miRTarBase - #MIRT609660


—
pre-miRNA Information
pre-miRNA hsa-mir-2117   
Genomic Coordinates chr17: 43444806 - 43444885
Description Homo sapiens miR-2117 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2117
Sequence 51| UGUUCUCUUUGCCAAGGACAG |71
Evidence Experimental
Experiments 454
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1255384593 12 dbSNP
rs1227862494 14 dbSNP
rs1458444919 16 dbSNP
rs1309101018 17 dbSNP
rs1159219853 18 dbSNP
rs1344029538 19 dbSNP
rs747666550 20 dbSNP
rs770495894 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ITIH5   
Synonyms ITI-HC5, PP14776
Description inter-alpha-trypsin inhibitor heavy chain family member 5
Transcript NM_030569   
Other Transcripts NM_001001851 , NM_032817   
Expression
Putative miRNA Targets on ITIH5
3'UTR of ITIH5
(miRNA target sites are highlighted)		 
>ITIH5|NM_030569|3'UTR
   1 AGCTGGCAGCCTTAAAGATGCAAGTGCATGAAGGACAGTGATGTGGGGAGGCCGTGGGGCAGCTCTTTTCATGGCTTGTA
  81 CACGCCTCAGCTCCTGGCAATTAGCTGGACTCCATGACCCACCCCTGGTGCAGCATAGATCCGACGTCTGTCTGGGCGAA
 161 GGGTAGGGGTGGGTAGGGGCGGGAAGCCTGAGTGCAAATGTCATTTCCCTCTACTGCCTCTTCCTGCCTCTCCCCACCCT
 241 GCCCACATCCACAGAGGGGAGAGAAGGGTCATAGCTAAATGCAACAAAGTCTGTATCTTGTCCCAACCTGCTTTTCTGTT
 321 CTGTTAGCATATCATAAAGTAAGCCTTTCTGGTGAAGGAAGGTTGCTATGAAACTTTTTTTCTTGGTGGAAATGGACAAG
 401 TTTAGGCACTCTGCTTTTTGCCTTACACTAATGCTTAGAAAGCTGTCTTTTCAGTGGTGTTGCAGCCCCCAGATGTGTGG
 481 CCAACCTCTGCTGCAAAGGAATCTCTTGCTGAGTCCAGGCCACCAATCAGGCAAATAGCCCATACATTTGATCGTTGTAA
 561 ACCATGAAGTCTTTTCTTGCAAGACGTTTTTCTTCTGCTGTGGTATCTTGCCCTTAAAAATTAGTTTTCATTAAAAAGAA
 641 ATTTGATTGAAAATAGAAACATCTACAGCTCAGATACTGATCTCTTTCTAATGGGCTTTGTAAACCACTTGACTTTGCTA
 721 ATGGCTATTCTCCAATTTGTTCCAATAAGCTAAGGGCTTTTCATACACAGGACAACTCCATGTGGTTGATTTTACTGGCA
 801 TGTCTTGGTGACGAAGAGTTGGCCAAGTGAATGATGCATCTTTTACTTGGAGCTCTCCAGCCTTTGTCATAGTTCCCAGA
 881 CCTTTTTTCCTTGTGGTCATCCAGGAGGTGATCAATTACATGTGCACAGTGCTAGGACGGGAGGCAGAGCCGGCTCAGAG
 961 CAGGTCCACCAGCCCACCTATAGCAGGAAGCGTGTCGGTGCTTAGGAAATCTAGGACTTCCAGCTTCCCTCATGTCAGAT
1041 AGAAAAAAAGTCAGGAAACCAGCTCGTGGACAGGGGCTTTGGTTCCAAAACTTGGACAAACCTGATGCCTTAAGGAAAAG
1121 GTTAAGATGAGAGGGGACTTCCAGAGTCAATGAACGTCACCCTTCAGCGGACGGATACCGGGAGCGCTTGGGCGAAACAG
1201 CAGAGAAAGAAAGACTGTGGTCGGGGAAGTGGAATGCTTCGATGCAGGCCAGAGTTCAAGGCTCTGGGGCTGGCCTCACA
1281 AGAGGCTTCTTCCACGGGGCTTGACACCAGAGCAGCCCCCGCGTGAAATGAGAAGGCATGCTTAGCACTGGGAGGAAAAG
1361 CTGAGTTAAGAAAATTCTTTATCATGTTTGCCTTCCCTGGGGAAACATTCAGGCAGTAAAATGACATCCACGTGTTCCTG
1441 TCGGACGCAGCGGCTTCGGGAACAAGTTAGCGCTGGGGGACTATCTGGGCTCGTCTCTCTCTGCTTCGTGAACCCACCAC
1521 ACCAGGGCCTGTCTGCTGTGCTATTTATTTGCCTTCCGTCTTCCCAACCTCAGCTGCCTGTATTCATGCCAGAGGTGCAA
1601 AGGCTGCCAGCCAGTGCTGCTGACAGATGCTTTCAGACTGTAGAGCTCAGAGAAAGGGAGCGGCAGCTAGAGGTAGCCAG
1681 GGAGCTGGCCAGGCTCCCCGGGGCCTTCCTATTATGTAAATCCCAGCTGGACAGACAGCCCTGGAGCCAGGTGGCCCTGT
1761 CCCCTGTGGAGCACTTGGAGCAGTGATCTGTTGTTCCAGGTGTAAGTCTCGACACTGCAGAAATGAGGACGTTATTAGGA
1841 AAGACCAGTTCCTACTGCCTGTGTTGCTACTTTAAGAGCTGAGAAAAACATTCCAATGAGCTATCCATAGCTAACTTGCT
1921 TGCTCAGAAAAACATAAGTAACAAAGTTGAGCTTTCATTTTTAAAAATTATATTTTACTTTAGAAAAATATCACCTTTTT
2001 TCTTCCTCTTCTTTACGTGTAGATCTTTTTTTTTTTTTTCAAATGGGGTCAGTACCTGAAAGCCCGAAACCCCATACCAA
2081 GCTTATAGTTAGGACCTTTGCATTTGATAAAAAAAAAATATAGTATTTTCTGTTGTCCAGAAAATCTTCCCAGATAGGGA
2161 AACTGAGGCAGAGAGTGCCGTGGAGTGGTTTTTGCCAAGTCATACAACATACTTAATGCAGGGCTACACTGAACCTCCAG
2241 AATCATTTTGTTTGCTTTGACCCTGTTTCACCATCTGGGCAATCATTTATTTTCCTTGAGCATTTATAAACCAGGGCGAG
2321 GGTTGTTCCAAAATGAGTAATTGAATGAGATGAAGAAATATGTCATAATTAGAGGAGATAAATCTCCTTGTTATCACAAT
2401 AGTTAATGTGTCATGATCACTGACTAACTGGGACCTTGAACAAGTCAGCATCTCTGCCTTTCAAAATGAAGGAACATTGT
2481 TCTCTATCCTCCCCTGACCCCCGACGGCCCCATGCTAGGTGCACCATCTTCCTCCATTTGACTTTTTAATGCTTTACAAC
2561 TTCAGGCTAAAGGGAGGGGATGTTGGGAGGAGAAACCATCACAAGATTCCCTCGGTGCCACAGCTGTGCTGAGGAGGCCG
2641 GGGACTGGGAATCGGAGTGGGCACCTCTGTGTTTCTCTAGGGAGTAACATTCAACATTTAATTGAATCGTGTGTCCTGAT
2721 AGGTGGATTAGGAACAGGATTCATTCCTTTAACTTTAACTTTTGGCTAAACGACATGCCTTGGATTGAGTGTATATGTCT
2801 TCCCCAAATTCATATGTTGAAGCTTAAATCCTGAATGTGATGGTTCTTGGAATTGGGACCTTTGGAAGGTTATTGGGTCT
