pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KLK2   
Synonyms KLK2A2, hGK-1, hK2
Description kallikrein related peptidase 2
Transcript NM_001002231   
Other Transcripts NM_005551   
Expression
Putative miRNA Targets on KLK2
3'UTR of KLK2
(miRNA target sites are highlighted)
>KLK2|NM_001002231|3'UTR
   1 TTCTGGGGGTCCACTTGTCTGTAATGGTGTGCTTCAAGGTATCACATCATGGGGCCCTGAGCCATGTGCCCTGCCTGAAA
  81 AGCCTGCTGTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGCAGCCAACCCCTGAGTGCCCCTG
 161 TCCCACCCCTACCTCTAGTAAATTTAAGTCCACCTCACGTTCTGGCATCACTTGGCCTTTCTGGATGCTGGACACCTGAA
 241 GCTTGGAACTCACCTGGCCGAAGCTCGAGCCTCCTGAGTCCTACTGACCTGTGCTTTCTGGTGTGGAGTCCAGGGCTGCT
 321 AGGAAAAGGAATGGGCAGACACAGGTGTATGCCAATGTTTCTGAAATGGGTATAATTTCGTCCTCTCCTTCGGAACACTG
 401 GCTGTCTCTGAAGACTTCTCGCTCAGTTTCAGTGAGGACACACACAAAGACGTGGGTGACCATGTTGTTTGTGGGGTGCA
 481 GAGATGGGAGGGGTGGGGCCCACCCTGGAAGAGTGGACAGTGACACAAGGTGGACACTCTCTACAGATCACTGAGGATAA
 561 GCTGGAGCCACAATGCATGAGGCACACACACAGCAAGGATGACGCTGTAAACATAGCCCACGCTGTCCTGGGGGCACTGG
 641 GAAGCCTAGATAAGGCCGTGAGCAGAAAGAAGGGGAGGATCCTCCTATGTTGTTGAAGGAGGGACTAGGGGGAGAAACTG
 721 AAAGCTGATTAATTACAGGAGGTTTGTTCAGGTCCCCCAAACCACCGTCAGATTTGATGATTTCCTAGCAGGACTTACAG
 801 AAATAAAGAGCTATCATGCTGTGGTTTATTATGGTTTGTTACATTGATAGGATACATACTGAAATCAGCAAACAAAACAG
 881 ATGTATAGATTAGAGTGTGGAGAAAACAGAGGAAAACTTGCAGTTACGAAGACTGGCAACTTGGCTTTACTAAGTTTTCA
 961 GACTGGCAGGAAGTCAAACCTATTAGGCTGAGGACCTTGTGGAGTGTAGCTGATCCAGCTGATAGAGGAACTAGCCAGGT
1041 GGGGGCCTTTCCCTTTGGATGGGGGGCATATCTGACAGTTATTCTCTCCAAGTGGAGACTTACGGACAGCATATAATTCT
1121 CCCTGCAAGGATGTATGATAATATGTACAAAGTAATTCCAACTGAGGAAGCTCACCTGATCCTTAGTGTCCAGGGTTTTT
1201 ACTGGGGGTCTGTAGGACGAGTATGGAGTACTTGAATAATTGACCTGAAGTCCTCAGACCTGAGGTTCCCTAGAGTTCAA
1281 ACAGATACAGCATGGTCCAGAGTCCCAGATGTACAAAAACAGGGATTCATCACAAATCCCATCTTTAGCATGAAGGGTCT
1361 GGCATGGCCCAAGGCCCCAAGTATATCAAGGCACTTGGGCAGAACATGCCAAGGAATCAAATGTCATCTCCCAGGAGTTA
1441 TTCAAGGGTGAGCCCTTTACTTGGGATGTACAGGCTTTGAGCAGTGCAGGGCTGCTGAGTCAACCTTTTATTGTACAGGG
1521 GATGAGGGAAAGGGAGAGGATGAGGAAGCCCCCCTGGGGATTTGGTTTGGTCTTGTGATCAGGTGGTCTATGGGGCTATC
1601 CCTACAAAGAAGAATCCAGAAATAGGGGCACATTGAGGAATGATACTGAGCCCAAAGAGCATTCAATCATTGTTTTATTT
1681 GCCTTCTTTTCACACCATTGGTGAGGGAGGGATTACCACCCTGGGGTTATGAAGATGGTTGAACACCCCACACATAGCAC
1761 CGGAGATATGAGATCAACAGTTTCTTAGCCATAGAGATTCACAGCCCAGAGCAGGAGGACGCTGCACACCATGCAGGATG
1841 ACATGGGGGATGCGCTCGGGATTGGTGTGAAGAAGCAAGGACTGTTAGAGGCAGGCTTTATAGTAACAAGACGGTGGGGC
