miRTarBase - #MIRT610432


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pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ASAH2B   
Synonyms ASAH2C, ASAH2L, bA449O16.3, bA98I6.3
Description N-acylsphingosine amidohydrolase 2B
Transcript NM_001079516   
Expression
Putative miRNA Targets on ASAH2B
3'UTR of ASAH2B
(miRNA target sites are highlighted)		 
>ASAH2B|NM_001079516|3'UTR
   1 TGAAAAGTTGATAGATCATTTAAAGAACAGCTTTACTCTCTACACATTATATAAGTGATTTCAAATGAATGTGAACTAGT
  81 GAACTACCATGTTGACTTCTATAATCGTCCCTGTTTGGGGACAGATAGTTTACTGCTAATGGGGTGGAGGGGTGTGTGTG
 161 TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGAGAGAGAGAGAGAGAGAGAGGTTTGTCCCATATATC
 241 TTGTTCCAGCAGCCATATATCTTGTGGTCTACAGCCTAAAGCATGATTTCCCTTGAAGTCTTGGGGTTGTTTAAAGGAGA
 321 GTCCCTTCAATATAAAACCTCTGAAATATTAGTGAGAATGGCTCACTAATGTGAACAATGTTTAAATTATTTATTTATAT
 401 ATAGAATTACTGAATATTAGTACTGGGAAAATTTATAGAAATCATCTAGTCTTACCCTTCATCTTACATATAAGAAAAAT
 481 GGTCTTTTCTTCTAATCACATTTACAAAATATGATATAAACCTTGACCATGAATGTATGAGCCTAATTAGAGAAACAGAA
 561 AATCAGCATGTCAGTTTTCCTTCATTCAAAATAACATAGTCTTTCTAAGCAGTCATTCTGGAGTTAACATGCCTAGTTCA
 641 GAGCCGCTGTGGATGCTCAAATCATTTCTGGAATTGCCTTCAGGACACAATTATGAGAAAGTCAGACTTCCAATATTTTG
 721 ATCATGCCTTGTGTCTTCCTAAGTGTCCTTATCCCACTGGATTGTGTCTCTTACTCCCAAGACTTATTCCAAATGATTTT
 801 TTGACTCTTTTCATTAATCAAATTCACCCCAAACCAGAAAGTTTTGCCATTAGCGTAGATATTAAAAATATTACTGGCTG
 881 GGAAAGCACTCCTCAAAGCAGAGGTTCTAAATTAATTTATCTGTTCTTTTACCATTTGCTCACTCACTCACTCATGGACC
 961 CATTCAATCATAGAATATTTAAGATTTATATGCCCAGAATTATAATAGTGCCTAGGCCTTGATAATTAGTGAATTTGTAC
1041 TTGGGGTGAATGTGTAAGTGTCAAAAGGTAACTATTATGAAGGAGAAAATAATCGATTTAATATGTAAATTCTGGGGAGG
1121 CATTTAAAAAATCAGTAATCTTCAAGTTATATCTTGTGTATCATCTGTGTTGGATACTCTAATTTGGGGGGAAAGAGGCT
1201 CCAGACAGTTTGCTAAATACTATTTTGAAAGTTATTTTTGGGCATTGTAAAATACCTTGCTTCATACCCCAAAGAATAAG
1281 ATATGACAATCTGACATCGATTGTCTGAAAGTACTAATTGCATTTAAAATTCTTTAAGTTAACTACAACCTCCCAGACTG
1361 CAAAGCAAATTTCCAAACCCCAGGTCATACTTTTGTATGTATGTAAAAGCTTTAGCATTTTAGGGAAAAAAATCAATCTG
1441 TATTTCAAAAATAAACTTTGAGGTTTGAAAATAATAACAATATTCATAATGGTAGTATTAACATCTATTATGTATAACTT
1521 AATCTCAACATAATTTATTGAATTAGAATGAACCTGGAACACTTTTTGATGAATTGGTATCCTAGAGGCTGTTTCCTTGG
1601 GCCTTAACTGCTGGAGGATTAGGTAATCAGGGATTCCAAGTGTTGTGATCTTTTTTCTGATGACGCCACAGTCTTCAGTG
1681 TAAAAGTTCAGAAGCCTAAAAGAACAAGTGATCCTGAAAGTAGCTGATTCCAGACAAGAAAATTATATTAGAACTCATGA
1761 TATGGTTTTTTAAAGTATTTGTTATTACTCAGAAGGGTTCATGAATCAGTTTCCACTACCTCTATTCCTTCTATTGAAGC
1841 TTTCCTCAAATCTACTTGTGATTCCTGATAGCTCACTGGCAACTGTACCAAGGTGGCCACTGTATCATCTACTGATCCTT
1921 CTGCACCTAGCACTCTTGGCTCCAGATAACGCACAGAAACCTATTTTCTCACCAGCTGTCATTTCTTCTAGGGCATGCAG
2001 TTCTATGTTCACAGTTCATGTGTAAAAATAAAACCAAATTCCTGGATTATCAATATCAGTTCTTTACCTGTGCATAAAAG
2081 AATATCATGAAGTAATTGAACTTATCTGTTGATATAAAAACACAGATCCAATTCGTGTCTGTGGATGCTGCAAGGACTGG
2161 CTCACTGGAGCCAAACCATGTGGCGGAAACTCCTGAAATTGGTGGAAAAAGTGGAATATGGCAGATTGGGTAGGTAGGAG
2241 AACAATTTTGGAGATTTTGTTTCTCATGTTAAAGTGTCTGCATTTTATTTGCTGTACCCTGCCTACTCTGGTTTTAAGGA
2321 TTTTTTGACTTCTTCGAAAAGCACTGAATAATCTCTTTGCCGGGTCTAGATTTTTTGATGAGTACTGTGTAAAATTGTCA
2401 ATATTCAATGGATTATTTAATAATAAATTAAGAATTACACTCATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauaCCCACCCUGUCUCUCCc 5'
              | | | || ||||||| 
Target 5' gagaGAGAGAGAGAGAGAGGt 3'
 206 - 226 153.00 -13.60
2 
miRNA  3' gauacccACCCUGUCUCUCCc 5'
                 ||||:::|||:|| 
Target 5' ctgctaaTGGGGTGGAGGGGt 3'
 133 - 153 130.00 -20.00
3 
miRNA  3' gauACCCACCCUGUCUCUCCc 5'
             |||| |||  | ||||| 
Target 5' attTGGG-GGG--AAAGAGGc 3'
 1182 - 1199 125.00 -18.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28579798 197 COSMIC
COSN28734318 201 COSMIC
COSN8640301 204 COSMIC
COSN31870666 224 COSMIC
COSN31871231 225 COSMIC
COSN20340891 279 COSMIC