2881 TGAGGGCAGAGCCCTCACGAATGGGATTAAGGCCCTTATAAGAAGAGACATGGGGCCAGGTGCAGTGGCTCACACCTGTA
2961 ATCCCAACATTTTGGGAGGCCGAGAAGGGTGGATCATGAGGTCAGGAGATGGAGACCATCCTGGCCAACATGGTGAAACC
3041 TCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGCGTGCCTGTAGTTCCAGCTACTTGGGAGGCTGAGGCA
3121 GGAGAATCGCTTGAACCAGGCAGTCGGAACTTGTAGTGAGCCAAGATCACGCCACTGCACTCCAGCTGGAGTGACAGAGC
3201 CAAACTCCGTCAAAAAAAAACAAAACAAAACAAAAAAAAGACATGGGAGAGATGGTGTTTTTCCTCTCCACCACCTGGGG
3281 ATACGATGAGAAGATGGCCACCTGCAAGCCAGGAAGACGGCCCTCACCAGACACCATGTCTGCTGGCACCTTGATCTTGG
3361 ACCTCCCAGCCTCCAGAACTGTGAGAAATAAATGTGTTTTGTTTAAGCTACTCAAGTCTGTGGTATTCTTGTTAAGGCAG
3441 CCCAAGCTGACTAAGACACCAAATCATTCAAAACGTTAATTCTTTTTCTGTTCTTTAAGCTTCCCAGAATGTACACAAAC
3521 AATGCTGTTATTAAAATTTAAAGGACTCTTGGAACTGTAGGACATGATCCAGCTAAAATAAATAACAAATAACACAGCTA
3601 AGCAAATACTTATAAATGTAGCTTTAAATATTTATTTTAGTTTTAAATAATTAGTGGGGTACGAGACAGTTCACATTCAA
3681 GAGACATTTTACTTAGACAAAAAATTTATAAGAGAACGATGCATAAAAACAAACAACATATTGGTCTGTTTATTTTTCTA
3761 AGGGAAAATGGAATTGGAGCTGTTGAGAATAAAACTTGAAGAATCTAACTGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacaggaaccguUUCUCUUGu 5'
                      |||||||| 
Target 5' caaaaaatttatAAGAGAACg 3'
 3698 - 3718 145.00 -10.10
2 
miRNA  3' gacaGGAACCGUU------UCUCUUgu 5'
              |:| |||:|      ||||||  
Target 5' agcgCTTGGGCGAAACAGCAGAGAAag 3'
 1183 - 1209 131.00 -11.70
3 
miRNA  3' gacaggaacCGUUUCUCUUgu 5'
                   | ::||||||  
Target 5' atccacagaGGGGAGAGAAgg 3'
 247 - 267 124.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6688517 2 COSMIC
COSM8205092 6 COSMIC
COSM8482204 16 COSMIC
COSM7673935 19 COSMIC
COSN30158372 43 COSMIC
COSN30522439 80 COSMIC
COSN26980778 83 COSMIC
COSN30143309 85 COSMIC
COSN30143236 88 COSMIC
COSN30539449 101 COSMIC
COSN18965870 105 COSMIC
COSN30483917 107 COSMIC
COSN30514839 128 COSMIC
COSN30156926 138 COSMIC
COSN31577337 143 COSMIC
COSN30500573 152 COSMIC
COSN28647014 158 COSMIC
COSN26980777 166 COSMIC
COSN30449143 167 COSMIC
COSN8720423 180 COSMIC
COSN7068473 183 COSMIC
COSN30192367 194 COSMIC
COSN5253756 348 COSMIC
COSN17594865 372 COSMIC
COSN25276789 375 COSMIC
COSN32057849 571 COSMIC
COSN14532109 669 COSMIC
COSN17697675 951 COSMIC
COSN25897234 1767 COSMIC
COSN21965430 1811 COSMIC
COSN20106857 2026 COSMIC
COSN20106859 2026 COSMIC
COSN20106852 2109 COSMIC
COSN16376536 2131 COSMIC
COSN22769624 2457 COSMIC
COSN15872839 2666 COSMIC
COSN15251127 2758 COSMIC
COSN15234090 2760 COSMIC
COSN5290680 2808 COSMIC
COSN7068467 3084 COSMIC
COSM3665882 3205 COSMIC
COSM6048651 3211 COSMIC
COSM7260891 3212 COSMIC
COSM7257030 3217 COSMIC
COSM1659618 3221 COSMIC
COSM8651981 3231 COSMIC
COSM8498794 3232 COSMIC
COSM5446818 3275 COSMIC
COSM8845962 3276 COSMIC
COSM5825563 3288 COSMIC
COSM6200224 3289 COSMIC
COSN30560748 3290 COSMIC
COSN30172570 3302 COSMIC
COSN26551077 3318 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1203190123 4 dbSNP
rs767819986 7 dbSNP
rs1194112302 9 dbSNP
rs1321492158 10 dbSNP
rs1225319139 11 dbSNP
rs745730124 14 dbSNP
rs769360539 17 dbSNP
rs1201531531 20 dbSNP
rs1235949786 23 dbSNP
rs370035012 24 dbSNP
rs1481707274 25 dbSNP
rs1335565363 27 dbSNP
rs1259708265 28 dbSNP
rs1177874997 29 dbSNP
rs1214446877 30 dbSNP
rs1305371032 39 dbSNP
rs745354070 41 dbSNP
rs577124049 42 dbSNP
rs780619028 43 dbSNP
rs778576459 44 dbSNP
rs757209123 49 dbSNP
rs1468845257 50 dbSNP
rs746989629 51 dbSNP
rs371417970 53 dbSNP
rs748929215 54 dbSNP
rs758210295 61 dbSNP
rs752564412 65 dbSNP
rs765517964 67 dbSNP
rs755201966 68 dbSNP
rs1182852157 69 dbSNP
rs1355944795 70 dbSNP
rs1460043428 70 dbSNP
rs1462145119 73 dbSNP
rs78641295 78 dbSNP
rs1205763520 80 dbSNP
rs367635992 83 dbSNP
rs113088088 84 dbSNP
rs1247516154 86 dbSNP
rs1322637319 90 dbSNP
rs1457308709 96 dbSNP
rs1221476484 99 dbSNP
rs925907508 116 dbSNP
rs192882574 120 dbSNP
rs570194598 123 dbSNP
rs1250945869 127 dbSNP
rs1482146690 128 dbSNP
rs550778981 129 dbSNP
rs1019203348 132 dbSNP
rs1270233906 134 dbSNP
rs1449411359 138 dbSNP
rs535689333 139 dbSNP
rs112976615 142 dbSNP
rs950466402 143 dbSNP
