pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SSX5   
Synonyms -
Description SSX family member 5
Transcript NM_021015   
Other Transcripts NM_175723   
Expression
Putative miRNA Targets on SSX5
3'UTR of SSX5
(miRNA target sites are highlighted)
>SSX5|NM_021015|3'UTR
   1 CTCCCCTCGGGGATATGACACATGCCCATGATGAGAAGCAGAACGTGGTGACCTTTCACGAACATGGGCATGGCTGCGGA
  81 TCCCTCGTCATCAGGTGTATAGCAAGTGAAAGCAAGTGTTCACAACAGTGAAAAGTTGAGCGTCATTTTTCTTAGTGTGC
 161 CAAGAGTTCGATGTTAGTGTTTCTGTTGTATTTTGTTACAGTGTGCCATTCTGTTAGATATTAGCGTTTTCACTGATGAG
 241 CAAGACATACTTAATGCATATTTCAGTTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATCGTCAGGTATTCTCTGC
 321 ATAGAACAACACTACCCTCCTCTCTTCCCAGATGTGACCACTGAGGGCAGTTCTGAGTGTTTAATTTCAGATTTTTTCCT
 401 CTGCATTTACACAAACACACACACATGCCACACAGACACACATGCGCGCGCGCGCGCACACACACACACACACACACACA
 481 CACACACACACACACCAAGTACCAGTATAGGCATCTCCCAACTGCTTTTCCCCATGTGTCCTGGTCAAGCCCCCCTCACT
 561 CTGTTTCCTGTTCAGCATGTACTCCCCTCATCCGATTCCCCTCTATCAGTCACTGCCAGTTAATAAACCTTTGCAAACGT
 641 TAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggucGAUUGUUAUGUGACGGa 5'
               ||| ||:| ||||||| 
Target 5' cccctCTATCAGT-CACTGCCa 3'
598 - 618 160.00 -18.70
2
miRNA  3' cgGUCGAUUGU-UAUGUG-ACGGa 5'
            || | |||| | |||| |||| 
Target 5' taCA-CAAACACACACACATGCCa 3'
408 - 430 131.00 -10.20
3
miRNA  3' cgGUCG-AUUGUUAUGUGACGGa 5'
            | || ||: |  ||||| || 
Target 5' ctCTGCATAGAACAACACTACCc 3'
315 - 337 124.00 -9.70
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs781842474 3 dbSNP
rs375263417 4 dbSNP
rs782532019 5 dbSNP
rs1389632814 10 dbSNP
rs782090375 15 dbSNP
rs782793210 16 dbSNP
rs782008100 18 dbSNP
rs1310662884 19 dbSNP
rs1246901872 20 dbSNP
rs781917277 21 dbSNP
rs782383729 22 dbSNP
rs782073938 24 dbSNP
rs56888577 25 dbSNP
rs782302311 27 dbSNP
rs782024248 28 dbSNP
rs782634789 29 dbSNP
rs1269671244 37 dbSNP
rs782331532 41 dbSNP
rs1465064366 44 dbSNP
rs782614168 47 dbSNP
rs782483642 50 dbSNP
rs1443577169 59 dbSNP
rs1188892381 61 dbSNP
rs1411813115 63 dbSNP
rs782272653 65 dbSNP
rs1471844933 72 dbSNP
rs1161791300 83 dbSNP
rs1413068118 86 dbSNP
rs1465724202 140 dbSNP
rs782588070 141 dbSNP
rs1404477234 144 dbSNP
rs1396627288 153 dbSNP
rs782124096 154 dbSNP
rs375983586 156 dbSNP
rs1349762127 158 dbSNP
rs782096126 158 dbSNP
rs782302531 159 dbSNP
rs1232083672 161 dbSNP
rs1253843876 163 dbSNP
rs868915346 164 dbSNP
rs1346536258 167 dbSNP
rs200731189 167 dbSNP
rs1251782732 181 dbSNP
rs1482359706 190 dbSNP
rs1184863950 192 dbSNP
rs1253009738 194 dbSNP
rs782222865 198 dbSNP
rs1432921873 199 dbSNP
rs781976388 206 dbSNP