COSN17452849 504 COSMIC
COSN17964000 625 COSMIC
COSN28526328 743 COSMIC
COSN27700338 1057 COSMIC
COSN28514578 1131 COSMIC
COSN20397405 1457 COSMIC
COSN17221453 1954 COSMIC
COSN17086668 2030 COSMIC
COSN19595393 2145 COSMIC
COSN6972764 2145 COSMIC
COSN26496954 2441 COSMIC
COSN27812459 2672 COSMIC
COSN17446400 2738 COSMIC
COSN6478844 3395 COSMIC
COSN6478845 3908 COSMIC
COSN21110844 4081 COSMIC
COSN19282724 4404 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1206868709 4 dbSNP
rs1410760760 6 dbSNP
rs917428223 7 dbSNP
rs1252000376 8 dbSNP
rs1481485700 9 dbSNP
rs1269446055 16 dbSNP
rs779042145 17 dbSNP
rs1198637100 18 dbSNP
rs557273123 30 dbSNP
rs1179367807 50 dbSNP
rs1276525436 51 dbSNP
rs1467988823 58 dbSNP
rs1306556108 68 dbSNP
rs1191135793 108 dbSNP
rs1220433338 111 dbSNP
rs1323654690 112 dbSNP
rs1396427913 121 dbSNP
rs949122682 132 dbSNP
rs1404886740 133 dbSNP
rs1478143385 138 dbSNP
rs1157677444 140 dbSNP
rs1405385848 144 dbSNP
rs1402752280 149 dbSNP
rs1168628197 152 dbSNP
rs1211841484 152 dbSNP
rs1221219493 152 dbSNP
rs1230770854 152 dbSNP
rs1261984769 152 dbSNP
rs1296596982 152 dbSNP
rs1323542137 152 dbSNP
rs1336156973 152 dbSNP
rs1344584147 152 dbSNP
rs1373092070 152 dbSNP
rs1407187196 152 dbSNP
rs1454792142 152 dbSNP
rs1480216040 152 dbSNP
rs201403156 152 dbSNP
rs61180777 152 dbSNP
rs754624545 152 dbSNP
rs1160387084 154 dbSNP
rs1394308055 155 dbSNP
rs1439429675 156 dbSNP
rs1327993737 158 dbSNP
rs1456014093 158 dbSNP
rs1371883349 159 dbSNP
rs1292761889 160 dbSNP
rs1277960870 161 dbSNP
rs1385367766 162 dbSNP
rs1418249355 163 dbSNP
rs1383903846 164 dbSNP
rs1353131736 165 dbSNP
rs1296257496 166 dbSNP
rs1268530007 167 dbSNP
rs1334063891 168 dbSNP
rs1338611456 170 dbSNP
rs1461482695 173 dbSNP
rs1242226995 175 dbSNP
rs1254307563 176 dbSNP
rs1451638561 177 dbSNP
rs1180498376 179 dbSNP
rs1230763309 181 dbSNP
rs1316638839 183 dbSNP
rs1436208036 183 dbSNP
rs1248679524 185 dbSNP
rs1470963547 185 dbSNP
rs1314699578 186 dbSNP
rs1383794000 186 dbSNP
rs1387237236 187 dbSNP
rs1450466680 187 dbSNP
rs1165201451 188 dbSNP
rs1289333128 188 dbSNP
rs1343409888 188 dbSNP
rs1452989635 188 dbSNP
rs1384162549 189 dbSNP
rs1445081944 189 dbSNP
rs747683751 189 dbSNP
rs1160367436 190 dbSNP
rs1181378052 191 dbSNP
rs1390952328 191 dbSNP
rs1429735522 191 dbSNP
rs1204090545 193 dbSNP
rs1261850042 193 dbSNP
rs1417671212 193 dbSNP
rs1485810316 193 dbSNP
rs1029860448 194 dbSNP
rs1225167641 194 dbSNP
rs1284593492 194 dbSNP
rs1360634016 194 dbSNP
rs1328223427 195 dbSNP
rs574003933 195 dbSNP
rs1296356536 196 dbSNP
rs1293924980 197 dbSNP
rs1460321398 197 dbSNP
rs1304936651 198 dbSNP
rs1438730421 199 dbSNP
rs866705507 199 dbSNP
rs536502238 200 dbSNP
rs1202232366 202 dbSNP
rs1215056619 202 dbSNP
rs1261583639 202 dbSNP
rs868590870 202 dbSNP
rs879237401 202 dbSNP
rs1490603826 203 dbSNP
rs1491091974 203 dbSNP
rs878887691 204 dbSNP
rs1409396831 205 dbSNP
rs1326946598 206 dbSNP
rs1337688460 208 dbSNP
rs1410739458 212 dbSNP
rs1341693909 224 dbSNP
rs1288731803 225 dbSNP
rs1226761707 227 dbSNP
rs554958650 235 dbSNP
rs1231263296 239 dbSNP
rs1405510536 241 dbSNP
rs571691847 244 dbSNP
rs2495522 245 dbSNP
rs1392990029 268 dbSNP
rs1396754295 276 dbSNP
rs74638595 279 dbSNP
rs1270358385 283 dbSNP
rs926259128 295 dbSNP
rs1179147616 304 dbSNP
rs577807891 305 dbSNP
rs1439185310 307 dbSNP
rs1182515899 319 dbSNP
rs1481036240 357 dbSNP
rs1257222354 363 dbSNP
rs937662455 368 dbSNP
rs1197190742 377 dbSNP
rs1474405927 400 dbSNP
rs1195481322 403 dbSNP
rs1456465219 405 dbSNP
rs1224248994 421 dbSNP
rs1190535989 424 dbSNP
rs1273065285 428 dbSNP
rs1037361441 434 dbSNP
rs1336132778 446 dbSNP
rs1327719436 447 dbSNP
rs1444151293 457 dbSNP