rs1025967093 144 dbSNP
rs994533161 145 dbSNP
rs1169380683 146 dbSNP
rs148944686 155 dbSNP
rs899406609 156 dbSNP
rs546874607 157 dbSNP
rs11255191 158 dbSNP
rs372342625 161 dbSNP
rs1362453499 163 dbSNP
rs563897768 170 dbSNP
rs201369624 176 dbSNP
rs1015803384 180 dbSNP
rs552178384 180 dbSNP
rs528171383 181 dbSNP
rs1004145913 182 dbSNP
rs902022110 184 dbSNP
rs1490199041 192 dbSNP
rs12244206 198 dbSNP
rs563081618 201 dbSNP
rs945436864 203 dbSNP
rs185371167 204 dbSNP
rs1053709198 210 dbSNP
rs894461717 213 dbSNP
rs1387952764 222 dbSNP
rs1163701159 225 dbSNP
rs1446031269 225 dbSNP
rs1384112202 228 dbSNP
rs1425607619 230 dbSNP
rs1422188748 234 dbSNP
rs753769934 236 dbSNP
rs1345707514 241 dbSNP
rs12244143 253 dbSNP
rs41290271 254 dbSNP
rs756955210 258 dbSNP
rs1248498335 259 dbSNP
rs1408396049 263 dbSNP
rs974654807 286 dbSNP
rs9329 289 dbSNP
rs1226676911 300 dbSNP
rs911705814 301 dbSNP
rs987734299 302 dbSNP
rs868808076 303 dbSNP
rs1476969465 306 dbSNP
rs1245689344 316 dbSNP
rs1246532806 318 dbSNP
rs1026102220 321 dbSNP
rs1242127186 327 dbSNP
rs577490775 334 dbSNP
rs962999385 339 dbSNP
rs558660640 344 dbSNP
rs1400004957 345 dbSNP
rs1002429228 346 dbSNP
rs973852240 351 dbSNP
rs1453086277 357 dbSNP
rs1337719096 362 dbSNP
rs906794416 368 dbSNP
rs908273708 370 dbSNP
rs1281306320 373 dbSNP
rs1374734893 375 dbSNP
rs1223754595 382 dbSNP
rs12024 396 dbSNP
rs1009727310 398 dbSNP
rs1326167725 401 dbSNP
rs144714919 408 dbSNP
rs576602262 410 dbSNP
rs1053760054 426 dbSNP
rs936766485 434 dbSNP
rs191501980 441 dbSNP
rs758544921 447 dbSNP
rs1366107447 454 dbSNP
rs1274398388 456 dbSNP
rs1405609091 467 dbSNP
rs899803751 479 dbSNP
rs1024263074 484 dbSNP
rs1040127697 485 dbSNP
rs1367734550 493 dbSNP
rs1431350289 496 dbSNP
rs1012807886 497 dbSNP
rs1296620658 503 dbSNP
rs1401795835 520 dbSNP
rs943281422 523 dbSNP
rs1412942417 531 dbSNP
rs958738393 539 dbSNP
rs1336478641 541 dbSNP
rs1441548036 543 dbSNP
rs1345585192 545 dbSNP
rs911826426 546 dbSNP
rs1033405913 550 dbSNP
rs987314096 553 dbSNP
rs536749072 554 dbSNP
rs750447296 556 dbSNP
rs568224986 557 dbSNP
rs1273256403 558 dbSNP
rs1436790762 564 dbSNP
rs919093869 569 dbSNP
rs74577999 571 dbSNP
rs963134606 580 dbSNP
rs563579228 581 dbSNP
rs1047407 585 dbSNP
rs890614770 586 dbSNP
rs1169924981 593 dbSNP
rs1485951945 593 dbSNP
rs1050643635 600 dbSNP
rs1261750495 602 dbSNP
rs932185881 605 dbSNP
rs970998395 617 dbSNP
rs570757809 628 dbSNP
rs775428030 633 dbSNP
rs1406043577 641 dbSNP
rs892603167 646 dbSNP
rs1323457074 663 dbSNP
rs545366475 682 dbSNP
rs1329774726 689 dbSNP
rs10795550 691 dbSNP
rs530571478 692 dbSNP
rs141043152 701 dbSNP
rs547838587 706 dbSNP
rs1338280673 707 dbSNP
rs899940130 708 dbSNP
rs1039695524 716 dbSNP
rs1008678083 720 dbSNP
rs1347495055 732 dbSNP
rs982522548 733 dbSNP
rs529878467 735 dbSNP
rs1399638069 736 dbSNP
rs1448585576 742 dbSNP
rs1193547645 744 dbSNP
rs917050071 748 dbSNP
rs529757062 749 dbSNP
rs1387217122 762 dbSNP
rs12242295 764 dbSNP
rs1293529313 767 dbSNP
rs929215585 768 dbSNP
rs1445495844 774 dbSNP
rs41290269 775 dbSNP
rs979192518 785 dbSNP
rs1319338377 801 dbSNP
rs1037556071 808 dbSNP
rs1364047694 812 dbSNP
rs532681429 813 dbSNP
rs967400784 818 dbSNP
rs1359605426 836 dbSNP
rs1177093316 848 dbSNP
rs565612551 855 dbSNP
rs543450035 860 dbSNP
rs576459569 862 dbSNP
rs1263613227 863 dbSNP
rs1008901730 865 dbSNP
rs555017870 869 dbSNP
rs1470881170 870 dbSNP
rs980463020 876 dbSNP
rs1420842129 881 dbSNP
rs1260723410 894 dbSNP
rs970761859 899 dbSNP
rs1169334599 903 dbSNP
rs190367770 908 dbSNP
rs1186976195 922 dbSNP
rs1029093869 928 dbSNP
rs41290267 938 dbSNP
rs148147907 939 dbSNP
rs60587565 951 dbSNP
rs1242869981 952 dbSNP
rs941058450 963 dbSNP
rs769504818 964 dbSNP
rs573269009 968 dbSNP
rs747734367 970 dbSNP
rs781551405 971 dbSNP
rs1309894710 975 dbSNP
rs187974557 977 dbSNP
rs1256317410 978 dbSNP
rs140020461 981 dbSNP
rs1047105587 991 dbSNP
rs558767673 992 dbSNP
rs1267416813 996 dbSNP
rs755287123 997 dbSNP
rs1298036230 998 dbSNP
rs1205262822 999 dbSNP
rs1394459663 1008 dbSNP