rs1379564102 219 dbSNP
rs1466649934 222 dbSNP
rs1168031116 223 dbSNP
rs1369934936 235 dbSNP
rs1407936010 240 dbSNP
rs1309703223 246 dbSNP
rs191453308 247 dbSNP
rs1385965754 254 dbSNP
rs782518885 255 dbSNP
rs1313560580 256 dbSNP
rs1234473448 258 dbSNP
rs1273272927 263 dbSNP
rs1339377634 269 dbSNP
rs1207954945 271 dbSNP
rs1252351284 273 dbSNP
rs1488385762 284 dbSNP
rs1189810149 285 dbSNP
rs1269818397 288 dbSNP
rs782247783 290 dbSNP
rs1188101734 291 dbSNP
rs1388405273 292 dbSNP
rs1431663402 300 dbSNP
rs1355017745 302 dbSNP
rs1457255564 304 dbSNP
rs782682373 306 dbSNP
rs1369360624 307 dbSNP
rs782415281 311 dbSNP
rs1296338689 313 dbSNP
rs1362423745 315 dbSNP
rs1229942514 317 dbSNP
rs1296967121 329 dbSNP
rs1321636144 329 dbSNP
rs782537500 341 dbSNP
rs1219898447 356 dbSNP
rs1469132814 357 dbSNP
rs781808587 360 dbSNP
rs782709089 363 dbSNP
rs782482681 380 dbSNP
rs782272639 394 dbSNP
rs1420224597 401 dbSNP
rs4535865 402 dbSNP
rs782785994 403 dbSNP
rs1351413418 406 dbSNP
rs782124626 408 dbSNP
rs1461722206 410 dbSNP
rs782042733 411 dbSNP
rs188061972 421 dbSNP
rs1270255955 437 dbSNP
rs531166291 438 dbSNP
rs1227110145 449 dbSNP
rs182967376 450 dbSNP
rs140000904 453 dbSNP
rs1228144275 456 dbSNP
rs1266518208 457 dbSNP
rs1466421089 464 dbSNP
rs1216665928 468 dbSNP
rs782313714 470 dbSNP
rs1482281702 471 dbSNP
rs1180080806 481 dbSNP
rs560040083 485 dbSNP
rs111859329 492 dbSNP
rs111366620 499 dbSNP
rs1409381529 510 dbSNP
rs1402097206 518 dbSNP
rs1318493566 521 dbSNP
rs1358095295 528 dbSNP
rs1445121922 532 dbSNP
rs1305151939 533 dbSNP
rs563802614 534 dbSNP
rs1356634410 536 dbSNP
rs1409660856 537 dbSNP
rs192984405 543 dbSNP
rs1224552406 548 dbSNP
rs1278118592 552 dbSNP
rs1310563191 553 dbSNP
rs1212313177 556 dbSNP
rs1259606138 562 dbSNP
rs1485957249 565 dbSNP
rs1181282170 566 dbSNP
rs369750595 580 dbSNP
rs146156383 581 dbSNP
rs782234652 583 dbSNP
rs1423991679 584 dbSNP
rs1412307436 586 dbSNP
rs1174958664 590 dbSNP
rs1376663666 596 dbSNP
rs1409751568 604 dbSNP
rs1306653363 610 dbSNP
rs782253395 612 dbSNP
rs781982565 615 dbSNP
rs1274540224 617 dbSNP
rs1365743911 618 dbSNP
rs782422107 623 dbSNP
rs1221083272 625 dbSNP
rs1341478207 631 dbSNP
rs1204378124 632 dbSNP
rs143052306 638 dbSNP
rs12842603 639 dbSNP
rs782441246 646 dbSNP
rs1195036821 647 dbSNP
rs782229190 648 dbSNP
rs782598110 652 dbSNP
rs1167294926 655 dbSNP
rs782536011 662 dbSNP
rs781855212 664 dbSNP
rs1410940409 677 dbSNP
rs1323310666 683 dbSNP
rs1348435357 685 dbSNP
rs1443400234 687 dbSNP
rs188295993 689 dbSNP
rs1364587730 691 dbSNP
rs782817918 692 dbSNP
