miRTarBase - #MIRT609449


—
pre-miRNA Information
pre-miRNA hsa-mir-4747   
Genomic Coordinates chr19: 4932687 - 4932740
Description Homo sapiens miR-4747 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4747-5p
Sequence 1| AGGGAAGGAGGCUUGGUCUUAG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs560927363 4 dbSNP
rs1471226927 10 dbSNP
rs763137545 12 dbSNP
rs767337154 15 dbSNP
rs775298039 16 dbSNP
rs760472311 19 dbSNP
rs1207950315 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CCDC149   
Synonyms -
Description coiled-coil domain containing 149
Transcript NM_001130726   
Other Transcripts NM_173463   
Expression
Putative miRNA Targets on CCDC149
3'UTR of CCDC149
(miRNA target sites are highlighted)		 
>CCDC149|NM_001130726|3'UTR
   1 AGGGGAGAGGGATCTGACACAATGACACATTGAAAGCCCCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGCGCTCAC
  81 GTCGCCTTCTCCTGAAATACCTCCGAGTCTGCAAGTGAGAAAACGCACTGATCCTGTTGCAAACTGTGAATATTCTGATG
 161 ATGCCAGTACAGTTTGATTTATTAAATGTAGGTCCTCAAGCTTCTCAGTGTCATCTCTTTTCTGCCAGAGAGTGCTACTG
 241 TGAACAGGGCCAGGCCCAGGAATCGTGTCCACCATATGGCTGGTTTTCAGCATCCGTCTTTCTGTCAGCTTTTGTTTTAT
 321 CAGAGATAAGATGTTTTTGTATTAGCATTTAATGTTGTCAATCAAAATTATGGGAAGAGCTAGAAACTGATGGGGTTTTT
 401 AATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGCTGGAGAGGAAGGTATAATTGAGCAAAACGTGTCCAGAGGACCCATG
 481 GCTGCACCCCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATGGGTGTGCTTGGCATTGTGCCCACAGCACTGCTGTCG
 561 TGGTACAGACTGGCAGTTGGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTTCTGGGTTGAAATCCACAGCCCCGGTT
 641 GAGGCCTGTGTGCTGAGTGCCAGAGCTGGAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGATCTGAAGTGACTGGGA
 721 GGGGTGAGCATAAAAGCCGGGGAACAGGACTCCCAGTGGTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCTACCACC
 801 TGGAAATGCTCATTCTCTGCATTCAGCCTGTCTCACATACAGGATTGTATGGCCATTTCAGGTTTGGGAAAGATCTACCT
 881 GCTGGGAGCCAGTCTAGTTTCCTGCACCACCTGGAACTTCCAAACCCTTCACTCCTTCAACAGAATGTTGAGGCTGCCTC
 961 ATTTGTGCCACCAAGTACGGGAATCTTAAAGACAGAAACAGAGCTCATGACCTTTTATGGGAAAGAGAGAGGAAAACAAA
1041 ACAACTTCACAACAGCATGGCAAGGGGGGATGTGGAACCAAGGACATGATACAGGGATGGGAAAGGAGGGCATGCTCAAT
1121 TCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAGCTTTTCTAGTTGGCATCCGGCACTGCAGAAAACTAAAAGTCATCCA
1201 GCCATAGCTTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCAAAGCTCAGAATGCCTCTGAGAACCAGAATCACTCCT
1281 TTGAGAGGCGCTCCTTGCAGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCAGTGAAAATGCATCCTAAAAATTCAAT
1361 GTTTATACCAGGCTCATGACACTAAGATGTGACATCTGGACACGAGGGGTCAGCCACGTGGATACATCCCTCCCAGATTG
1441 CATCTCCAGGAATCACTCTGCTAGCAGAATGGGCGCCCCATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGCCCAGAA
1521 GGACCCAGGCCTTTGATGCACATTGGGTGGGTCTCCCACTACTTTAGTTGAAATGGGAGCATGCTGGAGTCGGCGTTCTG
1601 TTGCTTCTGGTGAGAAGGACATCCCATTGACCCCTGGCCACCAGGTCCAGTATTCCATCCTTCCTTCTGTCCCAGCCTAT
1681 CGCCCTCCCCACCAGGCCCACCCCCACAACTTCTCCTCAAGGGAGGTTGCTCCCGCAGCTGGAGGGCTTGCACAGACCAG
1761 CAGTCACAGAAATCATTCTTCCTGCTGTACTGGGCCTTAACTGCCTGCAAATGTCCAGCACTACTGCATAGGATGCCAGA
1841 GCCACCGAAGGAAAACACAGCCAAGTTTAATAATAATAAAAGGAAAAATCTCAGCCTGCAGAACTCTGGTTTTGACCCAC
1921 CATCGGCCAGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTGAAAAGCAGGGCTCGTAATAGACTCCAGCACATTCCA
2001 TCAGAGTCAGGAAAACTGCAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGGAGCAGGAGTCATAAGGAGTGATAACC
2081 TAAACTGTGTGTAGTCAGCGGGGAGGGTCTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTAGTTGATCCTGTCACAG
2161 ATATAACCCTGATAACACCCCATAGATACGCGACACGTGTGTCCTGCCCCTGCTTTCCCCATCCAACATGGTTCTTCTGT