rs536955257 1017 dbSNP
rs897767261 1024 dbSNP
rs1265251492 1025 dbSNP
rs1461905439 1027 dbSNP
rs1181386537 1034 dbSNP
rs991763221 1039 dbSNP
rs1037523990 1040 dbSNP
rs1337072146 1049 dbSNP
rs1454577244 1050 dbSNP
rs1411865852 1055 dbSNP
rs1398009113 1059 dbSNP
rs747342372 1065 dbSNP
rs1406384429 1066 dbSNP
rs1465193144 1067 dbSNP
rs926482367 1070 dbSNP
rs1374256879 1075 dbSNP
rs1398068549 1077 dbSNP
rs925899734 1079 dbSNP
rs561123516 1082 dbSNP
rs1045181524 1091 dbSNP
rs1391462309 1091 dbSNP
rs949178281 1101 dbSNP
rs1162288842 1107 dbSNP
rs917559701 1111 dbSNP
rs1348497223 1119 dbSNP
rs547806720 1120 dbSNP
rs1283640353 1127 dbSNP
rs529722356 1136 dbSNP
rs2050355 1137 dbSNP
rs7083988 1138 dbSNP
rs1254473044 1145 dbSNP
rs1481696609 1146 dbSNP
rs1020201550 1152 dbSNP
rs1463085159 1155 dbSNP
rs1471866447 1156 dbSNP
rs1202077212 1165 dbSNP
rs2050354 1169 dbSNP
rs532788763 1170 dbSNP
rs1173606381 1172 dbSNP
rs1374373363 1173 dbSNP
rs1462065873 1176 dbSNP
rs1195687717 1178 dbSNP
rs964520591 1179 dbSNP
rs565341381 1180 dbSNP
rs1366720767 1185 dbSNP
rs1242887318 1186 dbSNP
rs7909046 1190 dbSNP
rs7909044 1191 dbSNP
rs577866727 1193 dbSNP
rs2050353 1194 dbSNP
rs386740582 1194 dbSNP
rs751598956 1202 dbSNP
rs1306240329 1205 dbSNP
rs76071648 1207 dbSNP
rs886794460 1211 dbSNP
rs1291226201 1213 dbSNP
rs764258570 1215 dbSNP
rs1421239775 1217 dbSNP
rs1428707837 1221 dbSNP
rs1046738533 1222 dbSNP
rs772169848 1223 dbSNP
rs35920614 1227 dbSNP
rs1425992182 1240 dbSNP
rs1164210298 1241 dbSNP
rs1164650569 1243 dbSNP
rs1349162185 1251 dbSNP
rs949689106 1260 dbSNP
rs994197118 1265 dbSNP
rs1290362149 1277 dbSNP
rs1378798691 1278 dbSNP
rs1436136156 1279 dbSNP
rs1181735819 1284 dbSNP
rs1297109396 1285 dbSNP
rs1340198595 1291 dbSNP
rs111557625 1294 dbSNP
rs1055544357 1295 dbSNP
rs745609090 1296 dbSNP
rs1208123454 1309 dbSNP
rs1321596165 1315 dbSNP
rs754060794 1320 dbSNP
rs371768073 1321 dbSNP
rs576926965 1322 dbSNP
rs1187604354 1323 dbSNP
rs1245813513 1330 dbSNP
rs1351266221 1337 dbSNP
rs1445928760 1338 dbSNP
rs937204000 1339 dbSNP
rs147963450 1350 dbSNP
rs1044924583 1352 dbSNP
rs949141234 1360 dbSNP
rs1345616468 1364 dbSNP
rs1456493821 1368 dbSNP
rs1320216669 1370 dbSNP
rs1363223029 1382 dbSNP
rs896269169 1384 dbSNP
rs1378496925 1385 dbSNP
rs536922280 1386 dbSNP
rs1286940576 1401 dbSNP
rs750723834 1402 dbSNP
rs1330332687 1405 dbSNP
rs935036682 1411 dbSNP
rs987460801 1413 dbSNP
rs759448288 1422 dbSNP
rs980057599 1431 dbSNP
rs942978488 1432 dbSNP
rs541185403 1436 dbSNP
rs1236423741 1441 dbSNP
rs1471508640 1442 dbSNP
rs1304603622 1443 dbSNP
rs911353647 1446 dbSNP
rs987008363 1447 dbSNP
rs575961833 1451 dbSNP
rs963883343 1452 dbSNP
rs1016411286 1454 dbSNP
rs1416424671 1456 dbSNP
rs1025765931 1457 dbSNP
rs1358715215 1458 dbSNP
rs1445909694 1459 dbSNP
rs972817228 1460 dbSNP
rs550904510 1462 dbSNP
rs1281788695 1463 dbSNP
rs1351576810 1470 dbSNP
rs183829116 1471 dbSNP
rs757042091 1472 dbSNP
rs191421761 1479 dbSNP
rs905133647 1485 dbSNP
rs1025214366 1488 dbSNP
rs1013966447 1492 dbSNP
rs895473968 1493 dbSNP
rs535887380 1496 dbSNP
rs1201879903 1499 dbSNP
rs3814699 1501 dbSNP
rs1283383080 1503 dbSNP
rs1431231425 1503 dbSNP
rs187412402 1507 dbSNP
rs1013454458 1508 dbSNP
rs1424645669 1517 dbSNP
rs896238099 1521 dbSNP
rs74119444 1523 dbSNP
rs1309875244 1529 dbSNP
rs755560361 1533 dbSNP
rs1409790653 1536 dbSNP
rs1306694246 1543 dbSNP
rs571779020 1556 dbSNP
rs935089487 1557 dbSNP
rs1273883640 1558 dbSNP
rs945870103 1565 dbSNP
rs1342379713 1567 dbSNP
rs1215851984 1569 dbSNP
rs1274791371 1579 dbSNP
rs550424166 1589 dbSNP
rs1270955578 1593 dbSNP
rs1451973038 1597 dbSNP
rs1051624116 1607 dbSNP
rs1246366893 1611 dbSNP
rs933332378 1617 dbSNP
rs1284563971 1643 dbSNP
rs376670119 1647 dbSNP
rs1170684206 1649 dbSNP
rs942926964 1660 dbSNP
rs372090288 1661 dbSNP
rs911505962 1662 dbSNP
rs987364180 1666 dbSNP
rs1393427923 1670 dbSNP
rs532027389 1671 dbSNP
rs918768700 1685 dbSNP
rs1329683084 1689 dbSNP
rs1383096343 1692 dbSNP
rs972785979 1693 dbSNP
rs1297866550 1699 dbSNP
