame 61 | ![]() |
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2 | 2 | ||||||
MIRT449738 | TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | ![]() |
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2 | 2 | ||||||
MIRT450531 | PGLS | 6-phosphogluconolactonase | ![]() |
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2 | 2 | ||||||
MIRT455650 | YARS | tyrosyl-tRNA synthetase | ![]() |
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2 | 2 | ||||||
MIRT458036 | MRPL12 | mitochondrial ribosomal protein L12 | ![]() |
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2 | 2 | ||||||
MIRT463468 | ZC3HAV1L | zinc finger CCCH-type containing, antiviral 1 like | ![]() |
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2 | 2 | ||||||
MIRT466677 | TAF1D | TATA-box binding protein associated factor, RNA polymerase I subunit D | ![]() |
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2 | 4 | ||||||
MIRT467789 | SLC2A14 | solute carrier family 2 member 14 | ![]() |
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2 | 2 | ||||||
MIRT468167 | SGPL1 | sphingosine-1-phosphate lyase 1 | ![]() |
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2 | 2 | ||||||
MIRT468652 | SECISBP2L | SECIS binding protein 2 like | ![]() |
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2 | 6 | ||||||
MIRT469380 | RER1 | retention in endoplasmic reticulum sorting receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT470346 | PPP2R5E | protein phosphatase 2 regulatory subunit B'epsilon | ![]() |
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2 | 2 | ||||||
MIRT472418 | NCKAP1 | NCK associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT474612 | KLF3 | Kruppel like factor 3 | ![]() |
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2 | 2 | ||||||
MIRT478703 | CSRNP2 | cysteine and serine rich nuclear protein 2 | ![]() |
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2 | 2 | ||||||
MIRT481008 | BBC3 | BCL2 binding component 3 | ![]() |
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2 | 4 | ||||||
MIRT483098 | TFPI | tissue factor pathway inhibitor | ![]() |
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2 | 2 | ||||||
MIRT485113 | SHISA6 | shisa family member 6 | ![]() |
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2 | 2 | ||||||
MIRT497533 | ZNF607 | zinc finger protein 607 | ![]() |
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2 | 2 | ||||||
MIRT500644 | TUBB2A | tubulin beta 2A class IIa | ![]() |
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2 | 6 | ||||||
MIRT500890 | STRN | striatin | ![]() |
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2 | 4 | ||||||
MIRT501900 | MED13 | mediator complex subunit 13 | ![]() |
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2 | 2 | ||||||
MIRT506646 | MAPK1 | mitogen-activated protein kinase 1 | ![]() |
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2 | 4 | ||||||
MIRT512675 | ENO4 | enolase family member 4 | ![]() |
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2 | 2 | ||||||
MIRT516977 | OR7D2 | olfactory receptor family 7 subfamily D member 2 | ![]() |
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2 | 2 | ||||||
MIRT528754 | RPS27 | ribosomal protein S27 | ![]() |
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2 | 6 | ||||||
MIRT539670 | ZBTB44 | zinc finger and BTB domain containing 44 | ![]() |
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2 | 2 | ||||||
MIRT544129 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 2 | ||||||
MIRT546382 | STOX2 | storkhead box 2 | ![]() |
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2 | 4 | ||||||
MIRT562143 | IGFBP5 | insulin like growth factor binding protein 5 | ![]() |
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2 | 2 | ||||||
MIRT568713 | TMEM30B | transmembrane protein 30B | ![]() |
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2 | 2 | ||||||
MIRT571029 | CENPP | centromere protein P | ![]() |
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2 | 2 | ||||||
MIRT572781 | ZNF277 | zinc finger protein 277 | ![]() |
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2 | 2 | ||||||
MIRT573162 | SLC30A9 | solute carrier family 30 member 9 | ![]() |
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2 | 2 | ||||||
MIRT609126 | NUDT3 | nudix hydrolase 3 | ![]() |
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2 | 2 | ||||||
MIRT609284 | OAS3 | 2'-5'-oligoadenylate synthetase 3 | ![]() |
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2 | 2 | ||||||
MIRT613430 | GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | ![]() |
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2 | 2 | ||||||
MIRT613770 | TTC38 | tetratricopeptide repeat domain 38 | ![]() |
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2 | 2 | ||||||
MIRT616645 | LRAT | lecithin retinol acyltransferase | ![]() |
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2 | 4 | ||||||
MIRT630892 | SLC25A33 | solute carrier family 25 member 33 | ![]() |
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2 | 2 | ||||||
MIRT636526 | FAXC | failed axon connections homolog | ![]() |
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2 | 4 | ||||||
MIRT641394 | NUBPL | nucleotide binding protein like | ![]() |
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2 | 2 | ||||||