2241 TCCACAGACATTAAAGGGGCTTTCTGCAATTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauUCUGGU-UCG---GAGGAAGGGa 5'
             || ||| |||   :|||||||| 
Target 5' tccAG-CCATAGCTTTTTCCTTCCCt 3'
 1197 - 1221 158.00 -20.90
2 
miRNA  3' gauuCUGGUUCGGAGGAAGGGa 5'
              | :|| |:| |||||:| 
Target 5' gtgcGCTCACGTCGCCTTCTCc 3'
 71 - 92 142.00 -14.00
3 
miRNA  3' gauUCUGGUUC----GG-AGGAAGGGa 5'
             ||::| ||    || |||||||: 
Target 5' accAGGTCCAGTATTCCATCCTTCCTt 3'
 1640 - 1666 141.00 -19.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28691754 24 COSMIC
COSN31545040 61 COSMIC
COSN30112080 74 COSMIC
COSN31577948 99 COSMIC
COSN31591703 126 COSMIC
COSN30534380 133 COSMIC
COSN24711777 190 COSMIC
COSN31962248 589 COSMIC
COSN396565 605 COSMIC
COSN30144547 1125 COSMIC
COSN31962247 1361 COSMIC
COSN28378543 1924 COSMIC
COSN21381786 2019 COSMIC
COSN27283743 2033 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1026279655 3 dbSNP
rs1362529811 7 dbSNP
rs577130267 12 dbSNP
rs1401204182 20 dbSNP
rs1467076410 22 dbSNP
rs1252220770 23 dbSNP
rs1278057251 27 dbSNP
rs1338911336 28 dbSNP
rs1214062420 41 dbSNP
rs1235484411 41 dbSNP
rs972476367 43 dbSNP
rs1340019866 47 dbSNP
rs1218887702 53 dbSNP
rs1462042595 55 dbSNP
rs144796698 60 dbSNP
rs1215825895 62 dbSNP
rs1019292024 64 dbSNP
rs977550356 65 dbSNP
rs946329442 71 dbSNP
rs1412761396 74 dbSNP
rs922876369 75 dbSNP
rs1162927189 76 dbSNP
rs750691869 77 dbSNP
rs1420310812 78 dbSNP
rs976944952 80 dbSNP
rs566623313 81 dbSNP
rs964401558 83 dbSNP
rs1450792966 84 dbSNP
rs1018239017 86 dbSNP
rs1260827165 94 dbSNP
rs534232631 100 dbSNP
rs568339940 104 dbSNP
rs952819311 105 dbSNP
rs1238728044 124 dbSNP
rs1308445202 125 dbSNP
rs554940726 126 dbSNP
rs1019229 127 dbSNP
rs906340224 128 dbSNP
rs1014353016 130 dbSNP
rs370249514 134 dbSNP
rs777189934 146 dbSNP
rs1057100998 157 dbSNP
rs1378523218 163 dbSNP
rs552204978 166 dbSNP
rs1379074119 172 dbSNP
rs894805919 176 dbSNP
rs1358964349 180 dbSNP
rs1390071624 181 dbSNP
rs112253047 188 dbSNP
rs76181756 190 dbSNP
rs902257645 191 dbSNP
rs775021625 207 dbSNP
rs1387509688 208 dbSNP
rs771602291 222 dbSNP
rs1219750409 224 dbSNP
rs1277744861 233 dbSNP
rs1185808912 240 dbSNP
rs1049267678 251 dbSNP
rs930673968 264 dbSNP
rs370636331 265 dbSNP
rs188904497 270 dbSNP
rs946232928 274 dbSNP
rs1261917262 278 dbSNP
rs1394005290 284 dbSNP
rs1178256932 294 dbSNP
rs777802526 295 dbSNP
rs972061257 296 dbSNP
rs1192290390 299 dbSNP
rs376548787 300 dbSNP
rs1413242258 304 dbSNP
rs911918399 306 dbSNP
rs1401477088 309 dbSNP
rs1464827670 314 dbSNP
rs1285288128 319 dbSNP
rs986007640 326 dbSNP
rs369406037 338 dbSNP
rs953327932 341 dbSNP
rs1436520998 353 dbSNP
rs1246578568 357 dbSNP
rs1032770348 361 dbSNP
rs1365467778 363 dbSNP
rs1361449772 372 dbSNP
rs1258550703 388 dbSNP
rs1000005494 390 dbSNP
rs1317056495 394 dbSNP
rs1198265206 402 dbSNP
rs942965271 411 dbSNP
rs911249296 424 dbSNP
rs1340098717 430 dbSNP
rs967128614 431 dbSNP
rs529675455 436 dbSNP
rs1477364516 447 dbSNP
rs1020442840 455 dbSNP
rs952797570 461 dbSNP
rs1424797753 462 dbSNP
rs562010381 462 dbSNP
rs573826669 463 dbSNP
rs548488847 476 dbSNP
rs562950515 479 dbSNP
rs1405573260 486 dbSNP
rs184446029 490 dbSNP
rs1347611524 492 dbSNP
rs1401834889 502 dbSNP
rs1425872226 506 dbSNP
rs1278699864 510 dbSNP
rs1024771744 511 dbSNP
rs1216528113 514 dbSNP
rs1367943785 515 dbSNP
rs1012617242 517 dbSNP
rs147319393 520 dbSNP
rs1472673988 522 dbSNP
rs1373354827 530 dbSNP