rs963467793 1700 dbSNP
rs772786153 1711 dbSNP
rs909278452 1714 dbSNP
rs1356906369 1715 dbSNP
rs181794144 1716 dbSNP
rs1209053449 1724 dbSNP
rs962807928 1731 dbSNP
rs1448495452 1739 dbSNP
rs769237159 1758 dbSNP
rs865830521 1759 dbSNP
rs950857142 1761 dbSNP
rs980156414 1762 dbSNP
rs1370736491 1765 dbSNP
rs1430079579 1768 dbSNP
rs1163167195 1770 dbSNP
rs568591245 1780 dbSNP
rs1459152668 1782 dbSNP
rs1320816297 1786 dbSNP
rs1023592464 1793 dbSNP
rs1432291733 1797 dbSNP
rs1314195472 1799 dbSNP
rs1476999504 1802 dbSNP
rs959695643 1805 dbSNP
rs1282343336 1806 dbSNP
rs1013458229 1811 dbSNP
rs549392031 1814 dbSNP
rs1269021803 1830 dbSNP
rs77402848 1831 dbSNP
rs1241726237 1835 dbSNP
rs142345534 1843 dbSNP
rs1207025810 1855 dbSNP
rs1258412806 1856 dbSNP
rs1448539708 1858 dbSNP
rs7924140 1864 dbSNP
rs903634016 1870 dbSNP
rs766828296 1873 dbSNP
rs1202961808 1885 dbSNP
rs1324179721 1898 dbSNP
rs7907148 1901 dbSNP
rs1160303899 1905 dbSNP
rs1216228520 1905 dbSNP
rs1006590307 1906 dbSNP
rs1455351406 1911 dbSNP
rs1304197350 1918 dbSNP
rs1043180243 1934 dbSNP
rs1338391551 1937 dbSNP
rs371498216 1937 dbSNP
rs1394938502 1940 dbSNP
rs10752109 1941 dbSNP
rs1228799913 1947 dbSNP
rs1229098670 1956 dbSNP
rs891597568 1959 dbSNP
rs1326789428 1968 dbSNP
rs147690462 1972 dbSNP
rs934245374 1977 dbSNP
rs1483624890 1978 dbSNP
rs918737569 1991 dbSNP
rs1254718051 1993 dbSNP
rs150021422 1998 dbSNP
rs941413031 2008 dbSNP
rs910001686 2011 dbSNP
rs980509166 2016 dbSNP
rs970045423 2017 dbSNP
rs917246163 2022 dbSNP
rs1408251382 2036 dbSNP
rs1418827907 2038 dbSNP
rs1377774163 2039 dbSNP
rs1267685146 2040 dbSNP
rs1491066040 2040 dbSNP
rs564800233 2040 dbSNP
rs71383917 2040 dbSNP
rs771601881 2041 dbSNP
rs773241643 2041 dbSNP
rs1307324810 2042 dbSNP
rs1348472705 2045 dbSNP
rs1476473825 2045 dbSNP
rs1383220674 2048 dbSNP
rs1182735231 2051 dbSNP
rs1461750144 2052 dbSNP
rs1232669169 2065 dbSNP
rs115227616 2066 dbSNP
rs1344377834 2071 dbSNP
rs1196634025 2084 dbSNP
rs1206571478 2096 dbSNP
rs1436753832 2097 dbSNP
rs536144425 2103 dbSNP
rs1267638444 2107 dbSNP
rs1197194480 2108 dbSNP
rs1391543616 2109 dbSNP
rs1429822660 2110 dbSNP
rs1167888086 2112 dbSNP
rs1368572156 2114 dbSNP
rs1353802215 2116 dbSNP
rs1293859928 2117 dbSNP
rs1366608511 2118 dbSNP
rs1274569075 2119 dbSNP
rs1386468469 2119 dbSNP
rs1491041633 2119 dbSNP
rs571706229 2119 dbSNP
rs71383916 2119 dbSNP
rs75645386 2119 dbSNP
rs1313458027 2120 dbSNP
rs1245658675 2121 dbSNP
rs983524845 2123 dbSNP
rs929466316 2126 dbSNP
rs960629929 2135 dbSNP
rs918048855 2143 dbSNP
rs1030772622 2151 dbSNP
rs190827732 2153 dbSNP
rs1440567617 2162 dbSNP
rs1187336740 2174 dbSNP
rs1388286272 2176 dbSNP
rs563262551 2179 dbSNP
rs1329612092 2180 dbSNP
rs1349144034 2188 dbSNP
rs553504597 2193 dbSNP
rs1456193069 2202 dbSNP
rs1411932749 2204 dbSNP
rs1363912360 2208 dbSNP
rs139556820 2212 dbSNP
rs10508330 2214 dbSNP
rs968782363 2219 dbSNP
rs1386817030 2222 dbSNP
rs889432204 2227 dbSNP
rs550385389 2235 dbSNP
rs1469512497 2246 dbSNP
rs1314062108 2249 dbSNP
rs998422235 2265 dbSNP
rs1321502505 2271 dbSNP
rs1233009889 2284 dbSNP
rs757369334 2285 dbSNP
rs1269657995 2288 dbSNP
rs1207681851 2296 dbSNP
rs150550827 2296 dbSNP
rs1239913313 2298 dbSNP
rs769005342 2300 dbSNP
rs997293659 2301 dbSNP
rs538485014 2302 dbSNP
rs1360629421 2307 dbSNP
rs1474108862 2316 dbSNP
rs1294334600 2317 dbSNP
rs760799738 2318 dbSNP
rs1039363486 2324 dbSNP
rs910044979 2334 dbSNP
rs1373245328 2337 dbSNP
rs1044450858 2351 dbSNP
rs1450220172 2358 dbSNP
rs1444438559 2369 dbSNP
rs150992463 2375 dbSNP
rs917234310 2378 dbSNP
rs549656301 2380 dbSNP
rs1290646751 2389 dbSNP
rs1227467730 2394 dbSNP
rs1281688415 2395 dbSNP
rs574762079 2399 dbSNP
rs778194301 2416 dbSNP
rs1236854279 2429 dbSNP
rs923891495 2430 dbSNP
rs1184217646 2444 dbSNP
rs1412500014 2462 dbSNP
rs977890891 2470 dbSNP
rs531661362 2471 dbSNP
rs771622027 2473 dbSNP
rs1405992091 2474 dbSNP
rs1416264748 2476 dbSNP
rs1425464560 2479 dbSNP
rs1367222857 2494 dbSNP
rs1156651052 2501 dbSNP
rs1310377863 2502 dbSNP