rs1407904703 458 dbSNP
rs1336777155 475 dbSNP
rs899081716 480 dbSNP
rs1429179293 485 dbSNP
rs1171347127 488 dbSNP
rs1471340941 497 dbSNP
rs1364764419 500 dbSNP
rs201952244 504 dbSNP
rs1438032439 512 dbSNP
rs1245273384 513 dbSNP
rs1204373388 516 dbSNP
rs1460939446 518 dbSNP
rs1276338192 523 dbSNP
rs1475374751 526 dbSNP
rs1351067031 527 dbSNP
rs1278713514 530 dbSNP
rs1166225562 533 dbSNP
rs1384534154 538 dbSNP
rs1315374180 558 dbSNP
rs1451201490 560 dbSNP
rs1356930281 567 dbSNP
rs1332722627 568 dbSNP
rs1402934394 580 dbSNP
rs1386365586 581 dbSNP
rs1398801127 584 dbSNP
rs1418320277 586 dbSNP
rs1387252566 594 dbSNP
rs1184447343 602 dbSNP
rs929265834 607 dbSNP
rs1430618047 610 dbSNP
rs1235828661 612 dbSNP
rs1047978688 613 dbSNP
rs1312538639 616 dbSNP
rs1447479440 624 dbSNP
rs1373895096 625 dbSNP
rs890301200 642 dbSNP
rs1314617269 646 dbSNP
rs1291962990 647 dbSNP
rs1340993165 650 dbSNP
rs1226679597 657 dbSNP
rs1267875853 672 dbSNP
rs1009365170 677 dbSNP
rs1039135939 678 dbSNP
rs1340918068 684 dbSNP
rs1298137840 691 dbSNP
rs1418182600 695 dbSNP
rs1367884902 700 dbSNP
rs1164397083 712 dbSNP
rs1404963347 723 dbSNP
rs1411946286 724 dbSNP
rs1205289241 729 dbSNP
rs1279101832 732 dbSNP
rs1475814488 734 dbSNP
rs2813180 736 dbSNP
rs543259828 743 dbSNP
rs1257381854 744 dbSNP
rs1319551928 763 dbSNP
rs1274752736 770 dbSNP
rs900612124 774 dbSNP
rs1214588805 775 dbSNP
rs1000184813 778 dbSNP
rs1338187711 782 dbSNP
rs1278079741 784 dbSNP
rs1398718208 793 dbSNP
rs199894488 796 dbSNP
rs1191726387 797 dbSNP
rs956272069 797 dbSNP
rs1348343842 806 dbSNP
rs1374832993 813 dbSNP
rs1450112448 819 dbSNP
rs1173107695 824 dbSNP
rs563424445 825 dbSNP
rs1393427894 828 dbSNP
rs1423042249 837 dbSNP
rs1168685993 841 dbSNP
rs1010496772 842 dbSNP
rs529222784 848 dbSNP
rs1487391528 849 dbSNP
rs1204815764 850 dbSNP
rs199771164 850 dbSNP
rs1304358752 851 dbSNP
rs1402713556 854 dbSNP
rs1381551155 856 dbSNP
rs1316090627 859 dbSNP
rs1326271091 860 dbSNP
rs1367291315 861 dbSNP
rs1218945294 863 dbSNP
rs971608145 879 dbSNP
rs1300069135 886 dbSNP
rs1228415863 888 dbSNP
rs1443227842 896 dbSNP
rs980702182 903 dbSNP
rs1471031586 905 dbSNP
rs1406658236 917 dbSNP
rs1345284575 921 dbSNP
rs1409917771 939 dbSNP
rs1431192662 939 dbSNP
rs1177618207 943 dbSNP
rs1438661452 946 dbSNP
rs1236050523 947 dbSNP
rs1204999299 953 dbSNP
rs1461386344 971 dbSNP
rs1264224905 972 dbSNP
rs1210064581 988 dbSNP
rs1310756424 991 dbSNP
rs1235032917 1011 dbSNP
rs1256933215 1012 dbSNP
rs1376425314 1016 dbSNP
rs1485768005 1024 dbSNP
rs1203786345 1032 dbSNP
rs1264404951 1033 dbSNP
rs1302143892 1035 dbSNP
rs1464465363 1038 dbSNP
rs1465750895 1039 dbSNP
rs926364408 1043 dbSNP
rs1418929609 1046 dbSNP
rs1193082647 1054 dbSNP
rs1185051857 1068 dbSNP
rs1444670056 1071 dbSNP
rs1254894582 1073 dbSNP
rs1179653479 1084 dbSNP
rs1482562507 1086 dbSNP
rs1263079329 1089 dbSNP
rs1217735823 1090 dbSNP
rs1251283693 1095 dbSNP
rs1455731865 1096 dbSNP
rs959151695 1104 dbSNP
rs1394432231 1114 dbSNP
rs1363973434 1115 dbSNP
rs2820783 1120 dbSNP
rs1289386863 1121 dbSNP
rs1399089634 1122 dbSNP
rs920264954 1123 dbSNP
rs1165032532 1126 dbSNP
rs1424874110 1126 dbSNP
rs200580949 1131 dbSNP
rs1429793604 1132 dbSNP
rs1166398684 1133 dbSNP
rs1264396416 1136 dbSNP
rs1156604601 1143 dbSNP
rs61843944 1145 dbSNP
rs1488140138 1146 dbSNP
rs1261454241 1147 dbSNP
rs1225238035 1151 dbSNP
rs929188914 1152 dbSNP
rs1265140229 1153 dbSNP
rs1242624841 1160 dbSNP
rs1324617096 1161 dbSNP
rs1296152715 1163 dbSNP
rs1217956436 1167 dbSNP
rs1047651841 1169 dbSNP
rs1368206488 1171 dbSNP
rs1405395590 1181 dbSNP
rs1389496719 1183 dbSNP
rs1291438912 1187 dbSNP
rs1463038146 1188 dbSNP
rs1388118193 1190 dbSNP