rs1295379306 697 dbSNP
rs782446566 698 dbSNP
rs781783194 702 dbSNP
rs1196227431 704 dbSNP
rs562336569 711 dbSNP
rs144774349 718 dbSNP
rs782686321 723 dbSNP
rs182964550 725 dbSNP
rs1215197721 730 dbSNP
rs58213034 736 dbSNP
rs186298043 740 dbSNP
rs1253193554 750 dbSNP
rs781811484 754 dbSNP
rs149280282 761 dbSNP
rs1163129432 762 dbSNP
rs1389054449 772 dbSNP
rs782744115 778 dbSNP
rs138476997 779 dbSNP
rs1433062015 792 dbSNP
rs1327029255 796 dbSNP
rs1228078607 798 dbSNP
rs1283473989 802 dbSNP
rs1332450589 814 dbSNP
rs782329246 815 dbSNP
rs782185119 817 dbSNP
rs7061112 820 dbSNP
rs782347787 828 dbSNP
rs1263240414 829 dbSNP
rs368441649 832 dbSNP
rs782263239 834 dbSNP
rs782025102 838 dbSNP
rs782649208 840 dbSNP
rs1367204163 847 dbSNP
rs1476419491 848 dbSNP
rs782422858 851 dbSNP
rs1411591270 852 dbSNP
rs1455846804 854 dbSNP
rs782282175 857 dbSNP
rs1395482240 864 dbSNP
rs782560962 868 dbSNP
rs1353455851 879 dbSNP
rs1416464609 880 dbSNP
rs1328161856 887 dbSNP
rs183443247 892 dbSNP
rs781820270 895 dbSNP
rs1236460917 896 dbSNP
rs1262085132 898 dbSNP
rs782751800 900 dbSNP
rs1199366989 905 dbSNP
rs782247681 907 dbSNP
rs1486937348 911 dbSNP
rs1189186037 912 dbSNP
rs1251560333 915 dbSNP
rs1471785435 930 dbSNP
rs1161591397 934 dbSNP
rs1364565358 935 dbSNP
rs1465647141 938 dbSNP
rs143419961 939 dbSNP
rs1377288204 940 dbSNP
rs1436522185 943 dbSNP
rs544342481 956 dbSNP
rs1313363609 958 dbSNP
rs137861486 963 dbSNP
rs1389433249 965 dbSNP
rs1308759737 968 dbSNP
rs1335969967 976 dbSNP
rs1231975479 983 dbSNP
rs1277577763 988 dbSNP
rs1349340815 989 dbSNP
rs1212251764 991 dbSNP
rs1274496535 994 dbSNP
rs781899809 996 dbSNP
rs1251582504 1003 dbSNP
rs1432828470 1007 dbSNP
rs190741790 1008 dbSNP
rs186217702 1009 dbSNP
rs781792583 1019 dbSNP
rs1174229469 1022 dbSNP
rs1369852783 1026 dbSNP
rs181195768 1034 dbSNP
rs2314191 1035 dbSNP
rs782007552 1037 dbSNP
rs1300740104 1045 dbSNP
rs1372576755 1050 dbSNP
rs782373446 1058 dbSNP
rs1297570368 1067 dbSNP
rs782167292 1072 dbSNP
rs369285320 1074 dbSNP
rs73495262 1075 dbSNP
rs1255090323 1077 dbSNP
rs1469003881 1079 dbSNP
rs1187990394 1084 dbSNP
rs1418798161 1086 dbSNP
rs151205458 1089 dbSNP
rs782708691 1097 dbSNP
rs143141338 1099 dbSNP
rs1373453038 1100 dbSNP
rs1457182362 1102 dbSNP
rs189924597 1103 dbSNP
rs1396192051 1105 dbSNP
rs1441075702 1109 dbSNP
rs1319295021 1110 dbSNP
rs1359187017 1114 dbSNP
rs781972255 1116 dbSNP
rs782348818 1117 dbSNP
rs1296874735 1129 dbSNP
rs1321539987 1131 dbSNP
rs1231819392 1142 dbSNP
rs1275350630 1145 dbSNP
rs868984684 1150 dbSNP
rs1469072529 1153 dbSNP