1921 AAACTCTGATTTCCGTGGGGGAATGTCATGGTCTTGCTTTACTAAGTTTTGAGACTGGCAGGTAGTGAAACTCATTAGGC
2001 TGAGAACCTTGTGGAATGCAGCTGACCCAGCTGATAGAGGAAGTAGCCAGGTGGGAGCCTTTCCCAGTGGGTGTGGGACA
2081 TATCTGGCAAGATTTTGTGGCACTCCTGGTTACAGATACTGGGGCAGCAAATAAAACTGAATCTTGTTTTCAGACCTTAA
2161 AAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acggucGGAGCGGGUCg 5'
                :|||||:||| 
Target 5' aagactTCTCGCTCAGt 3'
411 - 427 135.00 -16.30
2
miRNA  3' acggucggagCGGGUCg 5'
                    |||||| 
Target 5' gagattcacaGCCCAGa 3'
1794 - 1810 120.00 -11.40
3
miRNA  3' acggUCGGAGCGGGUCg 5'
              |||||: ||||| 
Target 5' tgggAGCCTTTCCCAGt 3'
2052 - 2068 117.00 -17.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM999842 4 COSMIC
COSM7870937 8 COSMIC
COSM6696968 11 COSMIC
COSM8673047 12 COSMIC
COSM9670169 13 COSMIC
COSM7800710 16 COSMIC
COSM6195791 44 COSMIC
COSM9883444 49 COSMIC
COSM5476101 71 COSMIC
COSM6696974 72 COSMIC
COSM71364 75 COSMIC
COSM8281554 78 COSMIC
COSM440078 85 COSMIC
COSM3797420 93 COSMIC
COSM2755442 96 COSMIC
COSM9218511 104 COSMIC
COSM9218512 105 COSMIC
COSM8713393 108 COSMIC
COSM4000836 114 COSMIC
COSM4417581 114 COSMIC
COSM7880441 115 COSMIC
COSM9193649 120 COSMIC
COSM6696971 121 COSMIC
COSM8352092 125 COSMIC
COSM2755444 126 COSMIC
COSM5578844 129 COSMIC
COSM6539252 137 COSMIC
COSM7424030 144 COSMIC
COSM6696969 145 COSMIC
COSM6151834 146 COSMIC
COSM6225444 149 COSMIC
COSM5987457 151 COSMIC
COSN31508878 158 COSMIC
COSN30518164 167 COSMIC
COSN30482578 188 COSMIC
COSN13822814 200 COSMIC
COSN31570523 200 COSMIC
COSN30469604 217 COSMIC
COSN30474472 224 COSMIC
COSN30132854 225 COSMIC
COSN20065965 230 COSMIC
COSN30181996 231 COSMIC
COSN30467879 246 COSMIC
COSN28791440 256 COSMIC
COSN30183916 261 COSMIC
COSN30543496 261 COSMIC
COSN30524930 268 COSMIC
COSN31504251 280 COSMIC
COSN30152123 287 COSMIC
COSN31571034 296 COSMIC
COSN22209354 381 COSMIC
COSN19599232 468 COSMIC
COSN30107395 484 COSMIC
COSN17182081 494 COSMIC
COSN1770613 598 COSMIC
COSN26093739 694 COSMIC
COSN8261651 905 COSMIC
COSN31961580 1286 COSMIC
COSN5438953 1287 COSMIC
COSN26247414 1388 COSMIC
COSN7448220 1535 COSMIC
COSN22687225 1626 COSMIC
COSN27877223 1687 COSMIC
COSN1770614 1707 COSMIC
COSN7448221 1752 COSMIC
COSN29552359 1887 COSMIC
COSN8343937 1940 COSMIC
COSN15677067 1963 COSMIC
COSN26792121 2075 COSMIC
COSN30445500 2133 COSMIC
COSN9226791 2144 COSMIC
