pre-miRNA Information
pre-miRNA hsa-mir-6511b-1   
Genomic Coordinates chr16: 2106669 - 2106753
Description Homo sapiens miR-6511b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511b-2   
Genomic Coordinates chr16: 15134075 - 15134145
Description Homo sapiens miR-6511b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6511b-3p
Sequence 53| CCUCACCACCCCUUCUGCCUGCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
993639 5 ClinVar
1196654 15 ClinVar
256998 15 ClinVar
433980 16 ClinVar
586295 18 ClinVar
433979 19 ClinVar
COSM3948368 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs769351879 1 dbSNP
rs1001283562 2 dbSNP
rs763611191 3 dbSNP
rs1465530682 4 dbSNP
rs1227492873 4 dbSNP
rs745502224 5 dbSNP
rs551972801 6 dbSNP
rs538162642 6 dbSNP
rs751438298 7 dbSNP
rs1285683081 7 dbSNP
rs1340898267 8 dbSNP
rs4018164 9 dbSNP
rs370568831 9 dbSNP
rs1180919709 10 dbSNP
rs1339482497 10 dbSNP
rs758216756 11 dbSNP
rs1323026290 11 dbSNP
rs1239445091 12 dbSNP
rs1310601001 12 dbSNP
rs1431093969 13 dbSNP
rs752690118 15 dbSNP
rs1371790714 15 dbSNP
rs746463189 16 dbSNP
rs1209415208 17 dbSNP
rs761022804 17 dbSNP
rs1242038386 17 dbSNP
rs370411414 18 dbSNP
rs759723934 19 dbSNP
rs1428318191 19 dbSNP
rs1416441031 20 dbSNP
rs754040914 21 dbSNP
rs776062795 21 dbSNP
rs1273686335 22 dbSNP
rs1182772456 22 dbSNP
rs1472619959 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GGT7   
Synonyms D20S101, GGT4, GGTL3, GGTL5
Description gamma-glutamyltransferase 7
Transcript NM_178026   
Expression
Putative miRNA Targets on GGT7
3'UTR of GGT7
(miRNA target sites are highlighted)
>GGT7|NM_178026|3'UTR
   1 AGCAGCGGGGTGGGGCGGGGTCTCTGCTCCCCCACTTTGCATGTTCCCAGAGTCCCTCCTTCTCCCAGGTTTGGTCTCAG
  81 GGGGACCCCAGGGATGCCCCAGATCAGGGGCCAGAGGGGATGCTTAGCAAACCCAATCCCAGAGTAACTGGAAAATTCTC
 161 CATCAGGAGGCCTGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGGTGAGTGTCAGCATCTACAGTACAGCCA
 241 GGCAGGCAGGACCTTGAGGAATCAGACTATCTGTCTGTGTGTCACCTCTCCTCCTTCAGCCATGCTGGCCCCGAGCTTAG
 321 GGATGTGCTTGCAAACCCTTCTCAAGGGTCTCACAACCCCAACATCTTCAGACTGGCCTGACCTGGGCCTTGTCTTCCAG
 401 TTCCTTTCTCCCATTCCCAGCCTCATTTCTTAAATGACTAGGAATTTTTTAATGGACCATCATAGGGAGGGGGTGCTCCT
 481 CTTTTCCCACCAGGTTGAGGTGGGGGCCTTGCATCGGGGGTCCCCAGGGTATGGGGTAGGGGTGGGGGTGGGCACCAGCT
 561 CAGGGGCTTCCATTTGCAAAGGGAAATTAAAGAAAGAATGTTGCTTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acguCCGUCUUCCCCACCACUCc 5'
              ||::| :| ||||||||| 
Target 5' tggtGGTGGTGGTGGTGGTGAGt 3'
196 - 218 167.00 -23.30
2
miRNA  3' acguCCGUCUUCCCCACCACUcc 5'
              ||::| :| |||||||:  
Target 5' ctgtGGTGGTGGTGGTGGTGGtg 3'
172 - 194 131.00 -21.70
3
miRNA  3' acgUCCGUCUUCCCCACCACUCc 5'
             :||:||::| || ||||:| 
Target 5' atgGGGTAGGGGTGGGGGTGGGc 3'
531 - 553 128.00 -27.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26566532 16 COSMIC
COSN30117323 16 COSMIC
COSN21487795 33 COSMIC
COSN30460897 55 COSMIC
COSN21800418 111 COSMIC
COSN27249508 173 COSMIC
COSN27269593 173 COSMIC
COSN26632763 177 COSMIC
COSN26558131 180 COSMIC
COSN26559367 183 COSMIC
COSN26505083 186 COSMIC
COSN31490305 297 COSMIC
COSN31519042 313 COSMIC
COSN31530284 444 COSMIC
COSN25334612 526 COSMIC
COSN31519039 553 COSMIC
COSN7089846 593 COSMIC
COSN31484491 596 COSMIC
COSN31490828 596 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1346173281 3 dbSNP
rs762022378 6 dbSNP
rs763908318 7 dbSNP
rs1407761075 9 dbSNP
rs1174606440 12 dbSNP
rs1455321142 15 dbSNP
rs367598879 16 dbSNP
rs764689585 17 dbSNP
rs763595297 21 dbSNP
rs376226679 24 dbSNP
rs776258537 26 dbSNP