rs1194852222 540 dbSNP
rs905445948 552 dbSNP
rs1219434436 553 dbSNP
rs1264474368 556 dbSNP
rs1049234076 557 dbSNP
rs376585587 560 dbSNP
rs1261871243 565 dbSNP
rs371821427 577 dbSNP
rs1000517182 586 dbSNP
rs749106247 595 dbSNP
rs540618994 596 dbSNP
rs1411013743 598 dbSNP
rs919461839 601 dbSNP
rs997182738 607 dbSNP
rs901390094 612 dbSNP
rs1041211174 613 dbSNP
rs942975899 614 dbSNP
rs911461873 615 dbSNP
rs1339814135 619 dbSNP
rs1271041675 622 dbSNP
rs1049100177 627 dbSNP
rs931313528 628 dbSNP
rs918555822 630 dbSNP
rs2361079 631 dbSNP
rs758649691 633 dbSNP
rs917776793 636 dbSNP
rs967600611 637 dbSNP
rs1258771067 639 dbSNP
rs548607847 641 dbSNP
rs1186412056 644 dbSNP
rs959574942 666 dbSNP
rs1032274355 669 dbSNP
rs868191596 675 dbSNP
rs1348009507 689 dbSNP
rs1441030178 696 dbSNP
rs528637377 703 dbSNP
rs1379145044 707 dbSNP
rs1001158256 713 dbSNP
rs1033977701 719 dbSNP
rs966352252 725 dbSNP
rs1395197727 726 dbSNP
rs796392977 738 dbSNP
rs1380916358 739 dbSNP
rs1397624937 741 dbSNP
rs114358954 742 dbSNP
rs369681293 747 dbSNP
rs1376237368 754 dbSNP
rs1237541514 756 dbSNP
rs1258222108 758 dbSNP
rs901589937 759 dbSNP
rs1200192749 760 dbSNP
rs905414768 764 dbSNP
rs1041634358 767 dbSNP
rs369113763 770 dbSNP
rs1178846425 771 dbSNP
rs1027894529 774 dbSNP
rs1416720764 776 dbSNP
rs1422393565 776 dbSNP
rs752709535 780 dbSNP
rs889921148 792 dbSNP
rs995122217 797 dbSNP
rs897983260 800 dbSNP
rs1048646767 811 dbSNP
rs1467434781 815 dbSNP
rs1244968165 820 dbSNP
rs192241451 831 dbSNP
rs931511606 835 dbSNP
rs780229088 840 dbSNP
rs187041258 850 dbSNP
rs1389706826 861 dbSNP
rs1198053436 911 dbSNP
rs890560670 918 dbSNP
rs1332230302 924 dbSNP
rs138285987 934 dbSNP
rs150813469 935 dbSNP
rs1447578979 936 dbSNP
rs1281836649 941 dbSNP
rs1320374386 945 dbSNP
rs1198883724 948 dbSNP
rs1274884842 954 dbSNP
rs11936137 956 dbSNP
rs1316301889 958 dbSNP
rs1211161839 961 dbSNP
rs925981011 971 dbSNP
rs1432590377 977 dbSNP
rs182709518 978 dbSNP
rs1425524798 995 dbSNP
rs917988887 996 dbSNP
rs1347194574 1004 dbSNP
rs1354111729 1007 dbSNP
rs1460640890 1037 dbSNP
rs558051335 1039 dbSNP
rs1436427485 1044 dbSNP
rs1336815762 1046 dbSNP
rs1301761552 1048 dbSNP
rs1333802862 1055 dbSNP
rs1219579716 1059 dbSNP
rs992678686 1065 dbSNP
rs1305446917 1066 dbSNP
rs1246526191 1069 dbSNP
rs1265580266 1072 dbSNP
rs1487841136 1073 dbSNP
rs537706131 1078 dbSNP
rs1265197863 1084 dbSNP
rs1444939289 1089 dbSNP
rs890284242 1094 dbSNP
rs959244854 1108 dbSNP
rs952339238 1109 dbSNP
rs925069915 1112 dbSNP
rs979357166 1115 dbSNP
rs1167107103 1119 dbSNP
rs749484828 1122 dbSNP
rs1424048486 1126 dbSNP
rs1026688595 1127 dbSNP
rs141469859 1135 dbSNP
rs1401109163 1141 dbSNP
rs765621066 1143 dbSNP
rs1171433197 1144 dbSNP
rs757626533 1150 dbSNP
rs1288721558 1152 dbSNP
rs1360300180 1160 dbSNP
rs1397433303 1163 dbSNP
rs1312905817 1164 dbSNP
rs548822071 1169 dbSNP
rs898083497 1172 dbSNP
rs569726282 1173 dbSNP
rs1457142159 1180 dbSNP
rs1009082376 1186 dbSNP
rs762337272 1189 dbSNP
rs1017368107 1196 dbSNP
rs1007686332 1203 dbSNP
rs1050454689 1205 dbSNP
rs1314119548 1209 dbSNP
rs1484072165 1215 dbSNP
rs754226085 1218 dbSNP
rs148317952 1220 dbSNP
rs1444210149 1222 dbSNP
rs995792450 1235 dbSNP
rs1420895097 1241 dbSNP
rs897397971 1242 dbSNP
rs1158945027 1243 dbSNP
rs111989420 1256 dbSNP
rs1467865393 1265 dbSNP
rs1303090940 1268 dbSNP
rs1381655585 1269 dbSNP
rs949382334 1272 dbSNP
rs896444720 1285 dbSNP
rs1337028516 1289 dbSNP
rs761047367 1290 dbSNP
rs1055218203 1296 dbSNP