rs80050017 1537 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1229917803 5 dbSNP
rs760976334 7 dbSNP
rs550336155 8 dbSNP
rs776972549 12 dbSNP
rs1292384058 20 dbSNP
rs1464956347 28 dbSNP
rs1064703 29 dbSNP
rs370841038 39 dbSNP
rs761089063 40 dbSNP
rs765217792 46 dbSNP
rs1360784488 47 dbSNP
rs554497468 48 dbSNP
rs1434880603 54 dbSNP
rs1015998422 55 dbSNP
rs1226855036 55 dbSNP
rs1199259963 56 dbSNP
rs755023510 57 dbSNP
rs1032399091 60 dbSNP
rs1174538762 62 dbSNP
rs750451077 63 dbSNP
rs764423224 64 dbSNP
rs766661904 70 dbSNP
rs375847560 72 dbSNP
rs754792382 78 dbSNP
rs1473350463 79 dbSNP
rs1383383168 83 dbSNP
rs781350069 84 dbSNP
rs1324557261 96 dbSNP
rs748025939 98 dbSNP
rs754386452 99 dbSNP
rs140321127 101 dbSNP
rs1289824741 104 dbSNP
rs1329492054 106 dbSNP
rs1464044045 108 dbSNP
rs1227213048 112 dbSNP
rs198977 114 dbSNP
rs770590385 115 dbSNP
rs1210361467 116 dbSNP
rs765323753 126 dbSNP
rs377555535 129 dbSNP
rs60268688 130 dbSNP
rs1414420068 131 dbSNP
rs777251727 134 dbSNP
rs566614502 137 dbSNP
rs1059712 138 dbSNP
rs946944071 139 dbSNP
rs372001120 148 dbSNP
rs1392507975 150 dbSNP
rs1042761457 151 dbSNP
rs753274832 152 dbSNP
rs758762283 155 dbSNP
rs1403474201 156 dbSNP
rs1310283253 159 dbSNP
rs1416491310 160 dbSNP
rs763103633 161 dbSNP
rs778210185 162 dbSNP
rs924271982 162 dbSNP
rs1249211354 164 dbSNP
rs1408865790 168 dbSNP
rs766751727 169 dbSNP
rs545312487 170 dbSNP
rs1244956643 172 dbSNP
rs751829292 173 dbSNP
rs759466542 174 dbSNP
rs752465616 180 dbSNP
rs150357173 181 dbSNP
rs867456317 188 dbSNP
rs777714551 193 dbSNP
rs1181739401 199 dbSNP
rs1314329967 200 dbSNP
rs370593708 200 dbSNP
rs1425622150 203 dbSNP
rs1188397563 210 dbSNP
rs778601575 211 dbSNP
rs745505792 212 dbSNP
rs771653557 223 dbSNP
rs781441844 230 dbSNP
rs1299778453 231 dbSNP
rs748498875 235 dbSNP
rs1005878451 242 dbSNP
rs11549921 251 dbSNP
rs1293150498 254 dbSNP
rs1437371037 255 dbSNP
rs1015597146 260 dbSNP
rs576636585 261 dbSNP
rs192810530 267 dbSNP
rs556033447 268 dbSNP
rs540100380 275 dbSNP
rs1266139444 285 dbSNP
rs1019742182 286 dbSNP
rs113358789 292 dbSNP
rs144992183 299 dbSNP
rs1453312634 309 dbSNP
rs1173714493 315 dbSNP
rs954109024 322 dbSNP
rs1028559383 323 dbSNP
rs77177726 324 dbSNP
rs984469547 332 dbSNP
rs915385008 337 dbSNP
rs1219908316 343 dbSNP
rs747230481 344 dbSNP
rs968370579 346 dbSNP
rs527965028 348 dbSNP
rs1296708097 354 dbSNP
rs978713132 356 dbSNP
rs924310901 357 dbSNP
rs1386075974 367 dbSNP