rs1035391864 27 dbSNP
rs1316227399 28 dbSNP
rs770296764 29 dbSNP
rs760261764 30 dbSNP
rs76569361 33 dbSNP
rs554686403 34 dbSNP
rs778746783 35 dbSNP
rs1362806605 37 dbSNP
rs768554178 41 dbSNP
rs749275473 46 dbSNP
rs1360387096 49 dbSNP
rs1012709917 53 dbSNP
rs1343217569 62 dbSNP
rs1025576704 64 dbSNP
rs1206639717 70 dbSNP
rs560541041 81 dbSNP
rs995800120 81 dbSNP
rs1276798056 84 dbSNP
rs1232190654 98 dbSNP
rs994123048 99 dbSNP
rs897191972 105 dbSNP
rs1420715761 108 dbSNP
rs898399094 112 dbSNP
rs11546156 116 dbSNP
rs1471787678 119 dbSNP
rs1302615473 136 dbSNP
rs564344297 139 dbSNP
rs1036219300 160 dbSNP
rs1290328211 166 dbSNP
rs1006112777 170 dbSNP
rs1298033404 173 dbSNP
rs1413674913 173 dbSNP
rs1429982285 175 dbSNP
rs1040132412 186 dbSNP
rs1357307787 194 dbSNP
rs1372037384 197 dbSNP
rs1006893681 204 dbSNP
rs1317680628 204 dbSNP
rs931846173 210 dbSNP
rs1254528958 213 dbSNP
rs1378081906 213 dbSNP
rs1200883920 214 dbSNP
rs1211714158 216 dbSNP
rs1260181892 216 dbSNP
rs1409162007 216 dbSNP
rs143837915 216 dbSNP
rs1485373872 216 dbSNP
rs369783775 216 dbSNP
rs79530197 216 dbSNP
rs878960520 216 dbSNP
rs878968321 216 dbSNP
rs923036883 216 dbSNP
rs775512227 218 dbSNP
rs1340206968 226 dbSNP
rs934963913 227 dbSNP
rs1051146903 237 dbSNP
rs1234004883 237 dbSNP
rs923618505 250 dbSNP
rs879087471 251 dbSNP
rs1189860021 258 dbSNP
rs935489734 259 dbSNP
rs1182652411 267 dbSNP
rs866630713 269 dbSNP
rs1173653047 275 dbSNP
rs1396347412 279 dbSNP
rs1043997975 283 dbSNP
rs1407778982 286 dbSNP
rs1169631552 291 dbSNP
rs1208761361 297 dbSNP
rs866220442 299 dbSNP
rs968295510 301 dbSNP
rs1370457875 302 dbSNP
rs1344373487 304 dbSNP
rs946990009 312 dbSNP
rs765706136 313 dbSNP
rs1305988616 319 dbSNP
rs1363083954 321 dbSNP
rs1236065463 323 dbSNP
rs991594743 327 dbSNP
rs1315722911 328 dbSNP
rs1288053594 330 dbSNP
rs1410832983 338 dbSNP
rs1219733140 343 dbSNP
rs546061490 345 dbSNP
rs1351905159 346 dbSNP
rs1310717142 352 dbSNP
rs555539696 354 dbSNP
rs1193872337 358 dbSNP
rs928389114 362 dbSNP
rs961197887 374 dbSNP
rs981131488 393 dbSNP
rs1185463267 397 dbSNP
rs1173884431 399 dbSNP
rs1411604499 410 dbSNP
rs556526128 421 dbSNP
rs1393456952 422 dbSNP
rs1451470605 430 dbSNP
rs1461806997 432 dbSNP
rs951230018 437 dbSNP
rs1328141111 440 dbSNP
rs1343672865 447 dbSNP
rs866016177 452 dbSNP
rs1430054320 455 dbSNP
rs994237240 458 dbSNP
rs1159577969 461 dbSNP
rs1364628282 463 dbSNP
rs1231985605 464 dbSNP
rs1293283422 468 dbSNP
rs753315200 475 dbSNP
rs1025927030 478 dbSNP
rs1274621588 491 dbSNP
rs1444929678 492 dbSNP
rs1016903425 495 dbSNP
rs1242184384 498 dbSNP
rs1476149144 501 dbSNP
rs765844314 504 dbSNP
rs1417145484 505 dbSNP
rs867311033 513 dbSNP
rs1382975433 515 dbSNP
rs1400350931 516 dbSNP
rs1050806837 520 dbSNP
rs1347035261 521 dbSNP
rs1413053698 526 dbSNP
rs760330622 528 dbSNP
rs1202260098 531 dbSNP
rs879764104 532 dbSNP
rs1268084764 537 dbSNP
rs879580733 538 dbSNP
rs1278160856 540 dbSNP
rs1350482367 542 dbSNP
rs1331635262 543 dbSNP
rs1291863250 544 dbSNP
rs973914520 547 dbSNP
rs901695887 548 dbSNP
rs1448202826 549 dbSNP
rs535464086 551 dbSNP
rs574447358 552 dbSNP
rs1018183174 553 dbSNP
rs1006905136 555 dbSNP
rs1335546280 562 dbSNP
rs1380062835 564 dbSNP
rs1485958686 566 dbSNP
rs891093002 572 dbSNP
rs1387757425 579 dbSNP
rs1189727428 599 dbSNP
rs1029772334 604 dbSNP
rs935080203 607 dbSNP
rs999583378 609 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Liver Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2550620. RNA binding protein: AGO2. Condition:Patient 2 Tumor 1 ...

- Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al., 2017, Molecular cell.

Article - Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al.
- Molecular cell, 2017
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. We observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites. Motif analysis of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs. A large number of miR-122 targets were found to be species specific. Upregulation of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients. These results broadly define the molecular consequences of miR-122 downregulation in hepatocellular carcinoma.
LinkOut: [PMID: 28735896]
CLIP-seq Support 1 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000336431.5 | 3UTR | CUGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000336431.5 | 3UTR | CUGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000336431.5 | 3UTR | GUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000336431.5 | 3UTR | CCUGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000336431.5 | 3UTR | CUGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000336431.5 | 3UTR | UGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGUGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-6511b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059269 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061287 IPO7 importin 7 2 2
MIRT115533 MAZ MYC associated zinc finger protein 2 2
MIRT345986 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT379536 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT442491 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 2 8
MIRT443701 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT459167 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT497179 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT497846 GATA6 GATA binding protein 6 2 4
MIRT519625 ZNF781 zinc finger protein 781 2 2
MIRT519838 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT528560 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT530718 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530810 GPR182 G protein-coupled receptor 182 2 2
MIRT533265 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533726 TMEM246 transmembrane protein 246 2 2
MIRT535547 P2RY2 purinergic receptor P2Y2 2 2
MIRT536019 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539494 ACTN4 actinin alpha 4 2 2
MIRT541793 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 8
MIRT554509 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT558784 CEP55 centrosomal protein 55 2 2
MIRT560013 ZNF525 zinc finger protein 525 2 2
MIRT560078 ZNF195 zinc finger protein 195 2 2
MIRT570135 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570890 ZNF780A zinc finger protein 780A 2 2
MIRT607972 SNX22 sorting nexin 22 2 2
MIRT608104 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT610471 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 2 4
MIRT611134 GGT7 gamma-glutamyltransferase 7 2 2
MIRT611448 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT613019 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT615753 C6 complement C6 2 2
MIRT620464 CERS6 ceramide synthase 6 2 2
MIRT632248 VPS41 VPS41, HOPS complex subunit 2 2
MIRT636099 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637452 ZNF324B zinc finger protein 324B 2 2
MIRT638927 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT646768 WDR3 WD repeat domain 3 2 2
MIRT652610 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT652868 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT653655 SLC27A4 solute carrier family 27 member 4 2 2
MIRT657089 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657884 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT662919 MED18 mediator complex subunit 18 2 2
MIRT685622 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687427 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692304 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT695127 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695144 PRY PTPN13-like, Y-linked 2 2
MIRT696286 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT699350 SLC35E1 solute carrier family 35 member E1 2 2
MIRT709901 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT710877 SLC25A42 solute carrier family 25 member 42 2 2
MIRT711365 MED7 mediator complex subunit 7 2 2
MIRT711444 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT713221 RCAN2 regulator of calcineurin 2 2 2
MIRT713281 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT714195 TRAF7 TNF receptor associated factor 7 2 2
MIRT715152 IL12B interleukin 12B 2 2
MIRT719197 CASP10 caspase 10 2 2
MIRT719469 SRF serum response factor 2 2
MIRT720197 MPP6 membrane palmitoylated protein 6 2 2
MIRT720449 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720461 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721646 ZNF207 zinc finger protein 207 2 2
MIRT722001 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT725521 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6511b-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-6511b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6511b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6511b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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