rs2050351 2503 dbSNP
rs985205629 2505 dbSNP
rs142624633 2506 dbSNP
rs1219337922 2507 dbSNP
rs938158945 2508 dbSNP
rs1029321105 2510 dbSNP
rs997886222 2512 dbSNP
rs562684374 2516 dbSNP
rs1482614575 2519 dbSNP
rs1015816824 2522 dbSNP
rs139380169 2525 dbSNP
rs10508329 2526 dbSNP
rs1191974045 2532 dbSNP
rs1394617940 2534 dbSNP
rs1199718818 2536 dbSNP
rs1432941763 2537 dbSNP
rs968416318 2540 dbSNP
rs1021223822 2546 dbSNP
rs1490735469 2549 dbSNP
rs1248889360 2557 dbSNP
rs988534308 2559 dbSNP
rs1044976052 2563 dbSNP
rs1273865851 2568 dbSNP
rs35539951 2568 dbSNP
rs955819919 2570 dbSNP
rs1030021092 2579 dbSNP
rs547779910 2580 dbSNP
rs560760573 2585 dbSNP
rs948813795 2586 dbSNP
rs1341322358 2588 dbSNP
rs900327438 2593 dbSNP
rs1291827147 2595 dbSNP
rs542481582 2597 dbSNP
rs1225936492 2598 dbSNP
rs1252534217 2604 dbSNP
rs1452670961 2605 dbSNP
rs1057050997 2607 dbSNP
rs541232967 2613 dbSNP
rs1321512373 2614 dbSNP
rs934698131 2615 dbSNP
rs924615812 2625 dbSNP
rs887794352 2631 dbSNP
rs977942814 2635 dbSNP
rs1405841204 2639 dbSNP
rs1324821077 2640 dbSNP
rs572274802 2641 dbSNP
rs896596144 2642 dbSNP
rs1325331822 2643 dbSNP
rs915062480 2646 dbSNP
rs985728223 2653 dbSNP
rs1285880764 2654 dbSNP
rs1356796743 2655 dbSNP
rs1208953338 2660 dbSNP
rs1429738194 2661 dbSNP
rs1467276371 2689 dbSNP
rs553710984 2690 dbSNP
rs1248776462 2696 dbSNP
rs576932141 2701 dbSNP
rs377042722 2703 dbSNP
rs749046026 2709 dbSNP
rs10905182 2713 dbSNP
rs1468118981 2722 dbSNP
rs1473344080 2726 dbSNP
rs1164612758 2729 dbSNP
rs370817543 2732 dbSNP
rs1044002271 2736 dbSNP
rs367610718 2737 dbSNP
rs1481237948 2753 dbSNP
rs556247088 2758 dbSNP
rs1340936130 2763 dbSNP
rs1232485511 2764 dbSNP
rs1185524854 2771 dbSNP
rs1485764613 2772 dbSNP
rs1330919717 2774 dbSNP
rs914143836 2775 dbSNP
rs1015280532 2782 dbSNP
rs988461728 2784 dbSNP
rs540365158 2790 dbSNP
rs1258914755 2791 dbSNP
rs1211141194 2793 dbSNP
rs1443542094 2796 dbSNP
rs777413364 2807 dbSNP
rs976200179 2812 dbSNP
rs747686302 2814 dbSNP
rs964576248 2836 dbSNP
rs1362804504 2855 dbSNP
rs1451017541 2856 dbSNP
rs115130446 2859 dbSNP
rs556016667 2860 dbSNP
rs534486859 2865 dbSNP
rs1310978252 2868 dbSNP
rs1026216695 2869 dbSNP
rs1410131737 2873 dbSNP
rs73615783 2875 dbSNP
rs557960302 2878 dbSNP
rs1362421476 2891 dbSNP
rs533217468 2898 dbSNP
rs1043476361 2899 dbSNP
rs568917393 2901 dbSNP
rs1278736650 2908 dbSNP
rs114089354 2912 dbSNP
rs1044314396 2916 dbSNP
rs529365555 2917 dbSNP
rs1249414767 2919 dbSNP
rs946888291 2920 dbSNP
rs914196702 2924 dbSNP
rs1377754162 2931 dbSNP
rs1405228797 2938 dbSNP
rs373091712 2938 dbSNP
rs1433555476 2942 dbSNP
rs1336875394 2947 dbSNP
rs1372267857 2953 dbSNP
rs1430202214 2975 dbSNP
rs1297434395 2978 dbSNP
rs915178953 2979 dbSNP
rs560724095 2981 dbSNP
rs1389948832 2982 dbSNP
rs1052631136 2988 dbSNP
rs1371827417 2998 dbSNP
rs61836565 3000 dbSNP
rs1169316068 3009 dbSNP
rs932437738 3019 dbSNP
rs1428683528 3024 dbSNP
rs1251152386 3025 dbSNP
rs1420739168 3031 dbSNP
rs1211335253 3033 dbSNP
rs1253166027 3034 dbSNP
rs922438268 3036 dbSNP
rs768361862 3039 dbSNP
rs1443369066 3042 dbSNP
rs111506888 3043 dbSNP
rs556917361 3046 dbSNP
rs1169642299 3049 dbSNP
rs1204808508 3050 dbSNP
rs775934130 3055 dbSNP
rs1459193297 3070 dbSNP
rs560231808 3072 dbSNP
rs952984026 3074 dbSNP
rs545288858 3075 dbSNP
rs1367411338 3077 dbSNP
rs577670767 3080 dbSNP
rs1295492363 3081 dbSNP
rs1306128716 3082 dbSNP
rs369350050 3084 dbSNP
rs544294832 3085 dbSNP
rs960716021 3087 dbSNP
rs1035404707 3089 dbSNP
rs1485906984 3090 dbSNP
rs772273237 3091 dbSNP
rs1002198410 3108 dbSNP
rs1417233876 3112 dbSNP
rs573806615 3117 dbSNP
rs1315684070 3121 dbSNP
rs1165172658 3126 dbSNP
rs746414239 3127 dbSNP
rs779599514 3128 dbSNP
rs185185286 3129 dbSNP
rs1043057132 3136 dbSNP
rs1393709470 3137 dbSNP
rs1012032560 3138 dbSNP
rs1360433912 3141 dbSNP
rs1462236408 3145 dbSNP
rs771546680 3146 dbSNP
rs1314968361 3150 dbSNP
rs1451045011 3151 dbSNP
rs1050075480 3152 dbSNP
rs1322030681 3153 dbSNP
rs1382267970 3154 dbSNP
rs932570025 3155 dbSNP