rs938092282 1297 dbSNP
rs775999231 1298 dbSNP
rs1332935198 1299 dbSNP
rs1255164280 1306 dbSNP
rs979224495 1313 dbSNP
rs191941565 1315 dbSNP
rs116207491 1317 dbSNP
rs386672628 1318 dbSNP
rs549806623 1320 dbSNP
rs1385664744 1327 dbSNP
rs1440326598 1330 dbSNP
rs979843463 1331 dbSNP
rs952473433 1337 dbSNP
rs1416637574 1355 dbSNP
rs773992157 1357 dbSNP
rs1405808047 1363 dbSNP
rs1467963868 1368 dbSNP
rs919556438 1375 dbSNP
rs372092749 1379 dbSNP
rs1400428207 1381 dbSNP
rs1209592952 1386 dbSNP
rs1440764952 1387 dbSNP
rs1447644403 1397 dbSNP
rs1017647616 1403 dbSNP
rs1215048769 1406 dbSNP
rs985936125 1407 dbSNP
rs560539092 1408 dbSNP
rs1321077172 1409 dbSNP
rs1202016356 1417 dbSNP
rs1027184738 1418 dbSNP
rs540754983 1421 dbSNP
rs897303558 1422 dbSNP
rs1203976901 1425 dbSNP
rs574840753 1426 dbSNP
rs369919097 1438 dbSNP
rs770550181 1442 dbSNP
rs1429046737 1449 dbSNP
rs1055529076 1450 dbSNP
rs749090968 1453 dbSNP
rs1227242709 1474 dbSNP
rs544639931 1475 dbSNP
rs532686850 1480 dbSNP
rs1043428481 1484 dbSNP
rs1010250100 1487 dbSNP
rs78968249 1488 dbSNP
rs187831266 1493 dbSNP
rs1220188236 1496 dbSNP
rs1421833002 1498 dbSNP
rs1214203458 1501 dbSNP
rs1271044757 1511 dbSNP
rs377178315 1514 dbSNP
rs1411972325 1516 dbSNP
rs1453345181 1525 dbSNP
rs140992354 1526 dbSNP
rs572721723 1536 dbSNP
rs1181477267 1540 dbSNP
rs1057029468 1541 dbSNP
rs1264342018 1565 dbSNP
rs913705248 1573 dbSNP
rs1165733812 1574 dbSNP
rs938619534 1577 dbSNP
rs927101630 1583 dbSNP
rs1162877734 1585 dbSNP
rs1363690602 1591 dbSNP
rs975972226 1592 dbSNP
rs1265467693 1594 dbSNP
rs552601598 1595 dbSNP
rs535950401 1600 dbSNP
rs919703376 1601 dbSNP
rs116996920 1603 dbSNP
rs11557557 1607 dbSNP
rs550304001 1615 dbSNP
rs34085070 1617 dbSNP
rs912256200 1621 dbSNP
rs537078365 1623 dbSNP
rs1027422878 1636 dbSNP
rs1262880252 1646 dbSNP
rs954966722 1650 dbSNP
rs971777607 1655 dbSNP
rs569434012 1660 dbSNP
rs1472909624 1661 dbSNP
rs996320285 1664 dbSNP
rs968745698 1679 dbSNP
rs1021698243 1681 dbSNP
rs552853284 1682 dbSNP
rs1383983852 1686 dbSNP
rs1398686107 1689 dbSNP
rs891791488 1691 dbSNP
rs2270224 1693 dbSNP
rs781277215 1696 dbSNP
rs1314527517 1697 dbSNP
rs1380598501 1703 dbSNP
rs1242956316 1705 dbSNP
rs1013872507 1710 dbSNP
rs1261784877 1715 dbSNP
rs140258264 1729 dbSNP
rs1203806708 1730 dbSNP
rs182714229 1734 dbSNP
rs1002636317 1735 dbSNP
rs1170833561 1753 dbSNP
rs1240743433 1754 dbSNP
rs1440934612 1757 dbSNP
rs1182480672 1774 dbSNP
rs113944342 1775 dbSNP
rs1468504345 1778 dbSNP
rs1425966910 1781 dbSNP
rs567449853 1785 dbSNP
rs1402623721 1786 dbSNP
rs1470432614 1787 dbSNP
rs1477528522 1801 dbSNP
rs1404039805 1806 dbSNP
rs1449025693 1808 dbSNP
rs1307770236 1809 dbSNP
rs757459934 1810 dbSNP
rs1237519051 1812 dbSNP
rs1268723948 1819 dbSNP
rs1324647393 1829 dbSNP
rs1193396326 1830 dbSNP
rs192201567 1831 dbSNP
rs1036782633 1832 dbSNP
rs1458797147 1836 dbSNP
rs1195909689 1839 dbSNP
rs575607757 1846 dbSNP
rs912196726 1847 dbSNP
rs986433164 1850 dbSNP
rs149654839 1873 dbSNP
rs1176005857 1874 dbSNP
rs1427521707 1878 dbSNP
rs910441202 1886 dbSNP
rs1298887747 1891 dbSNP
rs1395848360 1907 dbSNP
rs922201562 1911 dbSNP
rs764316677 1918 dbSNP
rs1346578074 1919 dbSNP
rs187310531 1924 dbSNP
rs753136599 1925 dbSNP
rs768081762 1931 dbSNP
rs1227684070 1939 dbSNP
rs971847723 1942 dbSNP
rs1217547982 1952 dbSNP
rs1323597176 1953 dbSNP
rs140783926 1955 dbSNP
rs908739823 1958 dbSNP
rs182770101 1973 dbSNP
rs960884412 1974 dbSNP
rs34066951 1975 dbSNP