rs185950141 1160 dbSNP
rs1208272835 1162 dbSNP
rs782242863 1169 dbSNP
rs1240442279 1184 dbSNP
rs1486861275 1185 dbSNP
rs1188238925 1188 dbSNP
rs1262304593 1188 dbSNP
rs1474784702 1192 dbSNP
rs1162508749 1195 dbSNP
rs782414187 1197 dbSNP
rs1461655660 1209 dbSNP
rs1342959526 1211 dbSNP
rs1432253717 1213 dbSNP
rs1290021372 1214 dbSNP
rs1379066864 1215 dbSNP
rs1413395031 1216 dbSNP
rs1295505929 1217 dbSNP
rs1335836521 1217 dbSNP
rs1228038606 1218 dbSNP
rs1282372097 1219 dbSNP
rs782681390 1219 dbSNP
rs782527836 1220 dbSNP
rs1485299481 1221 dbSNP
rs181620064 1221 dbSNP
rs1259387468 1222 dbSNP
rs1475392413 1222 dbSNP
rs1176311019 1223 dbSNP
rs1405321992 1223 dbSNP
rs201287901 1224 dbSNP
rs782559946 1225 dbSNP
rs200246810 1226 dbSNP
rs1433418175 1227 dbSNP
rs1315296517 1228 dbSNP
rs1327257757 1228 dbSNP
rs1356536166 1228 dbSNP
rs1409567106 1228 dbSNP
rs7058018 1228 dbSNP
rs1443218811 1229 dbSNP
rs1274448183 1230 dbSNP
rs1368926035 1230 dbSNP
rs1491394702 1230 dbSNP
rs184913384 1230 dbSNP
rs112821791 1231 dbSNP
rs1204813955 1232 dbSNP
rs1251952319 1232 dbSNP
rs1270641758 1232 dbSNP
rs797038372 1232 dbSNP
rs868930186 1232 dbSNP
rs1194943633 1233 dbSNP
rs1166602054 1234 dbSNP
rs1396277322 1234 dbSNP
rs1422137020 1234 dbSNP
rs1475374612 1234 dbSNP
rs1325544663 1236 dbSNP
rs1392543389 1236 dbSNP
rs1410852358 1236 dbSNP
rs1443286255 1239 dbSNP
rs1325872718 1240 dbSNP
rs1226634279 1241 dbSNP
rs1268304400 1244 dbSNP
rs1341255718 1246 dbSNP
rs782263573 1247 dbSNP
rs1214917702 1248 dbSNP
rs868958416 1250 dbSNP
rs782122288 1252 dbSNP
rs1215098413 1254 dbSNP
rs1253095582 1256 dbSNP
rs1445865887 1260 dbSNP
rs1191720909 1262 dbSNP
rs202051434 1264 dbSNP
rs1475981492 1265 dbSNP
rs1164660799 1266 dbSNP
rs1165867959 1266 dbSNP
rs1349394725 1266 dbSNP
rs1380571503 1266 dbSNP
rs1384390391 1266 dbSNP
rs1400454886 1266 dbSNP
rs1416059400 1266 dbSNP
rs1463224859 1266 dbSNP
rs61004107 1266 dbSNP
rs61128307 1266 dbSNP
rs782339874 1266 dbSNP
rs782484849 1266 dbSNP
rs782637459 1266 dbSNP
rs879969567 1266 dbSNP
rs879980526 1266 dbSNP
rs1287041433 1267 dbSNP
rs1444205955 1267 dbSNP
rs1448087702 1269 dbSNP
rs1187786451 1271 dbSNP
rs1255877580 1275 dbSNP
rs868982771 1278 dbSNP
rs192670316 1280 dbSNP
rs868944108 1282 dbSNP
rs1363414802 1287 dbSNP
rs1451792376 1288 dbSNP
rs868977676 1291 dbSNP
rs868968963 1301 dbSNP
rs1420242112 1302 dbSNP
rs34679909 1304 dbSNP
rs1312145199 1305 dbSNP
rs782813305 1307 dbSNP
rs782071781 1308 dbSNP
rs1334803602 1320 dbSNP
rs1236354119 1321 dbSNP
rs1280798958 1324 dbSNP
rs1353739340 1341 dbSNP
rs1210838500 1360 dbSNP