rs911688747 1195 dbSNP
rs1477763756 1199 dbSNP
rs1422190505 1200 dbSNP
rs200991040 1209 dbSNP
rs1315983251 1211 dbSNP
rs1452563164 1221 dbSNP
rs1208314691 1226 dbSNP
rs1481627942 1229 dbSNP
rs1237251456 1232 dbSNP
rs1218132838 1235 dbSNP
rs1315978016 1236 dbSNP
rs1285133909 1243 dbSNP
rs1233621694 1249 dbSNP
rs1330337270 1256 dbSNP
rs1298677845 1268 dbSNP
rs1513250 1290 dbSNP
rs1330414922 1292 dbSNP
rs1330089709 1297 dbSNP
rs1463658199 1299 dbSNP
rs1398665732 1312 dbSNP
rs1213679992 1314 dbSNP
rs1179217600 1321 dbSNP
rs1251187659 1339 dbSNP
rs1478537563 1349 dbSNP
rs879969423 1350 dbSNP
rs1197254496 1351 dbSNP
rs1421071485 1356 dbSNP
rs1191873588 1358 dbSNP
rs1198028423 1360 dbSNP
rs1513248 1362 dbSNP
rs900579459 1364 dbSNP
rs1179386689 1367 dbSNP
rs1344284051 1384 dbSNP
rs559821638 1387 dbSNP
rs1253993141 1388 dbSNP
rs1241006110 1392 dbSNP
rs1000319728 1398 dbSNP
rs1308093396 1402 dbSNP
rs1054425642 1404 dbSNP
rs891816609 1426 dbSNP
rs528455452 1427 dbSNP
rs1024541973 1430 dbSNP
rs1402166658 1435 dbSNP
rs1171177940 1438 dbSNP
rs1455689083 1439 dbSNP
rs1381082460 1447 dbSNP
rs1178296224 1455 dbSNP
rs74231934 1457 dbSNP
rs1001705935 1460 dbSNP
rs1188382462 1464 dbSNP
rs1254069585 1473 dbSNP
rs1206612840 1479 dbSNP
rs1392239927 1480 dbSNP
rs61857137 1486 dbSNP
rs1034520567 1495 dbSNP
rs530994864 1503 dbSNP
rs1361211255 1509 dbSNP
rs1284238165 1513 dbSNP
rs1389378134 1525 dbSNP
rs1340379491 1539 dbSNP
rs1332777269 1540 dbSNP
rs1402196950 1554 dbSNP
rs1361601103 1563 dbSNP
rs1158477087 1564 dbSNP
rs1418063883 1570 dbSNP
rs550765413 1578 dbSNP
rs920231912 1581 dbSNP
rs1233096707 1583 dbSNP
rs1235598726 1586 dbSNP
rs1271773207 1589 dbSNP
rs950429647 1597 dbSNP
rs983544654 1598 dbSNP
rs1214226220 1601 dbSNP
rs189968509 1603 dbSNP
rs2820784 1604 dbSNP
rs1227184552 1609 dbSNP
rs1353688304 1616 dbSNP
rs911799054 1622 dbSNP
rs1220984558 1631 dbSNP
rs1341724294 1638 dbSNP
rs200878825 1651 dbSNP
rs1398603971 1652 dbSNP
rs1351777230 1657 dbSNP
rs1324458358 1660 dbSNP
rs1404797123 1662 dbSNP
rs2669827 1665 dbSNP
rs1172973693 1666 dbSNP
rs1207619483 1667 dbSNP
rs1422908643 1672 dbSNP
rs944653996 1675 dbSNP
rs1253664068 1682 dbSNP
rs1220405335 1683 dbSNP
rs1449567019 1684 dbSNP
rs1274464664 1695 dbSNP
rs1198799086 1696 dbSNP
rs1472772825 1712 dbSNP
rs1217115550 1713 dbSNP
rs1370217539 1714 dbSNP
rs1186985720 1715 dbSNP
rs1275610476 1735 dbSNP
rs1415495815 1736 dbSNP
rs1435999116 1738 dbSNP
rs1348394948 1739 dbSNP
rs1333438166 1747 dbSNP
rs1425555622 1748 dbSNP
rs1399378343 1762 dbSNP
rs1164849727 1764 dbSNP
rs1434641280 1766 dbSNP
rs202143024 1770 dbSNP
rs921764897 1773 dbSNP
rs1476834678 1775 dbSNP
rs1234311762 1776 dbSNP
rs1178654567 1785 dbSNP
rs1456935596 1795 dbSNP
rs1257930578 1798 dbSNP
rs1197324233 1802 dbSNP
rs936042814 1804 dbSNP
rs1279746206 1806 dbSNP
rs1219073161 1815 dbSNP
rs1054563733 1817 dbSNP
rs1370814362 1826 dbSNP
rs891908905 1833 dbSNP
rs553229262 1834 dbSNP
rs1376286911 1835 dbSNP
rs1291824586 1836 dbSNP
rs1467497358 1850 dbSNP
rs1359743224 1853 dbSNP
rs1175075951 1854 dbSNP
rs1412561414 1855 dbSNP
rs1381707817 1870 dbSNP
rs1158906862 1873 dbSNP
rs1438489116 1877 dbSNP
rs1235804054 1890 dbSNP
rs1381958693 1892 dbSNP
rs1183136344 1894 dbSNP
rs1046184080 1903 dbSNP
rs1229450735 1907 dbSNP
rs1209780347 1915 dbSNP
rs1294912412 1918 dbSNP
rs2820785 1921 dbSNP
rs1288371388 1924 dbSNP
rs868653689 1931 dbSNP
rs1353315435 1932 dbSNP
rs1307177500 1945 dbSNP
rs1397920101 1951 dbSNP
rs371885450 1952 dbSNP
rs1362240749 1957 dbSNP
rs1159078997 1962 dbSNP
rs1418682729 1964 dbSNP
rs1378170473 1972 dbSNP
rs1166271278 1976 dbSNP
rs1423898804 1981 dbSNP
rs1002197749 1982 dbSNP
rs1415070732 1983 dbSNP