rs1459041170 371 dbSNP
rs183710386 380 dbSNP
rs992596884 381 dbSNP
rs971769510 383 dbSNP
rs564658423 384 dbSNP
rs1405310829 388 dbSNP
rs949220843 392 dbSNP
rs777671817 393 dbSNP
rs1059711 394 dbSNP
rs1441820684 396 dbSNP
rs926542905 399 dbSNP
rs1208479236 405 dbSNP
rs1044271433 408 dbSNP
rs531987005 418 dbSNP
rs1053707722 421 dbSNP
rs541371645 422 dbSNP
rs1332773699 432 dbSNP
rs749259468 434 dbSNP
rs562073596 437 dbSNP
rs1041078960 441 dbSNP
rs1037326411 445 dbSNP
rs1210329004 447 dbSNP
rs1413350767 452 dbSNP
rs897180258 453 dbSNP
rs901366822 463 dbSNP
rs773912267 468 dbSNP
rs1029029419 472 dbSNP
rs952982873 491 dbSNP
rs1472679557 494 dbSNP
rs1029603603 496 dbSNP
rs1185479637 501 dbSNP
rs1005771296 502 dbSNP
rs1015941318 504 dbSNP
rs961684417 506 dbSNP
rs971821805 507 dbSNP
rs889900567 516 dbSNP
rs369146825 521 dbSNP
rs529403038 526 dbSNP
rs1364854116 537 dbSNP
rs1330034309 539 dbSNP
rs745433266 542 dbSNP
rs968589009 544 dbSNP
rs1243035153 545 dbSNP
rs11090 553 dbSNP
rs1340301621 560 dbSNP
rs1163217830 565 dbSNP
rs1394094112 574 dbSNP
rs1398230366 582 dbSNP
rs970991077 590 dbSNP
rs1363655147 591 dbSNP
rs978382876 595 dbSNP
rs4846 600 dbSNP
rs1390343837 602 dbSNP
rs960929683 604 dbSNP
rs1394364877 617 dbSNP
rs936609825 622 dbSNP
rs1368906018 623 dbSNP
rs1189369579 628 dbSNP
rs566068251 629 dbSNP
rs1187962526 630 dbSNP
rs1465435639 633 dbSNP
rs9884 635 dbSNP
rs1208350727 647 dbSNP
rs916912512 658 dbSNP
rs533797092 659 dbSNP
rs1041132078 673 dbSNP
rs141318172 688 dbSNP
rs901253519 706 dbSNP
rs932845493 707 dbSNP
rs1366810248 709 dbSNP
rs570311646 713 dbSNP
rs751822538 715 dbSNP
rs1049932358 718 dbSNP
rs1230067171 721 dbSNP
rs1164731020 725 dbSNP
rs537678710 727 dbSNP
rs980224693 729 dbSNP
rs145052361 730 dbSNP
rs574417004 731 dbSNP
rs909729454 739 dbSNP
rs897526680 740 dbSNP
rs1196856705 746 dbSNP
rs941166497 755 dbSNP
rs1059709 764 dbSNP
rs535561695 767 dbSNP
rs565164543 768 dbSNP
rs74431145 773 dbSNP
rs572109065 793 dbSNP
rs1229870019 820 dbSNP
rs3179240 828 dbSNP
rs1344941429 830 dbSNP
rs138813375 833 dbSNP
rs1231919151 835 dbSNP
rs980896909 838 dbSNP
rs1033535007 841 dbSNP
rs1051083768 841 dbSNP
rs1369786832 856 dbSNP
rs889746612 857 dbSNP
rs1308561809 874 dbSNP
rs760292011 882 dbSNP
rs1422997233 888 dbSNP
rs1253249404 892 dbSNP
rs564795725 896 dbSNP
rs1477761677 897 dbSNP
rs1378398972 901 dbSNP
rs1186272058 904 dbSNP
rs1201352053 905 dbSNP