MIRT641412 | SCN2B | sodium voltage-gated channel beta subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT642528 | CERS4 | ceramide synthase 4 | ![]() |
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2 | 2 | ||||||
MIRT643186 | HYPK | huntingtin interacting protein K | ![]() |
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2 | 2 | ||||||
MIRT647800 | FRMD8 | FERM domain containing 8 | ![]() |
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2 | 2 | ||||||
MIRT652150 | TRIM71 | tripartite motif containing 71 | ![]() |
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2 | 2 | ||||||
MIRT652602 | TIMM8A | translocase of inner mitochondrial membrane 8A | ![]() |
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2 | 2 | ||||||
MIRT661606 | C2orf15 | chromosome 2 open reading frame 15 | ![]() |
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2 | 2 | ||||||
MIRT666339 | SKAP2 | src kinase associated phosphoprotein 2 | ![]() |
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2 | 2 | ||||||
MIRT670414 | ELP2 | elongator acetyltransferase complex subunit 2 | ![]() |
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2 | 2 | ||||||
MIRT671122 | ZNF573 | zinc finger protein 573 | ![]() |
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2 | 2 | ||||||
MIRT671155 | ANKRD9 | ankyrin repeat domain 9 | ![]() |
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2 | 2 | ||||||
MIRT671338 | FAM71F2 | family with sequence similarity 71 member F2 | ![]() |
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2 | 2 | ||||||
MIRT671869 | ZNF429 | zinc finger protein 429 | ![]() |
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2 | 2 | ||||||
MIRT671974 | IKZF3 | IKAROS family zinc finger 3 | ![]() |
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2 | 2 | ||||||
MIRT672064 | KIAA0930 | KIAA0930 | ![]() |
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2 | 2 | ||||||
MIRT672654 | SLC25A16 | solute carrier family 25 member 16 | ![]() |
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2 | 4 | ||||||
MIRT672673 | GTF2H5 | general transcription factor IIH subunit 5 | ![]() |
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2 | 2 | ||||||
MIRT672771 | UBE2V2 | ubiquitin conjugating enzyme E2 V2 | ![]() |
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2 | 2 | ||||||
MIRT672929 | LRRC2 | leucine rich repeat containing 2 | ![]() |
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2 | 2 | ||||||
MIRT673159 | C1orf50 | chromosome 1 open reading frame 50 | ![]() |
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2 | 2 | ||||||
MIRT673272 | RUNDC1 | RUN domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT673332 | THAP1 | THAP domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT673351 | SLC35F6 | solute carrier family 35 member F6 | ![]() |
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2 | 2 | ||||||
MIRT673667 | ZNF440 | zinc finger protein 440 | ![]() |
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2 | 2 | ||||||
MIRT673904 | DCTN6 | dynactin subunit 6 | ![]() |
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2 | 2 | ||||||
MIRT674096 | PLEKHA1 | pleckstrin homology domain containing A1 | ![]() |
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2 | 2 | ||||||
MIRT674401 | MYCBP | MYC binding protein | ![]() |
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2 | 2 | ||||||
MIRT674525 | PRR23A | proline rich 23A | ![]() |
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2 | 2 | ||||||
MIRT674793 | NPR1 | natriuretic peptide receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT674833 | ADAMTS4 | ADAM metallopeptidase with thrombospondin type 1 motif 4 | ![]() |
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2 | 2 | ||||||
MIRT675066 | FGD6 | FYVE, RhoGEF and PH domain containing 6 | ![]() |
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2 | 2 | ||||||
MIRT675080 | CCR6 | C-C motif chemokine receptor 6 | ![]() |
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2 | 2 | ||||||
MIRT675126 | FSD2 | fibronectin type III and SPRY domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT679401 | IL10RB | interleukin 10 receptor subunit beta | ![]() |
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2 | 2 | ||||||
MIRT689229 | RPS19 | ribosomal protein S19 | ![]() |
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2 | 2 | ||||||
MIRT694008 | PPIL4 | peptidylprolyl isomerase like 4 | ![]() |
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2 | 2 | ||||||
MIRT699671 | SFT2D2 | SFT2 domain containing 2 | ![]() |
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2 | 2 | ||||||
MIRT706213 | ACOT9 | acyl-CoA thioesterase 9 | ![]() |
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2 | 2 | ||||||
MIRT706548 | GJD2 | gap junction protein delta 2 | ![]() |
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2 | 2 | ||||||
MIRT707418 | RRP7A | ribosomal RNA processing 7 homolog A | ![]() |
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2 | 2 | ||||||
MIRT710648 | GLUL | glutamate-ammonia ligase | ![]() |
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2 | 2 | ||||||
MIRT719393 | NPCA1 | Nasopharyngeal carcinoma 1 | ![]() |
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2 | 2 | ||||||
MIRT720166 | PNPO | pyridoxamine 5'-phosphate oxidase | ![]() |
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2 | 2 |
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