rs1181818994 1986 dbSNP
rs1485006428 1991 dbSNP
rs1265758492 1994 dbSNP
rs1217894633 1998 dbSNP
rs1275560196 1999 dbSNP
rs3802531 2001 dbSNP
rs1209884428 2006 dbSNP
rs1247004888 2009 dbSNP
rs1235582242 2010 dbSNP
rs1322442285 2011 dbSNP
rs150388291 2012 dbSNP
rs775791959 2013 dbSNP
rs1296046293 2014 dbSNP
rs1298573969 2023 dbSNP
rs1418756146 2026 dbSNP
rs1398707 2030 dbSNP
rs577665087 2035 dbSNP
rs1457932276 2036 dbSNP
rs898679006 2037 dbSNP
rs1390327657 2042 dbSNP
rs1433782776 2054 dbSNP
rs994520568 2056 dbSNP
rs1270056007 2069 dbSNP
rs1311426194 2071 dbSNP
rs1027339537 2073 dbSNP
rs1361309066 2075 dbSNP
rs1477704036 2076 dbSNP
rs1259870637 2084 dbSNP
rs543511468 2085 dbSNP
rs375168193 2086 dbSNP
rs950547294 2088 dbSNP
rs1288754452 2093 dbSNP
rs983129660 2097 dbSNP
rs1211970721 2105 dbSNP
rs573867634 2106 dbSNP
rs1278778139 2115 dbSNP
rs1217717980 2119 dbSNP
rs528600458 2120 dbSNP
rs1386961122 2129 dbSNP
rs542974123 2135 dbSNP
rs1398706 2136 dbSNP
rs546545862 2136 dbSNP
rs1347412307 2137 dbSNP
rs1232433406 2146 dbSNP
rs1276206766 2150 dbSNP
rs965949325 2152 dbSNP
rs2813184 2154 dbSNP
rs1241394547 2158 dbSNP
rs1133222 2166 dbSNP
rs1189930461 2169 dbSNP
rs1191755915 2171 dbSNP
rs1459146691 2177 dbSNP
rs935803462 2180 dbSNP
rs1197957431 2183 dbSNP
rs990013023 2185 dbSNP
rs2820787 2186 dbSNP
rs1330088937 2197 dbSNP
rs1170484787 2208 dbSNP
rs1300817230 2210 dbSNP
rs907498021 2212 dbSNP
rs1448305208 2215 dbSNP
rs1415349885 2217 dbSNP
rs1446656022 2219 dbSNP
rs944963708 2221 dbSNP
rs1395046352 2227 dbSNP
rs1174659048 2236 dbSNP
rs545083205 2236 dbSNP
rs1466884142 2239 dbSNP
rs946164505 2246 dbSNP
rs1343879329 2247 dbSNP
rs1238841982 2248 dbSNP
rs1437975416 2249 dbSNP
rs565236686 2258 dbSNP
rs530931027 2260 dbSNP
rs907208094 2261 dbSNP
rs937578028 2264 dbSNP
rs13189 2266 dbSNP
rs898773768 2268 dbSNP
rs1276785150 2269 dbSNP
rs1241844521 2275 dbSNP
rs995618010 2301 dbSNP
rs1025801583 2309 dbSNP
rs1236322547 2329 dbSNP
rs1368593359 2333 dbSNP
rs3001847 2336 dbSNP
rs180890279 2337 dbSNP
rs1018578157 2349 dbSNP
rs1326973209 2356 dbSNP
rs15558 2360 dbSNP
rs974429499 2362 dbSNP
rs1028903148 2363 dbSNP
rs1370082299 2365 dbSNP
rs1196157593 2370 dbSNP
rs1248035505 2376 dbSNP
rs1188195991 2381 dbSNP
rs1478154680 2387 dbSNP
rs1441821451 2398 dbSNP
rs1218601951 2399 dbSNP
rs1176973448 2400 dbSNP
rs1410278069 2402 dbSNP
rs1221502624 2404 dbSNP
rs957309391 2407 dbSNP
rs1286420192 2408 dbSNP
rs556388384 2410 dbSNP
rs1355426365 2414 dbSNP
rs1291807381 2425 dbSNP
rs1402258110 2426 dbSNP
rs1361336493 2439 dbSNP
rs1160506941 2443 dbSNP
rs913061374 2454 dbSNP
rs546929226 2456 dbSNP
rs981948259 2457 dbSNP
rs1472425488 2464 dbSNP
rs1325618585 2471 dbSNP
rs1415654778 2475 dbSNP
rs1331900756 2481 dbSNP
rs1478025959 2482 dbSNP
rs1441823843 2484 dbSNP
rs1278709869 2490 dbSNP
rs567059378 2494 dbSNP
rs1230033194 2497 dbSNP
rs141575527 2501 dbSNP
rs1334707052 2516 dbSNP
rs937322064 2526 dbSNP
rs1055750364 2528 dbSNP
rs187388809 2534 dbSNP
rs1270036837 2543 dbSNP
rs1428855749 2544 dbSNP
rs1333116591 2546 dbSNP
rs192127654 2547 dbSNP
rs1460997309 2563 dbSNP
rs1392112554 2567 dbSNP
rs931604257 2573 dbSNP
rs1451798944 2579 dbSNP
rs1418500406 2582 dbSNP
rs1203428759 2584 dbSNP
rs1478802737 2593 dbSNP
rs1249208397 2595 dbSNP
rs1246939563 2600 dbSNP
rs1197469366 2605 dbSNP
rs1047188463 2607 dbSNP
rs1271769875 2608 dbSNP
rs183445348 2614 dbSNP
rs1183374129 2616 dbSNP
rs1272739974 2619 dbSNP
rs1213241238 2628 dbSNP
rs887281434 2629 dbSNP
rs1275664110 2636 dbSNP
rs1440208609 2639 dbSNP
rs1104810 2641 dbSNP
rs1472136581 2642 dbSNP
rs61857139 2646 dbSNP
rs1353930019 2662 dbSNP
rs1167988804 2666 dbSNP
rs1040508888 2669 dbSNP