rs771420965 1977 dbSNP
rs536089639 1978 dbSNP
rs1298548126 1980 dbSNP
rs1372585200 1983 dbSNP
rs573634710 1984 dbSNP
rs1366774168 1988 dbSNP
rs1034362971 1992 dbSNP
rs1404867074 1995 dbSNP
rs557053057 2019 dbSNP
rs2324580 2020 dbSNP
rs1168763606 2025 dbSNP
rs1294355162 2029 dbSNP
rs1305281900 2034 dbSNP
rs1246409693 2047 dbSNP
rs1291831132 2048 dbSNP
rs1358726349 2067 dbSNP
rs1220143860 2070 dbSNP
rs1465201633 2074 dbSNP
rs762459781 2081 dbSNP
rs1486035536 2084 dbSNP
rs1022248785 2087 dbSNP
rs1261245191 2096 dbSNP
rs558507995 2099 dbSNP
rs1009639170 2100 dbSNP
rs1002892090 2104 dbSNP
rs13129946 2107 dbSNP
rs1040230823 2113 dbSNP
rs1366293591 2117 dbSNP
rs1347347726 2119 dbSNP
rs1179731767 2120 dbSNP
rs1459360936 2121 dbSNP
rs1236034469 2122 dbSNP
rs1454584444 2129 dbSNP
rs1197588707 2137 dbSNP
rs1022871793 2141 dbSNP
rs1359480747 2148 dbSNP
rs1461459303 2151 dbSNP
rs1381329363 2157 dbSNP
rs552550089 2158 dbSNP
rs1257267822 2165 dbSNP
rs190547499 2167 dbSNP
rs1311600810 2182 dbSNP
rs113632496 2183 dbSNP
rs770537338 2189 dbSNP
rs898322459 2189 dbSNP
rs567214454 2190 dbSNP
rs769405688 2191 dbSNP
rs1182312096 2192 dbSNP
rs185290807 2196 dbSNP
rs930544692 2197 dbSNP
rs1158922858 2203 dbSNP
rs1343792053 2208 dbSNP
rs1446346851 2217 dbSNP
rs1336907655 2227 dbSNP
rs1404764369 2237 dbSNP
rs1449774184 2238 dbSNP
rs1280768661 2247 dbSNP
rs748020190 2249 dbSNP
rs530350136 2253 dbSNP
rs1304610963 2260 dbSNP
rs142417106 2265 dbSNP
rs1225611897 2273 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000504487.1 | 3UTR | CACAUACGUGUGUGUGUGUGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000504487.1 | 3UTR | CACAUACGUGUGUGUGUGUGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000504487.1 | 3UTR | GAAGGAAGUUUCUUCCCACAUACGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000504487.1 | 3UTR | GAAGGAAGUUUCUUCCCACAUACGUGUGUGUGUGUGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000504487.1 | 3UTR | CACAUACGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
215 hsa-miR-4747-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061689 BTG2 BTG anti-proliferation factor 2 2 2
MIRT062834 BCL7A BCL tumor suppressor 7A 2 2
MIRT079371 CCDC137 coiled-coil domain containing 137 2 2
MIRT081190 MIDN midnolin 2 4
MIRT081724 ZNF507 zinc finger protein 507 2 2
MIRT110565 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT133724 SKI SKI proto-oncogene 2 4
MIRT146689 MINK1 misshapen like kinase 1 2 2
MIRT150676 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159196 NRBP1 nuclear receptor binding protein 1 2 2
MIRT180865 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT190659 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196111 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT232390 SP1 Sp1 transcription factor 2 2
MIRT331070 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT338632 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT407441 CTDSP1 CTD small phosphatase 1 2 2
MIRT444276 NKX6-1 NK6 homeobox 1 2 2
MIRT444834 PDE6D phosphodiesterase 6D 2 2
MIRT445452 EXT1 exostosin glycosyltransferase 1 2 2
MIRT445644 NPY4R neuropeptide Y receptor Y4 2 2
MIRT446157 RPL12 ribosomal protein L12 2 2
MIRT446608 HIP1 huntingtin interacting protein 1 2 2
MIRT447108 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT449314 MRO maestro 2 2
MIRT450305 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451245 ZNF444 zinc finger protein 444 2 2