rs769044753 906 dbSNP
rs1424639243 908 dbSNP
rs904041099 910 dbSNP
rs1484350464 918 dbSNP
rs776935345 928 dbSNP
rs1371523840 929 dbSNP
rs989384306 931 dbSNP
rs767846240 946 dbSNP
rs1276257981 952 dbSNP
rs186879233 955 dbSNP
rs913803195 981 dbSNP
rs945416876 983 dbSNP
rs1461605724 988 dbSNP
rs1411397919 995 dbSNP
rs1388469405 998 dbSNP
rs1357392833 1015 dbSNP
rs976711258 1015 dbSNP
rs113018093 1016 dbSNP
rs1298808885 1018 dbSNP
rs1413992457 1019 dbSNP
rs1475117373 1024 dbSNP
rs1402922512 1038 dbSNP
rs1000127141 1044 dbSNP
rs140465509 1046 dbSNP
rs1411480795 1047 dbSNP
rs1183403986 1060 dbSNP
rs1050250918 1062 dbSNP
rs888636135 1063 dbSNP
rs562327849 1066 dbSNP
rs1187383537 1067 dbSNP
rs1442497598 1068 dbSNP
rs529322928 1085 dbSNP
rs1280204384 1087 dbSNP
rs960983481 1099 dbSNP
rs191767061 1104 dbSNP
rs1228648836 1105 dbSNP
rs1314477103 1110 dbSNP
rs1376627589 1110 dbSNP
rs993196969 1114 dbSNP
rs1023984087 1116 dbSNP
rs1342180902 1128 dbSNP
rs969682293 1131 dbSNP
rs1338839265 1132 dbSNP
rs183546409 1134 dbSNP
rs1274654898 1137 dbSNP
rs1388218169 1139 dbSNP
rs909646702 1145 dbSNP
rs1411986736 1148 dbSNP
rs962477078 1150 dbSNP
rs560914677 1154 dbSNP
rs973009153 1156 dbSNP
rs533201309 1158 dbSNP
rs957889419 1176 dbSNP
rs1209305018 1183 dbSNP
rs1248276194 1185 dbSNP
rs918415580 1189 dbSNP
rs552033195 1196 dbSNP
rs1210134642 1203 dbSNP
rs1319550380 1203 dbSNP
rs570449470 1209 dbSNP
rs1010689093 1213 dbSNP
rs143825608 1219 dbSNP
rs1020860574 1220 dbSNP
rs1183962068 1222 dbSNP
rs1259985901 1226 dbSNP
rs1428084652 1246 dbSNP
rs1364471857 1251 dbSNP
rs1321472174 1252 dbSNP
rs765597068 1254 dbSNP
rs1392061525 1264 dbSNP
rs1431572905 1266 dbSNP
rs977033944 1271 dbSNP
rs922648634 1278 dbSNP
rs954156235 1278 dbSNP
rs148175263 1286 dbSNP
rs985593491 1287 dbSNP
rs73592873 1291 dbSNP
rs941548505 1294 dbSNP
rs1448566054 1296 dbSNP
rs1037195767 1298 dbSNP
rs543560490 1303 dbSNP
rs1359444557 1309 dbSNP
rs114048794 1310 dbSNP
rs1222068573 1311 dbSNP
rs1490764908 1321 dbSNP
rs950283397 1327 dbSNP
rs903965230 1329 dbSNP
rs1046375629 1336 dbSNP
rs1297733442 1337 dbSNP
rs906226034 1345 dbSNP
rs553876525 1347 dbSNP
rs750938313 1349 dbSNP
rs1343740033 1351 dbSNP
rs1298492640 1355 dbSNP
rs1231401339 1362 dbSNP
rs1216377466 1363 dbSNP
rs750546421 1373 dbSNP
rs999609028 1376 dbSNP
rs1293113850 1378 dbSNP
rs1313285471 1384 dbSNP
rs1437649163 1387 dbSNP
rs1367776952 1388 dbSNP