rs1391602168 2670 dbSNP
rs1409571000 2678 dbSNP
rs1306362856 2683 dbSNP
rs1425384479 2684 dbSNP
rs901623449 2692 dbSNP
rs1411367962 2695 dbSNP
rs1308416107 2699 dbSNP
rs1239439407 2700 dbSNP
rs1178788085 2701 dbSNP
rs1458597712 2709 dbSNP
rs1232821455 2715 dbSNP
rs995836361 2717 dbSNP
rs1242578063 2721 dbSNP
rs1444519154 2723 dbSNP
rs1279533061 2727 dbSNP
rs1233811761 2737 dbSNP
rs1104808 2738 dbSNP
rs573930643 2741 dbSNP
rs1213504821 2742 dbSNP
rs1372446775 2745 dbSNP
rs1028704275 2749 dbSNP
rs1449896634 2754 dbSNP
rs1413526096 2760 dbSNP
rs1312097586 2767 dbSNP
rs1432480988 2781 dbSNP
rs1381845766 2784 dbSNP
rs957237116 2799 dbSNP
rs1483836854 2801 dbSNP
rs1176005251 2808 dbSNP
rs1011510502 2810 dbSNP
rs1258616525 2811 dbSNP
rs1020089831 2813 dbSNP
rs1288443029 2814 dbSNP
rs967632074 2820 dbSNP
rs981319067 2824 dbSNP
rs1229933856 2829 dbSNP
rs1379897411 2830 dbSNP
rs1292436955 2837 dbSNP
rs1412719104 2855 dbSNP
rs1361988577 2857 dbSNP
rs1257334342 2858 dbSNP
rs1441164290 2859 dbSNP
rs1342901981 2860 dbSNP
rs1166341522 2863 dbSNP
rs1426070267 2865 dbSNP
rs1419282178 2871 dbSNP
rs1187607810 2880 dbSNP
rs1474449913 2882 dbSNP
rs1265548417 2890 dbSNP
rs928696344 2893 dbSNP
rs1190267051 2894 dbSNP
rs1259038122 2900 dbSNP
rs1223946211 2903 dbSNP
rs1369578237 2909 dbSNP
rs1272481875 2911 dbSNP
rs1475096116 2913 dbSNP
rs1166808878 2914 dbSNP
rs958813608 2916 dbSNP
rs1381271240 2918 dbSNP
rs1392183878 2927 dbSNP
rs991445247 2932 dbSNP
rs1294758332 2944 dbSNP
rs1457981125 2946 dbSNP
rs1395770632 2947 dbSNP
rs1430716323 2948 dbSNP
rs1164861756 2955 dbSNP
rs1308395672 2970 dbSNP
rs1460385538 2972 dbSNP
rs1426192686 2996 dbSNP
rs1401283173 2997 dbSNP
rs542837091 3008 dbSNP
rs879749586 3009 dbSNP
rs1192929445 3010 dbSNP
rs1341010977 3018 dbSNP
rs1433628034 3026 dbSNP
rs1294856168 3027 dbSNP
rs1252240621 3029 dbSNP
rs1211716368 3030 dbSNP
rs1319963165 3032 dbSNP
rs1251667181 3036 dbSNP
rs1343845014 3038 dbSNP
rs1047775093 3047 dbSNP
rs1280017970 3048 dbSNP
rs908818101 3050 dbSNP
rs1202568897 3051 dbSNP
rs1323358287 3052 dbSNP
rs1257405082 3059 dbSNP
rs1403162958 3082 dbSNP
rs1446933431 3083 dbSNP
rs1186750949 3088 dbSNP
rs2820790 3089 dbSNP
rs553093904 3097 dbSNP
rs944191520 3100 dbSNP
rs1450292238 3112 dbSNP
rs1041251136 3160 dbSNP
rs1454904655 3167 dbSNP
rs1394523008 3169 dbSNP
rs901591830 3170 dbSNP
rs995931413 3173 dbSNP
rs1194947788 3175 dbSNP
rs1174113996 3186 dbSNP
rs1479553801 3186 dbSNP
rs573057453 3200 dbSNP
rs1050056156 3203 dbSNP
rs545260612 3205 dbSNP
rs1234531303 3206 dbSNP
rs1346788829 3212 dbSNP
rs892822510 3217 dbSNP
rs1241704779 3225 dbSNP
rs1011470954 3228 dbSNP
rs565169008 3229 dbSNP
rs1394748819 3230 dbSNP
rs1175908376 3232 dbSNP
rs1003110562 3234 dbSNP
rs1366783700 3239 dbSNP
rs1435221730 3245 dbSNP
rs1300102226 3246 dbSNP
rs1035566691 3247 dbSNP
rs958742414 3258 dbSNP
rs2820791 3259 dbSNP
rs1364268600 3260 dbSNP
rs991540125 3271 dbSNP
rs1026913198 3272 dbSNP
rs1329007236 3289 dbSNP
rs952697093 3292 dbSNP
rs1485109219 3293 dbSNP
rs1235795452 3294 dbSNP
rs575572941 3295 dbSNP
rs982832047 3298 dbSNP
rs1207444082 3316 dbSNP
rs1238917624 3325 dbSNP
rs908780111 3327 dbSNP
rs1334578825 3330 dbSNP
rs1295483739 3333 dbSNP
rs1415796127 3342 dbSNP
rs1270610953 3344 dbSNP
rs1465365030 3351 dbSNP
rs1375004154 3358 dbSNP
rs1193103224 3364 dbSNP
rs1421538554 3368 dbSNP
rs1385723595 3373 dbSNP
rs1265454135 3382 dbSNP
rs944344207 3384 dbSNP
rs61843942 3385 dbSNP
rs1188312642 3392 dbSNP
rs1474778183 3393 dbSNP
rs61843941 3395 dbSNP
rs1195364772 3398 dbSNP
rs1447258090 3400 dbSNP
rs1282933049 3409 dbSNP
rs1202910408 3413 dbSNP
rs1456615445 3419 dbSNP
rs1156813927 3423 dbSNP