MIRT451714 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451908 ILK integrin linked kinase 2 2
MIRT452183 KIAA1456 KIAA1456 2 2
MIRT452610 REPIN1 replication initiator 1 2 2
MIRT453422 GLG1 golgi glycoprotein 1 2 2
MIRT454006 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455072 ARHGAP39 Rho GTPase activating protein 39 2 2
MIRT455319 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT455357 KDM5C lysine demethylase 5C 2 2
MIRT455589 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455711 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT455860 TMEM254 transmembrane protein 254 2 2
MIRT455919 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT455946 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456935 LRP10 LDL receptor related protein 10 2 2
MIRT457223 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT457431 NOL10 nucleolar protein 10 2 2
MIRT457470 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457907 ZNF212 zinc finger protein 212 2 2
MIRT458046 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458073 RNLS renalase, FAD dependent amine oxidase 2 2
MIRT458234 NXPH3 neurexophilin 3 2 2
MIRT458307 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458378 ITM2C integral membrane protein 2C 2 2
MIRT458967 ZNF436 zinc finger protein 436 2 2
MIRT459099 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459446 TMEM37 transmembrane protein 37 2 2
MIRT459671 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460727 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT460744 SRP14 signal recognition particle 14 2 2
MIRT461531 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461752 DDX11 DEAD/H-box helicase 11 2 2
MIRT461837 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT462019 RIF1 replication timing regulatory factor 1 2 2
MIRT462631 PHF5A PHD finger protein 5A 2 2
MIRT462772 ZNF8 zinc finger protein 8 2 2
MIRT463032 ZNF689 zinc finger protein 689 2 2
MIRT463886 WNT7B Wnt family member 7B 2 2
MIRT463995 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464371 URM1 ubiquitin related modifier 1 2 2
MIRT465342 TPM3 tropomyosin 3 2 4
MIRT465515 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465602 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT465697 TNPO2 transportin 2 2 10
MIRT466988 SSRP1 structure specific recognition protein 1 2 4
MIRT467630 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468132 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468322 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468502 SESN2 sestrin 2 2 2
MIRT468881 RREB1 ras responsive element binding protein 1 2 2
MIRT469322 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469562 RARA retinoic acid receptor alpha 2 2
MIRT469898 PTRF caveolae associated protein 1 2 2
MIRT470045 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470068 PTGES2 prostaglandin E synthase 2 2 2
MIRT470238 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470390 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470500 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470689 POLR2D RNA polymerase II subunit D 2 2
MIRT470704 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471083 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472482 NACC2 NACC family member 2 2 2
MIRT473583 MAT2A methionine adenosyltransferase 2A 2 2
MIRT474554 KLHDC3 kelch domain containing 3 2 2
MIRT474651 KLF13 Kruppel like factor 13 2 2
MIRT474843 KHSRP KH-type splicing regulatory protein 2 2