rs1156436782 3160 dbSNP
rs1334598614 3164 dbSNP
rs534169605 3170 dbSNP
rs180822291 3171 dbSNP
rs1162891710 3172 dbSNP
rs1214401703 3175 dbSNP
rs567151571 3178 dbSNP
rs1391912849 3181 dbSNP
rs1484215984 3182 dbSNP
rs1194072014 3183 dbSNP
rs749440025 3191 dbSNP
rs1259931154 3196 dbSNP
rs1165980536 3200 dbSNP
rs1410365220 3202 dbSNP
rs934223181 3203 dbSNP
rs1211790385 3204 dbSNP
rs1490624154 3208 dbSNP
rs139837866 3209 dbSNP
rs1244211137 3212 dbSNP
rs535782876 3216 dbSNP
rs543261983 3217 dbSNP
rs568880787 3217 dbSNP
rs756367280 3220 dbSNP
rs111905334 3221 dbSNP
rs1289861544 3221 dbSNP
rs550585550 3221 dbSNP
rs752495316 3221 dbSNP
rs762297733 3222 dbSNP
rs770828467 3222 dbSNP
rs760226864 3224 dbSNP
rs984549741 3225 dbSNP
rs141248725 3226 dbSNP
rs368850950 3226 dbSNP
rs746524069 3226 dbSNP
rs1365783556 3227 dbSNP
rs866600273 3231 dbSNP
rs762122030 3232 dbSNP
rs1372389663 3234 dbSNP
rs755998339 3235 dbSNP
rs1355451031 3236 dbSNP
rs201992976 3236 dbSNP
rs377582767 3236 dbSNP
rs774735406 3236 dbSNP
rs1475127438 3237 dbSNP
rs529327910 3239 dbSNP
rs1207173713 3240 dbSNP
rs1234306890 3240 dbSNP
rs1345593791 3240 dbSNP
rs1201308149 3241 dbSNP
rs1480915197 3243 dbSNP
rs780604984 3248 dbSNP
rs1220808010 3249 dbSNP
rs750933717 3250 dbSNP
rs1484234405 3252 dbSNP
rs971987041 3255 dbSNP
rs1437012808 3259 dbSNP
rs1195667012 3264 dbSNP
rs1338220202 3265 dbSNP
rs1288872095 3266 dbSNP
rs1035809008 3269 dbSNP
rs1224775472 3271 dbSNP
rs1214852085 3273 dbSNP
rs1345819874 3274 dbSNP
rs7074077 3275 dbSNP
rs1402883585 3280 dbSNP
rs759172763 3281 dbSNP
rs372673504 3283 dbSNP
rs1409251028 3284 dbSNP
rs1394220171 3285 dbSNP
rs1022089393 3291 dbSNP
rs1174429198 3292 dbSNP
rs770280366 3294 dbSNP
rs190002333 3297 dbSNP
rs1022806980 3301 dbSNP
rs1010903445 3311 dbSNP
rs527445081 3318 dbSNP
rs758088192 3319 dbSNP
rs560304395 3321 dbSNP
rs1181751138 3322 dbSNP
rs1436616456 3329 dbSNP
rs1230606498 3332 dbSNP
rs1281337719 3333 dbSNP
rs1205077263 3335 dbSNP
rs1323545592 3336 dbSNP
rs7092583 3337 dbSNP
rs1253988413 3352 dbSNP
rs1446213078 3356 dbSNP
rs1197553645 3358 dbSNP
rs184577521 3360 dbSNP
rs562445255 3362 dbSNP
rs1271189450 3370 dbSNP
rs544260108 3385 dbSNP
rs1040890817 3394 dbSNP
rs939874969 3396 dbSNP
rs1214534346 3404 dbSNP
rs1252522673 3413 dbSNP
rs901447161 3422 dbSNP
rs886946813 3429 dbSNP
rs1374076375 3446 dbSNP
rs1475303599 3450 dbSNP
rs181929187 3453 dbSNP
rs76061127 3459 dbSNP
rs915537199 3465 dbSNP
rs888753831 3471 dbSNP
rs540326292 3474 dbSNP
rs7074766 3475 dbSNP
rs928931596 3478 dbSNP
rs1404027356 3479 dbSNP
rs977648666 3480 dbSNP
rs967485142 3482 dbSNP
rs1294958495 3486 dbSNP
rs558348277 3495 dbSNP
rs1234199766 3497 dbSNP
rs990616970 3510 dbSNP
rs774963134 3520 dbSNP
rs1029395213 3523 dbSNP
rs918995988 3525 dbSNP
rs1263081445 3526 dbSNP
rs189865411 3531 dbSNP
rs1321591231 3534 dbSNP
rs184965095 3539 dbSNP
rs1019500934 3549 dbSNP
rs927903243 3551 dbSNP
rs1004137762 3564 dbSNP
rs1163779572 3570 dbSNP
rs980677408 3572 dbSNP
rs1228685760 3575 dbSNP
rs1454925730 3579 dbSNP
rs1158685621 3584 dbSNP
rs1480255154 3586 dbSNP
rs1430215345 3593 dbSNP
rs1314636737 3595 dbSNP
rs1355864236 3595 dbSNP
rs1201212249 3612 dbSNP
rs772274228 3615 dbSNP
rs1413882682 3616 dbSNP
rs556925577 3624 dbSNP
rs969794656 3627 dbSNP
rs886911316 3634 dbSNP
rs778750482 3641 dbSNP
rs140564993 3642 dbSNP
rs200847373 3642 dbSNP
rs1205655326 3654 dbSNP
rs774847077 3662 dbSNP
rs1260755579 3663 dbSNP
rs774282806 3667 dbSNP
rs74531682 3674 dbSNP
rs1187628968 3675 dbSNP
rs1255807561 3683 dbSNP
rs1323562076 3686 dbSNP
rs1420551662 3705 dbSNP
rs149126000 3705 dbSNP
rs989540195 3708 dbSNP
rs894261663 3712 dbSNP
rs1468101463 3716 dbSNP
rs956817811 3717 dbSNP
rs1224705910 3718 dbSNP
rs1433904375 3721 dbSNP
rs570917261 3723 dbSNP
rs1393417247 3724 dbSNP
rs938313827 3733 dbSNP
rs80334034 3734 dbSNP
rs1335260089 3736 dbSNP
rs1436551664 3736 dbSNP
rs1237988343 3737 dbSNP
rs3814698 3737 dbSNP
rs1349283282 3739 dbSNP
rs1210767037 3743 dbSNP
rs1018951120 3744 dbSNP