rs762991291 1392 dbSNP
rs1052644800 1397 dbSNP
rs1054921137 1401 dbSNP
rs199562567 1403 dbSNP
rs561604217 1405 dbSNP
rs1371692487 1406 dbSNP
rs188281012 1407 dbSNP
rs198978 1409 dbSNP
rs1013857179 1415 dbSNP
rs1191355079 1415 dbSNP
rs557801818 1419 dbSNP
rs751761070 1422 dbSNP
rs866740128 1429 dbSNP
rs1483367296 1431 dbSNP
rs1010575952 1436 dbSNP
rs1206746341 1440 dbSNP
rs576780491 1446 dbSNP
rs169178 1447 dbSNP
rs562100086 1448 dbSNP
rs998127867 1449 dbSNP
rs1424443681 1453 dbSNP
rs1029982974 1462 dbSNP
rs1286899221 1465 dbSNP
rs1409568745 1466 dbSNP
rs1351679901 1468 dbSNP
rs1300365979 1483 dbSNP
rs193241860 1486 dbSNP
rs1177971206 1491 dbSNP
rs1358003482 1496 dbSNP
rs1176145987 1504 dbSNP
rs541164669 1505 dbSNP
rs918428891 1507 dbSNP
rs1456398467 1511 dbSNP
rs1181232793 1518 dbSNP
rs955180843 1519 dbSNP
rs113437337 1522 dbSNP
rs80050017 1537 dbSNP
rs75200917 1538 dbSNP
rs569514251 1539 dbSNP
rs1368926425 1541 dbSNP
rs538440697 1543 dbSNP
rs1221400653 1546 dbSNP
rs1204363138 1549 dbSNP
rs1282627616 1549 dbSNP
rs925306467 1550 dbSNP
rs1325974197 1556 dbSNP
rs1266429291 1558 dbSNP
rs1318123840 1561 dbSNP
rs918778418 1564 dbSNP
rs1336665969 1566 dbSNP
rs950249871 1573 dbSNP
rs1209712835 1576 dbSNP
rs1394868713 1579 dbSNP
rs1046003707 1582 dbSNP
rs1302967584 1583 dbSNP
rs1270322802 1592 dbSNP
rs927531829 1602 dbSNP
rs1157888230 1631 dbSNP
rs1457580194 1634 dbSNP
rs937726846 1636 dbSNP
rs1055206200 1641 dbSNP
rs1325409208 1646 dbSNP
rs1256734872 1650 dbSNP
rs1184324262 1654 dbSNP
rs190661015 1660 dbSNP
rs1246438066 1663 dbSNP
rs1208270490 1665 dbSNP
rs1052489202 1668 dbSNP
rs896673208 1676 dbSNP
rs1262924534 1681 dbSNP
rs1247294794 1683 dbSNP
rs1010628455 1685 dbSNP
rs1042093294 1686 dbSNP
rs187930 1687 dbSNP
rs1192800114 1689 dbSNP
rs1405661917 1691 dbSNP
rs1045243846 1699 dbSNP
rs1159613197 1702 dbSNP
rs1390403915 1706 dbSNP
rs1291612539 1723 dbSNP
rs1029619272 1727 dbSNP
rs879304472 1730 dbSNP
rs1006776866 1731 dbSNP
rs1165329693 1740 dbSNP
rs1322344404 1743 dbSNP
rs1016951087 1747 dbSNP
rs568156313 1750 dbSNP
rs571872462 1754 dbSNP
rs962681259 1755 dbSNP
rs529111756 1758 dbSNP
rs547158039 1762 dbSNP
rs114688296 1763 dbSNP
rs142002082 1770 dbSNP
rs962371208 1775 dbSNP
rs971626310 1776 dbSNP
rs1340645905 1778 dbSNP
rs1332965124 1787 dbSNP
rs557738502 1793 dbSNP
rs1327862237 1805 dbSNP
rs982006986 1808 dbSNP
rs1386020817 1810 dbSNP
rs569678370 1821 dbSNP