MIRT474934 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475573 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT476045 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476080 GRB2 growth factor receptor bound protein 2 2 2
MIRT476440 GBA2 glucosylceramidase beta 2 2 2
MIRT476764 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT478785 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479287 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT479505 CDH6 cadherin 6 2 2
MIRT479732 CCND1 cyclin D1 2 6
MIRT480352 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480407 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480859 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT481445 ARRB2 arrestin beta 2 2 2
MIRT481732 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT481824 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482566 ABHD2 abhydrolase domain containing 2 2 2
MIRT482607 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483144 SYCE1L synaptonemal complex central element protein 1 like 2 2
MIRT483214 APOA1 apolipoprotein A1 2 6
MIRT483878 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483917 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483939 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484420 SNX19 sorting nexin 19 2 2
MIRT484489 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484612 SIX3 SIX homeobox 3 2 6
MIRT484705 RNF11 ring finger protein 11 2 2
MIRT485107 SHISA6 shisa family member 6 2 2
MIRT485354 MYO1C myosin IC 2 4
MIRT485609 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT487311 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487417 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487695 CDK14 cyclin dependent kinase 14 2 2
MIRT487791 GPR20 G protein-coupled receptor 20 2 4
MIRT488042 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488058 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488237 DNLZ DNL-type zinc finger 2 4
MIRT488764 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489401 TUBB2A tubulin beta 2A class IIa 2 2
MIRT489777 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490099 FN3K fructosamine 3 kinase 2 2
MIRT490290 ISL2 ISL LIM homeobox 2 2 2
MIRT490378 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491329 GFER growth factor, augmenter of liver regeneration 2 2
MIRT491435 MSX2 msh homeobox 2 2 2
MIRT491769 ZNF385A zinc finger protein 385A 2 2
MIRT491922 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT491983 UNK unkempt family zinc finger 2 2
MIRT492228 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492404 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT492767 PDGFB platelet derived growth factor subunit B 2 2
MIRT492966 NCS1 neuronal calcium sensor 1 2 2
MIRT493295 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493650 HDLBP high density lipoprotein binding protein 2 2
MIRT493913 FAM127B retrotransposon Gag like 8A 2 4
MIRT495601 NKX2-5 NK2 homeobox 5 2 2
MIRT496875 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT498514 MYH14 myosin heavy chain 14 2 2
MIRT499178 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT502143 KIF5B kinesin family member 5B 2 8
MIRT502692 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT508460 HOXB6 homeobox B6 2 4
MIRT510430 ZNF207 zinc finger protein 207 2 6
MIRT511837 GPATCH8 G-patch domain containing 8 2 4
MIRT512368 CPM carboxypeptidase M 2 2