rs1390779587 3434 dbSNP
rs1234239900 3437 dbSNP
rs1355249902 3441 dbSNP
rs1291866934 3446 dbSNP
rs1457259222 3452 dbSNP
rs199567122 3465 dbSNP
rs977287527 3469 dbSNP
rs1380610519 3472 dbSNP
rs1396550046 3473 dbSNP
rs1388212529 3474 dbSNP
rs1415350388 3484 dbSNP
rs1460904446 3484 dbSNP
rs1172635153 3501 dbSNP
rs1475527886 3505 dbSNP
rs1302388055 3510 dbSNP
rs1350212192 3511 dbSNP
rs1241168039 3519 dbSNP
rs921441705 3520 dbSNP
rs1452863403 3545 dbSNP
rs1255387607 3550 dbSNP
rs931693151 3551 dbSNP
rs1334839187 3561 dbSNP
rs1050192323 3562 dbSNP
rs1220920437 3563 dbSNP
rs1340240226 3568 dbSNP
rs1263815550 3573 dbSNP
rs1428668488 3579 dbSNP
rs1373264672 3580 dbSNP
rs1326707750 3592 dbSNP
rs1440070650 3595 dbSNP
rs892913220 3598 dbSNP
rs1330568953 3602 dbSNP
rs1489573946 3605 dbSNP
rs1410326696 3615 dbSNP
rs1418302505 3621 dbSNP
rs1165813489 3624 dbSNP
rs1210699857 3625 dbSNP
rs1395156960 3635 dbSNP
rs1192527110 3644 dbSNP
rs1468385625 3646 dbSNP
rs1251689742 3659 dbSNP
rs947026159 3661 dbSNP
rs1438778622 3664 dbSNP
rs1272810228 3667 dbSNP
rs1472116493 3672 dbSNP
rs1350402709 3676 dbSNP
rs1304231133 3678 dbSNP
rs1233671658 3679 dbSNP
rs1179767740 3682 dbSNP
rs1041415567 3686 dbSNP
rs1281243123 3691 dbSNP
rs1442601384 3696 dbSNP
rs1353684836 3701 dbSNP
rs1326651597 3702 dbSNP
rs1436182973 3704 dbSNP
rs1375693222 3712 dbSNP
rs1172402643 3713 dbSNP
rs1452067015 3718 dbSNP
rs1423627876 3730 dbSNP
rs1179444603 3735 dbSNP
rs1232655397 3736 dbSNP
rs1470824197 3736 dbSNP
rs1202932310 3740 dbSNP
rs1486741677 3741 dbSNP
rs1281310017 3748 dbSNP
rs1210200820 3750 dbSNP
rs1345843572 3752 dbSNP
rs903095175 3765 dbSNP
rs1224242710 3773 dbSNP
rs1372594637 3776 dbSNP
rs1277498333 3780 dbSNP
rs1416396785 3782 dbSNP
rs1355655678 3783 dbSNP
rs1002794359 3787 dbSNP
rs1432536026 3790 dbSNP
rs1472916733 3794 dbSNP
rs1159285612 3795 dbSNP
rs1407905819 3796 dbSNP
rs1163446525 3808 dbSNP
rs773923652 3811 dbSNP
rs1258428650 3812 dbSNP
rs1187464983 3813 dbSNP
rs1035451975 3817 dbSNP
rs894325307 3823 dbSNP
rs1316203433 3832 dbSNP
rs1282105476 3835 dbSNP
rs1234854111 3840 dbSNP
rs1335215542 3851 dbSNP
rs1012931296 3853 dbSNP
rs1412538148 3856 dbSNP
rs1293704343 3857 dbSNP
rs1027014532 3867 dbSNP
rs952832901 3869 dbSNP
rs1157620746 3871 dbSNP
rs1345076621 3871 dbSNP
rs1463522479 3873 dbSNP
rs1418990741 3874 dbSNP
rs1422224257 3875 dbSNP
rs1264129209 3876 dbSNP
rs1187142755 3883 dbSNP
rs1485596266 3886 dbSNP
rs1408315929 3887 dbSNP
rs1215449124 3888 dbSNP
rs983187304 3898 dbSNP
rs1272294609 3901 dbSNP
rs1231246637 3902 dbSNP
rs1543963 3908 dbSNP
rs1213429518 3909 dbSNP
rs1359231033 3909 dbSNP
rs1327380544 3910 dbSNP
rs1443746434 3922 dbSNP
rs1395928234 3926 dbSNP
rs1325571075 3927 dbSNP
rs1456740628 3928 dbSNP
rs1228299503 3932 dbSNP
rs1374952402 3933 dbSNP
rs1310621434 3936 dbSNP
rs1171368733 3937 dbSNP
rs1323534450 3938 dbSNP
rs1218724010 3942 dbSNP
rs1388393636 3943 dbSNP
rs1245647720 3944 dbSNP
rs1468817621 3946 dbSNP
rs867506463 3947 dbSNP
rs1481507354 3951 dbSNP
rs1015598662 3953 dbSNP
rs1202759109 3954 dbSNP
rs965981660 3956 dbSNP
rs1339717507 3957 dbSNP
rs1304973795 3962 dbSNP
rs1372311011 3963 dbSNP
rs1303341416 3973 dbSNP
rs1385640652 3974 dbSNP
rs1399040942 3982 dbSNP
rs1299165206 3983 dbSNP
rs1461656596 3986 dbSNP
rs977045931 3989 dbSNP
rs1368959606 3994 dbSNP
rs1175531305 3995 dbSNP
rs1454791561 4000 dbSNP
rs1394355195 4012 dbSNP
rs1196640423 4020 dbSNP
rs921410874 4027 dbSNP
rs1250967749 4033 dbSNP
rs1195069849 4036 dbSNP
rs932790747 4037 dbSNP
rs187277093 4040 dbSNP
rs1210915745 4041 dbSNP
rs989673458 4044 dbSNP
rs1253777300 4046 dbSNP
rs1231701613 4052 dbSNP
rs1543962 4059 dbSNP
rs1409600828 4060 dbSNP