rs1304724625 1823 dbSNP
rs1427803098 1827 dbSNP
rs115119431 1830 dbSNP
rs1167447648 1832 dbSNP
rs955109552 1836 dbSNP
rs1475757297 1838 dbSNP
rs1453448545 1846 dbSNP
rs986627752 1854 dbSNP
rs1196947967 1855 dbSNP
rs1018099619 1858 dbSNP
rs563158115 1859 dbSNP
rs1482384373 1873 dbSNP
rs1274502565 1874 dbSNP
rs914921105 1896 dbSNP
rs556071429 1901 dbSNP
rs964345538 1902 dbSNP
rs979335312 1907 dbSNP
rs771525123 1913 dbSNP
rs181510070 1914 dbSNP
rs1414025531 1918 dbSNP
rs1407728847 1921 dbSNP
rs1329396453 1924 dbSNP
rs933873510 1924 dbSNP
rs1051381124 1926 dbSNP
rs1398817574 1928 dbSNP
rs889590845 1929 dbSNP
rs1469529472 1932 dbSNP
rs988120779 1935 dbSNP
rs866058714 1936 dbSNP
rs949438951 1937 dbSNP
rs1410910125 1938 dbSNP
rs1183080358 1940 dbSNP
rs530604832 1941 dbSNP
rs905318779 1943 dbSNP
rs1353903419 1944 dbSNP
rs942282188 1947 dbSNP
rs1199365939 1948 dbSNP
rs553168056 1949 dbSNP
rs1244490590 1950 dbSNP
rs1285075312 1958 dbSNP
rs1037929953 1964 dbSNP
rs1212892840 1965 dbSNP
rs746690449 1966 dbSNP
rs993820465 1979 dbSNP
rs1272294823 1982 dbSNP
rs985581859 1984 dbSNP
rs577689903 1987 dbSNP
rs553680159 1997 dbSNP
rs1444365975 1999 dbSNP
rs1205721173 2001 dbSNP
rs890910703 2003 dbSNP
rs1007929774 2007 dbSNP
rs1407142285 2018 dbSNP
rs768240929 2021 dbSNP
rs776984310 2025 dbSNP
rs762234160 2028 dbSNP
rs573409017 2029 dbSNP
rs1455979671 2035 dbSNP
rs529689254 2044 dbSNP
rs1407797405 2049 dbSNP
rs1159495163 2053 dbSNP
rs1471469854 2057 dbSNP
rs958872301 2066 dbSNP
rs879110147 2069 dbSNP
rs1461334134 2070 dbSNP
rs963879530 2081 dbSNP
rs979775561 2099 dbSNP
rs1464153417 2101 dbSNP
rs946424565 2103 dbSNP
rs1225232803 2106 dbSNP
rs1165657147 2111 dbSNP
rs1283477355 2115 dbSNP
rs550276969 2118 dbSNP
rs1383534284 2146 dbSNP
rs923598714 2151 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000358049.4 | 3UTR | GAGCAGGAGGACGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000358049.4 | 3UTR | GAGCAGGAGGACGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000358049.4 | 3UTR | GAGCAGGAGGACGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000358049.4 | 3UTR | GAGCAGGAGGACGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000358049.4 | 3UTR | GAGCAGGAGGACGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000358049.4 | 3UTR | GAGCAGGAGGACGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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