rs189119250 1363 dbSNP
rs1486885086 1364 dbSNP
rs1212024331 1369 dbSNP
rs184600484 1373 dbSNP
rs371652142 1386 dbSNP
rs1184172861 1394 dbSNP
rs1364477546 1396 dbSNP
rs1453826179 1401 dbSNP
rs1172974859 1408 dbSNP
rs1436430848 1409 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cggucgAUUGUUAUGUGACGGa 5'
                || ||:| ||||||| 
Target 5' ------UAUCAGU-CACUGCCa 3'
1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000376923.1 | 3UTR | UAUCAGUCACUGCCAGUUAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.728 2.4e-3 0.527 3.2e-2 13 Click to see details
GSE19783 ER- ER- breast cancer 0.21 3.2e-2 0.283 5.7e-3 79 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.578 6.7e-2 -0.548 8.0e-2 8 Click to see details
GSE28544 Breast cancer -0.268 1.0e-1 -0.217 1.5e-1 24 Click to see details
GSE21687 Ependynoma primary tumors -0.157 1.1e-1 -0.152 1.2e-1 64 Click to see details
GSE19350 CNS germ cell tumors 0.364 1.2e-1 0.357 1.3e-1 12 Click to see details
GSE26953 Aortic valvular endothelial cells -0.239 1.3e-1 -0.163 2.2e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.187 1.9e-1 -0.045 4.2e-1 25 Click to see details
GSE21849 B cell lymphoma 0.166 1.9e-1 0.282 6.9e-2 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.171 2.1e-1 0.278 8.9e-2 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.183 2.2e-1 0.299 1.0e-1 20 Click to see details
GSE14794 Lymphoblastoid cells -0.079 2.3e-1 -0.012 4.6e-1 90 Click to see details
GSE19536 Breast cancer -0.068 2.5e-1 -0.053 3.0e-1 100 Click to see details
GSE19783 ER+ ER+ breast cancer -0.119 3.1e-1 -0.161 2.5e-1 20 Click to see details
GSE17306 Multiple myeloma -0.06 3.4e-1 0.064 3.3e-1 49 Click to see details
GSE32688 Pancreatic cancer -0.064 3.6e-1 -0.022 4.5e-1 32 Click to see details
GSE38226 Liver fibrosis -0.073 3.8e-1 0.018 4.7e-1 21 Click to see details
GSE27834 Pluripotent stem cells 0.062 4.1e-1 -0.050 4.3e-1 16 Click to see details
GSE42095 Differentiated embryonic stem cells -0.04 4.3e-1 -0.022 4.6e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.945 0.03 -0.800 0.1 4 Click to see details
LUSC -0.826 0.09 -1.000 0.5 4 Click to see details
THCA 0.921 0.13 0.500 0.33 3 Click to see details
UCEC -0.215 0.3 0.042 0.46 8 Click to see details
UCEC -0.215 0.3 0.042 0.46 8 Click to see details
UCEC -0.215 0.3 0.042 0.46 8 Click to see details
UCEC -0.215 0.3 0.042 0.46 8 Click to see details
UCEC -0.215 0.3 0.042 0.46 8 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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