rs1007103897 3758 dbSNP
rs888791968 3779 dbSNP
rs769715686 3782 dbSNP
rs1249317482 3786 dbSNP
rs946339546 3789 dbSNP
rs1194921887 3792 dbSNP
rs1395131630 3805 dbSNP
rs535134934 3805 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000446830.2 | 3UTR | UAUAAGAGAACGAUGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000446830.2 | 3UTR | UAUAAGAGAACGAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000446830.2 | 3UTR | UAUAAGAGAACGAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000446830.2 | 3UTR | UAUAAGAGAACGAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000446830.2 | 3UTR | UAUAAGAGAACGAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
50 hsa-miR-2117 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080059 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT253245 ZNF264 zinc finger protein 264 2 4
MIRT279706 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT359344 TMEM167A transmembrane protein 167A 2 2
MIRT465598 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT479860 CCDC6 coiled-coil domain containing 6 2 2
MIRT512413 KIAA0391 KIAA0391 2 2
MIRT525342 TUBGCP4 tubulin gamma complex associated protein 4 2 2
MIRT528092 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT529254 TRIM4 tripartite motif containing 4 2 4
MIRT550782 VAV3 vav guanine nucleotide exchange factor 3 2 2
MIRT554467 SAMD12 sterile alpha motif domain containing 12 2 2
MIRT560164 ZNF286A zinc finger protein 286A 2 2
MIRT562613 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT568507 ARF1 ADP ribosylation factor 1 2 2
MIRT571536 ZNF286B zinc finger protein 286B 2 2
MIRT609660 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT612022 PAK6 p21 (RAC1) activated kinase 6 2 8
MIRT615677 NAV2 neuron navigator 2 2 2
MIRT616035 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT617771 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT628757 MX2 MX dynamin like GTPase 2 2 4
MIRT635089 AKIRIN1 akirin 1 2 2
MIRT638261 SIX1 SIX homeobox 1 2 2
MIRT638492 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT639400 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT641791 USP32 ubiquitin specific peptidase 32 2 2
MIRT642309 FPR1 formyl peptide receptor 1 2 2
MIRT645902 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT649701 ZNF175 zinc finger protein 175 2 2
MIRT656848 KLF13 Kruppel like factor 13 2 2
MIRT659911 CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 2 2
MIRT667275 NAV1 neuron navigator 1 2 2
MIRT674145 ZNF793 zinc finger protein 793 2 2
MIRT692839 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT698520 TFRC transferrin receptor 2 2
MIRT698731 STX6 syntaxin 6 2 4
MIRT700931 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT706080 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT710008 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT711059 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711285 PSME3 proteasome activator subunit 3 2 2
MIRT716172 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT716761 TRABD2A TraB domain containing 2A 2 2
MIRT718683 FZD2 frizzled class receptor 2 2 2
MIRT719675 SPDYE1 speedy/RINGO cell cycle regulator family member E1 2 2
MIRT721610 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT722188 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT725156 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT725239 PDE1B phosphodiesterase 1B 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-2117 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miR-2117 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-2117 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2117 Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-2117 Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-2117 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-2117 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-2117 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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