MIRT512506 BTBD19 BTB domain containing 19 2 2
MIRT513065 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513267 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 2 4
MIRT513575 EVX1 even-skipped homeobox 1 2 2
MIRT515051 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515790 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT521657 PRKD3 protein kinase D3 2 2
MIRT522679 LUZP1 leucine zipper protein 1 2 6
MIRT528845 RAB32 RAB32, member RAS oncogene family 2 2
MIRT533569 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT543738 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544295 TSPYL1 TSPY like 1 2 2
MIRT544857 MYH2 myosin heavy chain 2 2 4
MIRT557323 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT560522 TMEM98 transmembrane protein 98 2 2
MIRT561565 SLC6A9 solute carrier family 6 member 9 2 2
MIRT562374 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT565780 SEMA6D semaphorin 6D 2 2
MIRT569548 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569944 PRRT2 proline rich transmembrane protein 2 2 2
MIRT570016 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572163 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT572322 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573495 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574139 MARVELD1 MARVEL domain containing 1 2 2
MIRT609449 CCDC149 coiled-coil domain containing 149 2 2
MIRT610619 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT623355 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT629854 ACOX1 acyl-CoA oxidase 1 2 2
MIRT630516 CDC73 cell division cycle 73 2 2
MIRT632535 PSMB2 proteasome subunit beta 2 2 2
MIRT633975 SLC35E2 solute carrier family 35 member E2 2 2
MIRT636408 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT641722 LTBR lymphotoxin beta receptor 2 2
MIRT642661 RGS6 regulator of G protein signaling 6 2 2
MIRT649649 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT650367 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT651355 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT664840 HUS1 HUS1 checkpoint clamp component 2 2
MIRT667322 MYH9 myosin heavy chain 9 2 2
MIRT670680 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT674922 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT675919 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT676493 GJD3 gap junction protein delta 3 2 2
MIRT680162 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT688008 GSN gelsolin 2 2
MIRT688997 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT700337 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT701344 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703519 FKBP15 FK506 binding protein 15 2 2
MIRT703901 EPT1 selenoprotein I 2 2
MIRT705565 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 2 2
MIRT709709 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 2 2
MIRT713108 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT718426 ZNF85 zinc finger protein 85 2 2
MIRT719236 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719326 STAC SH3 and cysteine rich domain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4747 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4747-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4747-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4747-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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