rs1348818916 4064 dbSNP
rs530092902 4066 dbSNP
rs1435628033 4074 dbSNP
rs866242265 4078 dbSNP
rs947194250 4079 dbSNP
rs2820792 4080 dbSNP
rs546792282 4082 dbSNP
rs1471499985 4086 dbSNP
rs902854659 4087 dbSNP
rs1188181323 4090 dbSNP
rs938568035 4096 dbSNP
rs1206389530 4102 dbSNP
rs1353383176 4104 dbSNP
rs1056994460 4106 dbSNP
rs1228119797 4109 dbSNP
rs894426539 4110 dbSNP
rs1415626009 4112 dbSNP
rs1340158466 4116 dbSNP
rs1012696364 4122 dbSNP
rs1026816093 4130 dbSNP
rs1280744329 4131 dbSNP
rs1371598693 4132 dbSNP
rs1447797136 4135 dbSNP
rs12240702 4142 dbSNP
rs1381989197 4143 dbSNP
rs1004309740 4144 dbSNP
rs1419754867 4147 dbSNP
rs1297047664 4151 dbSNP
rs532707722 4152 dbSNP
rs1474641482 4153 dbSNP
rs1235383724 4154 dbSNP
rs552822644 4155 dbSNP
rs1230952647 4159 dbSNP
rs1276477405 4160 dbSNP
rs998212847 4171 dbSNP
rs1208621470 4173 dbSNP
rs1209180443 4174 dbSNP
rs1235598879 4181 dbSNP
rs1234300024 4183 dbSNP
rs190165323 4193 dbSNP
rs1282665968 4194 dbSNP
rs1229951946 4199 dbSNP
rs537043043 4208 dbSNP
rs1246930554 4210 dbSNP
rs538606663 4210 dbSNP
rs954309190 4215 dbSNP
rs989642403 4217 dbSNP
rs1404579882 4230 dbSNP
rs1543961 4238 dbSNP
rs1190058955 4245 dbSNP
rs915413299 4254 dbSNP
rs968838099 4256 dbSNP
rs1414209137 4260 dbSNP
rs1186191005 4262 dbSNP
rs977211065 4264 dbSNP
rs550737925 4266 dbSNP
rs1288219211 4271 dbSNP
rs144854613 4271 dbSNP
rs567379603 4271 dbSNP
rs1543960 4274 dbSNP
rs1340390437 4285 dbSNP
rs1363167189 4285 dbSNP
rs367643705 4286 dbSNP
rs372375918 4287 dbSNP
rs375396093 4288 dbSNP
rs368389944 4289 dbSNP
rs1226278218 4290 dbSNP
rs372289651 4291 dbSNP
rs1373038428 4292 dbSNP
rs1437407507 4292 dbSNP
rs915826046 4293 dbSNP
rs948642089 4296 dbSNP
rs1048182742 4297 dbSNP
rs1435738568 4298 dbSNP
rs1298533605 4305 dbSNP
rs1347875811 4308 dbSNP
rs1367173703 4314 dbSNP
rs1330727504 4338 dbSNP
rs1410171671 4344 dbSNP
rs1369576241 4354 dbSNP
rs552913406 4355 dbSNP
rs1166103177 4356 dbSNP
rs888301243 4372 dbSNP
rs1395209467 4375 dbSNP
rs1192252386 4386 dbSNP
rs1276311514 4390 dbSNP
rs1313858252 4395 dbSNP
rs1245331581 4396 dbSNP
rs1004683192 4399 dbSNP
rs572959695 4407 dbSNP
rs1472596853 4412 dbSNP
rs1037102335 4418 dbSNP
rs538582952 4424 dbSNP
rs1203044780 4425 dbSNP
rs1350122277 4429 dbSNP
rs558403760 4430 dbSNP
rs182651745 4444 dbSNP
rs1463121633 4445 dbSNP
rs1210073199 4447 dbSNP
rs1242275005 4448 dbSNP
rs1190162753 4449 dbSNP
rs202072958 4449 dbSNP
rs1298078997 4450 dbSNP
rs1389925203 4450 dbSNP
rs1428235036 4451 dbSNP
rs1310013525 4452 dbSNP
rs1371434587 4452 dbSNP
rs1442672114 4458 dbSNP
rs571798837 4465 dbSNP
rs80098532 4466 dbSNP
rs1436243327 4501 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000374007.1 | 3UTR | AUGUGAGAGAGAGAGAGAGAGAGAGAGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000374007.1 | 3UTR | UAAUGGGGUGGAGGGGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGAGAGAGAGAGAGAGAGAGAGAGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000374007.1 | 3UTR | AUGUGAGAGAGAGAGAGAGAGAGAGAGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000374007.1 | 3UTR | UAUGUGAGAGAGAGAGAGAGAGAGAGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000374007.1 | 3UTR | AGAGAGAGAGAGAGAGGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000374007.1 | 3UTR | AUGUGAGAGAGAGAGAGAGAGAGAGAGGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000374007.1 | 3UTR | GAGAGAGAGAGAGAGAGAGAGGUUUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000374007.1 | 3UTR | AGAGAGAGAGAGAGAGAGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000374007.1 | 3UTR | GAGAGAGAGAGAGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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